CA3010015A1 - Mutated viruses, preparation method and use thereof - Google Patents
Mutated viruses, preparation method and use thereof Download PDFInfo
- Publication number
- CA3010015A1 CA3010015A1 CA3010015A CA3010015A CA3010015A1 CA 3010015 A1 CA3010015 A1 CA 3010015A1 CA 3010015 A CA3010015 A CA 3010015A CA 3010015 A CA3010015 A CA 3010015A CA 3010015 A1 CA3010015 A1 CA 3010015A1
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- virus
- mutated
- amino acid
- trna
- influenza
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| CN201511029463.1 | 2015-12-31 | ||
| CN201511029463.1A CN106929482A (zh) | 2015-12-31 | 2015-12-31 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| PCT/CN2016/092778 WO2017113786A1 (zh) | 2015-12-31 | 2016-08-02 | 突变的病毒、其制备方法和应用 |
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| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN109295100A (zh) * | 2017-07-25 | 2019-02-01 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN107964035B (zh) * | 2017-12-06 | 2020-07-24 | 中国科学院微生物研究所 | 一种用于流感病毒的有限复制型黏膜免疫疫苗 |
| CN109180680B (zh) * | 2018-08-01 | 2020-05-08 | 苏州大学 | 一种紫外光触发交联型近红外分子探针及其制备方法与应用 |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| CN110846311A (zh) * | 2018-08-20 | 2020-02-28 | 北京大学 | 利用抑制性tRNA系统制备PTC稳定细胞系及应用 |
| CN109111508B (zh) * | 2018-09-19 | 2021-03-19 | 天康生物股份有限公司 | 禽流感病毒血凝素抗原及表达其的cho细胞株、制备方法和疫苗 |
| CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
| CN109957550B (zh) * | 2019-03-13 | 2020-10-20 | 浙江森卫生物医药发展有限公司 | 流感病毒的拯救方法及其组合物 |
| CN109943536B (zh) * | 2019-03-26 | 2021-09-14 | 昆明理工大学 | 一种戊型肝炎病毒的培养方法及其灭活疫苗的制备方法 |
| CN110042084A (zh) * | 2019-04-11 | 2019-07-23 | 浙江森卫生物医药发展有限公司 | 一种活病毒流感疫苗的生产方法以及制剂 |
| CN109971888A (zh) * | 2019-04-11 | 2019-07-05 | 浙江森卫生物医药发展有限公司 | 一种复制可控型流感病毒的检测方法 |
| WO2021004389A1 (zh) * | 2019-07-05 | 2021-01-14 | 司龙龙 | 蛋白水解靶向病毒、其活疫苗及其制备方法和用途 |
| CN110743007B (zh) * | 2019-09-10 | 2023-05-30 | 安徽智飞龙科马生物制药有限公司 | 一种联合疫苗及其制备方法、应用 |
| CN110845587B (zh) | 2019-10-15 | 2021-06-29 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| CN111533792B (zh) * | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| CN113502274A (zh) * | 2021-06-21 | 2021-10-15 | 武汉大学 | 一种表达人乳头瘤病毒衣壳蛋白l2的重组流感病毒株及其制备方法与应用 |
| CN115074330B (zh) * | 2022-04-19 | 2023-12-29 | 中国医学科学院医学生物学研究所 | 一种基于遗传密码子扩展技术的改造Vero细胞系 |
| WO2024040453A1 (zh) * | 2022-08-24 | 2024-02-29 | 北京大学宁波海洋药物研究院 | 突变的流感病毒、药物组合物及用途 |
| CN116804187A (zh) * | 2023-07-24 | 2023-09-26 | 中国农业科学院兰州兽医研究所 | 一种复制缺陷型口蹄疫病毒、构建方法及应用 |
| CN116904403B (zh) * | 2023-09-13 | 2024-01-09 | 北京民海生物科技有限公司 | 一种腮腺炎病毒突变体及其应用 |
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| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA04000589A (es) * | 2001-07-20 | 2005-06-17 | Univ Georgia Res Found | Virus de la rabia atenuado con mutacion de nucleoproteina en el sitio de fosforilacion para vacunacion contra la rabia y terapia genetica en el snc. |
| CN101970005A (zh) * | 2008-02-08 | 2011-02-09 | 斯克利普斯研究院 | 用遗传编码的非天然氨基酸打破免疫耐受 |
| PE20110480A1 (es) * | 2008-09-26 | 2011-07-01 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales |
| TW201125984A (en) * | 2009-10-09 | 2011-08-01 | Univ New York State Res Found | Attenuated influenza viruses and vaccines |
| CN102838663B (zh) * | 2011-06-23 | 2014-06-11 | 北京大学 | 定点突变和定点修饰的病毒膜蛋白、其制备方法及其应用 |
| SG10201702387YA (en) * | 2012-09-24 | 2017-04-27 | Medimmune Ltd | Cell lines |
| CN102964432B (zh) * | 2012-11-22 | 2014-02-05 | 中国科学院微生物研究所 | 抑制a型流感病毒m1蛋白发生磷酸化的方法及其应用 |
| CN104592364B (zh) * | 2013-10-30 | 2018-05-01 | 北京大学 | 定点突变和定点修饰的腺相关病毒、其制备方法及应用 |
| EP3087088B1 (en) * | 2013-12-23 | 2022-05-25 | University Of Rochester | Methods and compositions for ribosomal synthesis of macrocyclic peptides |
| CA2936615C (en) * | 2014-01-14 | 2023-06-13 | European Molecular Biology Laboratory | Multiple cycloaddition reactions for labeling of molecules |
| US10322172B2 (en) * | 2014-02-10 | 2019-06-18 | Nutech Ventures | Live, attenuated vaccines and methods of making and using |
| MA40773A (fr) * | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
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