JP2022542396A5 - - Google Patents
Info
- Publication number
- JP2022542396A5 JP2022542396A5 JP2022506169A JP2022506169A JP2022542396A5 JP 2022542396 A5 JP2022542396 A5 JP 2022542396A5 JP 2022506169 A JP2022506169 A JP 2022506169A JP 2022506169 A JP2022506169 A JP 2022506169A JP 2022542396 A5 JP2022542396 A5 JP 2022542396A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- imidazole
- alkyl
- pyrimidine
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025127017A JP2025160384A (ja) | 2019-07-31 | 2025-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880923P | 2019-07-31 | 2019-07-31 | |
| US62/880,923 | 2019-07-31 | ||
| US201962951604P | 2019-12-20 | 2019-12-20 | |
| US62/951,604 | 2019-12-20 | ||
| US202063034750P | 2020-06-04 | 2020-06-04 | |
| US63/034,750 | 2020-06-04 | ||
| PCT/US2020/044156 WO2021021986A1 (en) | 2019-07-31 | 2020-07-30 | Heterobicyclic amides as inhibitors of cd38 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025127017A Division JP2025160384A (ja) | 2019-07-31 | 2025-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022542396A JP2022542396A (ja) | 2022-10-03 |
| JP2022542396A5 true JP2022542396A5 (https=) | 2023-08-07 |
| JP7721501B2 JP7721501B2 (ja) | 2025-08-12 |
Family
ID=72139677
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506169A Active JP7721501B2 (ja) | 2019-07-31 | 2020-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
| JP2025127017A Pending JP2025160384A (ja) | 2019-07-31 | 2025-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025127017A Pending JP2025160384A (ja) | 2019-07-31 | 2025-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11535621B2 (https=) |
| EP (1) | EP4003980A1 (https=) |
| JP (2) | JP7721501B2 (https=) |
| KR (1) | KR20220061958A (https=) |
| CN (2) | CN119431323A (https=) |
| AU (1) | AU2020321956A1 (https=) |
| BR (1) | BR112022001291A2 (https=) |
| CA (1) | CA3147902A1 (https=) |
| IL (2) | IL324885A (https=) |
| MX (3) | MX2022001019A (https=) |
| TW (1) | TWI891649B (https=) |
| WO (1) | WO2021021986A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022001019A (es) | 2019-07-31 | 2022-02-22 | Ribon Therapeutics Inc | Amidas heterobiciclicas como inhibidoras del cumulo de diferenciacion 38 (cd38). |
| US20230025807A1 (en) * | 2019-10-30 | 2023-01-26 | Mitobridge Inc. | Cd38 inhibitors |
| CA3195121A1 (en) * | 2020-10-09 | 2022-04-14 | Robert A. Volkmann | Heteroaryl amide inhibitors of cd38 |
| HRP20251111T1 (hr) | 2021-01-29 | 2025-11-21 | Boehringer Ingelheim International Gmbh | Azakinolini kao inhibitori cd38 |
| WO2022228496A1 (en) * | 2021-04-30 | 2022-11-03 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| TW202310835A (zh) * | 2021-07-12 | 2023-03-16 | 美商胞質動力學公司 | Ｃｄ３８調節劑及其使用方法 |
| CN116041344A (zh) * | 2021-10-28 | 2023-05-02 | 北京望实智慧科技有限公司 | 双环杂芳基甲酰胺化合物作为sos1抑制剂 |
| WO2023084206A1 (en) | 2021-11-09 | 2023-05-19 | Cerevance Ltd | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as cd38 inhibitors |
| CN114306366B (zh) * | 2021-11-30 | 2023-01-06 | 合肥康诺生物制药有限公司 | 含nad和cd38抑制剂的药物组合物及其用途 |
| WO2023098699A1 (en) * | 2021-12-01 | 2023-06-08 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| GB202207721D0 (en) * | 2022-05-25 | 2022-07-06 | Cerevance Ltd | Novel Compounds |
| JP2025530999A (ja) * | 2022-08-05 | 2025-09-19 | ネクストジェン バイオサイエンス カンパニー リミテッド | 低酸素症誘導因子１（ｈｉｆ－１）抑制剤又は血管内皮成長因子（ｖｅｇｆ）抑制剤としての新規化合物及びそれを含む薬学組成物 |
