RU2020118554A - Экзосомы, содержащие рнк-терапевтические средства - Google Patents
Экзосомы, содержащие рнк-терапевтические средства Download PDFInfo
- Publication number
- RU2020118554A RU2020118554A RU2020118554A RU2020118554A RU2020118554A RU 2020118554 A RU2020118554 A RU 2020118554A RU 2020118554 A RU2020118554 A RU 2020118554A RU 2020118554 A RU2020118554 A RU 2020118554A RU 2020118554 A RU2020118554 A RU 2020118554A
- Authority
- RU
- Russia
- Prior art keywords
- extracellular vesicle
- extracellular
- polypeptide
- paragraphs
- cell
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 2
- 210000001808 exosome Anatomy 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 230000027455 binding Effects 0.000 claims 11
- 230000004927 fusion Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 4
- 239000002679 microRNA Substances 0.000 claims 4
- -1 rRNA Proteins 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 3
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 3
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 3
- 102100025390 Integrin beta-2 Human genes 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102100035721 Syndecan-1 Human genes 0.000 claims 2
- 102100026087 Syndecan-2 Human genes 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- BSDCIRGNJKZPFV-GWOFURMSSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-(2,5,6-trichlorobenzimidazol-1-yl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=CC(Cl)=C(Cl)C=C2N=C1Cl BSDCIRGNJKZPFV-GWOFURMSSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102100040026 Agrin Human genes 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 101100165655 Arabidopsis thaliana BRO1 gene Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 claims 1
- 102100035893 CD151 antigen Human genes 0.000 claims 1
- 108010045374 CD36 Antigens Proteins 0.000 claims 1
- 102000053028 CD36 Antigens Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 102100027221 CD81 antigen Human genes 0.000 claims 1
- 102100027217 CD82 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 108010040467 CRISPR-Associated Proteins Proteins 0.000 claims 1
- 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 108020004638 Circular DNA Proteins 0.000 claims 1
- 108091028075 Circular RNA Proteins 0.000 claims 1
- 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
- 108700020911 DNA-Binding Proteins Proteins 0.000 claims 1
- 102100036462 Delta-like protein 1 Human genes 0.000 claims 1
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102100032790 Flotillin-1 Human genes 0.000 claims 1
- 102100023513 Flotillin-2 Human genes 0.000 claims 1
- 102100030651 Glutamate receptor 2 Human genes 0.000 claims 1
- 102100030669 Glutamate receptor 3 Human genes 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 102100035716 Glycophorin-A Human genes 0.000 claims 1
- 108020005004 Guide RNA Proteins 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000959594 Homo sapiens Agrin Proteins 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101001000001 Homo sapiens Basement membrane-specific heparan sulfate proteoglycan core protein Proteins 0.000 claims 1
- 101000946874 Homo sapiens CD151 antigen Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 1
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 claims 1
- 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 claims 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
- 101000847538 Homo sapiens Flotillin-1 Proteins 0.000 claims 1
- 101000828609 Homo sapiens Flotillin-2 Proteins 0.000 claims 1
- 101001010449 Homo sapiens Glutamate receptor 2 Proteins 0.000 claims 1
- 101001010434 Homo sapiens Glutamate receptor 3 Proteins 0.000 claims 1
- 101001074244 Homo sapiens Glycophorin-A Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims 1
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims 1
- 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 claims 1
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims 1
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims 1
- 101001015006 Homo sapiens Integrin beta-4 Proteins 0.000 claims 1
- 101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 claims 1
