|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
US5350836A
(en)
|
1989-10-12 |
1994-09-27 |
Ohio University |
Growth hormone antagonists
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
WO1994003599A1
(fr)
|
1992-08-04 |
1994-02-17 |
Sagami Chemical Research Center |
ADNc HUMAIN ET PROTEINE POUR LAQUELLE CODE CET ADNc
|
|
US6180602B1
(en)
|
1992-08-04 |
2001-01-30 |
Sagami Chemical Research Center |
Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent
|
|
JPH07258293A
(ja)
|
1994-03-23 |
1995-10-09 |
Asahi Chem Ind Co Ltd |
新規な蛋白質ならびにその製造方法
|
|
US6521227B1
(en)
|
1999-11-18 |
2003-02-18 |
Peter L. Hudson |
Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
|
|
AU1830195A
(en)
|
1994-12-15 |
1996-07-03 |
Human Genome Sciences, Inc. |
Prostatic growth factor
|
|
US5994102A
(en)
|
1994-12-15 |
1999-11-30 |
Human Genome Sciences, Inc. |
Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
|
|
DE69637844D1
(de)
|
1995-06-22 |
2009-04-09 |
St Vincent S Hospital Sidney L |
Neues tgf-beta-ahnliches cytokin
|
|
CA2237641A1
(en)
|
1995-11-13 |
1997-05-22 |
Urmas Arumae |
Glial cell line-derived neurotrophic factor receptors
|
|
US6696259B1
(en)
|
1995-11-13 |
2004-02-24 |
Licentia Ltd. |
Assays using glial cell line-derived neurotrophic factor receptors
|
|
US6524802B1
(en)
|
1996-03-29 |
2003-02-25 |
The Johns Hopkins University School Of Medicine |
Methods of detecting growth differentiation factor-14
|
|
NZ334592A
(en)
|
1996-09-11 |
2000-10-27 |
Ortho Mcneil Pharm Inc |
Protein growth factor related to TNF-beta and coupled with a toxic moiety for use in treating prostate cancer
|
|
CA2289116A1
(en)
*
|
1997-05-06 |
1998-11-12 |
Human Genome Sciences, Inc. |
Enterococcus faecalis polynucleotides and polypeptides
|
|
NZ501199A
(en)
|
1997-05-22 |
2001-12-21 |
Carlos F |
Glial cell line-derived neurotrophic factor receptors (BDNFR-beta)
|
|
WO1999006445A1
(en)
|
1997-07-31 |
1999-02-11 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-15
|
|
WO2000005259A1
(en)
|
1998-07-23 |
2000-02-03 |
Smithkline Beecham Corporation |
Secreted cysteine rich protein-6 (scrp-6)
|
|
JP2002526775A
(ja)
|
1998-10-01 |
2002-08-20 |
テイテイエブスキ,アレクセイ・ウラデイミロビチ |
GDNFについての新規Ret非依存性シグナリング経路
|
|
US6905817B1
(en)
|
1998-10-01 |
2005-06-14 |
Licestia Ltd. |
Ret-independent signaling pathway for GDNF
|
|
US6465181B2
(en)
|
1999-03-25 |
2002-10-15 |
Abbott Laboratories |
Reagents and methods useful for detecting diseases of the prostate
|
|
US6974684B2
(en)
|
2001-08-08 |
2005-12-13 |
Curagen Corporation |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
WO2000070051A1
(en)
|
1999-05-17 |
2000-11-23 |
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh |
NEUROPROTECTIVE PROPERTIES OF GDF-15, A NOVEL MEMBER OF THE TGF-β SUPERFAMILY
|
|
US6866851B1
(en)
|
1999-12-28 |
2005-03-15 |
Washington University |
GFRα1-RET specific agonists and methods therefor
|
|
JP2003530838A
(ja)
|
2000-04-12 |
2003-10-21 |
ヒューマン ゲノム サイエンシズ インコーポレイテッド |
アルブミン融合タンパク質
|
|
ES2300325T3
(es)
|
2000-04-20 |
2008-06-16 |
St Vincent's Hospital Sydney Limited |
Ensayo diagnostico que implica la citoquina 1 inhibitoria de macrofagos (mc1).
