JP2018529731A5 - - Google Patents
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- Publication number
- JP2018529731A5 JP2018529731A5 JP2018516728A JP2018516728A JP2018529731A5 JP 2018529731 A5 JP2018529731 A5 JP 2018529731A5 JP 2018516728 A JP2018516728 A JP 2018516728A JP 2018516728 A JP2018516728 A JP 2018516728A JP 2018529731 A5 JP2018529731 A5 JP 2018529731A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- amino
- amine
- dimethylpentyl
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)CC(C*)(CO)N Chemical compound CC(C)CC(C*)(CO)N 0.000 description 2
- VRDXDROAZSDMSA-UHFFFAOYSA-N NC1(CO)CCC1 Chemical compound NC1(CO)CCC1 VRDXDROAZSDMSA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3169DE2015 | 2015-10-01 | ||
| IN3169/DEL/2015 | 2015-10-01 | ||
| PCT/US2016/054464 WO2017059080A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529731A JP2018529731A (ja) | 2018-10-11 |
| JP2018529731A5 true JP2018529731A5 (https=) | 2019-11-07 |
| JP6864674B2 JP6864674B2 (ja) | 2021-04-28 |
Family
ID=57137279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516728A Active JP6864674B2 (ja) | 2015-10-01 | 2016-09-29 | ビアリールキナーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10246469B2 (https=) |
| EP (1) | EP3356330B1 (https=) |
| JP (1) | JP6864674B2 (https=) |
| KR (1) | KR102707968B1 (https=) |
| CN (1) | CN108290843B (https=) |
| ES (1) | ES2767776T3 (https=) |
| WO (1) | WO2017059080A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201800665T1 (it) | 2014-04-02 | 2019-01-11 | Bristol Myers Squibb Co | Inibitori biarilici di chinasi |
| WO2017059085A1 (en) | 2015-10-01 | 2017-04-06 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| JP6864674B2 (ja) | 2015-10-01 | 2021-04-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ビアリールキナーゼ阻害剤 |
| AU2019370200B2 (en) | 2018-10-30 | 2024-12-19 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
| WO2020232330A1 (en) * | 2019-05-15 | 2020-11-19 | Biogen Ma Inc. | Inhibiting agents for bruton's tyrosine kinase |
| TW202317532A (zh) * | 2021-07-15 | 2023-05-01 | 大陸商四川海思科製藥有限公司 | Aak1抑制劑及其用途 |
| CN115872927A (zh) * | 2021-09-30 | 2023-03-31 | 武汉人福创新药物研发中心有限公司 | Aak1抑制剂及其用途 |
| AU2023252840A1 (en) * | 2022-04-15 | 2024-10-03 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating spasticity |
| CN115894353B (zh) * | 2022-10-18 | 2025-08-29 | 山西永津集团有限公司 | 一种2,3-二氨基-4-溴吡啶的合成方法 |
| KR20250103656A (ko) * | 2022-11-10 | 2025-07-07 | 시젱 하이스코 파마수티칼 씨오., 엘티디. | Aak1 억제제를 함유한 약학적 조성물 |
| WO2024125668A1 (zh) * | 2022-12-13 | 2024-06-20 | 上海海雁医药科技有限公司 | 杂环取代的五并六元杂芳基衍生物、其药物组合物及应用与制备方法 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| KR20250167096A (ko) | 2023-04-07 | 2025-11-28 | 앨리콘 파머슈티컬 컴퍼니 리미티드 | Aak1 억제제인 질소 함유 헤테로고리계 화합물 |
| CN118772152B (zh) * | 2023-04-07 | 2026-01-02 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| CN116396241A (zh) * | 2023-04-12 | 2023-07-07 | 南京优氟医药科技有限公司 | 一种叔丁基（r）-4-乙基-2,2-二氧化物-1,2,3-氧杂噻唑烷-3-羧酸的制备方法 |
| WO2025092928A1 (zh) * | 2023-11-02 | 2025-05-08 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025225608A1 (en) * | 2024-04-23 | 2025-10-30 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydropyrazolopyridine derivative |
| WO2025230262A1 (ko) * | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | 신규한 헤테로아릴 유도체 및 이의 aak1 억제 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| EP1560824A1 (en) | 2002-11-05 | 2005-08-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
| BRPI0709949A2 (pt) * | 2006-04-12 | 2011-08-30 | Wyeth Corp | composto de fórmula iii; método de inibir atividade quinase em uma célula; método de inibir atividade quinase em um mamìfero; composição farmacêutica; método de tratar uma condição dependente de quinase; método de tratar uma doença associada com ativação de nf-kb; método de tratar proliferação de célula tumoral, crescimento de célula tumoral, ou tumorigênese; método de reduzir inflamação; método de tratar uma condição inflamatória ou autoimune; método de tratar uma condição cardiovascular, metabólica ou isquêmica; método de tratar uma doença infecciosa; método de tratar uma condição pré ou pós menopausa; e método de tratar osteoporose |
| ES2524787T3 (es) | 2007-11-15 | 2014-12-12 | Msd Italia S.R.L. | Derivados de piridazinona como inhibidores de PARP |
| JP5745704B2 (ja) * | 2012-02-29 | 2015-07-08 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 新規イミノピリジン誘導体を含む有害生物防除用組成物 |
| DK2822555T3 (en) | 2012-03-09 | 2018-02-05 | Lexicon Pharmaceuticals Inc | Inhibition of adapter-associated kinase 1 for the treatment of pain |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| US9708337B2 (en) | 2013-02-22 | 2017-07-18 | Bristol-Myers Squibb Company | Aryl amide-based kinase inhibitors |
| US10253027B2 (en) | 2013-07-08 | 2019-04-09 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| EP3044226B1 (en) | 2013-09-11 | 2017-09-06 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| EA201600270A1 (ru) * | 2013-09-19 | 2016-08-31 | Басф Се | N-ацилимино гетероциклические соединения |
| JP6276865B2 (ja) | 2014-01-29 | 2018-02-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アリールラクタムキナーゼ阻害剤 |
| ES2701903T3 (es) | 2014-01-31 | 2019-02-26 | Bristol Myers Squibb Co | Inhibidores de cinasa a base de quinolina |
| SMT201800665T1 (it) * | 2014-04-02 | 2019-01-11 | Bristol Myers Squibb Co | Inibitori biarilici di chinasi |
| WO2016053794A1 (en) | 2014-09-30 | 2016-04-07 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| ES2740224T3 (es) | 2015-04-10 | 2020-02-05 | Bristol Myers Squibb Co | 6H-isocromeno[3,4-c]piridinas y benzo[c][1,7]naftiridin-6-(5H)-onas como inhibidores de la cinasa asociada a adaptador 1 (AAK1) |
| JP6864674B2 (ja) | 2015-10-01 | 2021-04-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ビアリールキナーゼ阻害剤 |
| WO2017059085A1 (en) | 2015-10-01 | 2017-04-06 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
-
2016
- 2016-09-29 JP JP2018516728A patent/JP6864674B2/ja active Active
- 2016-09-29 KR KR1020187011873A patent/KR102707968B1/ko active Active
- 2016-09-29 WO PCT/US2016/054464 patent/WO2017059080A1/en not_active Ceased
- 2016-09-29 CN CN201680070096.6A patent/CN108290843B/zh active Active
- 2016-09-29 ES ES16781938T patent/ES2767776T3/es active Active
- 2016-09-29 EP EP16781938.2A patent/EP3356330B1/en active Active
- 2016-09-29 US US15/763,281 patent/US10246469B2/en active Active
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