JP2019509257A5 - - Google Patents
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- JP2019509257A5 JP2019509257A5 JP2018536482A JP2018536482A JP2019509257A5 JP 2019509257 A5 JP2019509257 A5 JP 2019509257A5 JP 2018536482 A JP2018536482 A JP 2018536482A JP 2018536482 A JP2018536482 A JP 2018536482A JP 2019509257 A5 JP2019509257 A5 JP 2019509257A5
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- JP
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- cdr3 sequences
- Prior art date
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- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 124
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 116
- 239000000611 antibody drug conjugate Substances 0.000 claims description 113
- 201000001441 melanoma Diseases 0.000 claims description 66
- 239000003112 inhibitor Substances 0.000 claims description 54
- 230000035772 mutation Effects 0.000 claims description 44
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 42
- 229940124647 MEK inhibitor Drugs 0.000 claims description 40
- 229940125431 BRAF inhibitor Drugs 0.000 claims description 39
- 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims description 39
- 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims description 39
- 102000043136 MAP kinase family Human genes 0.000 claims description 36
- 108091054455 MAP kinase family Proteins 0.000 claims description 36
- 108010023337 axl receptor tyrosine kinase Proteins 0.000 claims description 33
- 229960004066 trametinib Drugs 0.000 claims description 33
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical group CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims description 33
- 229960002465 dabrafenib Drugs 0.000 claims description 32
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims description 32
- 230000037361 pathway Effects 0.000 claims description 32
- 229960003862 vemurafenib Drugs 0.000 claims description 32
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims description 32
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 28
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims description 28
- 229950003054 binimetinib Drugs 0.000 claims description 28
- ACWZRVQXLIRSDF-UHFFFAOYSA-N binimetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1F ACWZRVQXLIRSDF-UHFFFAOYSA-N 0.000 claims description 28
- 229960002271 cobimetinib Drugs 0.000 claims description 28
- RESIMIUSNACMNW-BXRWSSRYSA-N cobimetinib fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F RESIMIUSNACMNW-BXRWSSRYSA-N 0.000 claims description 28
- 229950001969 encorafenib Drugs 0.000 claims description 28
- CMJCXYNUCSMDBY-ZDUSSCGKSA-N lgx818 Chemical compound COC(=O)N[C@@H](C)CNC1=NC=CC(C=2C(=NN(C=2)C(C)C)C=2C(=C(NS(C)(=O)=O)C=C(Cl)C=2)F)=N1 CMJCXYNUCSMDBY-ZDUSSCGKSA-N 0.000 claims description 28
- 229960003787 sorafenib Drugs 0.000 claims description 28
- 102100039788 GTPase NRas Human genes 0.000 claims description 21
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims description 21
- 229950010746 selumetinib Drugs 0.000 claims description 20
- CYOHGALHFOKKQC-UHFFFAOYSA-N selumetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1Cl CYOHGALHFOKKQC-UHFFFAOYSA-N 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 101150022345 GAS6 gene Proteins 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 10
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 8
- -1 BAL-3833 Chemical compound 0.000 claims description 7
