JP2024103494A5 - - Google Patents
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- JP2024103494A5 JP2024103494A5 JP2024074429A JP2024074429A JP2024103494A5 JP 2024103494 A5 JP2024103494 A5 JP 2024103494A5 JP 2024074429 A JP2024074429 A JP 2024074429A JP 2024074429 A JP2024074429 A JP 2024074429A JP 2024103494 A5 JP2024103494 A5 JP 2024103494A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- poi
- construct
- polynucleotide
- release system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- -1 Lamp2b Proteins 0.000 claims 6
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 3
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 3
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 3
- 102100025390 Integrin beta-2 Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 108010040467 CRISPR-Associated Proteins Proteins 0.000 claims 2
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- 238000000034 method Methods 0.000 claims 2
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- 102100040026 Agrin Human genes 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101100165655 Arabidopsis thaliana BRO1 gene Proteins 0.000 claims 1
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- 101000634835 Homo sapiens M1-specific T cell receptor alpha chain Proteins 0.000 claims 1
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- 101000651890 Homo sapiens Slit homolog 2 protein Proteins 0.000 claims 1
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- 101000634836 Homo sapiens T cell receptor alpha chain MC.7.G5 Proteins 0.000 claims 1
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- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000759889 Homo sapiens Tetraspanin-14 Proteins 0.000 claims 1
- 101000612838 Homo sapiens Tetraspanin-7 Proteins 0.000 claims 1
- 101000847107 Homo sapiens Tetraspanin-8 Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000621459 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1A Proteins 0.000 claims 1
- 101000621456 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1B Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 102100025305 Integrin alpha-2 Human genes 0.000 claims 1
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- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100032999 Integrin beta-3 Human genes 0.000 claims 1
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- 102100033010 Integrin beta-5 Human genes 0.000 claims 1
- 102100033011 Integrin beta-6 Human genes 0.000 claims 1
- 102100033016 Integrin beta-7 Human genes 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 1
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 1
- 102100039648 Lactadherin Human genes 0.000 claims 1
- 102100027448 Laminin subunit beta-1 Human genes 0.000 claims 1
- 102100034710 Laminin subunit gamma-1 Human genes 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 101100341510 Mus musculus Itgal gene Proteins 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 1
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- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 102000001756 Notch2 Receptor Human genes 0.000 claims 1
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- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
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- 108010029741 Notch4 Receptor Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 claims 1
- 102100032733 Protein jagged-2 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100027340 Slit homolog 2 protein Human genes 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
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- 102100029454 T cell receptor alpha chain MC.7.G5 Human genes 0.000 claims 1
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- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102100024995 Tetraspanin-14 Human genes 0.000 claims 1
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- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
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- 238000003776 cleavage reaction Methods 0.000 claims 1
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
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- 208000016361 genetic disease Diseases 0.000 claims 1
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- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1609216.5 | 2016-05-25 | ||
| GBGB1609216.5A GB201609216D0 (en) | 2016-05-25 | 2016-05-25 | Exosomes comprising therapeutic polypeptides |
| JP2019514870A JP6855567B2 (ja) | 2016-05-25 | 2017-05-25 | 治療的ポリペプチドを含むエクソソーム |
| JP2021042290A JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021042290A Division JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024103494A JP2024103494A (ja) | 2024-08-01 |
| JP2024103494A5 true JP2024103494A5 (https=) | 2024-10-18 |
