JP2019524745A5 - - Google Patents
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- JP2019524745A5 JP2019524745A5 JP2019502697A JP2019502697A JP2019524745A5 JP 2019524745 A5 JP2019524745 A5 JP 2019524745A5 JP 2019502697 A JP2019502697 A JP 2019502697A JP 2019502697 A JP2019502697 A JP 2019502697A JP 2019524745 A5 JP2019524745 A5 JP 2019524745A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- polypeptide
- human
- binding polypeptide
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 229920001184 polypeptide Polymers 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 108020001507 fusion proteins Proteins 0.000 claims 9
- 102000037865 fusion proteins Human genes 0.000 claims 9
- 230000003278 mimic effect Effects 0.000 claims 8
- 210000001808 exosome Anatomy 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 102100025390 Integrin beta-2 Human genes 0.000 claims 4
- -1 Lamp2b Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 3
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 3
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 3
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 108010083130 Syntenins Proteins 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 108010024603 neurotensin mimic 1 Proteins 0.000 claims 2
- 108010024605 neurotensin mimic 2 Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- BSDCIRGNJKZPFV-GWOFURMSSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-(2,5,6-trichlorobenzimidazol-1-yl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=CC(Cl)=C(Cl)C=C2N=C1Cl BSDCIRGNJKZPFV-GWOFURMSSA-N 0.000 claims 1
- 102100040026 Agrin Human genes 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101100165655 Arabidopsis thaliana BRO1 gene Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 claims 1
- 101100334509 Bos taurus FCGR3A gene Proteins 0.000 claims 1
- 102100035893 CD151 antigen Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 102000049320 CD36 Human genes 0.000 claims 1
- 108010045374 CD36 Antigens Proteins 0.000 claims 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 102100027221 CD81 antigen Human genes 0.000 claims 1
- 102100027217 CD82 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 claims 1
- 102100036462 Delta-like protein 1 Human genes 0.000 claims 1
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
- 102100032790 Flotillin-1 Human genes 0.000 claims 1
- 102100023513 Flotillin-2 Human genes 0.000 claims 1
- 102100040510 Galectin-3-binding protein Human genes 0.000 claims 1
- 102100030651 Glutamate receptor 2 Human genes 0.000 claims 1
- 102100030669 Glutamate receptor 3 Human genes 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 102100035716 Glycophorin-A Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000959594 Homo sapiens Agrin Proteins 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101001000001 Homo sapiens Basement membrane-specific heparan sulfate proteoglycan core protein Proteins 0.000 claims 1
- 101000946874 Homo sapiens CD151 antigen Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 1
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 claims 1
- 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 claims 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
- 101000847538 Homo sapiens Flotillin-1 Proteins 0.000 claims 1
- 101000828609 Homo sapiens Flotillin-2 Proteins 0.000 claims 1
- 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 claims 1
- 101001010449 Homo sapiens Glutamate receptor 2 Proteins 0.000 claims 1
- 101001010434 Homo sapiens Glutamate receptor 3 Proteins 0.000 claims 1
- 101001074244 Homo sapiens Glycophorin-A Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000878580 Homo sapiens High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor Proteins 0.000 claims 1
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims 1
- 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims 1
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims 1
- 101001015006 Homo sapiens Integrin beta-4 Proteins 0.000 claims 1
- 101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 claims 1
- 101001015064 Homo sapiens Integrin beta-6 Proteins 0.000 claims 1
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000599858 Homo sapiens Intercellular adhesion molecule 2 Proteins 0.000 claims 1
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 claims 1
- 101001034314 Homo sapiens Lactadherin Proteins 0.000 claims 1
- 101001008568 Homo sapiens Laminin subunit beta-1 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 1
- 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 claims 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 1
- 101000917821 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-c Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000634835 Homo sapiens M1-specific T cell receptor alpha chain Proteins 0.000 claims 1
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 claims 1
