JP2019213567A5 - - Google Patents

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JP2019213567A5
JP2019213567A5 JP2019181613A JP2019181613A JP2019213567A5 JP 2019213567 A5 JP2019213567 A5 JP 2019213567A5 JP 2019181613 A JP2019181613 A JP 2019181613A JP 2019181613 A JP2019181613 A JP 2019181613A JP 2019213567 A5 JP2019213567 A5 JP 2019213567A5
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JP
Japan
Prior art keywords
rna molecule
linker
stranded oligo
oligo rna
seq
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JP2019181613A
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English (en)
Japanese (ja)
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JP2019213567A (ja
JP7363316B2 (ja
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Priority claimed from JP2019520762A external-priority patent/JP6631751B1/ja
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JP2019181613A 2018-03-30 2019-10-01 ヘアピン型一本鎖rna分子の製造方法 Active JP7363316B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018070423 2018-03-30
JP2018070423 2018-03-30
JP2019520762A JP6631751B1 (ja) 2018-03-30 2019-03-29 ヘアピン型一本鎖rna分子の製造方法

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JP2019520762A Division JP6631751B1 (ja) 2018-03-30 2019-03-29 ヘアピン型一本鎖rna分子の製造方法

Publications (3)

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JP2019213567A JP2019213567A (ja) 2019-12-19
JP2019213567A5 true JP2019213567A5 (https=) 2022-03-29
JP7363316B2 JP7363316B2 (ja) 2023-10-18

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JP2019520762A Expired - Fee Related JP6631751B1 (ja) 2018-03-30 2019-03-29 ヘアピン型一本鎖rna分子の製造方法
JP2019181613A Active JP7363316B2 (ja) 2018-03-30 2019-10-01 ヘアピン型一本鎖rna分子の製造方法

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JP2019520762A Expired - Fee Related JP6631751B1 (ja) 2018-03-30 2019-03-29 ヘアピン型一本鎖rna分子の製造方法

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US (2) US11920131B2 (https=)
EP (1) EP3778886A4 (https=)
JP (2) JP6631751B1 (https=)
KR (1) KR20200136363A (https=)
CN (1) CN111819280A (https=)
AU (1) AU2019242331A1 (https=)
BR (1) BR112020017769A2 (https=)
CA (1) CA3094160A1 (https=)
IL (1) IL277346A (https=)
MX (1) MX2020009556A (https=)
PH (1) PH12020551487A1 (https=)
RU (1) RU2020130258A (https=)
SA (1) SA520420072B1 (https=)
TW (1) TWI772632B (https=)
WO (1) WO2019189722A1 (https=)
ZA (1) ZA202005149B (https=)

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Publication number Priority date Publication date Assignee Title
TWI848981B (zh) 2018-10-02 2024-07-21 日商東麗股份有限公司 新穎亞磷醯胺、及髮夾型單股rna分子之製造方法
EP4069838A1 (en) * 2019-12-03 2022-10-12 Beam Therapeutics Inc. Synthetic guide rna, compositions, methods, and uses thereof
JP7613130B2 (ja) * 2020-03-25 2025-01-15 味の素株式会社 リガーゼ変異体
US12522629B2 (en) 2020-03-27 2026-01-13 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
KR20240046780A (ko) * 2021-08-27 2024-04-09 페킹 유니버시티 원형 rna를 제조하기 위한 구축물 및 방법
CN117660374A (zh) * 2022-09-08 2024-03-08 凯莱英医药集团(天津)股份有限公司 Rna连接酶在寡核苷酸制备上的应用
CN115774075B (zh) * 2023-02-15 2023-06-06 江苏耀海生物制药有限公司 一种基于RP-HPLC分析体外转录产物成分circRNA的方法

Family Cites Families (19)

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WO2001040516A2 (en) 1999-12-02 2001-06-07 Molecular Staging Inc. Generation of single-strand circular dna from linear self-annealing segments
AU2003256857A1 (en) * 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
JP5296328B2 (ja) * 2007-05-09 2013-09-25 独立行政法人理化学研究所 1本鎖環状rnaおよびその製造方法
EP2256191A4 (en) * 2008-02-15 2011-07-06 Riken CYCLIC SINGLE NUCLEIC ACID COMPLEX AND METHOD FOR THE PRODUCTION THEREOF
JPWO2011052013A1 (ja) 2009-10-29 2013-03-14 株式会社バイオダイナミクス研究所 核酸鎖の結合および修飾方法
HUE037500T2 (hu) 2010-07-08 2018-08-28 Bonac Corp Egyszálú nukleinsav molekula a génexpresszió szabályozására
ES2527660T3 (es) 2010-08-03 2015-01-28 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
WO2013077446A1 (ja) * 2011-11-26 2013-05-30 株式会社ボナック 遺伝子発現制御のための一本鎖核酸分子
US9528111B2 (en) 2012-01-07 2016-12-27 Bonac Corporation Single-stranded nucleic acid molecule having amino acid backbone
US9816120B2 (en) 2013-01-09 2017-11-14 The Penn State Research Foundation Low sequence bias single-stranded DNA ligation
KR20170129264A (ko) 2015-04-02 2017-11-24 가부시키가이샤 보낙 글리코시드 화합물의 제조 방법
US11535888B2 (en) * 2015-08-21 2022-12-27 Thomas Jefferson University Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences
MX2018005146A (es) * 2015-10-30 2018-08-23 Bonac Corp Composicion que contiene de manera estable molecula de acido nucleico de un solo filamento que suprime la expresion de gen tgf-b1.
GB201612011D0 (en) 2016-07-11 2016-08-24 Glaxosmithkline Ip Dev Ltd Novel processes for the production of oligonucleotides
JP6815601B2 (ja) 2016-11-01 2021-01-20 スタンレー電気株式会社 ウルツ鉱構造のZnOS混晶粒子の製造方法
EP3604528A4 (en) * 2017-03-31 2021-01-13 Bonac Corporation CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
EP3778914A4 (en) * 2018-03-30 2022-01-19 Sumitomo Chemical Company, Ltd. Method for producing single-strand rna

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