|
|
US7141661B2
(en)
|
2000-09-08 |
2006-11-28 |
The United States Of America As Represented By The Department Of Health And Human Services |
Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
|
|
EP1354042A2
(en)
|
2000-12-29 |
2003-10-22 |
Curagen Corporation |
Proteins and nucleic acids encoding same
|
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
EP1395605B8
(en)
|
2001-03-09 |
2014-12-17 |
Iterative Therapeutics, Inc. |
Polymeric immunoglobulin fusion proteins that target low-affinity fcgamma receptors
|
|
JP4516719B2
(ja)
|
2001-05-11 |
2010-08-04 |
アムジエン・インコーポレーテツド |
Tall−1と結合するペプチド及び関連分子
|
|
GB0115195D0
(en)
|
2001-06-21 |
2001-08-15 |
Bae Systems Plc |
Split-pin drill jig
|
|
US20030053431A1
(en)
|
2001-09-10 |
2003-03-20 |
Lila Madour |
Method for performing handoff in a radio telecommunications network
|
|
ES2425738T3
(es)
|
2001-12-21 |
2013-10-17 |
Human Genome Sciences, Inc. |
Proteínas de fusión de la albúmina
|
|
US20060253913A1
(en)
|
2001-12-21 |
2006-11-09 |
Yue-Jin Huang |
Production of hSA-linked butyrylcholinesterases in transgenic mammals
|
|
US7642242B2
(en)
|
2002-03-05 |
2010-01-05 |
Genentech, Inc. |
PRO34128 polypeptides
|
|
CA2478369A1
(en)
|
2002-03-05 |
2003-09-18 |
Genentech, Inc. |
Novel polypeptides having sequence similarity to gdnfr and nucleic acids encoding the same
|
|
US20100285016A1
(en)
|
2002-03-05 |
2010-11-11 |
Genentech, Inc. |
PRO34128 nucleic acids
|
|
US7919084B2
(en)
|
2002-06-17 |
2011-04-05 |
St. Vincent's Hospital Sydney Limited |
Methods of diagnosis, prognosis and treatment of cardiovascular disease
|
|
CA2390820A1
(en)
|
2002-06-17 |
2003-12-17 |
St. Vincent's Hospital Sydney Limited |
Methods of diagnosis, prognosis and treatment of cardiovascular disease
|
|
CN1241946C
(zh)
|
2002-07-01 |
2006-02-15 |
美国福源集团 |
对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
|
|
US20040253207A1
(en)
|
2002-11-08 |
2004-12-16 |
Barnes-Jewish Hospital |
Methods and compositions for prostate epithelial cell differentiation
|
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
ES2672640T3
(es)
|
2003-11-05 |
2018-06-15 |
Roche Glycart Ag |
Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas
|
|
CN1241941C
(zh)
*
|
2003-11-21 |
2006-02-15 |
中国科学院上海生命科学研究院 |
一种促进神经分化和抗细胞凋亡的蛋白质及其编码基因
|
|
PT2441466E
(pt)
|
2004-04-13 |
2014-09-09 |
St Vincents Hosp Sydney |
Agente de inibição de mic-1
|
|
US20090042780A1
(en)
|
2004-05-20 |
2009-02-12 |
Acceleron Pharma Inc |
Modified TGF-Beta Superfamily Polypeptides and Related Methods
|
|
WO2006078161A1
(en)
|
2005-01-24 |
2006-07-27 |
Pepscan Systems B.V. |
Binding compounds, immunogenic compounds and peptidomimetics
|
|
EP1937815B1
(en)
*
|
2005-09-13 |
2015-05-13 |
National Research Council of Canada |
Methods and compositions for modulating tumor cell activity
|
|
HRP20160990T1
(hr)
|
2006-03-24 |
2016-10-07 |
Biogen Hemophilia Inc. |
Pc5 kao enzim obrade faktor ix propeptida
|
|
US8974748B2
(en)
|
2007-04-05 |
2015-03-10 |
Corning Incorporated |
Dual inlet microchannel device and method for using same
|
|
JP2009536022A
(ja)
|
2006-04-19 |
2009-10-08 |
ジェネンテック・インコーポレーテッド |
新規の遺伝子破壊、それに関連する組成物および方法
|
|
US7754689B2
(en)
|
2006-06-02 |
2010-07-13 |
Wyeth Llc |
Finger-1 peptide analogs of the TGF-β superfamily
|
|
CA2659225A1
(en)
|
2006-07-26 |
2008-01-31 |
Pepscan Systems B.V. |
Immunogenic compounds and protein mimics
|
|
EP2047275B1
(en)
|
2006-08-04 |
2011-06-01 |
Medizinische Hochschule Hannover |
Methods for assessing the risk of cardiac interventions based on gdf-15
|
|
CL2007002987A1
(es)
*
|
2006-10-19 |
2008-06-06 |
Genentech Inc |
Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para tratar enfermedades relacionadas con notch3.
