JP2019510798A5 - - Google Patents
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- JP2019510798A5 JP2019510798A5 JP2018552846A JP2018552846A JP2019510798A5 JP 2019510798 A5 JP2019510798 A5 JP 2019510798A5 JP 2018552846 A JP2018552846 A JP 2018552846A JP 2018552846 A JP2018552846 A JP 2018552846A JP 2019510798 A5 JP2019510798 A5 JP 2019510798A5
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- JP
- Japan
- Prior art keywords
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- pharmaceutically acceptable
- solvate
- acceptable salt
- optionally substituted
- Prior art date
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- 150000003839 salts Chemical class 0.000 claims description 123
- 239000012453 solvate Substances 0.000 claims description 121
- 150000001875 compounds Chemical class 0.000 claims description 104
- 229910052739 hydrogen Inorganic materials 0.000 claims description 50
- 239000001257 hydrogen Substances 0.000 claims description 50
- 206010028980 Neoplasm Diseases 0.000 claims description 37
- 125000000217 alkyl group Chemical group 0.000 claims description 33
- 201000011510 cancer Diseases 0.000 claims description 27
- 125000005843 halogen group Chemical group 0.000 claims description 27
- 150000002431 hydrogen Chemical class 0.000 claims description 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 11
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 125000005466 alkylenyl group Chemical group 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 125000003107 substituted aryl group Chemical group 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 7
- 208000023275 Autoimmune disease Diseases 0.000 claims description 6
- 206010040047 Sepsis Diseases 0.000 claims description 6
- 208000036142 Viral infection Diseases 0.000 claims description 6
- 230000001684 chronic effect Effects 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 230000004968 inflammatory condition Effects 0.000 claims description 6
- 230000002062 proliferating effect Effects 0.000 claims description 6
- 230000009385 viral infection Effects 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- -1 alkylenyl compound Chemical class 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 10
- 208000000587 small cell lung carcinoma Diseases 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- 206010000871 Acute monocytic leukaemia Diseases 0.000 description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 5
- 208000011691 Burkitt lymphomas Diseases 0.000 description 5
- 206010008342 Cervix carcinoma Diseases 0.000 description 5
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 5
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 5
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 5
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 description 5
- 208000034578 Multiple myelomas Diseases 0.000 description 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 5
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 5
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 5
- 206010033128 Ovarian cancer Diseases 0.000 description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 description 5
- 206010035226 Plasma cell myeloma Diseases 0.000 description 5
- 206010060862 Prostate cancer Diseases 0.000 description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 5
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 201000010881 cervical cancer Diseases 0.000 description 5
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 5
- 201000004101 esophageal cancer Diseases 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 210000003757 neuroblast Anatomy 0.000 description 5
- 0 C[C@@]([C@](C(*)N*)N(**)[C@@]1(*)**)[C@@]11c(cccc2)c2NC1=* Chemical compound C[C@@]([C@](C(*)N*)N(**)[C@@]1(*)**)[C@@]11c(cccc2)c2NC1=* 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 2
- JLQHICJMQYMTDQ-RKUZKHJWSA-N O=C([C@@H]([C@@H]1c(cccc2Cl)c2F)NC2(CCCCC2)[C@@]1(c(c(N1)c2)ccc2Cl)C1=O)Nc(cc1)ccc1C(NCCCCOc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O)=O Chemical compound O=C([C@@H]([C@@H]1c(cccc2Cl)c2F)NC2(CCCCC2)[C@@]1(c(c(N1)c2)ccc2Cl)C1=O)Nc(cc1)ccc1C(NCCCCOc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O)=O JLQHICJMQYMTDQ-RKUZKHJWSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022033173A JP2022078201A (ja) | 2016-04-06 | 2022-03-04 | Ｍｄｍ２タンパク質分解剤 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318974P | 2016-04-06 | 2016-04-06 | |
| US62/318,974 | 2016-04-06 | ||
| US201662393874P | 2016-09-13 | 2016-09-13 | |
| US62/393,874 | 2016-09-13 | ||
| US201662409571P | 2016-10-18 | 2016-10-18 | |
| US62/409,571 | 2016-10-18 | ||
| PCT/US2017/026274 WO2017176957A1 (en) | 2016-04-06 | 2017-04-06 | Mdm2 protein degraders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022033173A Division JP2022078201A (ja) | 2016-04-06 | 2022-03-04 | Ｍｄｍ２タンパク質分解剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510798A JP2019510798A (ja) | 2019-04-18 |
| JP2019510798A5 true JP2019510798A5 (https=) | 2020-03-19 |
| JP7037500B2 JP7037500B2 (ja) | 2022-03-16 |
Family
ID=58549316
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552846A Active JP7037500B2 (ja) | 2016-04-06 | 2017-04-06 | Ｍｄｍ２タンパク質分解剤 |
| JP2022033173A Pending JP2022078201A (ja) | 2016-04-06 | 2022-03-04 | Ｍｄｍ２タンパク質分解剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022033173A Pending JP2022078201A (ja) | 2016-04-06 | 2022-03-04 | Ｍｄｍ２タンパク質分解剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11192898B2 (https=) |
| EP (1) | EP3440066B1 (https=) |
| JP (2) | JP7037500B2 (https=) |
| KR (1) | KR102387316B1 (https=) |
| CN (2) | CN109415336B (https=) |
| AU (1) | AU2017246452C1 (https=) |
| IL (1) | IL262103B (https=) |
| MX (1) | MX2018012174A (https=) |
| RU (2) | RU2743432C2 (https=) |
| SG (1) | SG11201808728QA (https=) |
| UA (1) | UA123786C2 (https=) |
| WO (1) | WO2017176957A1 (https=) |
| ZA (1) | ZA201806968B (https=) |
Families Citing this family (116)
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