JP2019500051A5 - - Google Patents
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- JP2019500051A5 JP2019500051A5 JP2018534937A JP2018534937A JP2019500051A5 JP 2019500051 A5 JP2019500051 A5 JP 2019500051A5 JP 2018534937 A JP2018534937 A JP 2018534937A JP 2018534937 A JP2018534937 A JP 2018534937A JP 2019500051 A5 JP2019500051 A5 JP 2019500051A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- mutant
- amino acid
- trna
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000700605 Viruses Species 0.000 claims 46
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 241000712461 unidentified influenza virus Species 0.000 claims 21
- 238000000034 method Methods 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 108020004705 Codon Proteins 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 14
- 108020005038 Terminator Codon Proteins 0.000 claims 12
- 101710102873 Polymerase basic protein 2 Proteins 0.000 claims 9
- 101710085035 RNA-directed RNA polymerase catalytic subunit Proteins 0.000 claims 9
- 210000004102 animal cell Anatomy 0.000 claims 8
- 102000003960 Ligases Human genes 0.000 claims 7
- 108090000364 Ligases Proteins 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 7
- 238000011144 upstream manufacturing Methods 0.000 claims 7
- 239000013612 plasmid Substances 0.000 claims 5
- 101710085938 Matrix protein Proteins 0.000 claims 4
- 101710127721 Membrane protein Proteins 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 108040001032 pyrrolysyl-tRNA synthetase activity proteins Proteins 0.000 claims 4
- 241000709721 Hepatovirus A Species 0.000 claims 3
- 108091081024 Start codon Proteins 0.000 claims 3
- 108010067390 Viral Proteins Proteins 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 241000710777 Classical swine fever virus Species 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 208000001528 Coronaviridae Infections Diseases 0.000 claims 2
- 241000709687 Coxsackievirus Species 0.000 claims 2
- 241000699800 Cricetinae Species 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 241000725619 Dengue virus Species 0.000 claims 2
- 241001115402 Ebolavirus Species 0.000 claims 2
- 241001466953 Echovirus Species 0.000 claims 2
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000991587 Enterovirus C Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims 2
- 208000020061 Hand, Foot and Mouth Disease Diseases 0.000 claims 2
- 208000025713 Hand-foot-and-mouth disease Diseases 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 241000724675 Hepatitis E virus Species 0.000 claims 2
- 208000037262 Hepatitis delta Diseases 0.000 claims 2
- 241000724709 Hepatitis delta virus Species 0.000 claims 2
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 208000025370 Middle East respiratory syndrome Diseases 0.000 claims 2
- 241000711386 Mumps virus Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 241000125945 Protoparvovirus Species 0.000 claims 2
- 241000711798 Rabies lyssavirus Species 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 241000702670 Rotavirus Species 0.000 claims 2
- 241000710799 Rubella virus Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 241000907316 Zika virus Species 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 208000037797 influenza A Diseases 0.000 claims 2
- 208000037798 influenza B Diseases 0.000 claims 2
- 208000037799 influenza C Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 210000003501 vero cell Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000032625 disorder of ear Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 229940124590 live attenuated vaccine Drugs 0.000 claims 1
- 229940023012 live-attenuated vaccine Drugs 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 238000009629 microbiological culture Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511029463.1 | 2015-12-31 | ||
| CN201511029463.1A CN106929482A (zh) | 2015-12-31 | 2015-12-31 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| PCT/CN2016/092778 WO2017113786A1 (zh) | 2015-12-31 | 2016-08-02 | 突变的病毒、其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019500051A JP2019500051A (ja) | 2019-01-10 |
| JP2019500051A5 true JP2019500051A5 (https=) | 2019-06-20 |
Family
ID=59224413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534937A Pending JP2019500051A (ja) | 2015-12-31 | 2016-08-02 | 変異ウイルス、その調製方法およびその用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11510974B2 (https=) |