Family
ID=56369954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514870A Active JP6855567B2 (ja) | 2016-05-25 | 2017-05-25 | 治療的ポリペプチドを含むエクソソーム |
| JP2021042290A Active JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
| JP2024074429A Pending JP2024103494A (ja) | 2016-05-25 | 2024-05-01 | 治療的ポリペプチドを含むエクソソーム |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514870A Active JP6855567B2 (ja) | 2016-05-25 | 2017-05-25 | 治療的ポリペプチドを含むエクソソーム |
| JP2021042290A Active JP7483648B2 (ja) | 2016-05-25 | 2021-03-16 | 治療的ポリペプチドを含むエクソソーム |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11534499B2 (https=) |
| EP (3) | EP3782646B1 (https=) |
| JP (3) | JP6855567B2 (https=) |
| KR (1) | KR102253731B1 (https=) |
| CN (2) | CN116103241A (https=) |
| AU (1) | AU2017270932B2 (https=) |
| BR (1) | BR112018074229A2 (https=) |
| CA (1) | CA3024020C (https=) |
| DK (1) | DK3463465T3 (https=) |
| ES (1) | ES2836553T3 (https=) |
| GB (1) | GB201609216D0 (https=) |
| MX (1) | MX378381B (https=) |
| PT (1) | PT3463465T (https=) |
| RU (1) | RU2737732C2 (https=) |
| SG (1) | SG11201810116VA (https=) |
| WO (1) | WO2017203260A1 (https=) |
| ZA (1) | ZA201807945B (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| GB201609216D0 (en) | 2016-05-25 | 2016-07-06 | Evox Therapeutics And Isis Innovation Ltd | Exosomes comprising therapeutic polypeptides |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| GB2568255A (en) * | 2017-11-08 | 2019-05-15 | Evox Therapeutics Ltd | Exosomes comprising RNA therapeutics |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| US20210115449A1 (en) * | 2018-04-19 | 2021-04-22 | Board Of Regents, The University Of Texas System | Therapeutic modulation of tumor suppressors using exosomes |
| CN108753822A (zh) * | 2018-06-20 | 2018-11-06 | 中国人民解放军第四军医大学 | 递送融合型rna结合蛋白的表达载体及其制备方法和应用 |
| CN108753806A (zh) * | 2018-06-20 | 2018-11-06 | 中国人民解放军第四军医大学 | 增强目标rna装载入外泌体的融合蛋白的表达载体及其构建方法和应用 |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020041725A1 (en) * | 2018-08-24 | 2020-02-27 | University Of Delaware | Extracellular vesicles as biomarkers and therapeutics for neuromuscular disorders |
| CN109293745A (zh) * | 2018-09-04 | 2019-02-01 | 暨南大学 | 一种运载蛋白、重组表达载体、外泌体及制备方法与应用 |
| CN109321596B (zh) * | 2018-09-05 | 2021-12-17 | 暨南大学 | 一种包载蛋白的外泌体的制备方法与应用 |
| CN109234237B (zh) * | 2018-09-30 | 2020-08-07 | 中国人民解放军第四军医大学 | 一种装载ABCA1 mRNA的外泌体及其构建方法和应用 |
| CN113272426A (zh) * | 2018-11-16 | 2021-08-17 | 医福斯治疗有限公司 | 用于尿素循环蛋白和核酸的替代的细胞外囊泡 |
| WO2020106997A1 (en) * | 2018-11-21 | 2020-05-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for reducing age-related striated muscle and cognitive decline |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020152298A1 (en) * | 2019-01-24 | 2020-07-30 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for producing enzymes |
| CA3128386A1 (en) * | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20240108747A1 (en) * | 2019-03-21 | 2024-04-04 | Lonza Sales Ag | Extracellular vesicle conjugates and uses thereof |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20240024220A1 (en) * | 2019-05-11 | 2024-01-25 | Youngsuk Yi | Neurotoxin compositions and methods |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| EP3986429A4 (en) * | 2019-06-21 | 2023-07-19 | Entelexo Biotherapeutics Inc. | PLATFORMS, COMPOSITIONS, AND METHODS OF ADMINISTRATION OF THERAPEUTICS |
| KR102125567B1 (ko) | 2019-07-02 | 2020-06-22 | 한양대학교 에리카산학협력단 | 식물 엑소좀의 대량 생산 방법 |
| US20220354963A1 (en) * | 2019-08-14 | 2022-11-10 | Codiak Biosciences, Inc. | Extracellular vesicle linked to molecules and uses thereof |
| JP7578991B2 (ja) * | 2019-08-28 | 2024-11-07 | 国立研究開発法人理化学研究所 | 細胞膜透過性ベシクル |
| GB201915855D0 (en) * | 2019-10-31 | 2019-12-18 | Univ Oxford Innovation Ltd | An extracellular vesicle |
| CN110954703A (zh) * | 2019-12-27 | 2020-04-03 | 杭州迪相实业有限公司 | 一种同时检测外泌体内蛋白和rna、外泌体膜蛋白的方法 |
| JP2023512562A (ja) | 2020-02-05 | 2023-03-27 | ダイアデム バイオセラピューティクス インコーポレイテッド | 人工シナプス |
| JP7479078B2 (ja) * | 2020-02-10 | 2024-05-08 | 株式会社エキソステムテック | 光切断性タンパク質を含むエクソソーム及びその用途 |
| KR102688170B1 (ko) * | 2020-02-10 | 2024-07-24 | 주식회사 엑소스템텍 | 광 절단성 단백질을 포함하는 엑소좀 및 이의 이용 |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| US12472228B2 (en) | 2020-03-31 | 2025-11-18 | Ilias Biologics Inc. | Use of exosome-based delivery of NF-κB inhibitors |
| KR102852789B1 (ko) * | 2020-03-31 | 2025-09-01 | 주식회사 일리아스바이오로직스 | NF-κB 억제제의 엑소솜 기반 전달의 사용 |
| WO2021223659A1 (en) * | 2020-05-06 | 2021-11-11 | Nanjing Iaso Biotherapeutics Co., Ltd. | Extracellular vesicles targeting cancer cells and uses thereof |
| CN111569077B (zh) * | 2020-05-29 | 2021-10-26 | 南方医科大学 | Flot2抑制剂在抑制破骨细胞形成和/或破骨活性中的应用 |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
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