BR112016021443A8 - Derivados de ácido acético azaindol e seu uso como moduladores de receptor de prostaglandina d2 - Google Patents

Derivados de ácido acético azaindol e seu uso como moduladores de receptor de prostaglandina d2

Info

Publication number
BR112016021443A8
BR112016021443A8 BR112016021443A BR112016021443A BR112016021443A8 BR 112016021443 A8 BR112016021443 A8 BR 112016021443A8 BR 112016021443 A BR112016021443 A BR 112016021443A BR 112016021443 A BR112016021443 A BR 112016021443A BR 112016021443 A8 BR112016021443 A8 BR 112016021443A8
Authority
BR
Brazil
Prior art keywords
prostaglandin
acetic acid
acid derivatives
receptor modulators
azaindol
Prior art date
Application number
BR112016021443A
Other languages
English (en)
Other versions
BR112016021443A2 (pt
Inventor
Aissaoui Hamed
Boss Christoph
Bouis Patrick
Hazemann Julien
Siegrist Romain
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR112016021443A2 publication Critical patent/BR112016021443A2/pt
Publication of BR112016021443A8 publication Critical patent/BR112016021443A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Abstract

DERIVADOS DE ÁCIDO ACÉTICO AZAINDOL E SEU USO COMO MODULADORES DE RECEPTOR DE PROSTAGLANDINA D2 A presente invenção diz respeito a derivados de ácido acético azaindol da fórmula (I), (I) Em que R1 e R2 são como descritos na descrição e seu uso como moduladores de receptor de prostaglandina, mais particularmente como moduladores receptores de prostaglandina D2, no tratamento de várias doenças e distúrbios mediados por prostaglandina, a composições farmacêuticas contendo estes compostos e a processos para sua preparação.
BR112016021443A 2014-03-18 2015-03-17 Derivados de ácido acético azaindol e seu uso como moduladores de receptor de prostaglandina d2 BR112016021443A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2014059927 2014-03-18
PCT/IB2015/051932 WO2015140701A1 (en) 2014-03-18 2015-03-17 Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators

Publications (2)

Publication Number Publication Date
BR112016021443A2 BR112016021443A2 (pt) 2017-08-15
BR112016021443A8 true BR112016021443A8 (pt) 2017-12-26

Family

ID=52808087

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016021443A BR112016021443A8 (pt) 2014-03-18 2015-03-17 Derivados de ácido acético azaindol e seu uso como moduladores de receptor de prostaglandina d2

Country Status (13)

Country Link
US (1) US9850241B2 (pt)
EP (1) EP3119780B1 (pt)
JP (1) JP6484644B2 (pt)
KR (1) KR20160133536A (pt)
CN (1) CN106103437A (pt)
AU (1) AU2015233046A1 (pt)
BR (1) BR112016021443A8 (pt)
CA (1) CA2938107A1 (pt)
ES (1) ES2699379T3 (pt)
MX (1) MX2016011900A (pt)
RU (1) RU2016140708A (pt)
TW (1) TW201620909A (pt)
WO (1) WO2015140701A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY179356A (en) 2014-03-17 2020-11-05 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
TWI711616B (zh) 2015-09-15 2020-12-01 瑞士商愛杜西亞製藥有限公司 結晶型式

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CA2938107A1 (en) 2015-09-24
JP2017507999A (ja) 2017-03-23
AU2015233046A1 (en) 2016-11-03
CN106103437A (zh) 2016-11-09
RU2016140708A (ru) 2018-04-18
WO2015140701A1 (en) 2015-09-24
MX2016011900A (es) 2016-12-05
RU2016140708A3 (pt) 2018-10-08
KR20160133536A (ko) 2016-11-22
ES2699379T3 (es) 2019-02-11
EP3119780A1 (en) 2017-01-25
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BR112016021443A2 (pt) 2017-08-15
US9850241B2 (en) 2017-12-26

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