CN110627777B - 一种苯并噻吩化合物的马来酸盐、其结晶形式及其用途 - Google Patents
一种苯并噻吩化合物的马来酸盐、其结晶形式及其用途 Download PDFInfo
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Classifications
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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Abstract
Description
元素 | C(%) | H(%) | N(%) | S(%) |
理论值 | 70.92 | 5.95 | 10.79 | 8.23 |
实测值 | 70.65 | 5.91 | 10.74 | 8.30 |
元素 | C(%) | H(%) | N(%) | S(%) |
理论值 | 64.14 | 5.38 | 8.31 | 6.34 |
实测值 | 64.14 | 5.32 | 8.31 | 6.49 |
去离子水 | pH=2 | pH=4.5 | pH=6.8 | |
化合物Z | 0 | 6.8 | 0.7 | 0 |
化合物Z磷酸盐 | 181.2 | 2.8 | 0.1 | 0 |
化合物Z富马酸盐 | 117.6 | 2.0 | 1.8 | 0 |
化合物Z马来酸盐 | 194.0 | 3.3 | 1.0 | 0 |
化合物Z柠檬酸盐 | 147.4 | 2.3 | 1.0 | 0 |
Claims (12)
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CN201810646314 | 2018-06-21 | ||
CN2018106463147 | 2018-06-21 |
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CN110627777A CN110627777A (zh) | 2019-12-31 |
CN110627777B true CN110627777B (zh) | 2021-01-26 |
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US (1) | US11384073B2 (zh) |
EP (1) | EP3812384B1 (zh) |
JP (1) | JP2021531329A (zh) |
CN (1) | CN110627777B (zh) |
WO (1) | WO2019242717A1 (zh) |
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Publication number | Priority date | Publication date | Assignee | Title |
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TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
CN104892589A (zh) * | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | 一类杂环化合物、其制备方法和用途 |
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2019
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- 2019-06-21 WO PCT/CN2019/092230 patent/WO2019242717A1/zh unknown
- 2019-06-21 EP EP19822932.0A patent/EP3812384B1/en active Active
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JP2021531329A (ja) | 2021-11-18 |
WO2019242717A1 (zh) | 2019-12-26 |
EP3812384A4 (en) | 2021-05-12 |
US20210309648A1 (en) | 2021-10-07 |
EP3812384B1 (en) | 2022-05-04 |
CN110627777A (zh) | 2019-12-31 |
EP3812384A1 (en) | 2021-04-28 |
US11384073B2 (en) | 2022-07-12 |
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