GB2552473A - Surface decoration of extracellular vesicles - Google Patents

Surface decoration of extracellular vesicles Download PDF

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Publication number
GB2552473A
GB2552473A GB1612643.5A GB201612643A GB2552473A GB 2552473 A GB2552473 A GB 2552473A GB 201612643 A GB201612643 A GB 201612643A GB 2552473 A GB2552473 A GB 2552473A
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GB
United Kingdom
Prior art keywords
protein
domain
evs
binder
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1612643.5A
Other languages
English (en)
Other versions
GB201612643D0 (en
Inventor
Wiklander Oscar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evox Therapeutics Ltd
Original Assignee
Evox Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evox Therapeutics Ltd filed Critical Evox Therapeutics Ltd
Priority to GB1612643.5A priority Critical patent/GB2552473A/en
Publication of GB201612643D0 publication Critical patent/GB201612643D0/en
Priority to EP17749395.4A priority patent/EP3487528B1/en
Priority to SG11201811151PA priority patent/SG11201811151PA/en
Priority to CN201780045139.XA priority patent/CN109689097B/zh
Priority to SG11201811152YA priority patent/SG11201811152YA/en
Priority to CN201780045183.0A priority patent/CN109689098A/zh
Priority to EP23192812.8A priority patent/EP4299137A3/en
Priority to AU2017299214A priority patent/AU2017299214A1/en
Priority to SG10202100598RA priority patent/SG10202100598RA/en
Priority to JP2019502697A priority patent/JP7254016B2/ja
Priority to CA3031183A priority patent/CA3031183A1/en
Priority to JP2019502253A priority patent/JP7140743B2/ja
Priority to US16/319,087 priority patent/US20230181757A1/en
Priority to US16/319,061 priority patent/US11236143B2/en
Priority to MX2019000863A priority patent/MX2019000863A/es
Priority to KR1020197005096A priority patent/KR102636776B1/ko
Priority to KR1020197005093A priority patent/KR20190032479A/ko
Priority to BR112019001099A priority patent/BR112019001099A2/pt
Priority to AU2017300035A priority patent/AU2017300035A1/en
Priority to BR112019001108A priority patent/BR112019001108A2/pt
Priority to CA3031186A priority patent/CA3031186A1/en
Priority to MX2019000861A priority patent/MX2019000861A/es
Priority to PCT/EP2017/068486 priority patent/WO2018015539A1/en
Priority to EP17749397.0A priority patent/EP3487529A1/en
Priority to SG10202100597TA priority patent/SG10202100597TA/en
Priority to PCT/EP2017/068476 priority patent/WO2018015535A1/en
Publication of GB2552473A publication Critical patent/GB2552473A/en
Priority to US17/551,582 priority patent/US20220098267A1/en
Priority to JP2022084613A priority patent/JP2022117998A/ja
Priority to JP2022192884A priority patent/JP2023026440A/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
GB1612643.5A 2016-07-21 2016-07-21 Surface decoration of extracellular vesicles Withdrawn GB2552473A (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
GB1612643.5A GB2552473A (en) 2016-07-21 2016-07-21 Surface decoration of extracellular vesicles
PCT/EP2017/068476 WO2018015535A1 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having fc binding capacity
MX2019000863A MX2019000863A (es) 2016-07-21 2017-07-21 Usos de vesicula extracelular que comprende una proteina de fusion que tiene capacidad de union a fc.
KR1020197005096A KR102636776B1 (ko) 2016-07-21 2017-07-21 결합능을 갖는 융합 단백질을 포함하는 세포외 소포
CN201780045139.XA CN109689097B (zh) 2016-07-21 2017-07-21 包含具有fc结合能力的融合蛋白的细胞外囊泡
SG11201811152YA SG11201811152YA (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
CN201780045183.0A CN109689098A (zh) 2016-07-21 2017-07-21 包括具有fc结合能力的融合蛋白的胞外囊泡的用途
EP23192812.8A EP4299137A3 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having fc binding capacity
AU2017299214A AU2017299214A1 (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having Fc binding capacity
SG10202100598RA SG10202100598RA (en) 2016-07-21 2017-07-21 Uses of Extracellular Vesicle Comprising a Fusion Protein Having FC Binding Capacity
JP2019502697A JP7254016B2 (ja) 2016-07-21 2017-07-21 Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞
CA3031183A CA3031183A1 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having fc binding capacity
JP2019502253A JP7140743B2 (ja) 2016-07-21 2017-07-21 Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用
US16/319,087 US20230181757A1 (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
US16/319,061 US11236143B2 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having Fc binding capacity
EP17749395.4A EP3487528B1 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having fc binding capacity
KR1020197005093A KR20190032479A (ko) 2016-07-21 2017-07-21 결합능을 갖는 융합 단백질을 포함하는 세포외 소포의 용도
MX2019000861A MX2019000861A (es) 2016-07-21 2017-07-21 Vesicula extracelular que comprende una proteina de fusion que tiene capacidad de union a fc.
EP17749397.0A EP3487529A1 (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
AU2017300035A AU2017300035A1 (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having Fc binding capacity
BR112019001108A BR112019001108A2 (pt) 2016-07-21 2017-07-21 usos de vesículas extracelulares compreendendo uma proteína de fusão tendo capacidade de ligação a fc
CA3031186A CA3031186A1 (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
SG11201811151PA SG11201811151PA (en) 2016-07-21 2017-07-21 Extracellular vesicle comprising a fusion protein having fc binding capacity
PCT/EP2017/068486 WO2018015539A1 (en) 2016-07-21 2017-07-21 Uses of extracellular vesicle comprising a fusion protein having fc binding capacity
BR112019001099A BR112019001099A2 (pt) 2016-07-21 2017-07-21 usos de vesículas extracelulares compreendendo uma proteína de fusão tendo capacidade de ligação a fc
SG10202100597TA SG10202100597TA (en) 2016-07-21 2017-07-21 Extracellular Vesicle Comprising a Fusion Protein Having FC Binding Capacity
US17/551,582 US20220098267A1 (en) 2016-07-21 2021-12-15 Extracellular vesicle comprising a fusion protein having fc binding capacity
JP2022084613A JP2022117998A (ja) 2016-07-21 2022-05-24 Ｆｃ結合能を有する融合タンパク質を含む細胞外小胞の使用
JP2022192884A JP2023026440A (ja) 2016-07-21 2022-12-01 Ｆｃ結合能力を有する融合タンパク質を含む細胞外小胞