|
|
WO2008133536A2
(en)
|
2007-04-25 |
2008-11-06 |
Akademia Medyczna Im. Piastow Slaskich We Wroclawiu |
New stem cell lines, their application and culture methods
|
|
BRPI0814465B1
(pt)
|
2007-07-26 |
2021-11-23 |
Novagen Holding Corporation |
Proteína de fusão, dímero, método para produzir uma proteína de fusão, linhagem de célula, usos de uma proteína de fusão e de uma composição farmacêutica e composição farmacêutica
|
|
CA2694863A1
(en)
|
2007-08-16 |
2009-02-19 |
Garvan Institute Of Medical Research |
Agents and methods for modulating macrophage inhibitory cytokine (mic-1) activity
|
|
US20100266707A1
(en)
|
2007-10-09 |
2010-10-21 |
Samuel Norbert Breit |
Method of treating cachexia with the removal or inactivation of macrophage inhibitory cytokine-1
|
|
CA2701945A1
(en)
|
2007-10-22 |
2009-04-30 |
Samuel Norbert Breit |
Methods of prognosis of overall survival using mic-1
|
|
SI2235064T1
(sl)
|
2008-01-07 |
2016-04-29 |
Amgen Inc. |
Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
|
|
JP2011509403A
(ja)
|
2008-01-08 |
2011-03-24 |
エフ.ホフマン−ラ ロシュ アーゲー |
Gdf−15に基づいて救急室を受診する患者のリスクを評価するための手段及び方法
|
|
WO2009089396A2
(en)
|
2008-01-08 |
2009-07-16 |
Neose Technologies, Inc. |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
|
WO2009126709A1
(en)
|
2008-04-09 |
2009-10-15 |
Transtech Pharma, Inc. |
Ligands for the glp-1 receptor and methods for discovery thereof
|
|
WO2009141357A1
(en)
|
2008-05-20 |
2009-11-26 |
Roche Diagnostics Gmbh |
Gdf-15 as biomarker in type 1 diabetes
|
|
EP2318844A1
(en)
|
2008-07-14 |
2011-05-11 |
Roche Diagnostics GmbH |
Multimarker panel for diagnosing, monitoring and selecting the therapy for patients with heart failure
|
|
WO2010019263A2
(en)
|
2008-08-15 |
2010-02-18 |
Genzyme Corporation |
Soluble flt constructs for treating cancers
|
|
CA2742267C
(en)
|
2008-10-31 |
2019-06-04 |
Centocor Ortho Biotech Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
CN102203619B
(zh)
|
2008-10-31 |
2015-12-16 |
圣文森特医院悉尼有限公司 |
慢性肾病中的预测方法
|
|
EP2209003A1
(en)
|
2009-01-16 |
2010-07-21 |
F. Hoffmann-Roche AG |
Means and methods for differentiating between fibrosis and cirrhosis
|
|
EP2211182A1
(en)
|
2009-01-16 |
2010-07-28 |
Roche Diagnostics GmbH |
Method for the assessment of severity of liver cirrhosis
|
|
CA2752157A1
(en)
|
2009-02-12 |
2010-08-19 |
Stryker Corporation |
Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease
|
|
GB0902737D0
(en)
|
2009-02-19 |
2009-04-01 |
Univ Gent |
GDF15 as a differential marker for spondyloarthropathy
|
|
KR101558642B1
(ko)
|
2009-02-24 |
2015-10-12 |
솔크 인스티튜트 포 바이올로지칼 스터디즈 |
Tgf-베타 슈퍼패밀리의 설계자 리간드
|
|
SMT202400036T1
(it)
|
2009-05-05 |
2024-03-13 |
Amgen Inc |
Mutanti fgf21 e loro utilizzi
|
|
AU2010270844A1
(en)
|
2009-07-08 |
2011-12-22 |
Amgen Inc. |
Design of stable and aggregation free antibody Fc molecules through CH3 domain interface engineering
|
|
WO2011008956A2
(en)
|
2009-07-15 |
2011-01-20 |
Zirus, Inc. |
Mammalian genes involved in infection
|
|
US20120309697A1
(en)
|
2009-10-28 |
2012-12-06 |
Samuel Norbert Breit |
Methods of diagnosing and prognosing colonic polyps
|
|
CN105274170A
(zh)
|
2009-11-05 |
2016-01-27 |
弗·哈夫曼-拉罗切有限公司 |
分泌异源多肽的方法和组合物
|
|
WO2011064758A2
(en)
|
2009-11-30 |
2011-06-03 |
Pfizer Limited |
Fusion protein
