CN106929482A - 定点突变的流感病毒、其活疫苗及其制备方法和应用 - Google Patents

定点突变的流感病毒、其活疫苗及其制备方法和应用 Download PDF

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Publication number
CN106929482A
CN106929482A CN201511029463.1A CN201511029463A CN106929482A CN 106929482 A CN106929482 A CN 106929482A CN 201511029463 A CN201511029463 A CN 201511029463A CN 106929482 A CN106929482 A CN 106929482A
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influenza virus
amino acid
site
virus
acid sequence
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Chinese (zh)
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周德敏
司龙龙
周雪莹
张子威
徐欢
田振宇
姚天卓
肖苏龙
张传领
夏青
张礼和
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Peking University
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Peking University
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Priority to CN201511029463.1A priority Critical patent/CN106929482A/zh
Priority to CN201680076047.3A priority patent/CN109563492B/zh
Priority to AU2016383201A priority patent/AU2016383201A1/en
Priority to JP2018534937A priority patent/JP2019500051A/ja
Priority to CA3010015A priority patent/CA3010015A1/en
Priority to BR112018013168-7A priority patent/BR112018013168A2/pt
Priority to PCT/CN2016/092778 priority patent/WO2017113786A1/zh
Priority to US16/066,283 priority patent/US11510974B2/en
Priority to EP16880581.0A priority patent/EP3399029A4/en
Publication of CN106929482A publication Critical patent/CN106929482A/zh
Priority to IL260258A priority patent/IL260258A/en
Priority to CONC2018/0006706A priority patent/CO2018006706A2/es
Priority to ZA2018/04362A priority patent/ZA201804362B/en
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    • C12Y601/01026—Pyrrolysine-tRNAPyl ligase (6.1.1.26)

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CN201511029463.1A 2015-12-31 2015-12-31 定点突变的流感病毒、其活疫苗及其制备方法和应用 Pending CN106929482A (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201511029463.1A CN106929482A (zh) 2015-12-31 2015-12-31 定点突变的流感病毒、其活疫苗及其制备方法和应用
BR112018013168-7A BR112018013168A2 (pt) 2015-12-31 2016-08-02 vírus mutantes, método de preparação e uso dos mesmos
AU2016383201A AU2016383201A1 (en) 2015-12-31 2016-08-02 Mutant virus, preparation method therefor and application thereof
JP2018534937A JP2019500051A (ja) 2015-12-31 2016-08-02 変異ウイルス、その調製方法およびその用途
CA3010015A CA3010015A1 (en) 2015-12-31 2016-08-02 Mutated viruses, preparation method and use thereof
CN201680076047.3A CN109563492B (zh) 2015-12-31 2016-08-02 突变的病毒、其制备方法和应用
PCT/CN2016/092778 WO2017113786A1 (zh) 2015-12-31 2016-08-02 突变的病毒、其制备方法和应用
US16/066,283 US11510974B2 (en) 2015-12-31 2016-08-02 Mutant virus, preparation method therefor and application thereof
EP16880581.0A EP3399029A4 (en) 2015-12-31 2016-08-02 MUTANT VIRUS, MANUFACTURING METHOD AND APPLICATION THEREOF
IL260258A IL260258A (en) 2015-12-31 2018-06-25 Mutated viruses, method for their preparation and use
CONC2018/0006706A CO2018006706A2 (es) 2015-12-31 2018-06-27 Virus mutados, método de preparación y uso de los mismos
ZA2018/04362A ZA201804362B (en) 2015-12-31 2018-06-28 Mutant virus, preparation method therefor and application thereof