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1612643.5A GB2552473A (en) 2016-07-21 2016-07-21 Surface decoration of extracellular vesicles

Publications (2)

Publication Number Publication Date
GB201612643D0 GB201612643D0 (en) 2016-09-07
GB2552473A true GB2552473A (en) 2018-01-31

Family

ID=56894359

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1612643.5A Withdrawn GB2552473A (en) 2016-07-21 2016-07-21 Surface decoration of extracellular vesicles

Country Status (12)

Country Link
US (3) US11236143B2 (https=)
EP (3) EP3487528B1 (https=)
JP (4) JP7140743B2 (https=)
KR (2) KR20190032479A (https=)
CN (2) CN109689098A (https=)
AU (2) AU2017299214A1 (https=)
BR (2) BR112019001099A2 (https=)
CA (2) CA3031183A1 (https=)
GB (1) GB2552473A (https=)
MX (2) MX2019000863A (https=)
SG (4) SG11201811152YA (https=)
WO (2) WO2018015539A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110655585A (zh) * 2018-06-28 2020-01-07 中央研究院 合成多肽及其用途

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013008697A2 (pt) 2010-09-24 2016-06-21 Massachusetts Inst Technology géis nanoestruturados capazes de liberação controlada de agentes encapsulados
GB2552774A (en) * 2016-07-12 2018-02-14 Evox Therapeutics Ltd EV-Mediated delivery of binding protein-small molecule conjugates
GB2552473A (en) * 2016-07-21 2018-01-31 Evox Therapeutics Ltd Surface decoration of extracellular vesicles
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
GB201702863D0 (en) * 2017-02-22 2017-04-05 Evox Therapeutics Ltd Improved loading of EVs with therapeutic proteins
WO2019032628A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS
GB201717446D0 (en) * 2017-10-24 2017-12-06 Evox Therapeutics Ltd Affinity purification of engineering extracellular vesicles
GB201804291D0 (en) * 2018-03-16 2018-05-02 Evox Therapeutics Ltd Cell-mediated exosome delivery
JP2021520352A (ja) 2018-04-04 2021-08-19 アリヴィオ セラピューティクス， インコーポレイテッド 生物製剤の制御送達用の自己組織化ゲルおよびその製造方法
KR102917499B1 (ko) 2018-07-20 2026-01-26 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 백혈병 억제 인자 활성을 억제하기 위한 가용성 폴리펩타이드 및 이의 사용 방법
GB201812992D0 (en) 2018-08-09 2018-09-26 Univ Greenwich Liposomes
SG11202100864VA (en) 2018-08-14 2021-02-25 Evercyte Gmbh Target-specific extracellular vesicles
CN108998402B (zh) * 2018-08-28 2020-05-29 江南大学 一种重组枯草芽孢杆菌及其构建方法与应用
WO2020051507A1 (en) 2018-09-06 2020-03-12 The Broad Institute, Inc. Nucleic acid assemblies for use in targeted delivery
BR112021007286A2 (pt) 2018-10-19 2021-07-27 Ohio State Innovation Foundation células furtivas terapêuticas nanoprojetadas
CN113286826A (zh) * 2018-10-19 2021-08-20 俄亥俄州国家创新基金会 用于针对髓源性抑制细胞的靶向治疗的细胞外囊泡
