AR123285A1 - Compuestos heteroarílicos sustituidos útiles como inhibidores de tlr9 - Google Patents
Compuestos heteroarílicos sustituidos útiles como inhibidores de tlr9Info
- Publication number
- AR123285A1 AR123285A1 ARP210102329A ARP210102329A AR123285A1 AR 123285 A1 AR123285 A1 AR 123285A1 AR P210102329 A ARP210102329 A AR P210102329A AR P210102329 A ARP210102329 A AR P210102329A AR 123285 A1 AR123285 A1 AR 123285A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted heteroaryl
- compounds useful
- heteroaryl compounds
- tlr9 inhibitors
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 title abstract 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen compuestos de la fórmula (1) o una sal o profármaco del mismo, en donde X, Y, Q¹, Q², R¹, y R⁵ se definen en el presente documento. También se describen métodos para usar tales compuestos como inhibidores de TLR9 y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles para tratar, prevenir o retardar enfermedades fibróticas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063067465P | 2020-08-19 | 2020-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123285A1 true AR123285A1 (es) | 2022-11-16 |
Family
ID=77711459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102329A AR123285A1 (es) | 2020-08-19 | 2021-08-18 | Compuestos heteroarílicos sustituidos útiles como inhibidores de tlr9 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230312565A1 (es) |
EP (1) | EP4200298A1 (es) |
JP (1) | JP2023538608A (es) |
KR (1) | KR20230053646A (es) |
CN (1) | CN115867549A (es) |
AR (1) | AR123285A1 (es) |
AU (1) | AU2021328577A1 (es) |
BR (1) | BR112023002646A2 (es) |
CA (1) | CA3189826A1 (es) |
IL (1) | IL300643A (es) |
MX (1) | MX2023001929A (es) |
TW (1) | TW202214233A (es) |
WO (1) | WO2022040267A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
WO2023159154A1 (en) * | 2022-02-18 | 2023-08-24 | Bristol-Myers Squibb Company | Substituted imidazopyridinyl compounds useful as inhibitors of tlr9 |
WO2024102884A1 (en) * | 2022-11-10 | 2024-05-16 | Bristol-Myers Squibb Company | Substituted quinolone compounds useful as inhibitors of tlr9 |
WO2024102886A1 (en) * | 2022-11-10 | 2024-05-16 | Bristol-Myers Squibb Company | Substituted benzimidazole compounds useful as inhibitors of tlr9 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016540013A (ja) * | 2013-12-13 | 2016-12-22 | 武田薬品工業株式会社 | Tlr阻害剤としてのピロロ[3,2−c]ピリジン誘導体 |
US11370794B2 (en) * | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
WO2019126082A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
-
2021
- 2021-08-18 TW TW110130428A patent/TW202214233A/zh unknown
- 2021-08-18 JP JP2023512162A patent/JP2023538608A/ja active Pending
- 2021-08-18 BR BR112023002646A patent/BR112023002646A2/pt unknown
- 2021-08-18 EP EP21769261.5A patent/EP4200298A1/en active Pending
- 2021-08-18 KR KR1020237009022A patent/KR20230053646A/ko unknown
- 2021-08-18 CA CA3189826A patent/CA3189826A1/en active Pending
- 2021-08-18 MX MX2023001929A patent/MX2023001929A/es unknown
- 2021-08-18 AR ARP210102329A patent/AR123285A1/es unknown
- 2021-08-18 IL IL300643A patent/IL300643A/en unknown
- 2021-08-18 US US18/042,069 patent/US20230312565A1/en active Pending
- 2021-08-18 AU AU2021328577A patent/AU2021328577A1/en active Pending
- 2021-08-18 CN CN202180050340.3A patent/CN115867549A/zh active Pending
- 2021-08-18 WO PCT/US2021/046434 patent/WO2022040267A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023538608A (ja) | 2023-09-08 |
WO2022040267A1 (en) | 2022-02-24 |
TW202214233A (zh) | 2022-04-16 |
EP4200298A1 (en) | 2023-06-28 |
CA3189826A1 (en) | 2022-02-24 |
KR20230053646A (ko) | 2023-04-21 |
IL300643A (en) | 2023-04-01 |
MX2023001929A (es) | 2023-03-09 |
CN115867549A (zh) | 2023-03-28 |
BR112023002646A2 (pt) | 2023-04-04 |
US20230312565A1 (en) | 2023-10-05 |
AU2021328577A1 (en) | 2023-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR123284A1 (es) | Compuestos heteroarílicos sustituidos útiles como inhibidores de tlr9 | |
AR123285A1 (es) | Compuestos heteroarílicos sustituidos útiles como inhibidores de tlr9 | |
ECSP20069418A (es) | Compuestos heterocíclicos como inmunomoduladores | |
CL2019002204A1 (es) | Compuestos inhibidores del vih. | |
CO2022010460A2 (es) | Compuestos tricíclicos sustituidos | |
CL2020001871A1 (es) | Dihidrobenzofurano e inden analogos como inhibidores de sarcómero cardíaco. | |
BR112022025037A2 (pt) | Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus | |
PE20181045A1 (es) | Compuestos utiles como inmunomoduladores | |
CL2017002207A1 (es) | Inhibidores del factor beta de crecimiento de transformación (tgf-beta) | |
CO2022002804A2 (es) | Piperidinil-metil-purinaminas como inhibidores de nsd2 y antineoplásicos | |
AR116283A1 (es) | Inhibidores del sarcómero cardíaco | |
AR123281A1 (es) | Compuestos bicíclicos sustituidos útiles como inhibidores de tlr9 | |
CL2020001752A1 (es) | Derivado de oxi-fluoropiperidina como inhibidor de quinasa. | |
CL2021001461A1 (es) | Moduladores de trex1 | |
DOP2021000077A (es) | Derivados de quinolina como inhibidores de la integrina alfa4beta7 | |
BR112018069147A2 (pt) | composto da fórmula iii, composição farmacêutica, método de inibição da função de fimh e método de tratamento de uma doença mediada por fimh | |
CO2023001668A2 (es) | Derivados de 1h-benzo[d]imidazol como inhibidores de tlr9 para el tratamiento de fibrosis | |
CO2021013749A2 (es) | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelmínticos | |
CO2020005420A2 (es) | Compuestos antibacterianos | |
CO2022012476A2 (es) | Hidrato cristalino de un compuesto inhibidor de jak | |
DOP2021000254A (es) | Compuestos de pirrolidina | |
DOP2019000119A (es) | Moduladores de ROR gamma (RORy) | |
CO2023004420A2 (es) | Compuestos heterocíclicos como inhibidores del bromodominio cbp/ep300 | |
AR126251A1 (es) | Inhibidores de cdk2 | |
CL2021003139A1 (es) | Compuestos tricíclicos |