JP7077404B2 - Rna治療薬を含むエクソソーム - Google Patents
Rna治療薬を含むエクソソーム Download PDFInfo
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- JP7077404B2 JP7077404B2 JP2020524832A JP2020524832A JP7077404B2 JP 7077404 B2 JP7077404 B2 JP 7077404B2 JP 2020524832 A JP2020524832 A JP 2020524832A JP 2020524832 A JP2020524832 A JP 2020524832A JP 7077404 B2 JP7077404 B2 JP 7077404B2
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Life Sciences & Earth Sciences (AREA)
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- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080936A JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Rna治療薬を含むエクソソーム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718471.4A GB2568255A (en) | 2017-11-08 | 2017-11-08 | Exosomes comprising RNA therapeutics |
| GB1718471.4 | 2017-11-08 | ||
| PCT/EP2018/080681 WO2019092145A1 (en) | 2017-11-08 | 2018-11-08 | Exosomes comprising rna therapeutics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080936A Division JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Rna治療薬を含むエクソソーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021507682A JP2021507682A (ja) | 2021-02-25 |
| JP2021507682A5 JP2021507682A5 (https=) | 2021-12-23 |
| JP7077404B2 true JP7077404B2 (ja) | 2022-05-30 |
Family
ID=60664781
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524832A Expired - Fee Related JP7077404B2 (ja) | 2017-11-08 | 2018-11-08 | Rna治療薬を含むエクソソーム |
| JP2022080936A Pending JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Rna治療薬を含むエクソソーム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080936A Pending JP2022113690A (ja) | 2017-11-08 | 2022-05-17 | Rna治療薬を含むエクソソーム |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20210369865A1 (https=) |
| EP (2) | EP3706796B1 (https=) |
| JP (2) | JP7077404B2 (https=) |
| KR (1) | KR102431418B1 (https=) |
| CN (1) | CN111629760B (https=) |
| AU (1) | AU2018365299B2 (https=) |
| BR (1) | BR112020006960A2 (https=) |
| CA (1) | CA3082194C (https=) |
| DK (1) | DK3706796T3 (https=) |
| ES (1) | ES2899857T3 (https=) |
| GB (1) | GB2568255A (https=) |
| IL (1) | IL274125B (https=) |
| MX (1) | MX389425B (https=) |
| PT (1) | PT3706796T (https=) |
| RU (1) | RU2020118554A (https=) |
| SG (1) | SG11202004199PA (https=) |
| WO (1) | WO2019092145A1 (https=) |
| ZA (1) | ZA202002537B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019122461A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019122462A (ja) * | 2018-01-12 | 2019-07-25 | 株式会社三洋物産 | 遊技機 |
| JP2019136400A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136401A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136398A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136399A (ja) * | 2018-02-14 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| FR3081169B1 (fr) * | 2018-05-15 | 2020-06-19 | Messenger Biopharma | Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5' |
| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| GB201810301D0 (en) * | 2018-06-22 | 2018-08-08 | Evox Therapeutics Ltd | Combinatorial gene therapy |
| GB201906482D0 (en) * | 2019-05-08 | 2019-06-19 | Evox Therapeutics Ltd | Exosome comprising stabilized RNA therapeutics |
| WO2021095842A1 (ja) * | 2019-11-15 | 2021-05-20 | 国立大学法人 東京大学 | バーコード化された細胞外小胞のライブラリー |
| WO2021172595A1 (ja) * | 2020-02-28 | 2021-09-02 | 国立大学法人金沢大学 | 抗原提示細胞外小胞、それを含む組成物、及びそれらを製造するための方法 |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| CN111424017B (zh) * | 2020-03-27 | 2022-08-09 | 暨南大学 | 一种装载shRNA的外泌体及其构建方法与应用 |
| WO2021207126A1 (en) * | 2020-04-06 | 2021-10-14 | The Trustees Of Dartmouth College | Compositions and methods for treating bacterial infections |
| WO2021223659A1 (en) * | 2020-05-06 | 2021-11-11 | Nanjing Iaso Biotherapeutics Co., Ltd. | Extracellular vesicles targeting cancer cells and uses thereof |
| WO2021231854A1 (en) * | 2020-05-14 | 2021-11-18 | Modernatx, Inc. | Lnp compositions comprising an mrna therapeutic and an effector molecule |
| CN111647045B (zh) * | 2020-06-17 | 2022-05-27 | 清华大学深圳国际研究生院 | 一种cd133拮抗多肽及其衍生物与应用 |