|
|
US20120321557A1
(en)
|
2010-02-26 |
2012-12-20 |
Forerunner Pharma Research Co., Ltd. |
Anti-icam3 antibody and use thereof
|
|
US9212221B2
(en)
|
2010-03-03 |
2015-12-15 |
Detroit R & D, Inc. |
Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses
|
|
JP5791335B2
(ja)
|
2010-04-07 |
2015-10-07 |
花王株式会社 |
オルガノポリシロキサン化合物の製造方法
|
|
US20130202564A1
(en)
|
2010-04-09 |
2013-08-08 |
University Of Southern California |
Systems and Methods of Cell Activated, Controlled Release Delivery of Growth Factors for Tissue Repair and Regeneration
|
|
EP2383571A1
(en)
|
2010-05-02 |
2011-11-02 |
Prof. Hess Medical Consulting GmbH |
Growth differntioation factor 15 (GDF 15) for risk prediction of diabetic foot ulcer
|
|
ES2534921T3
(es)
|
2010-08-26 |
2015-04-30 |
F. Hoffmann-La Roche Ag |
Uso de biomarcadores en la evaluación de la transición temprana de la hipertensión arterial a la insuficiencia cardíaca
|
|
WO2012047427A2
(en)
*
|
2010-08-31 |
2012-04-12 |
The Regents Of The University Of California |
Antibodies for botulinum neurotoxins
|
|
EP2439535A1
(en)
|
2010-10-07 |
2012-04-11 |
F. Hoffmann-La Roche AG |
Diagnosis of diabetes related heart disease and GDF-15 and Troponin as predictors for the development of type 2 diabetes mellitus
|
|
US10752664B2
(en)
|
2011-04-08 |
2020-08-25 |
Amgen Inc. |
Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
|
|
EP2697257B1
(en)
|
2011-04-13 |
2016-10-19 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
|
US9890218B2
(en)
|
2011-06-30 |
2018-02-13 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
BR112013030472A2
(pt)
|
2011-06-30 |
2019-09-24 |
Genentech Inc |
formulação farmacêutica, artigo de fabricação e método
|
|
WO2013012648A1
(en)
|
2011-07-15 |
2013-01-24 |
Emory University |
Gdf15 in diagnostic and therapeutic applications
|
|
US9714276B2
(en)
|
2012-01-26 |
2017-07-25 |
Amgen Inc. |
Growth differentiation factor 15 (GDF-15) polypeptides
|
|
JP6254146B2
(ja)
|
2012-03-27 |
2017-12-27 |
エヌジーエム バイオファーマシューティカルス,インコーポレーテッド |
代謝障害を治療するための組成物および方法
|
|
WO2013192388A1
(en)
|
2012-06-20 |
2013-12-27 |
University Of Virginia Patent Foundation |
Compositions and methods for regulating glucose homeostasis and insulin action
|
|
WO2014000042A1
(en)
|
2012-06-27 |
2014-01-03 |
Prince Henry's Institute Of Medical Research |
COMPOSITIONS AND METHODS FOR MODIFYING TGF-β FAMILY LIGANDS
|
|
WO2014011955A2
(en)
*
|
2012-07-12 |
2014-01-16 |
Abbvie, Inc. |
Il-1 binding proteins
|
|
ES2723885T3
(es)
|
2012-07-19 |
2019-09-03 |
Daiichi Sankyo Co Ltd |
Anticuerpos anti-Siglec-15
|
|
PE20150645A1
(es)
|
2012-08-08 |
2015-05-11 |
Roche Glycart Ag |
Proteinas de fusion de interleuquina 10 y usos de las mismas
|
|
JO3462B1
(ar)
*
|
2012-08-22 |
2020-07-05 |
Regeneron Pharma |
أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها
|
|
CN104853775B
(zh)
|
2012-09-26 |
2023-10-20 |
尤利乌斯·马克西米利安维尔茨堡大学 |
针对生长和分化因子15(gdf-15)的单克隆抗体
|
|
EP2912064B1
(en)
*
|
2012-10-24 |
2019-04-24 |
Research Development Foundation |
Jam-c antibodies and methods for treatment of cancer
|
|
US20150376294A1
(en)
*
|
2012-12-03 |
2015-12-31 |
Rigshospitalet |
Anti-pad2 antibodies and treatment of autoimmune diseases
|
|
MX370720B
(es)
*
|
2012-12-21 |
2019-12-20 |
Aveo Pharmaceuticals Inc |
Anticuerpos anti-gdf15.
