JP2019520852A5 - - Google Patents
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- JP2019520852A5 JP2019520852A5 JP2019514870A JP2019514870A JP2019520852A5 JP 2019520852 A5 JP2019520852 A5 JP 2019520852A5 JP 2019514870 A JP2019514870 A JP 2019514870A JP 2019514870 A JP2019514870 A JP 2019514870A JP 2019520852 A5 JP2019520852 A5 JP 2019520852A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- release system
- poi
- exosome
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021042290A JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
| JP2024074429A JP2024103494A (ja) | 2016-05-25 | 2024-05-01 | 治療的ポリペプチドを含むエクソソーム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1609216.5 | 2016-05-25 | ||
| GBGB1609216.5A GB201609216D0 (en) | 2016-05-25 | 2016-05-25 | Exosomes comprising therapeutic polypeptides |
| PCT/GB2017/051479 WO2017203260A1 (en) | 2016-05-25 | 2017-05-25 | Exosomes comprising therapeutic polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021042290A Division JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520852A JP2019520852A (ja) | 2019-07-25 |
| JP2019520852A5 true JP2019520852A5 (https=) | 2020-11-12 |
| JP6855567B2 JP6855567B2 (ja) | 2021-04-07 |
Family
ID=56369954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514870A Active JP6855567B2 (ja) | 2016-05-25 | 2017-05-25 | 治療的ポリペプチドを含むエクソソーム |
| JP2021042290A Active JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
| JP2024074429A Pending JP2024103494A (ja) | 2016-05-25 | 2024-05-01 | 治療的ポリペプチドを含むエクソソーム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021042290A Active JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
| JP2024074429A Pending JP2024103494A (ja) | 2016-05-25 | 2024-05-01 | 治療的ポリペプチドを含むエクソソーム |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11534499B2 (https=) |
| EP (3) | EP3782646B1 (https=) |
| JP (3) | JP6855567B2 (https=) |
| KR (1) | KR102253731B1 (https=) |
| CN (2) | CN116103241A (https=) |
| AU (1) | AU2017270932B2 (https=) |
| BR (1) | BR112018074229A2 (https=) |
| CA (1) | CA3024020C (https=) |
| DK (1) | DK3463465T3 (https=) |
| ES (1) | ES2836553T3 (https=) |
| GB (1) | GB201609216D0 (https=) |
| MX (1) | MX378381B (https=) |
| PT (1) | PT3463465T (https=) |
| RU (1) | RU2737732C2 (https=) |
| SG (1) | SG11201810116VA (https=) |
| WO (1) | WO2017203260A1 (https=) |
| ZA (1) | ZA201807945B (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| GB201609216D0 (en) | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| GB2568255A (en) * | 2017-11-08 | 2019-05-15 | Evox Therapeutics Ltd | Exosomes comprising RNA therapeutics |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| US20210115449A1 (en) * | 2018-04-19 | 2021-04-22 | Board Of Regents, The University Of Texas System | Therapeutic modulation of tumor suppressors using exosomes |
| CN108753822A (zh) * | 2018-06-20 | 2018-11-06 | 中国人民解放军第四军医大学 | 递送融合型rna结合蛋白的表达载体及其制备方法和应用 |
| CN108753806A (zh) * | 2018-06-20 | 2018-11-06 | 中国人民解放军第四军医大学 | 增强目标rna装载入外泌体的融合蛋白的表达载体及其构建方法和应用 |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020041725A1 (en) * | 2018-08-24 | 2020-02-27 | University Of Delaware | Extracellular vesicles as biomarkers and therapeutics for neuromuscular disorders |
| CN109293745A (zh) * | 2018-09-04 | 2019-02-01 | 暨南大学 | 一种运载蛋白、重组表达载体、外泌体及制备方法与应用 |
| CN109321596B (zh) * | 2018-09-05 | 2021-12-17 | 暨南大学 | 一种包载蛋白的外泌体的制备方法与应用 |
| CN109234237B (zh) * | 2018-09-30 | 2020-08-07 | 中国人民解放军第四军医大学 | 一种装载ABCA1 mRNA的外泌体及其构建方法和应用 |
| CN113272426A (zh) * | 2018-11-16 | 2021-08-17 | 医福斯治疗有限公司 | 用于尿素循环蛋白和核酸的替代的细胞外囊泡 |
| WO2020106997A1 (en) * | 2018-11-21 | 2020-05-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for reducing age-related striated muscle and cognitive decline |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020152298A1 (en) * | 2019-01-24 | 2020-07-30 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for producing enzymes |