- 101001015064 Homo sapiens Integrin beta-6 Proteins 0.000 claims 1
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000599858 Homo sapiens Intercellular adhesion molecule 2 Proteins 0.000 claims 1
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 claims 1
- 101001034314 Homo sapiens Lactadherin Proteins 0.000 claims 1
- 101001008568 Homo sapiens Laminin subunit beta-1 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 1
- 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 claims 1
- 101000634835 Homo sapiens M1-specific T cell receptor alpha chain Proteins 0.000 claims 1
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 claims 1
- 101100082597 Homo sapiens PDCD6IP gene Proteins 0.000 claims 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 1
- 101000994437 Homo sapiens Protein jagged-1 Proteins 0.000 claims 1
- 101000994434 Homo sapiens Protein jagged-2 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000651890 Homo sapiens Slit homolog 2 protein Proteins 0.000 claims 1
- 101000651893 Homo sapiens Slit homolog 3 protein Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000642688 Homo sapiens Syntaxin-3 Proteins 0.000 claims 1
- 101000634836 Homo sapiens T cell receptor alpha chain MC.7.G5 Proteins 0.000 claims 1
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000759889 Homo sapiens Tetraspanin-14 Proteins 0.000 claims 1
- 101000612838 Homo sapiens Tetraspanin-7 Proteins 0.000 claims 1
- 101000847107 Homo sapiens Tetraspanin-8 Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000621459 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1A Proteins 0.000 claims 1
- 101000621456 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1B Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000012330 Integrases Human genes 0.000 claims 1
- 108010061833 Integrases Proteins 0.000 claims 1
- 102100025305 Integrin alpha-2 Human genes 0.000 claims 1
- 102100032819 Integrin alpha-3 Human genes 0.000 claims 1
- 102100032817 Integrin alpha-5 Human genes 0.000 claims 1
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100022337 Integrin alpha-V Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100032999 Integrin beta-3 Human genes 0.000 claims 1
- 102100033000 Integrin beta-4 Human genes 0.000 claims 1
- 102100033010 Integrin beta-5 Human genes 0.000 claims 1
- 102100033011 Integrin beta-6 Human genes 0.000 claims 1
- 102100033016 Integrin beta-7 Human genes 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 1
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 1
- 102100039648 Lactadherin Human genes 0.000 claims 1
- 102100027448 Laminin subunit beta-1 Human genes 0.000 claims 1
- 102100034710 Laminin subunit gamma-1 Human genes 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 102000003939 Membrane transport proteins Human genes 0.000 claims 1
- 108090000301 Membrane transport proteins Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 1
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 1
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 claims 1
- 102100025246 Neurogenic locus notch homolog protein 2 Human genes 0.000 claims 1
- 102100025247 Neurogenic locus notch homolog protein 3 Human genes 0.000 claims 1
- 102100025254 Neurogenic locus notch homolog protein 4 Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 108010029751 Notch2 Receptor Proteins 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 108010029741 Notch4 Receptor Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091007412 Piwi-interacting RNA Proteins 0.000 claims 1
- 108091036407 Polyadenylation Proteins 0.000 claims 1
- 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 claims 1
- 102100032733 Protein jagged-2 Human genes 0.000 claims 1
- 230000007022 RNA scission Effects 0.000 claims 1
- 102000044126 RNA-Binding Proteins Human genes 0.000 claims 1
- 108700020471 RNA-Binding Proteins Proteins 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100027339 Slit homolog 3 protein Human genes 0.000 claims 1
- 108020004688 Small Nuclear RNA Proteins 0.000 claims 1
- 102000039471 Small Nuclear RNA Human genes 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 108090000058 Syndecan-1 Proteins 0.000 claims 1