BR112021007285A2 (pt) 2018-10-19 2021-07-27 Ohio State Innovation Foundation nanocarreadores para terapia de inflamação pulmonar
JP7659499B2 (ja) * 2018-10-25 2025-04-09 ネクセル カンパニー，リミテッド 線維症を治療又は予防するための組成物及び方法
CN113272426A (zh) * 2018-11-16 2021-08-17 医福斯治疗有限公司 用于尿素循环蛋白和核酸的替代的细胞外囊泡
BR112021012647A2 (pt) * 2018-12-27 2021-09-14 Akeso Biopharma, Inc Anticorpo, polipeptídeo isolado, polinucleotídeo isolado, vetor, célula hospedeira, métodos para preparar o anticorpo e para a prevenção e/ou tratamento e/ou tratamento adjuvante e/ou diagnóstico de uma doença, conjugado de anticorpo, anticorpo multiespecífico, proteína de fusão, composição farmacêutica, kit, usos do anticorpo, método in vivo ou in vitro, célula de hibridoma e anticorpo monoclonal
CA3128386A1 (en) * 2019-02-04 2020-08-13 Codiak Biosciences, Inc. Membrane protein scaffolds for exosome engineering
EP3965829A4 (en) * 2019-05-06 2023-05-24 Malcolm, Thomas ADAPTED HYPOIMMUNE NANOVESICULAR DELIVERY SYSTEM FOR CANCER TUMORS
WO2020252455A1 (en) * 2019-06-13 2020-12-17 The General Hospital Corporation Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
WO2020249757A1 (en) * 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
EP3986429A4 (en) * 2019-06-21 2023-07-19 Entelexo Biotherapeutics Inc. PLATFORMS, COMPOSITIONS, AND METHODS OF ADMINISTRATION OF THERAPEUTICS
US20210093567A1 (en) * 2019-08-06 2021-04-01 Ohio State Innovation Foundation Therapeutic extracellular vesicles
WO2021045501A1 (ko) * 2019-09-02 2021-03-11 경북대학교 산학협력단 Il-2 표면 발현 세포외 소포체를 유효성분으로 포함하는 암 질환 예방 또는 치료용 조성물
CN112941028A (zh) * 2019-12-09 2021-06-11 上海细胞治疗集团有限公司 纳米抗体基因修饰的间充质干细胞及其制备方法与应用
JP2023512562A (ja) 2020-02-05 2023-03-27 ダイアデム バイオセラピューティクス インコーポレイテッド 人工シナプス
WO2021211460A1 (en) * 2020-04-13 2021-10-21 City Of Hope Cell-receptor targeted exosomes
CN111544453B (zh) * 2020-04-27 2021-01-22 高连如 一种包含三种血管再生属性的混合干细胞注射液及其制备方法
CN111560352B (zh) * 2020-06-02 2023-03-24 新疆农业大学 一种病毒样囊泡及其制备方法和应用
CN111905105B (zh) * 2020-07-02 2023-05-05 华南师范大学 一种用于癌症靶向治疗的蛋白类纳米药物及其制备方法
CN112111513A (zh) * 2020-07-17 2020-12-22 深圳市第二人民医院 基于外泌体平台的新冠病毒疫苗制备方法
CA3189601A1 (en) 2020-07-24 2022-01-27 The General Hospital Corporation Enhanced virus-like particles and methods of use thereof for delivery to cells
CN113967254B (zh) * 2020-08-04 2022-08-12 华南理工大学 用于多特异性抗体递送的细胞膜包覆型纳米适配子及应用
JP2023536665A (ja) * 2020-08-05 2023-08-28 オハイオ・ステイト・イノベーション・ファウンデーション アダプターポリペプチドおよびその使用方法
CN112285195B (zh) * 2020-10-27 2021-08-10 江南大学 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法
WO2022149779A1 (ko) * 2021-01-11 2022-07-14 주식회사 엑소코바이오 과발현된 Fc 수용체 또는 이의 일부를 포함하는 엑소좀 및 이의 제조방법
KR102252325B1 (ko) * 2021-01-14 2021-05-14 이장호 태아 유래 태초 면역글로불린을 포함하는 세포외소포의 제조방법
