JP2021507682A5 - - Google Patents
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- Publication number
- JP2021507682A5 JP2021507682A5 JP2020524832A JP2020524832A JP2021507682A5 JP 2021507682 A5 JP2021507682 A5 JP 2021507682A5 JP 2020524832 A JP2020524832 A JP 2020524832A JP 2020524832 A JP2020524832 A JP 2020524832A JP 2021507682 A5 JP2021507682 A5 JP 2021507682A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- polypeptide
- cargo molecule
- domain
- mirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080936A JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Ｒｎａ治療薬を含むエクソソーム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718471.4A GB2568255A (en) | 2017-11-08 | 2017-11-08 | Exosomes comprising RNA therapeutics |
| GB1718471.4 | 2017-11-08 | ||
| PCT/EP2018/080681 WO2019092145A1 (en) | 2017-11-08 | 2018-11-08 | Exosomes comprising rna therapeutics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080936A Division JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Ｒｎａ治療薬を含むエクソソーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021507682A JP2021507682A (ja) | 2021-02-25 |
| JP2021507682A5 true JP2021507682A5 (https=) | 2021-12-23 |
| JP7077404B2 JP7077404B2 (ja) | 2022-05-30 |
Family
ID=60664781
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524832A Expired - Fee Related JP7077404B2 (ja) | 2017-11-08 | 2018-11-08 | Ｒｎａ治療薬を含むエクソソーム |
| JP2022080936A Pending JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Ｒｎａ治療薬を含むエクソソーム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080936A Pending JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Ｒｎａ治療薬を含むエクソソーム |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20210369865A1 (https=) |
| EP (2) | EP3706796B1 (https=) |
| JP (2) | JP7077404B2 (https=) |
| KR (1) | KR102431418B1 (https=) |
| CN (1) | CN111629760B (https=) |
| AU (1) | AU2018365299B2 (https=) |
| BR (1) | BR112020006960A2 (https=) |
| CA (1) | CA3082194C (https=) |
| DK (1) | DK3706796T3 (https=) |
| ES (1) | ES2899857T3 (https=) |
| GB (1) | GB2568255A (https=) |
| IL (1) | IL274125B (https=) |
| MX (1) | MX389425B (https=) |
| PT (1) | PT3706796T (https=) |
| RU (1) | RU2020118554A (https=) |
| SG (1) | SG11202004199PA (https=) |
| WO (1) | WO2019092145A1 (https=) |
| ZA (1) | ZA202002537B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019122461A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019122462A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019136400A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136401A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136398A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136399A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| FR3081169B1 (fr) * | 2018-05-15 | 2020-06-19 | Messenger Biopharma | Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5' |
| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| GB201810301D0 (en) * | 2018-06-22 | 2018-08-08 | Evox Therapeutics Ltd | Combinatorial gene therapy |
| GB201906482D0 (en) * | 2019-05-08 | 2019-06-19 | Evox Therapeutics Ltd | Exosome comprising stabilized RNA therapeutics |
| WO2021095842A1 (ja) * | 2019-11-15 | 2021-05-20 | 国立大学法人 東京大学 | バーコード化された細胞外小胞のライブラリー |
| WO2021172595A1 (ja) * | 2020-02-28 | 2021-09-02 | 国立大学法人金沢大学 | 抗原提示細胞外小胞、それを含む組成物、及びそれらを製造するための方法 |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| CN111424017B (zh) * | 2020-03-27 | 2022-08-09 | 暨南大学 | 一种装载shRNA的外泌体及其构建方法与应用 |
| WO2021207126A1 (en) * | 2020-04-06 | 2021-10-14 | The Trustees Of Dartmouth College | Compositions and methods for treating bacterial infections |
| WO2021223659A1 (en) * | 2020-05-06 | 2021-11-11 | Nanjing Iaso Biotherapeutics Co., Ltd. | Extracellular vesicles targeting cancer cells and uses thereof |
| WO2021231854A1 (en) * | 2020-05-14 | 2021-11-18 | Modernatx, Inc. | Lnp compositions comprising an mrna therapeutic and an effector molecule |
| CN111647045B (zh) * | 2020-06-17 | 2022-05-27 | 清华大学深圳国际研究生院 | 一种cd133拮抗多肽及其衍生物与应用 |
| GB202010278D0 (en) | 2020-07-03 | 2020-08-19 | Evox Therapeutics Ltd | Extracellular vesicles with improved half-life |
| EP4181935A1 (en) * | 2020-07-20 | 2023-05-24 | Brainstorm Cell Therapeutics Ltd. | Methods and compositions for treating lung conditions |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| CN112626068B (zh) * | 2020-12-21 | 2021-12-03 | 徐州医科大学 | 一种靶向Notch1基因的LncRNA及其应用 |
| CN115137835A (zh) * | 2021-03-30 | 2022-10-04 | 南京大学 | 一种用于治疗结肠炎的rna递送系统 |
| GB202105925D0 (en) | 2021-04-26 | 2021-06-09 | Evox Therapeutics Ltd | Modified extracellular vesicles (EVs) with improved half-life |