- 239000012824 ERK inhibitor Substances 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 108091000080 Phosphotransferase Proteins 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 230000005764 inhibitory process Effects 0.000 claims description 6
- 102000020233 phosphotransferase Human genes 0.000 claims description 6
- 231100000433 cytotoxic Toxicity 0.000 claims description 5
- 239000002254 cytotoxic agent Substances 0.000 claims description 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 5
- 230000001472 cytotoxic effect Effects 0.000 claims description 5
- 102200006532 rs112445441 Human genes 0.000 claims description 5
- 102220053950 rs121913238 Human genes 0.000 claims description 5
- 102200006520 rs121913240 Human genes 0.000 claims description 5
- 102200006525 rs121913240 Human genes 0.000 claims description 5
- 102200006531 rs121913529 Human genes 0.000 claims description 5
- 102200006539 rs121913529 Human genes 0.000 claims description 5
- 102200006538 rs121913530 Human genes 0.000 claims description 5
- 102200006541 rs121913530 Human genes 0.000 claims description 5
- 102200006533 rs121913535 Human genes 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- MLSAQOINCGAULQ-QFMPWRQOSA-N (E)-SB-590885 Chemical compound C1=CC(OCCN(C)C)=CC=C1C1=NC(C=2C=CN=CC=2)=C(C=2C=C3CCC(/C3=CC=2)=N\O)N1 MLSAQOINCGAULQ-QFMPWRQOSA-N 0.000 claims description 4
- DKNUPRMJNUQNHR-UHFFFAOYSA-N 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=1)=CC=CC=1NC(=O)NC=1C=C(C(C)(C)C(F)(F)F)ON=1 DKNUPRMJNUQNHR-UHFFFAOYSA-N 0.000 claims description 4
- YABJJWZLRMPFSI-UHFFFAOYSA-N 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine Chemical compound N=1C2=CC(OC=3C=C(N=CC=3)C=3NC(=CN=3)C(F)(F)F)=CC=C2N(C)C=1NC1=CC=C(C(F)(F)F)C=C1 YABJJWZLRMPFSI-UHFFFAOYSA-N 0.000 claims description 4
- GFMMXOIFOQCCGU-UHFFFAOYSA-N 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Chemical compound C=1C=C(I)C=C(Cl)C=1NC1=C(F)C(F)=CC=C1C(=O)NOCC1CC1 GFMMXOIFOQCCGU-UHFFFAOYSA-N 0.000 claims description 4
- ZGBGPEDJXCYQPH-UHFFFAOYSA-N 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide Chemical compound C1=C(NC=2C=C3C(=O)N(C)C=NC3=CC=2)C(C)=CC=C1NC(=O)C1=CC=CC(C(C)(C)C#N)=C1 ZGBGPEDJXCYQPH-UHFFFAOYSA-N 0.000 claims description 4
- ZGXOBLVQIVXKEB-UHFFFAOYSA-N 3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-N,N-dimethyl-1H-indole-6-carboxamide Chemical compound CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O ZGXOBLVQIVXKEB-UHFFFAOYSA-N 0.000 claims description 4
- NGFFVZQXSRKHBM-FKBYEOEOSA-N 5-[[(1r,1as,6br)-1-[6-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1h-1,8-naphthyridin-2-one Chemical compound N1C(=O)CCC2=C1N=CC=C2OC(C=C1[C@@H]23)=CC=C1O[C@@H]3[C@H]2C1=NC2=CC=C(C(F)(F)F)C=C2N1 NGFFVZQXSRKHBM-FKBYEOEOSA-N 0.000 claims description 4
- DEZZLWQELQORIU-RELWKKBWSA-N GDC-0879 Chemical compound N=1N(CCO)C=C(C=2C=C3CCC(/C3=CC=2)=N\O)C=1C1=CC=NC=C1 DEZZLWQELQORIU-RELWKKBWSA-N 0.000 claims description 4
- VWMJHAFYPMOMGF-ZCFIWIBFSA-N TAK-580 Chemical compound N([C@H](C)C=1SC(=CN=1)C(=O)NC=1N=CC(Cl)=C(C=1)C(F)(F)F)C(=O)C1=NC=NC(N)=C1Cl VWMJHAFYPMOMGF-ZCFIWIBFSA-N 0.000 claims description 4
- CFQULUVMLGZVAF-OYJDLGDISA-N U0126.EtOH Chemical compound CCO.C=1C=CC=C(N)C=1SC(\N)=C(/C#N)\C(\C#N)=C(/N)SC1=CC=CC=C1N CFQULUVMLGZVAF-OYJDLGDISA-N 0.000 claims description 4
- RDSACQWTXKSHJT-NSHDSACASA-N n-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide Chemical compound C1CC1(C[C@H](O)CO)S(=O)(=O)NC=1C(OC)=CC(F)=C(F)C=1NC1=CC=C(I)C=C1F RDSACQWTXKSHJT-NSHDSACASA-N 0.000 claims description 4
- 229950008933 refametinib Drugs 0.000 claims description 4