| EP (1) | EP3399029A4 (https=) |
| JP (1) | JP2019500051A (https=) |
| CN (2) | CN106929482A (https=) |
| AU (1) | AU2016383201A1 (https=) |
| BR (1) | BR112018013168A2 (https=) |
| CA (1) | CA3010015A1 (https=) |
| CO (1) | CO2018006706A2 (https=) |
| IL (1) | IL260258A (https=) |
| WO (1) | WO2017113786A1 (https=) |
| ZA (1) | ZA201804362B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN109295100A (zh) * | 2017-07-25 | 2019-02-01 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN107964035B (zh) * | 2017-12-06 | 2020-07-24 | 中国科学院微生物研究所 | 一种用于流感病毒的有限复制型黏膜免疫疫苗 |
| CN109180680B (zh) * | 2018-08-01 | 2020-05-08 | 苏州大学 | 一种紫外光触发交联型近红外分子探针及其制备方法与应用 |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| CN110846311A (zh) * | 2018-08-20 | 2020-02-28 | 北京大学 | 利用抑制性tRNA系统制备PTC稳定细胞系及应用 |
| CN109111508B (zh) * | 2018-09-19 | 2021-03-19 | 天康生物股份有限公司 | 禽流感病毒血凝素抗原及表达其的cho细胞株、制备方法和疫苗 |
| CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
| CN109957550B (zh) * | 2019-03-13 | 2020-10-20 | 浙江森卫生物医药发展有限公司 | 流感病毒的拯救方法及其组合物 |
| CN109943536B (zh) * | 2019-03-26 | 2021-09-14 | 昆明理工大学 | 一种戊型肝炎病毒的培养方法及其灭活疫苗的制备方法 |
| CN110042084A (zh) * | 2019-04-11 | 2019-07-23 | 浙江森卫生物医药发展有限公司 | 一种活病毒流感疫苗的生产方法以及制剂 |
| CN109971888A (zh) * | 2019-04-11 | 2019-07-05 | 浙江森卫生物医药发展有限公司 | 一种复制可控型流感病毒的检测方法 |
| WO2021004389A1 (zh) * | 2019-07-05 | 2021-01-14 | 司龙龙 | 蛋白水解靶向病毒、其活疫苗及其制备方法和用途 |
| CN110743007B (zh) * | 2019-09-10 | 2023-05-30 | 安徽智飞龙科马生物制药有限公司 | 一种联合疫苗及其制备方法、应用 |
| CN110845587B (zh) | 2019-10-15 | 2021-06-29 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| CN111533792B (zh) * | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| CN113502274A (zh) * | 2021-06-21 | 2021-10-15 | 武汉大学 | 一种表达人乳头瘤病毒衣壳蛋白l2的重组流感病毒株及其制备方法与应用 |
| CN115074330B (zh) * | 2022-04-19 | 2023-12-29 | 中国医学科学院医学生物学研究所 | 一种基于遗传密码子扩展技术的改造Vero细胞系 |
| WO2024040453A1 (zh) * | 2022-08-24 | 2024-02-29 | 北京大学宁波海洋药物研究院 | 突变的流感病毒、药物组合物及用途 |
| CN116804187A (zh) * | 2023-07-24 | 2023-09-26 | 中国农业科学院兰州兽医研究所 | 一种复制缺陷型口蹄疫病毒、构建方法及应用 |
| CN116904403B (zh) * | 2023-09-13 | 2024-01-09 | 北京民海生物科技有限公司 | 一种腮腺炎病毒突变体及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA04000589A (es) * | 2001-07-20 | 2005-06-17 | Univ Georgia Res Found | Virus de la rabia atenuado con mutacion de nucleoproteina en el sitio de fosforilacion para vacunacion contra la rabia y terapia genetica en el snc. |
| CN101970005A (zh) * | 2008-02-08 | 2011-02-09 | 斯克利普斯研究院 | 用遗传编码的非天然氨基酸打破免疫耐受 |
| PE20110480A1 (es) * | 2008-09-26 | 2011-07-01 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales |
| TW201125984A (en) * | 2009-10-09 | 2011-08-01 | Univ New York State Res Found | Attenuated influenza viruses and vaccines |
| CN102838663B (zh) * | 2011-06-23 | 2014-06-11 | 北京大学 | 定点突变和定点修饰的病毒膜蛋白、其制备方法及其应用 |
| SG10201702387YA (en) * | 2012-09-24 | 2017-04-27 | Medimmune Ltd | Cell lines |
| CN102964432B (zh) * | 2012-11-22 | 2014-02-05 | 中国科学院微生物研究所 | 抑制a型流感病毒m1蛋白发生磷酸化的方法及其应用 |
| CN104592364B (zh) * | 2013-10-30 | 2018-05-01 | 北京大学 | 定点突变和定点修饰的腺相关病毒、其制备方法及应用 |
| EP3087088B1 (en) * | 2013-12-23 | 2022-05-25 | University Of Rochester | Methods and compositions for ribosomal synthesis of macrocyclic peptides |
| CA2936615C (en) * | 2014-01-14 | 2023-06-13 | European Molecular Biology Laboratory | Multiple cycloaddition reactions for labeling of molecules |
| US10322172B2 (en) * | 2014-02-10 | 2019-06-18 | Nutech Ventures | Live, attenuated vaccines and methods of making and using |
| MA40773A (fr) * | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
-
2015
- 2015-12-31 CN CN201511029463.1A patent/CN106929482A/zh active Pending
-
2016
- 2016-08-02 AU AU2016383201A patent/AU2016383201A1/en not_active Abandoned
- 2016-08-02 WO PCT/CN2016/092778 patent/WO2017113786A1/zh not_active Ceased
- 2016-08-02 EP EP16880581.0A patent/EP3399029A4/en active Pending
- 2016-08-02 BR BR112018013168-7A patent/BR112018013168A2/pt not_active IP Right Cessation
- 2016-08-02 JP JP2018534937A patent/JP2019500051A/ja active Pending
- 2016-08-02 CN CN201680076047.3A patent/CN109563492B/zh active Active
- 2016-08-02 US US16/066,283 patent/US11510974B2/en active Active
- 2016-08-02 CA CA3010015A patent/CA3010015A1/en not_active Abandoned
-
2018
- 2018-06-25 IL IL260258A patent/IL260258A/en unknown
- 2018-06-27 CO CONC2018/0006706A patent/CO2018006706A2/es unknown
- 2018-06-28 ZA ZA2018/04362A patent/ZA201804362B/en unknown
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