|
|
DE102013100322A1
(de)
|
2013-01-14 |
2014-07-17 |
Claas Selbstfahrende Erntemaschinen Gmbh |
Schneidwerk
|
|
US9161966B2
(en)
|
2013-01-30 |
2015-10-20 |
Ngm Biopharmaceuticals, Inc. |
GDF15 mutein polypeptides
|
|
KR101993714B1
(ko)
|
2013-01-30 |
2019-06-28 |
엔지엠 바이오파마슈티컬스, 아이엔씨. |
대사 장애를 치료하는데 이용하기 위한 조성물과 방법
|
|
EP2970422B1
(en)
|
2013-03-15 |
2018-04-18 |
F.Hoffmann-La Roche Ag |
Il-22 polypeptides and il-22 fc fusion proteins and methods of use
|
|
WO2014140374A2
(en)
|
2013-03-15 |
2014-09-18 |
Novo Nordisk A/S |
Monovalent cd27 antibodies
|
|
WO2014200898A2
(en)
*
|
2013-06-10 |
2014-12-18 |
Merck Sharp & Dohme Corp. |
Cmv neutralizing antigen binding proteins
|
|
TN2016000035A1
(en)
|
2013-07-31 |
2017-07-05 |
Amgen Inc |
Growth differentiation factor 15 (gdf-15) constructs
|
|
US10174095B2
(en)
|
2014-07-21 |
2019-01-08 |
Novartis Ag |
Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor
|
|
UA123432C2
(uk)
|
2014-07-30 |
2021-04-07 |
Нджм Біофармасьютікалз, Інк. |
Димер та спосіб його застосування для лікування метаболічних розладів
|
|
MD20170035A2
(ro)
|
2014-10-31 |
2017-09-30 |
Ngm Biopharmaceuticals Inc |
Compoziţii şi metode de utilizare pentru tratamentul tulburărilor metabolice
|
|
GB201512733D0
(en)
|
2015-07-20 |
2015-08-26 |
Genagon Therapeutics Ab |
Therapeutic agents for treating conditions associated with elevated GDF15
|
|
WO2017121865A1
(en)
|
2016-01-15 |
2017-07-20 |
Novo Nordisk A/S |
Mic-1 receptor and uses thereof
|
|
WO2017147742A1
(en)
|
2016-02-29 |
2017-09-08 |
Eli Lilly And Company |
Gfral receptor therapies
|
|
WO2017152105A1
(en)
*
|
2016-03-04 |
2017-09-08 |
Ngm Biopharmaceuticals, Inc. |
Compositions and methods for modulating body weight
|
|
CN117986363A
(zh)
|
2016-03-31 |
2024-05-07 |
恩格姆生物制药公司 |
结合蛋白及其使用方法
|
|
CA3038846A1
(en)
|
2016-10-12 |
2018-04-19 |
Janssen Biotech, Inc. |
Methods for screening for modulators of gdf15-like biological activity
|
|
TWI803682B
(zh)
|
2018-08-20 |
2023-06-01 |
美商輝瑞股份有限公司 |
抗-gdf15抗體、組成物及使用方法
|
|
JP7495529B2
(ja)
|
2020-06-04 |
2024-06-04 |
テグ キョンプク インスティテュート オブ サイエンス アンド テクノロジー |
Gfral拮抗抗体及びその用途
|
|
EP4304647A1
(en)
|
2021-03-08 |
2024-01-17 |
MedImmune, LLC |
Antibodies directed against gdf-15
|
|
MX2023011655A
(es)
|
2021-03-31 |
2023-10-11 |
Cambridge Entpr Ltd |
Inhibidores terapeuticos de la se?alizacion de gdf15.
|
|
WO2022207785A1
(en)
|
2021-03-31 |
2022-10-06 |
Kymab Limited |
Antibodies to gfral
|
|
US20230107304A1
(en)
|
2021-09-10 |
2023-04-06 |
Ngm Biopharmaceuticals, Inc. |
Methods of treating cancer and tumor-related weight loss and cachexia
|