- 229940121742 Serine/threonine kinase inhibitor Drugs 0.000 claims description 3
- YFCIFWOJYYFDQP-PTWZRHHISA-N 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide Chemical group CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)[C@@H](F)C1)c1cc(F)cc(Br)c1 YFCIFWOJYYFDQP-PTWZRHHISA-N 0.000 claims description 2
- 102100031487 Growth arrest-specific protein 6 Human genes 0.000 claims description 2
- 101000923005 Homo sapiens Growth arrest-specific protein 6 Proteins 0.000 claims description 2
- YZDJQTHVDDOVHR-UHFFFAOYSA-N PLX-4720 Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(Cl)=CN=C3NC=2)=C1F YZDJQTHVDDOVHR-UHFFFAOYSA-N 0.000 claims description 2
- HDAJDNHIBCDLQF-RUZDIDTESA-N SCH772984 Chemical compound O=C([C@@H]1CCN(C1)CC(=O)N1CCN(CC1)C=1C=CC(=CC=1)C=1N=CC=CN=1)NC(C=C12)=CC=C1NN=C2C1=CC=NC=C1 HDAJDNHIBCDLQF-RUZDIDTESA-N 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims description 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims description 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 75
- 229940079593 drug Drugs 0.000 claims 4
- 239000000463 material Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021207104A JP2022037170A (ja) | 2016-01-13 | 2021-12-21 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662278283P | 2016-01-13 | 2016-01-13 | |
| US62/278,283 | 2016-01-13 | ||
| PCT/EP2016/066353 WO2017009258A1 (en) | 2015-07-10 | 2016-07-08 | Axl-specific antibody-drug conjugates for cancer treatment |
| EPPCT/EP2016/066353 | 2016-07-08 | ||
| PCT/EP2017/050718 WO2017121877A1 (en) | 2016-01-13 | 2017-01-13 | Axl-specific antibody-drug conjugates for cancer treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021207104A Division JP2022037170A (ja) | 2016-01-13 | 2021-12-21 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019509257A JP2019509257A (ja) | 2019-04-04 |
| JP2019509257A5 true JP2019509257A5 (enExample) | 2020-02-20 |
Family
ID=57756861
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500605A Expired - Fee Related JP6892431B2 (ja) | 2015-07-10 | 2016-07-08 | 癌治療用のａｘｌ特異的抗体−薬物コンジュゲート |
| JP2018536482A Pending JP2019509257A (ja) | 2016-01-13 | 2017-01-13 | 癌治療用のａｘｌ特異的抗体−薬物コンジュゲート |
| JP2021088877A Active JP7428680B2 (ja) | 2015-07-10 | 2021-05-27 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
| JP2021207104A Withdrawn JP2022037170A (ja) | 2016-01-13 | 2021-12-21 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
| JP2024009200A Pending JP2024038480A (ja) | 2015-07-10 | 2024-01-25 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500605A Expired - Fee Related JP6892431B2 (ja) | 2015-07-10 | 2016-07-08 | 癌治療用のａｘｌ特異的抗体−薬物コンジュゲート |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021088877A Active JP7428680B2 (ja) | 2015-07-10 | 2021-05-27 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
| JP2021207104A Withdrawn JP2022037170A (ja) | 2016-01-13 | 2021-12-21 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
| JP2024009200A Pending JP2024038480A (ja) | 2015-07-10 | 2024-01-25 | 癌治療用のａｘｌ特異的抗体－薬物コンジュゲート |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20180326084A1 (enExample) |
| EP (3) | EP3319993B1 (enExample) |
| JP (5) | JP6892431B2 (enExample) |
| KR (1) | KR20180033523A (enExample) |
| CN (3) | CN108368171A (enExample) |
| AU (3) | AU2016292762B2 (enExample) |
| CA (2) | CA2991805A1 (enExample) |
| CY (1) | CY1123983T1 (enExample) |
| DK (1) | DK3319993T3 (enExample) |
| EA (2) | EA201890272A1 (enExample) |
| ES (2) | ES2784685T3 (enExample) |