- 101100082597 Homo sapiens PDCD6IP gene Proteins 0.000 claims 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 1
- 101000994437 Homo sapiens Protein jagged-1 Proteins 0.000 claims 1
- 101000994434 Homo sapiens Protein jagged-2 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000651890 Homo sapiens Slit homolog 2 protein Proteins 0.000 claims 1
- 101000651893 Homo sapiens Slit homolog 3 protein Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000642688 Homo sapiens Syntaxin-3 Proteins 0.000 claims 1
- 101000634836 Homo sapiens T cell receptor alpha chain MC.7.G5 Proteins 0.000 claims 1
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000759889 Homo sapiens Tetraspanin-14 Proteins 0.000 claims 1
- 101000612838 Homo sapiens Tetraspanin-7 Proteins 0.000 claims 1
- 101000847107 Homo sapiens Tetraspanin-8 Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000621459 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1A Proteins 0.000 claims 1
- 101000621456 Homo sapiens Vesicle transport through interaction with t-SNAREs homolog 1B Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102100032819 Integrin alpha-3 Human genes 0.000 claims 1
- 102100032817 Integrin alpha-5 Human genes 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100022337 Integrin alpha-V Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100032999 Integrin beta-3 Human genes 0.000 claims 1
- 102100033000 Integrin beta-4 Human genes 0.000 claims 1
- 102100033010 Integrin beta-5 Human genes 0.000 claims 1
- 102100033011 Integrin beta-6 Human genes 0.000 claims 1
- 102100033016 Integrin beta-7 Human genes 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 1
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 1
- 102100039648 Lactadherin Human genes 0.000 claims 1
- 102100027448 Laminin subunit beta-1 Human genes 0.000 claims 1
- 102100034710 Laminin subunit gamma-1 Human genes 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 1
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 1
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 102000001756 Notch2 Receptor Human genes 0.000 claims 1
- 108010029751 Notch2 Receptor Proteins 0.000 claims 1
- 102000001760 Notch3 Receptor Human genes 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 102000001753 Notch4 Receptor Human genes 0.000 claims 1
- 108010029741 Notch4 Receptor Proteins 0.000 claims 1
- 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 claims 1
- 102100032733 Protein jagged-2 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100027340 Slit homolog 2 protein Human genes 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
- 102100035937 Syntaxin-3 Human genes 0.000 claims 1
- 102100037219 Syntenin-1 Human genes 0.000 claims 1
- 102100037225 Syntenin-2 Human genes 0.000 claims 1
- 102100029454 T cell receptor alpha chain MC.7.G5 Human genes 0.000 claims 1
- 102100026967 T cell receptor beta chain MC.7.G5 Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100024995 Tetraspanin-14 Human genes 0.000 claims 1
- 102100040952 Tetraspanin-7 Human genes 0.000 claims 1
- 102100032802 Tetraspanin-8 Human genes 0.000 claims 1
- 101710120037 Toxin CcdB Proteins 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100023019 Vesicle transport through interaction with t-SNAREs homolog 1A Human genes 0.000 claims 1
- 102100023018 Vesicle transport through interaction with t-SNAREs homolog 1B Human genes 0.000 claims 1
- 229940125644 antibody drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 102000054701 human FCAMR Human genes 0.000 claims 1
- 102000043832 human FCGR2A Human genes 0.000 claims 1
- 102000056145 human FCGR2B Human genes 0.000 claims 1
- 102000045862 human FCGR2C Human genes 0.000 claims 1
- 102000057266 human FCGR3A Human genes 0.000 claims 1
- 102000053350 human FCGR3B Human genes 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 108010093036 interleukin receptors Proteins 0.000 claims 1
- 102000002467 interleukin receptors Human genes 0.000 claims 1
- 108010090909 laminin gamma 1 Proteins 0.000 claims 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000014207 opsonization Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022192884A JP2023026440A (ja) | 2016-07-21 | 2022-12-01 | Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1612643.5A GB2552473A (en) | 2016-07-21 | 2016-07-21 | Surface decoration of extracellular vesicles |
| GB1612643.5 | 2016-07-21 | ||
| PCT/EP2017/068476 WO2018015535A1 (en) | 2016-07-21 | 2017-07-21 | Extracellular vesicle comprising a fusion protein having fc binding capacity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022192884A Division JP2023026440A (ja) | 2016-07-21 | 2022-12-01 | Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524745A JP2019524745A (ja) | 2019-09-05 |
| JP2019524745A5 true JP2019524745A5 (https=) | 2020-08-27 |
| JP7254016B2 JP7254016B2 (ja) | 2023-04-07 |
Family
ID=56894359
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502253A Active JP7140743B2 (ja) | 2016-07-21 | 2017-07-21 | Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用 |
