JP2019517996A5 - - Google Patents

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JP2019517996A5
JP2019517996A5 JP2018550733A JP2018550733A JP2019517996A5 JP 2019517996 A5 JP2019517996 A5 JP 2019517996A5 JP 2018550733 A JP2018550733 A JP 2018550733A JP 2018550733 A JP2018550733 A JP 2018550733A JP 2019517996 A5 JP2019517996 A5 JP 2019517996A5
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Japan
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methyl
pyrazolo
pyridin
tetrahydropyran
group
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JP2018550733A
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Japanese (ja)
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JP7093306B2 (ja
JP2019517996A (ja
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Priority claimed from PCT/EP2017/058332 external-priority patent/WO2017178350A1/en
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Publication of JP2019517996A5 publication Critical patent/JP2019517996A5/ja
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JP2018550733A 2016-04-12 2017-04-07 ＰＤＥ１阻害剤としての１，５－ジヒドロ－４Ｈ－ピラゾロ［３，４－ｄ］ピリミジン－４－オン及び１，５－ジヒドロ－４Ｈ－ピラゾロ［４，３－ｃ］ピリジン－４－オン Expired - Fee Related JP7093306B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201600221 2016-04-12
DKPA201600221 2016-04-12
PCT/EP2017/058332 WO2017178350A1 (en) 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors

Publications (3)

Publication Number Publication Date
JP2019517996A JP2019517996A (ja) 2019-06-27
JP2019517996A5 true JP2019517996A5 (https=) 2020-05-07
JP7093306B2 JP7093306B2 (ja) 2022-06-29

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ID=58489694

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JP2018550733A Expired - Fee Related JP7093306B2 (ja) 2016-04-12 2017-04-07 ＰＤＥ１阻害剤としての１，５－ジヒドロ－４Ｈ－ピラゾロ［３，４－ｄ］ピリミジン－４－オン及び１，５－ジヒドロ－４Ｈ－ピラゾロ［４，３－ｃ］ピリジン－４－オン

Country Status (43)