| HR (1) | HRP20200551T1 (enExample) |
| HU (1) | HUE049072T2 (enExample) |
| IL (2) | IL256790B (enExample) |
| LT (1) | LT3319993T (enExample) |
| ME (1) | ME03772B (enExample) |
| PL (1) | PL3319993T3 (enExample) |
| PT (1) | PT3319993T (enExample) |
| RS (1) | RS60141B1 (enExample) |
| SI (1) | SI3319993T1 (enExample) |
| SM (1) | SMT202000359T1 (enExample) |
| WO (2) | WO2017009258A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2774428T3 (es) | 2014-07-11 | 2020-07-21 | Genmab As | Anticuerpos que se unen a AXL |
| LT3319993T (lt) * | 2015-07-10 | 2020-05-11 | Genmab A/S | Axl specifiniai antikūno-vaistokonjugatai, skirti vėžiui gydyti |
| US12115227B2 (en) | 2016-01-13 | 2024-10-15 | Genmab A/S | Formulation for antibody and drug conjugate thereof |
| SG11201809751XA (en) | 2016-05-26 | 2018-12-28 | Zeno Royalties & Milestones Llc | Egfr inhibitor compounds |
| EP3481868A1 (en) | 2016-07-08 | 2019-05-15 | Genmab A/S | New dosage regimens for antibody drug conjugates based on anti-axl antibodies |
| CA3037456A1 (en) | 2016-09-19 | 2018-03-22 | Novartis Ag | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL270224B1 (en) | 2017-05-02 | 2024-04-01 | Novartis Ag | Combination therapy employing trametinib and a defined raf inhibitor |
| TW202428305A (zh) | 2017-09-08 | 2024-07-16 | 美商建南德克公司 | 癌症之診斷及治療方法 |
| JP7366886B2 (ja) * | 2017-09-13 | 2023-10-23 | ナショナル リサーチ カウンシル オブ カナダ | Ａｘｌ特異的抗体及びその使用 |
| AU2019250443A1 (en) * | 2018-04-10 | 2020-10-22 | Genmab A/S | AXL-specific antibodies for cancer treatment |
| CN110483639A (zh) | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
| CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
| JP2022502411A (ja) * | 2018-09-26 | 2022-01-11 | ゲンマブ エー／エス | 非小細胞肺がんの処置のためのａｘｌ特異的抗体 |
| EP3941940A1 (en) | 2019-03-20 | 2022-01-26 | Imcheck Therapeutics SAS | Antibodies having specificity for btn2 and uses thereof |
| US20220177593A1 (en) * | 2019-03-29 | 2022-06-09 | Celldex Therapeutics, Inc. | Anti-axl antibodies and methods of use thereof |
| EP4563150A3 (en) | 2019-05-13 | 2025-07-23 | Novartis AG | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl) isonicotinamide as raf inhibitors for the treatment of cancer |
| WO2021154156A1 (en) * | 2020-01-31 | 2021-08-05 | Agency For Science, Technology And Research | Anti-axl antibody and uses thereof |
| CN115210263A (zh) * | 2020-02-28 | 2022-10-18 | 西福根有限公司 | 抗axl抗体和组合物 |
| JP2023525100A (ja) * | 2020-05-12 | 2023-06-14 | ノバルティス アーゲー | Ｃｒａｆ阻害剤を含む治療的組み合わせ |
| WO2022026807A2 (en) * | 2020-07-30 | 2022-02-03 | Albert Einstein College Of Medicine | Antibodies targeting sars-cov-2 and uses thereof |
| MX2023005303A (es) * | 2020-11-06 | 2023-09-12 | Day One Biopharmaceuticals Inc | Inhibidor de raf para el tratamiento del glioma de bajo grado. |
| EP4286406A4 (en) | 2021-01-29 | 2025-07-23 | Illimis Therapeutics Inc | FUSION MOLECULE WITH NON-INFLAMMATORY PHAGOCYTOSIS-INDUCING ACTIVITY |
| CN117177754A (zh) * | 2021-02-19 | 2023-12-05 | 首日生物制药公司 | Raf抑制剂和mek抑制剂的组合 |
| WO2024178140A1 (en) * | 2023-02-22 | 2024-08-29 | Resolute Science, Inc. | Compositions and methods for targeting tumor-associated macrophages |
| CN120731092A (zh) * | 2023-02-22 | 2025-09-30 | 坚毅科学股份有限公司 | 用于靶向肿瘤相关巨噬细胞的组合物和方法 |
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| US761218A (en) | 1899-10-05 | 1904-05-31 | U S Standard Voting Machine Co | Register or counter. |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
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