JP2019500051A - 変異ウイルス、その調製方法およびその用途 - Google Patents

変異ウイルス、その調製方法およびその用途 Download PDF

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JP2019500051A
JP2019500051A JP2018534937A JP2018534937A JP2019500051A JP 2019500051 A JP2019500051 A JP 2019500051A JP 2018534937 A JP2018534937 A JP 2018534937A JP 2018534937 A JP2018534937 A JP 2018534937A JP 2019500051 A JP2019500051 A JP 2019500051A
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virus
mutant
amino acid
trna
protein
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JP2019500051A5 (https=
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デミン チョウ
デミン チョウ
ロンロン シ
ロンロン シ
シューイン チョウ
シューイン チョウ
ツィーウェイ チャン
ツィーウェイ チャン
ファン シュ
ファン シュ
チェンユー ティアン
チェンユー ティアン
チュアンリン チャン
チュアンリン チャン
スロン シャオ
スロン シャオ
チン シア
チン シア
リヘ チャン
リヘ チャン
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ペキン ユニヴァーシティー
ペキン ユニヴァーシティー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
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    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01026—Pyrrolysine-tRNAPyl ligase (6.1.1.26)

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  • Plant Pathology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Communicable Diseases (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018534937A 2015-12-31 2016-08-02 変異ウイルス、その調製方法およびその用途 Pending JP2019500051A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201511029463.1 2015-12-31
CN201511029463.1A CN106929482A (zh) 2015-12-31 2015-12-31 定点突变的流感病毒、其活疫苗及其制备方法和应用
PCT/CN2016/092778 WO2017113786A1 (zh) 2015-12-31 2016-08-02 突变的病毒、其制备方法和应用

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JP2019500051A true JP2019500051A (ja) 2019-01-10
JP2019500051A5 JP2019500051A5 (https=) 2019-06-20

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US (1) US11510974B2 (https=)
EP (1) EP3399029A4 (https=)
JP (1) JP2019500051A (https=)
CN (2) CN106929482A (https=)
AU (1) AU2016383201A1 (https=)
BR (1) BR112018013168A2 (https=)
CA (1) CA3010015A1 (https=)
CO (1) CO2018006706A2 (https=)
IL (1) IL260258A (https=)
WO (1) WO2017113786A1 (https=)
ZA (1) ZA201804362B (https=)

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CN107012121B (zh) * 2016-01-27 2021-01-26 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN109295100A (zh) * 2017-07-25 2019-02-01 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN107964035B (zh) * 2017-12-06 2020-07-24 中国科学院微生物研究所 一种用于流感病毒的有限复制型黏膜免疫疫苗
CN109180680B (zh) * 2018-08-01 2020-05-08 苏州大学 一种紫外光触发交联型近红外分子探针及其制备方法与应用
CN110835633B (zh) * 2018-08-13 2021-10-01 北京大学 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用
CN110846311A (zh) * 2018-08-20 2020-02-28 北京大学 利用抑制性tRNA系统制备PTC稳定细胞系及应用
CN109111508B (zh) * 2018-09-19 2021-03-19 天康生物股份有限公司 禽流感病毒血凝素抗原及表达其的cho细胞株、制备方法和疫苗
CN109652384B (zh) * 2019-02-21 2021-10-26 昆明理工大学 一种体外培养戊型肝炎病毒的方法
CN109957550B (zh) * 2019-03-13 2020-10-20 浙江森卫生物医药发展有限公司 流感病毒的拯救方法及其组合物
CN109943536B (zh) * 2019-03-26 2021-09-14 昆明理工大学 一种戊型肝炎病毒的培养方法及其灭活疫苗的制备方法
CN110042084A (zh) * 2019-04-11 2019-07-23 浙江森卫生物医药发展有限公司 一种活病毒流感疫苗的生产方法以及制剂
CN109971888A (zh) * 2019-04-11 2019-07-05 浙江森卫生物医药发展有限公司 一种复制可控型流感病毒的检测方法
WO2021004389A1 (zh) * 2019-07-05 2021-01-14 司龙龙 蛋白水解靶向病毒、其活疫苗及其制备方法和用途
CN110743007B (zh) * 2019-09-10 2023-05-30 安徽智飞龙科马生物制药有限公司 一种联合疫苗及其制备方法、应用
CN110845587B (zh) 2019-10-15 2021-06-29 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN111533792B (zh) * 2020-07-07 2020-10-16 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN113502274A (zh) * 2021-06-21 2021-10-15 武汉大学 一种表达人乳头瘤病毒衣壳蛋白l2的重组流感病毒株及其制备方法与应用
CN115074330B (zh) * 2022-04-19 2023-12-29 中国医学科学院医学生物学研究所 一种基于遗传密码子扩展技术的改造Vero细胞系
US20260061044A1 (en) * 2022-08-24 2026-03-05 Ningbo Institute of Marine Medicine, Peking University Mutated Influenza Virus, Pharmaceutical Composition, and Use
CN116804187A (zh) * 2023-07-24 2023-09-26 中国农业科学院兰州兽医研究所 一种复制缺陷型口蹄疫病毒、构建方法及应用
CN116904403B (zh) * 2023-09-13 2024-01-09 北京民海生物科技有限公司 一种腮腺炎病毒突变体及其应用

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WO2017113786A1 (zh) 2017-07-06
IL260258A (en) 2018-07-31
EP3399029A4 (en) 2019-07-17
US11510974B2 (en) 2022-11-29
ZA201804362B (en) 2019-04-24
EP3399029A1 (en) 2018-11-07
CO2018006706A2 (es) 2018-07-10
CN109563492B (zh) 2023-05-12
CN109563492A (zh) 2019-04-02
AU2016383201A1 (en) 2018-07-05
BR112018013168A2 (pt) 2018-12-11
CN106929482A (zh) 2017-07-07
US20200268870A1 (en) 2020-08-27
CA3010015A1 (en) 2017-07-06

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