CN106132956A - 一类杂环化合物、其制备方法和用途 - Google Patents

一类杂环化合物、其制备方法和用途 Download PDF

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Publication number
CN106132956A
CN106132956A CN201580008897.5A CN201580008897A CN106132956A CN 106132956 A CN106132956 A CN 106132956A CN 201580008897 A CN201580008897 A CN 201580008897A CN 106132956 A CN106132956 A CN 106132956A
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piperazin
alkyl
ethyl
benzothien
group
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CN106132956B (zh
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蒋华良
王震
李剑峰
张容霞
何洋
柳永建
毕明浩
刘正
田广辉
陈伟铭
杨飞瀑
吴春晖
王瑜
蒋翔锐
尹敬敬
王贯
沈敬山
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Suzhou Vigonvita Life Sciences Co ltd
Shanghai Institute of Materia Medica of CAS
Topharman Shandong Co Ltd
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Suzhou Vigonvita Life Sciences Co ltd
Shanghai Institute of Materia Medica of CAS
Topharman Shandong Co Ltd
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

本发明提供了一种由通式(I)表示的杂环化合物、其立体异构体或其药学上可接受的盐、其药物组合物、以及其在制备预防和/或治疗中枢神经系统疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201580008897.5A 2014-03-07 2015-03-09 一类杂环化合物、其制备方法和用途 Active CN106132956B (zh)

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CN201410083602 2014-03-07
CN2014100836028 2014-03-07
CN201410853950.9A CN104892589A (zh) 2014-03-07 2014-12-31 一类杂环化合物、其制备方法和用途
CN2014108539509 2014-12-31
PCT/CN2015/073854 WO2015131856A1 (zh) 2014-03-07 2015-03-09 一类杂环化合物、其制备方法和用途

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US (1) US10174011B2 (zh)
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AU (1) AU2015226578B2 (zh)
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EP3150591A1 (en) * 2015-10-02 2017-04-05 Crystal Pharma S.A.U Process and intermediates for the preparation of benzo[b]thiophene compounds
CN105461608B (zh) * 2015-11-23 2017-11-28 东南大学 二氢吲哚‑2‑酮类d3受体配体及其制备方法和用途
US10464931B2 (en) 2015-12-28 2019-11-05 Honour (R&D) Process for the preparation of Quinolin-2(1H)-one derivatives
CN106478548A (zh) * 2016-07-19 2017-03-08 贵州大学 一种6‑羟基灭草松的制备工艺
CN107098855A (zh) * 2017-04-05 2017-08-29 上海诺星医药科技有限公司 一种制备7‑羟基‑2‑喹啉酮的方法
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