PT3463465T - Exossomas que compreendem polipéptidos terapêuticos - Google Patents

Exossomas que compreendem polipéptidos terapêuticos

Info

Publication number
PT3463465T
PT3463465T PT177273257T PT17727325T PT3463465T PT 3463465 T PT3463465 T PT 3463465T PT 177273257 T PT177273257 T PT 177273257T PT 17727325 T PT17727325 T PT 17727325T PT 3463465 T PT3463465 T PT 3463465T
Authority
PT
Portugal
Prior art keywords
exosomes
therapeutic polypeptides
polypeptides
therapeutic
Prior art date
Application number
PT177273257T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Evox Therapeutics Ltd
Oxford Univ Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evox Therapeutics Ltd, Oxford Univ Innovation filed Critical Evox Therapeutics Ltd
Publication of PT3463465T publication Critical patent/PT3463465T/pt

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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/6425Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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PT177273257T 2016-05-25 2017-05-25 Exossomas que compreendem polipéptidos terapêuticos PT3463465T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1609216.5A GB201609216D0 (en) 2016-05-25 2016-05-25 Exosomes comprising therapeutic polypeptides

Publications (1)

Publication Number Publication Date
PT3463465T true PT3463465T (pt) 2020-11-04

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Application Number Title Priority Date Filing Date
PT177273257T PT3463465T (pt) 2016-05-25 2017-05-25 Exossomas que compreendem polipéptidos terapêuticos

Country Status (17)

Country Link
US (2) US11534499B2 (https=)
EP (3) EP3782646B1 (https=)
JP (3) JP6855567B2 (https=)
KR (1) KR102253731B1 (https=)
CN (2) CN116103241A (https=)
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