Country Link
US (3) US20170291901A1 (https=)
EP (1) EP3442975B1 (https=)
JP (1) JP7093306B2 (https=)
KR (1) KR20180133413A (https=)
CN (1) CN109071549B (https=)
AR (1) AR108109A1 (https=)
AU (1) AU2017250431B2 (https=)
BR (1) BR112017026278A2 (https=)
CA (1) CA3020053A1 (https=)
CL (1) CL2018002881A1 (https=)
CO (1) CO2018010323A2 (https=)
CR (1) CR20180470A (https=)
CY (1) CY1123269T1 (https=)
DK (1) DK3442975T3 (https=)
DO (1) DOP2018000201A (https=)
EA (1) EA035197B1 (https=)
EC (1) ECSP18074641A (https=)
ES (1) ES2814289T3 (https=)
GE (2) GEAP201914901A (https=)
HR (1) HRP20201331T1 (https=)
HU (1) HUE050320T2 (https=)
IL (1) IL262257B (https=)
LT (1) LT3442975T (https=)
MA (1) MA44656B1 (https=)
ME (1) ME03820B (https=)
MX (1) MX374251B (https=)
MY (1) MY194722A (https=)
NI (1) NI201800092A (https=)
PE (1) PE20181853A1 (https=)
PH (1) PH12018502168A1 (https=)
PL (1) PL3442975T3 (https=)
PT (1) PT3442975T (https=)
RS (1) RS60714B1 (https=)
RU (1) RU2018133391A (https=)
SG (1) SG11201808221QA (https=)
SI (1) SI3442975T1 (https=)
SM (1) SMT202000446T1 (https=)
SV (1) SV2018005753A (https=)
TN (1) TN2018000321A1 (https=)
TW (1) TWI729109B (https=)
UA (1) UA121925C2 (https=)
WO (1) WO2017178350A1 (https=)
ZA (1) ZA201806407B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
ES2967489T3 (es) 2016-10-18 2024-04-30 H Lundbeck As Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1
RU2019109039A (ru) 2016-10-28 2020-11-30 Х. Лундбекк А/С Комбинированные средства для лечения, предусматривающего введение имидазопиразинонов, предназначенные для лечения психических и/или когнитивных расстройств
MX2019004859A (es) 2016-10-28 2019-06-20 H Lundbeck As Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.
JP7111720B2 (ja) 2016-12-28 2022-08-02 ダート・ニューロサイエンス・エルエルシー Ｐｄｅ２阻害剤としての置換ピラゾロピリミジノン化合物
CA3120971A1 (en) 2017-11-27 2019-05-31 Dart Neuroscience, Llc Substituted furanopyrimidine compounds as pde1 inhibitors
AU2019275453B2 (en) 2018-05-25 2023-12-21 Intra-Cellular Therapies, Inc. Organic compounds
WO2020210614A1 (en) 2019-04-12 2020-10-15 Intra-Cellular Therapies, Inc. Organic compounds
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973361A (en) * 1960-05-11 1964-10-28 Ciba Ltd Pyrazolo-pyrimidines and process for their manufacture
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
DE10238723A1 (de) * 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238724A1 (de) * 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238722A1 (de) * 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
CA2524900C (en) 2003-05-09 2012-03-20 Bayer Healthcare Ag 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
EP1919287A4 (en) 2005-08-23 2010-04-28 Intra Cellular Therapies Inc ORGANIC COMPOUNDS FOR TREATING A REDUCED DOPAMINE RECEPTOR SIGNALING ACTIVITY
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US9006258B2 (en) 2006-12-05 2015-04-14 Intra-Cellular Therapies, Inc. Method of treating female sexual dysfunction with a PDE1 inhibitor
PT2152712E (pt) * 2007-05-11 2012-02-29 Pfizer Compostos amino-heterocíclicos
EP2227472A1 (en) 2007-11-30 2010-09-15 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
JP5453431B2 (ja) 2008-09-08 2014-03-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピラゾロピリミジン及びｃｎｓ障害の治療のためのそれらの使用
AU2009322904A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
TWI404721B (zh) 2009-01-26 2013-08-11 Pfizer 胺基－雜環化合物
US9434730B2 (en) * 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
US20130196986A1 (en) 2010-09-21 2013-08-01 Marc Labroli Triazolopyrazinones as p2x7 receptor antagonists
JO3089B1 (ar) 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
WO2012136552A1 (en) 2011-04-08 2012-10-11 H. Lundbeck A/S ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ
EP2717877B1 (en) 2011-06-10 2017-11-08 Intra-Cellular Therapies, Inc. Organic compounds
SG11201502728WA (en) 2011-10-10 2015-05-28 Lundbeck & Co As H Pde9i with imidazo pyrazinone backbone
BR112014018199A8 (pt) 2012-01-26 2021-03-02 H Lundbeck As inibidores da pde9 com cadeia principal imidazo triazinona, composição farmacêutica que os compreende, uso dos referidos inibidores e processo para sua preparação
MX357320B (es) 2012-06-18 2018-07-04 Dart Neuroscience Cayman Ltd Compuestos de la azolopirimidina-5-(6h)-ona de piridina sustituida.
CA2906640C (en) 2013-03-15 2021-07-20 Intra-Cellular Therapies, Inc. Substituted imidazo-[1,2-a]pyrazolo[4.3-e]pyrimidin-4[5h]-one compounds and pharmaceutical compositions and use therof as pde1 inhibitors
JP5783297B2 (ja) 2013-08-06 2015-09-24 株式会社デンソー 力学量センサ
TW201609713A (zh) * 2013-12-19 2016-03-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之喹唑啉－ｔｈｆ－胺
JP5797815B1 (ja) 2014-06-27 2015-10-21 細田建設株式会社 後施工アンカー及びその施工方法
US20160083391A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic piperazine derivative
WO2016042775A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic derivative
US20160083400A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
JP2018508555A (ja) 2015-03-16 2018-03-29 大日本住友製薬株式会社 二環性イミダゾロ誘導体
US20160311831A1 (en) 2015-04-22 2016-10-27 H. Lundbeck A/S Imidazotriazinones as PDE1 Inhibitors
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
JP2018076285A (ja) 2016-09-14 2018-05-17 大日本住友製薬株式会社 二環性イミダゾロ誘導体を含む医薬
ES2967489T3 (es) 2016-10-18 2024-04-30 H Lundbeck As Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1
MX2019004859A (es) 2016-10-28 2019-06-20 H Lundbeck As Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.
RU2019109039A (ru) 2016-10-28 2020-11-30 Х. Лундбекк А/С Комбинированные средства для лечения, предусматривающего введение имидазопиразинонов, предназначенные для лечения психических и/или когнитивных расстройств

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