| JP2024528547A (ja) * | 2021-06-30 | 2024-07-30 | プリモリス セラピューティクス カンパニー リミテッド | アンチセンスオリゴヌクレオチドに基づく薬物が搭載された細胞由来の自然又は人工ナノベシクルを含有する薬学組成物 |
| WO2023284380A1 (zh) * | 2021-07-15 | 2023-01-19 | 呈诺再生医学科技(北京)有限公司 | 细胞作为基因治疗的载体在临床中的应用 |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| US20240360198A1 (en) * | 2021-09-01 | 2024-10-31 | National University Corporation Kanazawa University | Immunoregulatory method, nucleic acid composition for immunoregulation, and use thereof |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| CN114569721B (zh) * | 2022-02-25 | 2023-03-24 | 浙江大学 | 载药的胞外囊泡在制备治疗肥胖或减轻肥胖相关代谢指标的药物中的应用 |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| GB202210861D0 (en) * | 2022-07-25 | 2022-09-07 | Univ Oxford Innovation Ltd | Loaded extracellular vesicle |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| WO2024112359A1 (en) * | 2022-11-21 | 2024-05-30 | The Johns Hopkins University | Genetic enhancement of exosome production |
| EP4434534A1 (en) | 2023-03-22 | 2024-09-25 | ADvantage Therapeutics, Inc. | Klotho mrna |
| WO2024194423A1 (en) | 2023-03-23 | 2024-09-26 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their use for vaccines and for immunomodulation |
| WO2024230738A1 (zh) * | 2023-05-08 | 2024-11-14 | 天津外泌体科技有限公司 | 外囊泡融合蛋白及其应用 |
| GB202307239D0 (en) | 2023-05-15 | 2023-06-28 | Evox Therapeutics Ltd | Gene therapies for Phenylketonuria |
| WO2025068572A2 (en) | 2023-09-29 | 2025-04-03 | Evox Therapeutics Limited | Polypeptides comprising inteins for engineered evs |
| CN120393034A (zh) * | 2023-11-10 | 2025-08-01 | 深圳市茵冠生物科技有限公司 | 一种寡核苷酸偶联物及含其外泌体偶联物与应用 |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
| WO2025247999A1 (en) | 2024-05-30 | 2025-12-04 | Conveyxo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
| EP4656187A1 (en) | 2024-05-30 | 2025-12-03 | ConvEyXo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130053426A1 (en) | 2009-04-17 | 2013-02-28 | Yiqi Seow | Composition For Delivery Of Genetic Material |
| MX2012013037A (es) * | 2010-05-10 | 2013-07-29 | Univ California | Composiciones de endorribonucleasa y metodos de uso de las mismas. |
| WO2013188638A2 (en) * | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| WO2015002956A1 (en) * | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| US10538570B2 (en) * | 2013-09-30 | 2020-01-21 | Northwestern University | Targeted and modular exosome loading system |
| JP7103750B2 (ja) * | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのＣＲＩＳＰＲ－Ｃａｓ系及び組成物の送達、使用及び治療適用 |
| EP3858992A1 (en) * | 2015-03-13 | 2021-08-04 | The Jackson Laboratory | A three-component crispr/cas complex system and uses thereof |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US10624849B2 (en) * | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| EP3440090B1 (en) * | 2016-04-06 | 2022-09-28 | Ohio State Innovation Foundation | Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology |
| GB201609216D0 (en) * | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
| US20210054404A1 (en) * | 2017-08-22 | 2021-02-25 | Napigen, Inc. | Organelle genome modification using polynucleotide guided endonuclease |
-
2017
- 2017-11-08 GB GB1718471.4A patent/GB2568255A/en not_active Withdrawn
-
2018
- 2018-11-08 RU RU2020118554A patent/RU2020118554A/ru unknown
- 2018-11-08 KR KR1020207016299A patent/KR102431418B1/ko active Active
- 2018-11-08 EP EP18806990.0A patent/EP3706796B1/en not_active Revoked
- 2018-11-08 WO PCT/EP2018/080681 patent/WO2019092145A1/en not_active Ceased
- 2018-11-08 SG SG11202004199PA patent/SG11202004199PA/en unknown
- 2018-11-08 JP JP2020524832A patent/JP7077404B2/ja not_active Expired - Fee Related
- 2018-11-08 CN CN201880072530.3A patent/CN111629760B/zh not_active Expired - Fee Related
- 2018-11-08 PT PT188069900T patent/PT3706796T/pt unknown
- 2018-11-08 MX MX2020004698A patent/MX389425B/es unknown
- 2018-11-08 CA CA3082194A patent/CA3082194C/en active Active
- 2018-11-08 EP EP21199121.1A patent/EP3973989A1/en not_active Withdrawn
- 2018-11-08 BR BR112020006960-4A patent/BR112020006960A2/pt not_active Application Discontinuation
- 2018-11-08 IL IL274125A patent/IL274125B/en unknown
- 2018-11-08 AU AU2018365299A patent/AU2018365299B2/en not_active Ceased
- 2018-11-08 ES ES18806990T patent/ES2899857T3/es active Active
- 2018-11-08 US US16/762,606 patent/US20210369865A1/en not_active Abandoned
- 2018-11-08 DK DK18806990.0T patent/DK3706796T3/da active
-
2020
- 2020-05-07 ZA ZA2020/02537A patent/ZA202002537B/en unknown
-
2022
- 2022-05-17 JP JP2022080936A patent/JP2022113690A/ja active Pending
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