- 108090000054 Syndecan-2 Proteins 0.000 claims 1
- 102100026084 Syndecan-3 Human genes 0.000 claims 1
- 108090000068 Syndecan-3 Proteins 0.000 claims 1
- 102100037220 Syndecan-4 Human genes 0.000 claims 1
- 108010055215 Syndecan-4 Proteins 0.000 claims 1
- 102100035937 Syntaxin-3 Human genes 0.000 claims 1
- 102100029454 T cell receptor alpha chain MC.7.G5 Human genes 0.000 claims 1
- 102100026967 T cell receptor beta chain MC.7.G5 Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102100024995 Tetraspanin-14 Human genes 0.000 claims 1
- 102100040952 Tetraspanin-7 Human genes 0.000 claims 1
- 102100032802 Tetraspanin-8 Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108020004566 Transfer RNA Proteins 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100023019 Vesicle transport through interaction with t-SNAREs homolog 1A Human genes 0.000 claims 1
- 102100023018 Vesicle transport through interaction with t-SNAREs homolog 1B Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 230000017730 intein-mediated protein splicing Effects 0.000 claims 1
- 102000002467 interleukin receptors Human genes 0.000 claims 1
- 108010093036 interleukin receptors Proteins 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010090909 laminin gamma 1 Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 239000003900 neurotrophic factor Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000026415 nucleotide binding proteins Human genes 0.000 claims 1
- 108091014756 nucleotide binding proteins Proteins 0.000 claims 1
- 238000010397 one-hybrid screening Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108091007428 primary miRNA Proteins 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718471.4A GB2568255A (en) | 2017-11-08 | 2017-11-08 | Exosomes comprising RNA therapeutics |
| GB1718471.4 | 2017-11-08 | ||
| PCT/EP2018/080681 WO2019092145A1 (en) | 2017-11-08 | 2018-11-08 | Exosomes comprising rna therapeutics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2020118554A true RU2020118554A (ru) | 2021-12-08 |
| RU2020118554A3 RU2020118554A3 (https=) | 2022-04-20 |
Family
ID=60664781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020118554A RU2020118554A (ru) | 2017-11-08 | 2018-11-08 | Экзосомы, содержащие рнк-терапевтические средства |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20210369865A1 (https=) |
| EP (2) | EP3706796B1 (https=) |
| JP (2) | JP7077404B2 (https=) |
| KR (1) | KR102431418B1 (https=) |
| CN (1) | CN111629760B (https=) |
| AU (1) | AU2018365299B2 (https=) |
| BR (1) | BR112020006960A2 (https=) |
| CA (1) | CA3082194C (https=) |
| DK (1) | DK3706796T3 (https=) |
| ES (1) | ES2899857T3 (https=) |
| GB (1) | GB2568255A (https=) |
| IL (1) | IL274125B (https=) |
| MX (1) | MX389425B (https=) |
| PT (1) | PT3706796T (https=) |
| RU (1) | RU2020118554A (https=) |
| SG (1) | SG11202004199PA (https=) |
| WO (1) | WO2019092145A1 (https=) |
| ZA (1) | ZA202002537B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019122461A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019122462A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019136400A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136401A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136398A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136399A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| FR3081169B1 (fr) * | 2018-05-15 | 2020-06-19 | Messenger Biopharma | Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5' |
| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| GB201810301D0 (en) * | 2018-06-22 | 2018-08-08 | Evox Therapeutics Ltd | Combinatorial gene therapy |
| GB201906482D0 (en) * | 2019-05-08 | 2019-06-19 | Evox Therapeutics Ltd | Exosome comprising stabilized RNA therapeutics |
| WO2021095842A1 (ja) * | 2019-11-15 | 2021-05-20 | 国立大学法人 東京大学 | バーコード化された細胞外小胞のライブラリー |
| WO2021172595A1 (ja) * | 2020-02-28 | 2021-09-02 | 国立大学法人金沢大学 | 抗原提示細胞外小胞、それを含む組成物、及びそれらを製造するための方法 |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| CN111424017B (zh) * | 2020-03-27 | 2022-08-09 | 暨南大学 | 一种装载shRNA的外泌体及其构建方法与应用 |
| WO2021207126A1 (en) * | 2020-04-06 | 2021-10-14 | The Trustees Of Dartmouth College | Compositions and methods for treating bacterial infections |