WO2022158836A1 (ko) * 2021-01-21 2022-07-28 주식회사 엑소코바이오 목적 단백질 또는 펩타이드가 융합가능한 Fc 수용체 또는 이의 일부를 포함하는 재조합 엑소좀 및 이의 용도
US20240218046A1 (en) * 2021-04-14 2024-07-04 Anjarium Biosciences Ag Fc-derived polypeptides
JP2024514157A (ja) * 2021-04-14 2024-03-28 アンジャリウム バイオサイエンシズ エージー 薬物送達のためのペプチド、ナノ小胞、及びその使用
CA3217654A1 (en) * 2021-04-23 2022-10-27 Spot Biosystems Ltd. Extracellular vesicles loaded with biomolecules
GB202107182D0 (en) * 2021-05-19 2021-06-30 Evox Therapeutics Ltd Nanoparticle delivery system for production of engineered extracellular vesicles
EP4355304A4 (en) * 2021-06-17 2025-04-30 Malcolm, Thomas PERSONALIZED HYPOIMMUNE NANOVESICULAR DELIVERY SYSTEMS FOR CANCERS, INHERITED DISEASES AND INFECTIOUS DISEASES
CN115770302A (zh) * 2021-08-13 2023-03-10 南京大学 一种rna递送系统及其应用
CN113599516B (zh) * 2021-08-16 2022-02-18 上海蒙彼利生物技术有限公司 制备外泌体方法及其药物组合物在组织修复中的应用
KR102907010B1 (ko) * 2021-09-08 2026-02-02 주식회사 꿈랩 핵산분자의 안정적인 전달을 위한 플라스미드 플랫폼
CN113897387B (zh) * 2021-10-09 2023-09-05 深圳市汉科生命工程有限公司 一种具有促进毛发再生功能的基因重组msc及其外泌体样纳米材料的制备方法和应用
DK4190349T3 (da) * 2021-12-03 2025-04-14 Univ China Medical Produktion af exosomer og anvendelse heraf
CN114107253B (zh) * 2021-12-17 2024-03-15 复旦大学附属华山医院 一种利用工程细胞进行基因编辑的系统及方法
CN114236113B (zh) * 2021-12-21 2023-07-21 南京农业大学 一种2,4-滴的即用型免疫传感器
WO2023133425A1 (en) * 2022-01-04 2023-07-13 The Broad Institute, Inc. Compositions and methods for delivering cargo to a target cell
EP4505178A4 (en) * 2022-04-07 2026-04-29 Univ Michigan Regents METHODS AND DEVICES FOR SCREENING EXTRACELLULAR VESICLES
WO2024064748A2 (en) * 2022-09-20 2024-03-28 North Carolina State University Compositions and methods related to exosomal delivery of therapeutic agents
CN116179582A (zh) * 2022-09-27 2023-05-30 南京医事达生物科技有限公司 一种通用型基因重组蛋白质a亲和纯化填料制备方法和应用
CN117802045A (zh) * 2022-09-30 2024-04-02 北京恩康医药有限公司 一种工程化细胞外囊泡的构建及其应用
CN115873905A (zh) * 2022-11-15 2023-03-31 重庆医科大学附属儿童医院 一种gd2纳米抗体靶向修饰的类外泌体的新型药物载体的制备方法
KR102929157B1 (ko) 2023-03-08 2026-02-23 차이나 메디칼 유니버시티 엑소좀의 생산 및 이의 용도
KR20240158824A (ko) * 2023-04-26 2024-11-05 (주)인엑소플랫 면역글로불린 Fc 영역 또는 이의 변이체를 포함하는 재조합 세포외 소포체 및 이를 이용한 세포외 소포체의 분리 방법
WO2024225847A1 (ko) * 2023-04-28 2024-10-31 연세대학교 산학협력단 유방암 유래 엑소좀 또는 세포외 소포체 분리 방법
GB202307239D0 (en) 2023-05-15 2023-06-28 Evox Therapeutics Ltd Gene therapies for Phenylketonuria
CN119120376A (zh) * 2023-07-10 2024-12-13 浙江大学医学院附属第一医院 一种用于清除致病抗体的嵌合基因工程化纳米囊泡及其制备方法、应用
WO2025068572A2 (en) 2023-09-29 2025-04-03 Evox Therapeutics Limited Polypeptides comprising inteins for engineered evs
WO2025102257A1 (zh) * 2023-11-15 2025-05-22 深圳先进技术研究院 一种靶向子宫工程化细胞外囊泡的制备方法及其应用
CN121100135A (zh) * 2024-04-18 2025-12-09 苏州鲲石一号生物科技有限公司 Gas6融合蛋白及其制备方法与应用
