JP2019523241A5 - - Google Patents
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- JP2019523241A5 JP2019523241A5 JP2018568837A JP2018568837A JP2019523241A5 JP 2019523241 A5 JP2019523241 A5 JP 2019523241A5 JP 2018568837 A JP2018568837 A JP 2018568837A JP 2018568837 A JP2018568837 A JP 2018568837A JP 2019523241 A5 JP2019523241 A5 JP 2019523241A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- och
- fluoroalkyl
- hydroxyalkyl
- cyanoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 57
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 56
- -1 2 - cyclopropyl Chemical group 0.000 claims 56
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 31
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 22
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000003386 piperidinyl group Chemical group 0.000 claims 16
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 16
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 15
- 125000002757 morpholinyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000003566 oxetanyl group Chemical group 0.000 claims 11
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000002393 azetidinyl group Chemical group 0.000 claims 9
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 9
- 125000002883 imidazolyl group Chemical group 0.000 claims 8
- 125000004193 piperazinyl group Chemical group 0.000 claims 8
- 125000003226 pyrazolyl group Chemical group 0.000 claims 8
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 8
- 125000000335 thiazolyl group Chemical group 0.000 claims 8
- 125000001425 triazolyl group Chemical group 0.000 claims 8
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 6
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 6
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000000168 pyrrolyl group Chemical group 0.000 claims 5
- 125000003831 tetrazolyl group Chemical group 0.000 claims 5
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004965 chloroalkyl group Chemical group 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 150000004867 thiadiazoles Chemical class 0.000 claims 3
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000003725 azepanyl group Chemical group 0.000 claims 2
- 125000004799 bromophenyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000005959 diazepanyl group Chemical group 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000006431 methyl cyclopropyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201611022328 | 2016-06-29 | ||
| IN201611022328 | 2016-06-29 | ||
| US15/635,055 | 2017-06-27 | ||
| US15/635,055 US10071079B2 (en) | 2016-06-29 | 2017-06-27 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| PCT/US2017/039633 WO2018005586A1 (en) | 2016-06-29 | 2017-06-28 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019523241A JP2019523241A (ja) | 2019-08-22 |
| JP2019523241A5 true JP2019523241A5 (https=) | 2020-08-06 |
| JP6995067B2 JP6995067B2 (ja) | 2022-01-14 |
| JP6995067B6 JP6995067B6 (ja) | 2023-12-14 |
Family
ID=60805851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568837A Active JP6995067B6 (ja) | 2016-06-29 | 2017-06-28 | ［１，２，４］トリアゾロ［１，５－ａ］ピリジニル置換インドール化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US10071079B2 (https=) |
| EP (1) | EP3478682B1 (https=) |
| JP (1) | JP6995067B6 (https=) |
| KR (1) | KR102473482B1 (https=) |
| CN (1) | CN109641895B (https=) |
| AR (1) | AR108905A1 (https=) |
| AU (1) | AU2017287902B2 (https=) |
| CL (1) | CL2018003821A1 (https=) |
| CO (1) | CO2019000686A2 (https=) |
| CY (1) | CY1124514T1 (https=) |
| DK (1) | DK3478682T3 (https=) |
| EA (1) | EA037530B1 (https=) |
| ES (1) | ES2886964T3 (https=) |
| HR (1) | HRP20211261T8 (https=) |
| HU (1) | HUE056091T2 (https=) |
| IL (1) | IL263961B (https=) |
| LT (1) | LT3478682T (https=) |
| MX (1) | MX376212B (https=) |
| MY (1) | MY196474A (https=) |
| PE (1) | PE20190324A1 (https=) |
| PL (1) | PL3478682T3 (https=) |
| PT (1) | PT3478682T (https=) |
| RS (1) | RS62292B1 (https=) |
| SG (1) | SG11201811590RA (https=) |
| SI (1) | SI3478682T1 (https=) |
| SM (1) | SMT202100513T1 (https=) |
| TW (1) | TWI636053B (https=) |
| UY (1) | UY37310A (https=) |
| WO (1) | WO2018005586A1 (https=) |
| ZA (1) | ZA201900571B (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
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| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| CN110997656B (zh) | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
| ES2921020T3 (es) * | 2017-08-04 | 2022-08-16 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con [1,2,4]triazolo[4,3-a]piridinilo |
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