| WO2021223659A1 (en) * | 2020-05-06 | 2021-11-11 | Nanjing Iaso Biotherapeutics Co., Ltd. | Extracellular vesicles targeting cancer cells and uses thereof |
| WO2021231854A1 (en) * | 2020-05-14 | 2021-11-18 | Modernatx, Inc. | Lnp compositions comprising an mrna therapeutic and an effector molecule |
| CN111647045B (zh) * | 2020-06-17 | 2022-05-27 | 清华大学深圳国际研究生院 | 一种cd133拮抗多肽及其衍生物与应用 |
| GB202010278D0 (en) | 2020-07-03 | 2020-08-19 | Evox Therapeutics Ltd | Extracellular vesicles with improved half-life |
| EP4181935A1 (en) * | 2020-07-20 | 2023-05-24 | Brainstorm Cell Therapeutics Ltd. | Methods and compositions for treating lung conditions |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| CN112626068B (zh) * | 2020-12-21 | 2021-12-03 | 徐州医科大学 | 一种靶向Notch1基因的LncRNA及其应用 |
| CN115137835A (zh) * | 2021-03-30 | 2022-10-04 | 南京大学 | 一种用于治疗结肠炎的rna递送系统 |
| GB202105925D0 (en) | 2021-04-26 | 2021-06-09 | Evox Therapeutics Ltd | Modified extracellular vesicles (EVs) with improved half-life |
| JP2024528547A (ja) * | 2021-06-30 | 2024-07-30 | プリモリス セラピューティクス カンパニー リミテッド | アンチセンスオリゴヌクレオチドに基づく薬物が搭載された細胞由来の自然又は人工ナノベシクルを含有する薬学組成物 |
| WO2023284380A1 (zh) * | 2021-07-15 | 2023-01-19 | 呈诺再生医学科技(北京)有限公司 | 细胞作为基因治疗的载体在临床中的应用 |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| US20240360198A1 (en) * | 2021-09-01 | 2024-10-31 | National University Corporation Kanazawa University | Immunoregulatory method, nucleic acid composition for immunoregulation, and use thereof |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| CN114569721B (zh) * | 2022-02-25 | 2023-03-24 | 浙江大学 | 载药的胞外囊泡在制备治疗肥胖或减轻肥胖相关代谢指标的药物中的应用 |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| GB202210861D0 (en) * | 2022-07-25 | 2022-09-07 | Univ Oxford Innovation Ltd | Loaded extracellular vesicle |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| WO2024112359A1 (en) * | 2022-11-21 | 2024-05-30 | The Johns Hopkins University | Genetic enhancement of exosome production |
| EP4434534A1 (en) | 2023-03-22 | 2024-09-25 | ADvantage Therapeutics, Inc. | Klotho mrna |
| WO2024194423A1 (en) | 2023-03-23 | 2024-09-26 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their use for vaccines and for immunomodulation |
| WO2024230738A1 (zh) * | 2023-05-08 | 2024-11-14 | 天津外泌体科技有限公司 | 外囊泡融合蛋白及其应用 |
| GB202307239D0 (en) | 2023-05-15 | 2023-06-28 | Evox Therapeutics Ltd | Gene therapies for Phenylketonuria |
| WO2025068572A2 (en) | 2023-09-29 | 2025-04-03 | Evox Therapeutics Limited | Polypeptides comprising inteins for engineered evs |
| CN120393034A (zh) * | 2023-11-10 | 2025-08-01 | 深圳市茵冠生物科技有限公司 | 一种寡核苷酸偶联物及含其外泌体偶联物与应用 |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
| WO2025247999A1 (en) | 2024-05-30 | 2025-12-04 | Conveyxo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
| EP4656187A1 (en) | 2024-05-30 | 2025-12-03 | ConvEyXo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130053426A1 (en) | 2009-04-17 | 2013-02-28 | Yiqi Seow | Composition For Delivery Of Genetic Material |
| MX2012013037A (es) * | 2010-05-10 | 2013-07-29 | Univ California | Composiciones de endorribonucleasa y metodos de uso de las mismas. |
| WO2013188638A2 (en) * | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| WO2015002956A1 (en) * | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| US10538570B2 (en) * | 2013-09-30 | 2020-01-21 | Northwestern University | Targeted and modular exosome loading system |
| JP7103750B2 (ja) * | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのＣＲＩＳＰＲ－Ｃａｓ系及び組成物の送達、使用及び治療適用 |
| EP3858992A1 (en) * | 2015-03-13 | 2021-08-04 | The Jackson Laboratory | A three-component crispr/cas complex system and uses thereof |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US10624849B2 (en) * | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| EP3440090B1 (en) * | 2016-04-06 | 2022-09-28 | Ohio State Innovation Foundation | Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology |
| GB201609216D0 (en) * | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
| US20210054404A1 (en) * | 2017-08-22 | 2021-02-25 | Napigen, Inc. | Organelle genome modification using polynucleotide guided endonuclease |
-
2017