CN118725135B (zh) * 2024-09-02 2025-02-07 中国科学院苏州纳米技术与纳米仿生研究所 外泌体的改造方法
CN119019494B (zh) * 2024-10-28 2025-02-07 广州飞来爱生命科技有限公司 一种治疗心梗的脐带间充质干细胞及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059643A2 (en) * 1998-05-20 1999-11-25 Sdg, Inc. Liposomal delivery complex
US20100086490A1 (en) * 2006-12-19 2010-04-08 Bracco Research S.A. Gas-filled microvesicles with targeting ligand or therapeutic agent
US20120207754A1 (en) * 2011-02-15 2012-08-16 Vaxiion Therapeutics, Inc. Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
JP2007295929A (ja) * 2006-04-05 2007-11-15 Geno Membrane:Kk イヌＢｓｅｐ遺伝子
CA2747020A1 (en) * 2007-08-30 2009-03-05 Virexx Medical Corp. Antigenic compositions and use of same in the targeted delivery of nucleic acids
JP2010540466A (ja) 2007-09-24 2010-12-24 ザ ユニバーシティ オブ クイーンズランド 分子送達ベシクル
US20130053426A1 (en) 2009-04-17 2013-02-28 Yiqi Seow Composition For Delivery Of Genetic Material
ES2623912T3 (es) * 2010-12-23 2017-07-12 Janssen Biotech, Inc. Mutantes FC de anticuerpo activo resistente a proteasa
GB201121069D0 (en) 2011-12-07 2012-01-18 Isis Innovation Delivery system
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
CA2910802A1 (en) 2013-04-12 2014-10-16 Samir El Andaloussi Therapeutic delivery vesicles
WO2015002956A1 (en) 2013-07-01 2015-01-08 Ohio State Innovation Foundation Exosome delivery system
US10538570B2 (en) * 2013-09-30 2020-01-21 Northwestern University Targeted and modular exosome loading system
EP3057662A4 (en) 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antibody dependent exosome therapy
WO2015143113A1 (en) * 2014-03-20 2015-09-24 Barb Ariel Cohen Preparations of derived extracellular vesicles, assays, and methods to modify therapeutic outcomes using such preparations
GB2552473A (en) * 2016-07-21 2018-01-31 Evox Therapeutics Ltd Surface decoration of extracellular vesicles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059643A2 (en) * 1998-05-20 1999-11-25 Sdg, Inc. Liposomal delivery complex
US20100086490A1 (en) * 2006-12-19 2010-04-08 Bracco Research S.A. Gas-filled microvesicles with targeting ligand or therapeutic agent
US20120207754A1 (en) * 2011-02-15 2012-08-16 Vaxiion Therapeutics, Inc. Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FEBS Letters (1998) 433 83-88 Nizard et al 'Anchoring antibodies to membranes using a diphtheria toxin T domain-ZZ fusion protein as a pH sensitive membrane anchor' *
Talanta (2005) 67 205-211 Chen et al 'Protein G-liposomal nanovesicles as universal reagents for immunoassays' *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110655585A (zh) * 2018-06-28 2020-01-07 中央研究院 合成多肽及其用途

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