| CN115825297B (zh) * | 2022-11-11 | 2025-03-28 | 武汉海特生物创新医药研究有限公司 | 一种(s)-3-氨基哌啶-2,6-二酮盐酸盐对映异构体的检测方法 |
| WO2024236316A1 (en) * | 2023-05-18 | 2024-11-21 | Cerevance, Inc. | 3-carbonyl imidazo[1,5-a]pyridine derivatives for use as cd38 inhibitors for the treatment of cns disorders |
| GB202307426D0 (en) * | 2023-05-18 | 2023-07-05 | Cerevance Inc | Novel compounds |
| WO2024254396A1 (en) * | 2023-06-07 | 2024-12-12 | Flagship Pioneering Innovations, Vi, Llc | Condensed azines as inhibitors of cyclic adp ribose hydrolase |
| WO2026000074A1 (en) * | 2024-06-25 | 2026-01-02 | Welnx Company Inc. | Use of cd38 inhibitors for reducing th2 inflammation |
| WO2026075971A1 (en) | 2024-10-01 | 2026-04-09 | Neolaia Inc. | Combination therapy for treatment of metabolic disorders and inflamation related disorders using incretin compounds and cd38 inhibitors |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2666624C (en) * | 2006-10-19 | 2015-12-29 | Signal Pharmaceuticals, Llc | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
| PL2520575T3 (pl) * | 2009-12-28 | 2017-05-31 | General Incorporated Association Pharma Valley Project Supporting Organization | Związek 1,3,4-oksadiazolo-2-karboksyamidowy |
| WO2012005805A1 (en) | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
| EP2646020B1 (en) | 2010-12-01 | 2016-09-21 | Glaxosmithkline LLC | Indoles |
| WO2012080729A2 (en) | 2010-12-14 | 2012-06-21 | Electrophoretics Limited | CASEIN KINASE 1δ (CK1δ) INHIBITORS |
| WO2012118812A2 (en) | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| EP2755962B1 (en) * | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
| PH12014500869A1 (en) * | 2011-10-19 | 2014-06-30 | Signal Pharm Llc | Treatment of cancer with tor kinase inhibitors |
| WO2013067302A1 (en) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
| CN104039956A (zh) * | 2011-11-04 | 2014-09-10 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 治疗方法 |
| EP2817029B1 (en) * | 2012-02-24 | 2019-07-10 | Signal Pharmaceuticals, LLC | Methods for treating non-small cell lung cancer using tor kinase inhibitor combination therapy |
| WO2013188848A2 (en) | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Antiviral compounds and methods of use |
| US20150216168A1 (en) * | 2012-09-05 | 2015-08-06 | Bayer Cropscience Ag | Use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles or salts thereof as active substances against abiotic plant stress |
| EA201591746A1 (ru) | 2013-03-14 | 2016-08-31 | КОНВЕРДЖЕН ЭлЭлСи | Способы и композиции для ингибирования бромодомен-содержащих белков |
| CN105017221B (zh) * | 2014-04-30 | 2019-05-28 | 中国医学科学院药物研究所 | 苯并咪唑衍生物及其制法和药物组合物与用途 |
| KR20170090478A (ko) * | 2014-12-03 | 2017-08-07 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Cd38 억제제 및 치료 방법 |
| WO2017053604A1 (en) | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2018151830A1 (en) * | 2017-02-17 | 2018-08-23 | Fronthera U.S. Pharmaceuticals Llc | Pyridinyl based apoptosis signal-regulation kinase inhibitors |
| EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| WO2019067623A1 (en) * | 2017-09-27 | 2019-04-04 | The Regents Of The University Of California | POWERFUL ANTIVIRAL COMPOUNDS CONTAINING PYRIDINE |
| MX2022001019A (es) | 2019-07-31 | 2022-02-22 | Ribon Therapeutics Inc | Amidas heterobiciclicas como inhibidoras del cumulo de diferenciacion 38 (cd38). |
| US20230025807A1 (en) | 2019-10-30 | 2023-01-26 | Mitobridge Inc. | Cd38 inhibitors |