| CA3128386A1 (en) * | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20240108747A1 (en) * | 2019-03-21 | 2024-04-04 | Lonza Sales Ag | Extracellular vesicle conjugates and uses thereof |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20240024220A1 (en) * | 2019-05-11 | 2024-01-25 | Youngsuk Yi | Neurotoxin compositions and methods |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| EP3986429A4 (en) * | 2019-06-21 | 2023-07-19 | Entelexo Biotherapeutics Inc. | PLATFORMS, COMPOSITIONS, AND METHODS OF ADMINISTRATION OF THERAPEUTICS |
| KR102125567B1 (ko) | 2019-07-02 | 2020-06-22 | 한양대학교 에리카산학협력단 | 식물 엑소좀의 대량 생산 방법 |
| US20220354963A1 (en) * | 2019-08-14 | 2022-11-10 | Codiak Biosciences, Inc. | Extracellular vesicle linked to molecules and uses thereof |
| JP7578991B2 (ja) * | 2019-08-28 | 2024-11-07 | 国立研究開発法人理化学研究所 | 細胞膜透過性ベシクル |
| GB201915855D0 (en) * | 2019-10-31 | 2019-12-18 | Univ Oxford Innovation Ltd | An extracellular vesicle |
| CN110954703A (zh) * | 2019-12-27 | 2020-04-03 | 杭州迪相实业有限公司 | 一种同时检测外泌体内蛋白和rna、外泌体膜蛋白的方法 |
| JP2023512562A (ja) | 2020-02-05 | 2023-03-27 | ダイアデム バイオセラピューティクス インコーポレイテッド | 人工シナプス |
| JP7479078B2 (ja) * | 2020-02-10 | 2024-05-08 | 株式会社エキソステムテック | 光切断性タンパク質を含むエクソソーム及びその用途 |
| KR102688170B1 (ko) * | 2020-02-10 | 2024-07-24 | 주식회사 엑소스템텍 | 광 절단성 단백질을 포함하는 엑소좀 및 이의 이용 |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| US12472228B2 (en) | 2020-03-31 | 2025-11-18 | Ilias Biologics Inc. | Use of exosome-based delivery of NF-κB inhibitors |
| KR102852789B1 (ko) * | 2020-03-31 | 2025-09-01 | 주식회사 일리아스바이오로직스 | NF-κB 억제제의 엑소솜 기반 전달의 사용 |
| WO2021223659A1 (en) * | 2020-05-06 | 2021-11-11 | Nanjing Iaso Biotherapeutics Co., Ltd. | Extracellular vesicles targeting cancer cells and uses thereof |
| CN111569077B (zh) * | 2020-05-29 | 2021-10-26 | 南方医科大学 | Flot2抑制剂在抑制破骨细胞形成和/或破骨活性中的应用 |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| RU2766707C1 (ru) * | 2020-11-13 | 2022-03-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М.В.Ломоносова» (МГУ) | Средство для лечения фиброза тканей на основе компонентов секретома мезенхимных стромальных клеток, способ получения и применения средства |
| CN112773775B (zh) * | 2021-01-13 | 2022-12-20 | 广东药科大学 | 一种负载去甲斑蝥素外泌体的制备方法及其应用 |
| WO2022158836A1 (ko) * | 2021-01-21 | 2022-07-28 | 주식회사 엑소코바이오 | 목적 단백질 또는 펩타이드가 융합가능한 Fc 수용체 또는 이의 일부를 포함하는 재조합 엑소좀 및 이의 용도 |
| WO2022214522A2 (en) | 2021-04-07 | 2022-10-13 | Astrazeneca Ab | Compositions and methods for site-specific modification |
| WO2022215078A1 (en) * | 2021-04-07 | 2022-10-13 | Ramot At Tel-Aviv University Ltd. | Modified cannabinoids and uses thereof |
| KR20230175237A (ko) * | 2021-04-22 | 2023-12-29 | 오하이오 스테이트 이노베이션 파운데이션 | 종양 관련 대식세포를 표적화하는 나노캐리어 |
| GB202107182D0 (en) * | 2021-05-19 | 2021-06-30 | Evox Therapeutics Ltd | Nanoparticle delivery system for production of engineered extracellular vesicles |
| EP4357611A4 (en) | 2021-06-16 | 2024-09-25 | NSK Ltd. | Load estimating device for rolling bearing, control device for mechanical device provided with rolling bearing, load estimating method, and program |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| EP4414455A4 (en) | 2021-10-07 | 2026-01-07 | H U Group Res Institute G K | STRUCTURE |
| EP4441074A2 (en) | 2021-12-03 | 2024-10-09 | The Broad Institute, Inc. | Compositions and methods for efficient in vivo delivery |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| CN120303407A (zh) | 2022-05-17 | 2025-07-11 | 恩维洛普治疗有限责任公司 | 用于有效体内递送的组合物和方法 |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| GB202211033D0 (en) * | 2022-07-28 | 2022-09-14 | Glaxosmithkline Biologicals Sa | Purification process |
| US20240050523A1 (en) * | 2022-08-11 | 2024-02-15 | Shiftbio Inc. | Method for inducing resolutive macrophage and uses therof |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| CN116803424B (zh) * | 2023-08-24 | 2023-11-28 | 上海懿贝瑞生物医药科技有限公司 | Slc17a5基因抑制剂及其用途 |
| WO2025058473A1 (ko) * | 2023-09-14 | 2025-03-20 | 주식회사 엑소스템텍 | 퇴행성 뇌질환 치료 단백질을 포함하는 엑소좀을 이용한 뇌 특이적 퇴행성 뇌질환 치료 단백질 전달 기술 |
