AR123281A1 - Compuestos bicíclicos sustituidos útiles como inhibidores de tlr9 - Google Patents
Compuestos bicíclicos sustituidos útiles como inhibidores de tlr9Info
- Publication number
- AR123281A1 AR123281A1 ARP210102325A ARP210102325A AR123281A1 AR 123281 A1 AR123281 A1 AR 123281A1 AR P210102325 A ARP210102325 A AR P210102325A AR P210102325 A ARP210102325 A AR P210102325A AR 123281 A1 AR123281 A1 AR 123281A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds useful
- substituted bicyclic
- bicyclic compounds
- tlr9 inhibitors
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 title abstract 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen compuestos de la fórmula (1), o una sal o profármaco del mismo, en donde X, G, Q¹, Q², R⁵, R⁵ᵃ, y R⁵ᵇ se definen aquí. También se describen métodos para usar tales compuestos como inhibidores de TLR9 y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles para tratar, prevenir o retardar enfermedades fibróticas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063067452P | 2020-08-19 | 2020-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123281A1 true AR123281A1 (es) | 2022-11-16 |
Family
ID=77693624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102325A AR123281A1 (es) | 2020-08-19 | 2021-08-18 | Compuestos bicíclicos sustituidos útiles como inhibidores de tlr9 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20240067638A1 (es) |
EP (1) | EP4200297A1 (es) |
JP (1) | JP2023538393A (es) |
KR (1) | KR20230053644A (es) |
CN (1) | CN116096717A (es) |
AR (1) | AR123281A1 (es) |
AU (1) | AU2021328575A1 (es) |
BR (1) | BR112023002737A2 (es) |
CA (1) | CA3190065A1 (es) |
IL (1) | IL300727A (es) |
MX (1) | MX2023001885A (es) |
TW (1) | TW202227432A (es) |
WO (1) | WO2022040259A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
TW202342016A (zh) * | 2022-02-18 | 2023-11-01 | 美商必治妥美雅史谷比公司 | 用作tlr9抑制劑之經取代雙環雜芳基化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017058503A1 (en) * | 2015-09-29 | 2017-04-06 | Oncotherapy Science, Inc. | Bicyclic compound and use thereof for inhibiting suv39h2 |
US11370794B2 (en) * | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
WO2018165112A1 (en) * | 2017-03-09 | 2018-09-13 | Oncotherapy Science, Inc. | Bicyclic compound and use thereof for inhibiting histone methyltransferase |
CN114981276A (zh) * | 2020-01-09 | 2022-08-30 | 住友化学株式会社 | 杂环化合物和含有其的有害节肢动物防除组合物 |
-
2021
- 2021-08-18 CN CN202180055737.1A patent/CN116096717A/zh active Pending
- 2021-08-18 KR KR1020237009016A patent/KR20230053644A/ko unknown
- 2021-08-18 EP EP21766786.4A patent/EP4200297A1/en active Pending
- 2021-08-18 US US18/042,036 patent/US20240067638A1/en active Pending
- 2021-08-18 MX MX2023001885A patent/MX2023001885A/es unknown
- 2021-08-18 BR BR112023002737A patent/BR112023002737A2/pt unknown
- 2021-08-18 JP JP2023512226A patent/JP2023538393A/ja active Pending
- 2021-08-18 TW TW110130427A patent/TW202227432A/zh unknown
- 2021-08-18 AU AU2021328575A patent/AU2021328575A1/en active Pending
- 2021-08-18 WO PCT/US2021/046420 patent/WO2022040259A1/en active Application Filing
- 2021-08-18 AR ARP210102325A patent/AR123281A1/es unknown
- 2021-08-18 CA CA3190065A patent/CA3190065A1/en active Pending
- 2021-08-18 IL IL300727A patent/IL300727A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2023001885A (es) | 2023-03-10 |
IL300727A (en) | 2023-04-01 |
BR112023002737A2 (pt) | 2023-03-14 |
US20240067638A1 (en) | 2024-02-29 |
WO2022040259A1 (en) | 2022-02-24 |
TW202227432A (zh) | 2022-07-16 |
CA3190065A1 (en) | 2022-02-24 |
KR20230053644A (ko) | 2023-04-21 |
CN116096717A (zh) | 2023-05-09 |
EP4200297A1 (en) | 2023-06-28 |
AU2021328575A1 (en) | 2023-03-16 |
JP2023538393A (ja) | 2023-09-07 |
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