- 2017-11-08 GB GB1718471.4A patent/GB2568255A/en not_active Withdrawn
-
2018
- 2018-11-08 RU RU2020118554A patent/RU2020118554A/ru unknown
- 2018-11-08 KR KR1020207016299A patent/KR102431418B1/ko active Active
- 2018-11-08 EP EP18806990.0A patent/EP3706796B1/en not_active Revoked
- 2018-11-08 WO PCT/EP2018/080681 patent/WO2019092145A1/en not_active Ceased
- 2018-11-08 SG SG11202004199PA patent/SG11202004199PA/en unknown
- 2018-11-08 JP JP2020524832A patent/JP7077404B2/ja not_active Expired - Fee Related
- 2018-11-08 CN CN201880072530.3A patent/CN111629760B/zh not_active Expired - Fee Related
- 2018-11-08 PT PT188069900T patent/PT3706796T/pt unknown
- 2018-11-08 MX MX2020004698A patent/MX389425B/es unknown
- 2018-11-08 CA CA3082194A patent/CA3082194C/en active Active
- 2018-11-08 EP EP21199121.1A patent/EP3973989A1/en not_active Withdrawn
- 2018-11-08 BR BR112020006960-4A patent/BR112020006960A2/pt not_active Application Discontinuation
- 2018-11-08 IL IL274125A patent/IL274125B/en unknown
- 2018-11-08 AU AU2018365299A patent/AU2018365299B2/en not_active Ceased
- 2018-11-08 ES ES18806990T patent/ES2899857T3/es active Active
- 2018-11-08 US US16/762,606 patent/US20210369865A1/en not_active Abandoned
- 2018-11-08 DK DK18806990.0T patent/DK3706796T3/da active
-
2020
- 2020-05-07 ZA ZA2020/02537A patent/ZA202002537B/en unknown
-
2022
- 2022-05-17 JP JP2022080936A patent/JP2022113690A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3082194A1 (en) | 2019-05-16 |
| KR20200086322A (ko) | 2020-07-16 |
| KR102431418B1 (ko) | 2022-08-16 |
| WO2019092145A1 (en) | 2019-05-16 |
| JP2021507682A (ja) | 2021-02-25 |
| RU2020118554A3 (https=) | 2022-04-20 |
| EP3706796A1 (en) | 2020-09-16 |
| JP7077404B2 (ja) | 2022-05-30 |
| ES2899857T3 (es) | 2022-03-15 |
| ZA202002537B (en) | 2022-07-27 |
| GB2568255A (en) | 2019-05-15 |
| MX2020004698A (es) | 2022-01-17 |
| IL274125B (en) | 2022-07-01 |
| JP2022113690A (ja) | 2022-08-04 |
| CN111629760A (zh) | 2020-09-04 |
| PT3706796T (pt) | 2021-11-24 |
| SG11202004199PA (en) | 2020-06-29 |
| GB201718471D0 (en) | 2017-12-20 |
| EP3706796B1 (en) | 2021-09-29 |
| DK3706796T3 (da) | 2021-11-22 |
| US20210369865A1 (en) | 2021-12-02 |
| CA3082194C (en) | 2022-10-04 |
| CN111629760B (zh) | 2023-09-05 |
| AU2018365299B2 (en) | 2021-12-16 |
| EP3973989A1 (en) | 2022-03-30 |
| IL274125A (en) | 2020-06-30 |
| BR112020006960A2 (pt) | 2020-10-13 |
| MX389425B (es) | 2025-03-20 |
| AU2018365299A1 (en) | 2020-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2020118554A (ru) | Экзосомы, содержащие рнк-терапевтические средства | |
| JP2021507682A5 (https=) | ||
| RU2018145738A (ru) | Экзосомы, содержащие терапевтические полипептиды | |
| Wu et al. | Chimeric antigen receptor therapy meets mRNA technology | |
| JP2024103494A5 (https=) | ||
| US20210238248A1 (en) | Engineering Extracellular Vesicles for Affinity Purification | |
| AR120566A1 (es) | Receptores de antígeno quiméricos y sus usos | |
| EP3965828B1 (en) | Exosome comprising stabilized rna therapeutics | |
| AU2016362129A1 (en) | Compositions and methods for immunooncology | |
| CN109055380B (zh) | 一种通用型car-t细胞的制备方法 | |
| KR20230117174A (ko) | 핵산을 세포에 전달하기 위한 조성물 및 방법 | |
| AU2023415250A1 (en) | Antibody or antibody fragment targeting b7-h3, and use thereof in field of chimeric antigen receptor immune cell therapy | |
| CN105505869A (zh) | 一种针对肿瘤干细胞的嵌合抗原受体t细胞 | |
| EP4561536A1 (en) | Loaded extracellular vesicle | |
| US20260108473A1 (en) | Bispecific stealth lipid nanoparticle compositions for cell targeting | |
| KR20250017213A (ko) | 폴리뉴클레오티드 | |
| WO2025096878A9 (en) | Rna for in vivo transfection with increased expression | |
| WO2024092126A1 (en) | Compositions and methods for improved immunotherapies | |
| US20250288695A1 (en) | Tspan2 as scaffold protein for engineered extracellular vesicles | |
| WO2025081084A1 (en) | Improved methods for determining sequences of nucleic acids | |
| AU2024370741A1 (en) | Rna for in vivo transfection with increased expression | |
| KR20250036843A (ko) | 면역 체크포인트 억제를 위한 폴리시스트론 miRNA 작제물 | |
| CN118853825A (zh) | 一种扩增鲨鱼单域抗体核酸文库的引物与应用 | |
| RU2022117055A (ru) | Химерные антигенные рецепторы и пути их применения |