KR102431418B1 - Rna 치료제를 포함하는 엑소좀 - Google Patents

Rna 치료제를 포함하는 엑소좀 Download PDF

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KR102431418B1
KR102431418B1 KR1020207016299A KR20207016299A KR102431418B1 KR 102431418 B1 KR102431418 B1 KR 102431418B1 KR 1020207016299 A KR1020207016299 A KR 1020207016299A KR 20207016299 A KR20207016299 A KR 20207016299A KR 102431418 B1 KR102431418 B1 KR 102431418B1
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KR20200086322A (ko
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로렌조 에리첼리
다누 굽타
저스틴 힌
조엘 노르딘
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에복스 테라퓨틱스 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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KR1020207016299A 2017-11-08 2018-11-08 Rna 치료제를 포함하는 엑소좀 Active KR102431418B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1718471.4A GB2568255A (en) 2017-11-08 2017-11-08 Exosomes comprising RNA therapeutics
GB1718471.4 2017-11-08
PCT/EP2018/080681 WO2019092145A1 (en) 2017-11-08 2018-11-08 Exosomes comprising rna therapeutics

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KR20200086322A KR20200086322A (ko) 2020-07-16
KR102431418B1 true KR102431418B1 (ko) 2022-08-16

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US (1) US20210369865A1 (https=)
EP (2) EP3706796B1 (https=)
JP (2) JP7077404B2 (https=)
KR (1) KR102431418B1 (https=)
CN (1) CN111629760B (https=)
AU (1) AU2018365299B2 (https=)
BR (1) BR112020006960A2 (https=)
CA (1) CA3082194C (https=)
DK (1) DK3706796T3 (https=)
ES (1) ES2899857T3 (https=)
GB (1) GB2568255A (https=)
IL (1) IL274125B (https=)
MX (1) MX389425B (https=)
PT (1) PT3706796T (https=)
RU (1) RU2020118554A (https=)
SG (1) SG11202004199PA (https=)
WO (1) WO2019092145A1 (https=)
ZA (1) ZA202002537B (https=)

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