| CN115697985B (zh) | 2020-04-07 | 2025-01-21 | 米托布里奇公司 | Cd38抑制剂 |
| HRP20251111T1 (hr) | 2021-01-29 | 2025-11-21 | Boehringer Ingelheim International Gmbh | Azakinolini kao inhibitori cd38 |
-
2020
- 2020-07-30 MX MX2022001019A patent/MX2022001019A/es unknown
- 2020-07-30 CN CN202411191364.2A patent/CN119431323A/zh active Pending
- 2020-07-30 BR BR112022001291A patent/BR112022001291A2/pt unknown
- 2020-07-30 WO PCT/US2020/044156 patent/WO2021021986A1/en not_active Ceased
- 2020-07-30 KR KR1020227006571A patent/KR20220061958A/ko active Pending
- 2020-07-30 EP EP20757729.7A patent/EP4003980A1/en active Pending
- 2020-07-30 JP JP2022506169A patent/JP7721501B2/ja active Active
- 2020-07-30 CN CN202080066542.2A patent/CN114423753B/zh active Active
- 2020-07-30 US US16/942,857 patent/US11535621B2/en active Active
- 2020-07-30 IL IL324885A patent/IL324885A/en unknown
- 2020-07-30 AU AU2020321956A patent/AU2020321956A1/en active Pending
- 2020-07-30 TW TW109125742A patent/TWI891649B/zh active
- 2020-07-30 CA CA3147902A patent/CA3147902A1/en active Pending
-
2022
- 2022-01-16 IL IL289878A patent/IL289878B1/en unknown
- 2022-01-25 MX MX2025003444A patent/MX2025003444A/es unknown
- 2022-01-25 MX MX2025003445A patent/MX2025003445A/es unknown
- 2022-12-05 US US18/074,746 patent/US11987584B2/en active Active
-
2024
- 2024-04-18 US US18/638,989 patent/US12398146B2/en active Active
-
2025
- 2025-07-15 US US19/269,389 patent/US20260078127A1/en active Pending
- 2025-07-30 JP JP2025127017A patent/JP2025160384A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022542396A5 (https=) | ||
| US11931363B2 (en) | Triazolopyrimidine compounds and uses thereof | |
| ES2638850T3 (es) | Compuestos de azabenzimidazol como inhibidores de las isoenzimas de la PDE4 para el tratamiento de trastornos del SNC y otros trastornos | |
| ES2648143T3 (es) | Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina útiles como inhibidores de la beta-secretasa (BACE) | |
| ES2543216T3 (es) | Moduladores de tiazolopirimidina como agentes inmunosupresores | |
| SI3106463T1 (en) | Compounds of substituted pyrazolo (1,5-) pyrimidine as inhibitors of TRK kinase | |
| RU2011116230A (ru) | Пиразолопиридиновые производные как ингибиторы надфн-оксидазы | |
| ES2733502T3 (es) | Compuestos de imidazopiridazina | |
| TW201619159A (zh) | 吡咯并［２，３－ｄ］嘧啶衍生物 | |
| JP2009529047A5 (https=) | ||
| JP2014531449A5 (https=) | ||
| JP2013500247A5 (https=) | ||
| JP6695353B2 (ja) | Ｆｇｆｒ４阻害剤としてのホルミル化ｎ−複素環式誘導体 | |
| WO2004100868A2 (en) | Method of treating transplant rejection | |
| RU2011116447A (ru) | Модуляторы амилоида бета | |
| JP2009519979A5 (https=) | ||
| BR112012000413B1 (pt) | Compostos para tratamento de doenças parasitárias, seus usos, e composição | |
| RU2014126750A (ru) | Ингибиторы тирозинкиназы брутона | |
| JP2013533868A (ja) | タンパク質チロシンキナーゼ阻害剤としての新規ホモピペラジン誘導体およびそれらの医薬使用 | |
| RU2018141084A (ru) | Соединения тетрагидропиримидодиазепина и дигидропиридодиазепина для лечения боли и связанных с болью состояний | |
| RU2014109748A (ru) | Морфолино-замещенные производные бициклических пиримидинмочевины или карбамата в качестве ингибиторов mtor | |
| JP6392352B2 (ja) | リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体 | |
| ES2775674T3 (es) | Compuestos de 6,7-dihidro-5H-pirazolo[5,1-b][1,3]oxazina-2-carboxamida | |
| JP2006512366A5 (https=) | ||
| KR20220028075A (ko) | 티로신 키나제 비-수용체 1 (tnk1) 억제제 및 그의 용도 |