| KR20250105276A (ko) * | 2023-12-29 | 2025-07-08 | (주)에스엔이바이오 | 신경 펩타이드가 탑재된 세포외소포 및 이의 용도 |
| WO2025172421A1 (en) | 2024-02-14 | 2025-08-21 | Astrazeneca Ab | Compositions and methods for treatment of huntington's disease |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834247A (en) * | 1992-12-09 | 1998-11-10 | New England Biolabs, Inc. | Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein |
| US5935822A (en) | 1995-03-21 | 1999-08-10 | The Regents Of The University Of Colorado | Product and process for membrane and soluble polypeptide segregation |
| GB0112687D0 (en) * | 2001-05-24 | 2001-07-18 | Microbiological Res Authority | Pharmaceutical use of secreted bacterial effector proteins |
| CN101827936B (zh) * | 2007-08-20 | 2014-12-10 | 肿瘤疗法科学股份有限公司 | Cdh3肽以及含有cdh3肽的药剂 |
| US8569244B2 (en) * | 2007-08-20 | 2013-10-29 | Oncotherapy Science, Inc. | FOXM1 peptide and medicinal agent comprising the same |
| EP2127640A1 (en) | 2008-05-27 | 2009-12-02 | Koninklijke Philips Electronics N.V. | Azide modified proteins |
| GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
| CN103205435A (zh) | 2013-04-11 | 2013-07-17 | 浙江大学 | 利用内含肽系统大肠杆菌表达乳铁蛋白改良肽lf-6的方法 |
| CA2910802A1 (en) * | 2013-04-12 | 2014-10-16 | Samir El Andaloussi | Therapeutic delivery vesicles |
| EP3008192B1 (en) * | 2013-06-11 | 2019-07-17 | Takara Bio USA, Inc. | Protein enriched microvesicles and methods of making and using the same |
| WO2015002956A1 (en) | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| WO2015120548A1 (en) | 2014-02-11 | 2015-08-20 | The Governors Of The University Of Alberta | Genetically encoded photocleavable proteins |
| WO2015138878A1 (en) | 2014-03-13 | 2015-09-17 | Research Institute At Nationwide Children's Hospital, Inc. | Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes |
| WO2016077639A2 (en) * | 2014-11-12 | 2016-05-19 | VL27, Inc. | Nanovesicular therapies |
| WO2016178532A1 (ko) | 2015-05-04 | 2016-11-10 | 한국과학기술원 | 목적 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법 |
| KR20160130937A (ko) * | 2015-05-04 | 2016-11-15 | 한국과학기술원 | 목적 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법 |
| WO2017182608A1 (en) * | 2016-04-22 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and vaccine compositions for the treatment of b-cell malignancies |
| GB201609216D0 (en) | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
-
2016
- 2016-05-25 GB GBGB1609216.5A patent/GB201609216D0/en not_active Ceased
-
2017
- 2017-05-25 WO PCT/GB2017/051479 patent/WO2017203260A1/en not_active Ceased
- 2017-05-25 KR KR1020187037527A patent/KR102253731B1/ko active Active
- 2017-05-25 ES ES17727325T patent/ES2836553T3/es active Active
- 2017-05-25 CN CN202211545146.5A patent/CN116103241A/zh active Pending
- 2017-05-25 BR BR112018074229-5A patent/BR112018074229A2/pt not_active Application Discontinuation
- 2017-05-25 EP EP20201528.5A patent/EP3782646B1/en active Active
- 2017-05-25 EP EP17727325.7A patent/EP3463465B1/en active Active
- 2017-05-25 CA CA3024020A patent/CA3024020C/en active Active
- 2017-05-25 DK DK17727325.7T patent/DK3463465T3/da active
- 2017-05-25 AU AU2017270932A patent/AU2017270932B2/en active Active
- 2017-05-25 SG SG11201810116VA patent/SG11201810116VA/en unknown
- 2017-05-25 EP EP24202068.3A patent/EP4523706A3/en active Pending
- 2017-05-25 US US16/304,580 patent/US11534499B2/en active Active
- 2017-05-25 JP JP2019514870A patent/JP6855567B2/ja active Active
- 2017-05-25 CN CN201780046456.3A patent/CN109715211B/zh active Active
- 2017-05-25 RU RU2018145738A patent/RU2737732C2/ru active
- 2017-05-25 PT PT177273257T patent/PT3463465T/pt unknown
- 2017-05-25 MX MX2018014509A patent/MX378381B/es unknown
-
2018
- 2018-11-23 ZA ZA2018/07945A patent/ZA201807945B/en unknown
-
2021
- 2021-03-16 JP JP2021042290A patent/JP7483648B2/ja active Active
-
2022
- 2022-11-21 US US18/057,359 patent/US20230201370A1/en active Pending
-
2024
- 2024-05-01 JP JP2024074429A patent/JP2024103494A/ja active Pending
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