| GB202010278D0 (en) | 2020-07-03 | 2020-08-19 | Evox Therapeutics Ltd | Extracellular vesicles with improved half-life |
| EP4181935A1 (en) * | 2020-07-20 | 2023-05-24 | Brainstorm Cell Therapeutics Ltd. | Methods and compositions for treating lung conditions |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Dna分子の組成物、その作製方法、及びその使用方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| CN112626068B (zh) * | 2020-12-21 | 2021-12-03 | 徐州医科大学 | 一种靶向Notch1基因的LncRNA及其应用 |
| CN115137835A (zh) * | 2021-03-30 | 2022-10-04 | 南京大学 | 一种用于治疗结肠炎的rna递送系统 |
| GB202105925D0 (en) | 2021-04-26 | 2021-06-09 | Evox Therapeutics Ltd | Modified extracellular vesicles (EVs) with improved half-life |
| JP2024528547A (ja) * | 2021-06-30 | 2024-07-30 | プリモリス セラピューティクス カンパニー リミテッド | アンチセンスオリゴヌクレオチドに基づく薬物が搭載された細胞由来の自然又は人工ナノベシクルを含有する薬学組成物 |
| WO2023284380A1 (zh) * | 2021-07-15 | 2023-01-19 | 呈诺再生医学科技(北京)有限公司 | 细胞作为基因治疗的载体在临床中的应用 |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| US20240360198A1 (en) * | 2021-09-01 | 2024-10-31 | National University Corporation Kanazawa University | Immunoregulatory method, nucleic acid composition for immunoregulation, and use thereof |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| CN114569721B (zh) * | 2022-02-25 | 2023-03-24 | 浙江大学 | 载药的胞外囊泡在制备治疗肥胖或减轻肥胖相关代谢指标的药物中的应用 |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| GB202210861D0 (en) * | 2022-07-25 | 2022-09-07 | Univ Oxford Innovation Ltd | Loaded extracellular vesicle |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| WO2024112359A1 (en) * | 2022-11-21 | 2024-05-30 | The Johns Hopkins University | Genetic enhancement of exosome production |
| EP4434534A1 (en) | 2023-03-22 | 2024-09-25 | ADvantage Therapeutics, Inc. | Klotho mrna |
| WO2024194423A1 (en) | 2023-03-23 | 2024-09-26 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their use for vaccines and for immunomodulation |
| WO2024230738A1 (zh) * | 2023-05-08 | 2024-11-14 | 天津外泌体科技有限公司 | 外囊泡融合蛋白及其应用 |
| GB202307239D0 (en) | 2023-05-15 | 2023-06-28 | Evox Therapeutics Ltd | Gene therapies for Phenylketonuria |
| WO2025068572A2 (en) | 2023-09-29 | 2025-04-03 | Evox Therapeutics Limited | Polypeptides comprising inteins for engineered evs |
| CN120393034A (zh) * | 2023-11-10 | 2025-08-01 | 深圳市茵冠生物科技有限公司 | 一种寡核苷酸偶联物及含其外泌体偶联物与应用 |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025196641A1 (ru) * | 2024-03-19 | 2025-09-25 | Биоплатформ Гмбх | Гибридные частицы, способ их получения и применение |
| WO2025247999A1 (en) | 2024-05-30 | 2025-12-04 | Conveyxo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
| EP4656187A1 (en) | 2024-05-30 | 2025-12-03 | ConvEyXo | Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles |
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|---|---|---|---|---|
| WO2015002956A1 (en) | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
Family Cites Families (11)
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| US20130053426A1 (en) | 2009-04-17 | 2013-02-28 | Yiqi Seow | Composition For Delivery Of Genetic Material |
| MX2012013037A (es) * | 2010-05-10 | 2013-07-29 | Univ California | Composiciones de endorribonucleasa y metodos de uso de las mismas. |
| WO2013188638A2 (en) * | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| US10538570B2 (en) * | 2013-09-30 | 2020-01-21 | Northwestern University | Targeted and modular exosome loading system |
| JP7103750B2 (ja) * | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用 |
| EP3858992A1 (en) * | 2015-03-13 | 2021-08-04 | The Jackson Laboratory | A three-component crispr/cas complex system and uses thereof |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US10624849B2 (en) * | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| EP3440090B1 (en) * | 2016-04-06 | 2022-09-28 | Ohio State Innovation Foundation | Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology |
| GB201609216D0 (en) * | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
| US20210054404A1 (en) * | 2017-08-22 | 2021-02-25 | Napigen, Inc. | Organelle genome modification using polynucleotide guided endonuclease |
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