BR112018074229A2 - exossomos compreendendo polipeptídeos terapêuticos - Google Patents

exossomos compreendendo polipeptídeos terapêuticos

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Publication number
BR112018074229A2
BR112018074229A2 BR112018074229-5A BR112018074229A BR112018074229A2 BR 112018074229 A2 BR112018074229 A2 BR 112018074229A2 BR 112018074229 A BR112018074229 A BR 112018074229A BR 112018074229 A2 BR112018074229 A2 BR 112018074229A2
Authority
BR
Brazil
Prior art keywords
relates
polypeptide
therapeutic polypeptides
exosomes
evs
Prior art date
Application number
BR112018074229-5A
Other languages
English (en)
Inventor
Hean Justin
Mager Imre
Wood Matthew
El Andaloussi Samir
Wiklander Oscar
Nordin Joel
Original Assignee
Evox Therapeutics Ltd
Oxford University Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evox Therapeutics Ltd, Oxford University Innovation filed Critical Evox Therapeutics Ltd
Publication of BR112018074229A2 publication Critical patent/BR112018074229A2/pt

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  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)

Abstract

a presente invenção se refere a um mecanismo de liberação inventivo para administração intracelular e intramembranar mediada por vesículas extracelulares (ev) de polipeptídeos terapêuticos. mais especificamente, a invenção se refere a evs compreendendo construtos polipeptídicos que compreendem um polipeptídeo terapêutico ligado de modo liberável a um polipeptídeo exossomal. além disso, a presente invenção se refere a métodos de fabricação, composições farmacêuticas, usos e aplicações médicas, e várias outras modalidades relacionadas com as evs inventivas.
BR112018074229-5A 2016-05-25 2017-05-25 exossomos compreendendo polipeptídeos terapêuticos BR112018074229A2 (pt)

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