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US (1) US11510974B2 (https=)
EP (1) EP3399029A4 (https=)
JP (1) JP2019500051A (https=)
CN (2) CN106929482A (https=)
AU (1) AU2016383201A1 (https=)
BR (1) BR112018013168A2 (https=)
CA (1) CA3010015A1 (https=)
CO (1) CO2018006706A2 (https=)
IL (1) IL260258A (https=)
WO (1) WO2017113786A1 (https=)
ZA (1) ZA201804362B (https=)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107012121A (zh) * 2016-01-27 2017-08-04 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN107964035A (zh) * 2017-12-06 2018-04-27 中国科学院微生物研究所 一种用于流感病毒的有限复制型黏膜免疫疫苗
CN109111508A (zh) * 2018-09-19 2019-01-01 天康生物股份有限公司 禽流感病毒血凝素抗原及表达其的cho细胞株、制备方法和疫苗
CN109180680A (zh) * 2018-08-01 2019-01-11 苏州大学 一种紫外光触发交联型近红外分子探针及其制备方法与应用
CN109295100A (zh) * 2017-07-25 2019-02-01 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN109652384A (zh) * 2019-02-21 2019-04-19 昆明理工大学 一种体外培养戊型肝炎病毒的方法
CN109943536A (zh) * 2019-03-26 2019-06-28 昆明理工大学 一种戊型肝炎病毒、培养方法及其灭活疫苗的制备方法
CN109957550A (zh) * 2019-03-13 2019-07-02 浙江森卫生物医药发展有限公司 流感病毒的拯救方法及其组合物
CN109971888A (zh) * 2019-04-11 2019-07-05 浙江森卫生物医药发展有限公司 一种复制可控型流感病毒的检测方法
CN110042084A (zh) * 2019-04-11 2019-07-23 浙江森卫生物医药发展有限公司 一种活病毒流感疫苗的生产方法以及制剂
CN110835633A (zh) * 2018-08-13 2020-02-25 北京大学 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用
CN110846311A (zh) * 2018-08-20 2020-02-28 北京大学 利用抑制性tRNA系统制备PTC稳定细胞系及应用
CN111533792A (zh) * 2020-07-07 2020-08-14 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN112175914A (zh) * 2019-07-05 2021-01-05 司龙龙 蛋白水解靶向病毒、其活疫苗及其制备方法和用途
WO2021073402A1 (zh) 2019-10-15 2021-04-22 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN113502274A (zh) * 2021-06-21 2021-10-15 武汉大学 一种表达人乳头瘤病毒衣壳蛋白l2的重组流感病毒株及其制备方法与应用
WO2024040453A1 (zh) * 2022-08-24 2024-02-29 北京大学宁波海洋药物研究院 突变的流感病毒、药物组合物及用途

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CN110743007B (zh) * 2019-09-10 2023-05-30 安徽智飞龙科马生物制药有限公司 一种联合疫苗及其制备方法、应用
CN115074330B (zh) * 2022-04-19 2023-12-29 中国医学科学院医学生物学研究所 一种基于遗传密码子扩展技术的改造Vero细胞系
CN116804187A (zh) * 2023-07-24 2023-09-26 中国农业科学院兰州兽医研究所 一种复制缺陷型口蹄疫病毒、构建方法及应用
CN116904403B (zh) * 2023-09-13 2024-01-09 北京民海生物科技有限公司 一种腮腺炎病毒突变体及其应用

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CN104592364B (zh) * 2013-10-30 2018-05-01 北京大学 定点突变和定点修饰的腺相关病毒、其制备方法及应用
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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107012121A (zh) * 2016-01-27 2017-08-04 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN112725282A (zh) * 2016-01-27 2021-04-30 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN109295100A (zh) * 2017-07-25 2019-02-01 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
CN107964035A (zh) * 2017-12-06 2018-04-27 中国科学院微生物研究所 一种用于流感病毒的有限复制型黏膜免疫疫苗
CN107964035B (zh) * 2017-12-06 2020-07-24 中国科学院微生物研究所 一种用于流感病毒的有限复制型黏膜免疫疫苗
CN109180680A (zh) * 2018-08-01 2019-01-11 苏州大学 一种紫外光触发交联型近红外分子探针及其制备方法与应用
CN109180680B (zh) * 2018-08-01 2020-05-08 苏州大学 一种紫外光触发交联型近红外分子探针及其制备方法与应用
CN110835633B (zh) * 2018-08-13 2021-10-01 北京大学 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用
CN110835633A (zh) * 2018-08-13 2020-02-25 北京大学 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用
CN110846311A (zh) * 2018-08-20 2020-02-28 北京大学 利用抑制性tRNA系统制备PTC稳定细胞系及应用
CN109111508B (zh) * 2018-09-19 2021-03-19 天康生物股份有限公司 禽流感病毒血凝素抗原及表达其的cho细胞株、制备方法和疫苗
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