| JP2019502697A Active JP7254016B2 (ja) | 2016-07-21 | 2017-07-21 | Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞 |
| JP2022084613A Pending JP2022117998A (ja) | 2016-07-21 | 2022-05-24 | Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用 |
| JP2022192884A Withdrawn JP2023026440A (ja) | 2016-07-21 | 2022-12-01 | Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502253A Active JP7140743B2 (ja) | 2016-07-21 | 2017-07-21 | Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022084613A Pending JP2022117998A (ja) | 2016-07-21 | 2022-05-24 | Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用 |
| JP2022192884A Withdrawn JP2023026440A (ja) | 2016-07-21 | 2022-12-01 | Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11236143B2 (https=) |
| EP (3) | EP3487528B1 (https=) |
| JP (4) | JP7140743B2 (https=) |
| KR (2) | KR20190032479A (https=) |
| CN (2) | CN109689098A (https=) |
| AU (2) | AU2017299214A1 (https=) |
| BR (2) | BR112019001099A2 (https=) |
| CA (2) | CA3031183A1 (https=) |
| GB (1) | GB2552473A (https=) |
| MX (2) | MX2019000863A (https=) |
| SG (4) | SG11201811152YA (https=) |
| WO (2) | WO2018015539A1 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013008697A2 (pt) | 2010-09-24 | 2016-06-21 | Massachusetts Inst Technology | géis nanoestruturados capazes de liberação controlada de agentes encapsulados |
| GB2552774A (en) * | 2016-07-12 | 2018-02-14 | Evox Therapeutics Ltd | EV-Mediated delivery of binding protein-small molecule conjugates |
| GB2552473A (en) * | 2016-07-21 | 2018-01-31 | Evox Therapeutics Ltd | Surface decoration of extracellular vesicles |
| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| GB201702863D0 (en) * | 2017-02-22 | 2017-04-05 | Evox Therapeutics Ltd | Improved loading of EVs with therapeutic proteins |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| GB201717446D0 (en) * | 2017-10-24 | 2017-12-06 | Evox Therapeutics Ltd | Affinity purification of engineering extracellular vesicles |
| GB201804291D0 (en) * | 2018-03-16 | 2018-05-02 | Evox Therapeutics Ltd | Cell-mediated exosome delivery |
| JP2021520352A (ja) | 2018-04-04 | 2021-08-19 | アリヴィオ セラピューティクス， インコーポレイテッド | 生物製剤の制御送達用の自己組織化ゲルおよびその製造方法 |
| TWI770396B (zh) * | 2018-06-28 | 2022-07-11 | 中央研究院 | 合成多肽及其用途 |
| KR102917499B1 (ko) | 2018-07-20 | 2026-01-26 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 백혈병 억제 인자 활성을 억제하기 위한 가용성 폴리펩타이드 및 이의 사용 방법 |
| GB201812992D0 (en) | 2018-08-09 | 2018-09-26 | Univ Greenwich | Liposomes |
| SG11202100864VA (en) | 2018-08-14 | 2021-02-25 | Evercyte Gmbh | Target-specific extracellular vesicles |
| CN108998402B (zh) * | 2018-08-28 | 2020-05-29 | 江南大学 | 一种重组枯草芽孢杆菌及其构建方法与应用 |
| WO2020051507A1 (en) | 2018-09-06 | 2020-03-12 | The Broad Institute, Inc. | Nucleic acid assemblies for use in targeted delivery |
| BR112021007286A2 (pt) | 2018-10-19 | 2021-07-27 | Ohio State Innovation Foundation | células furtivas terapêuticas nanoprojetadas |
| CN113286826A (zh) * | 2018-10-19 | 2021-08-20 | 俄亥俄州国家创新基金会 | 用于针对髓源性抑制细胞的靶向治疗的细胞外囊泡 |
| BR112021007285A2 (pt) | 2018-10-19 | 2021-07-27 | Ohio State Innovation Foundation | nanocarreadores para terapia de inflamação pulmonar |
| JP7659499B2 (ja) * | 2018-10-25 | 2025-04-09 | ネクセル カンパニー，リミテッド | 線維症を治療又は予防するための組成物及び方法 |
| CN113272426A (zh) * | 2018-11-16 | 2021-08-17 | 医福斯治疗有限公司 | 用于尿素循环蛋白和核酸的替代的细胞外囊泡 |
| BR112021012647A2 (pt) * | 2018-12-27 | 2021-09-14 | Akeso Biopharma, Inc | Anticorpo, polipeptídeo isolado, polinucleotídeo isolado, vetor, célula hospedeira, métodos para preparar o anticorpo e para a prevenção e/ou tratamento e/ou tratamento adjuvante e/ou diagnóstico de uma doença, conjugado de anticorpo, anticorpo multiespecífico, proteína de fusão, composição farmacêutica, kit, usos do anticorpo, método in vivo ou in vitro, célula de hibridoma e anticorpo monoclonal |
| CA3128386A1 (en) * | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| EP3965829A4 (en) * | 2019-05-06 | 2023-05-24 | Malcolm, Thomas | ADAPTED HYPOIMMUNE NANOVESICULAR DELIVERY SYSTEM FOR CANCER TUMORS |
| WO2020252455A1 (en) * | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| WO2020249757A1 (en) * | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| EP3986429A4 (en) * | 2019-06-21 | 2023-07-19 | Entelexo Biotherapeutics Inc. | PLATFORMS, COMPOSITIONS, AND METHODS OF ADMINISTRATION OF THERAPEUTICS |
| US20210093567A1 (en) * | 2019-08-06 | 2021-04-01 | Ohio State Innovation Foundation | Therapeutic extracellular vesicles |
| WO2021045501A1 (ko) * | 2019-09-02 | 2021-03-11 | 경북대학교 산학협력단 | Il-2 표면 발현 세포외 소포체를 유효성분으로 포함하는 암 질환 예방 또는 치료용 조성물 |
| CN112941028A (zh) * | 2019-12-09 | 2021-06-11 | 上海细胞治疗集团有限公司 | 纳米抗体基因修饰的间充质干细胞及其制备方法与应用 |
| JP2023512562A (ja) | 2020-02-05 | 2023-03-27 | ダイアデム バイオセラピューティクス インコーポレイテッド | 人工シナプス |
| WO2021211460A1 (en) * | 2020-04-13 | 2021-10-21 | City Of Hope | Cell-receptor targeted exosomes |
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