JP2005517436A5 - - Google Patents

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Publication number
JP2005517436A5
JP2005517436A5 JP2003569803A JP2003569803A JP2005517436A5 JP 2005517436 A5 JP2005517436 A5 JP 2005517436A5 JP 2003569803 A JP2003569803 A JP 2003569803A JP 2003569803 A JP2003569803 A JP 2003569803A JP 2005517436 A5 JP2005517436 A5 JP 2005517436A5
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JP
Japan
Prior art keywords
sina molecule
nucleotides
nucleotide
molecule
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003569803A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005517436A (ja
Filing date
Publication date
Priority claimed from PCT/US2002/017674 external-priority patent/WO2002096927A2/en
Priority claimed from US10/287,949 external-priority patent/US20040102389A1/en
Priority claimed from US10/306,747 external-priority patent/US20030216335A1/en
Application filed filed Critical
Priority claimed from PCT/US2003/005022 external-priority patent/WO2003070910A2/en
Publication of JP2005517436A publication Critical patent/JP2005517436A/ja
Publication of JP2005517436A5 publication Critical patent/JP2005517436A5/ja
Withdrawn legal-status Critical Current

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JP2003569803A 2002-02-20 2003-02-20 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害 Withdrawn JP2005517436A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US35858002P 2002-02-20 2002-02-20
US36312402P 2002-03-11 2002-03-11
PCT/US2002/017674 WO2002096927A2 (en) 2001-05-29 2002-05-29 Ribozyme based treatment of female reproductive diseases
US38678202P 2002-06-06 2002-06-06
US39379602P 2002-07-03 2002-07-03
US39934802P 2002-07-29 2002-07-29
US40678402P 2002-08-29 2002-08-29
US40837802P 2002-09-05 2002-09-05
US40929302P 2002-09-09 2002-09-09
US10/287,949 US20040102389A1 (en) 1995-10-26 2002-11-04 Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
US10/306,747 US20030216335A1 (en) 2001-11-30 2002-11-27 Method and reagent for the modulation of female reproductive diseases and conditions
US44012903P 2003-01-15 2003-01-15
PCT/US2003/005022 WO2003070910A2 (en) 2002-02-20 2003-02-20 INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008148548A Division JP2009000105A (ja) 2002-02-20 2008-06-05 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害

Publications (2)

Publication Number Publication Date
JP2005517436A JP2005517436A (ja) 2005-06-16
JP2005517436A5 true JP2005517436A5 (https=) 2006-09-21

Family

ID=40427642

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003569803A Withdrawn JP2005517436A (ja) 2002-02-20 2003-02-20 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害
JP2008148548A Pending JP2009000105A (ja) 2002-02-20 2008-06-05 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008148548A Pending JP2009000105A (ja) 2002-02-20 2008-06-05 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害

Country Status (6)

Country Link
US (1) US20030216335A1 (https=)
EP (1) EP1521768A4 (https=)
JP (2) JP2005517436A (https=)
AU (1) AU2003216323B2 (https=)
CA (1) CA2456444A1 (https=)
GB (2) GB2406569B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148530A1 (en) * 2002-02-20 2005-07-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20050054596A1 (en) * 2001-11-30 2005-03-10 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
AU2004266311B2 (en) * 2001-05-18 2009-07-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US20050222066A1 (en) * 2001-05-18 2005-10-06 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20040138163A1 (en) * 2002-05-29 2004-07-15 Mcswiggen James RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20070203333A1 (en) * 2001-11-30 2007-08-30 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20050075304A1 (en) * 2001-11-30 2005-04-07 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
EP1495120B1 (en) * 2002-04-18 2012-10-10 Acuity Pharmaceuticals, Inc Means and methods for the specific modulation of target genes in the eye
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
AU2004308484A1 (en) * 2003-12-23 2005-07-14 The Trustees Of The University Of Pennsylvania Compositions and methods for combined therapy of disease
US20070254291A1 (en) * 2004-06-14 2007-11-01 Xiaoxia Cui Gene Targeting in Eukaryotic Cells by Group II Intron Ribonucleoprotein Particles
WO2005123937A2 (en) * 2004-06-14 2005-12-29 The University Of Texas At Austin Methods for expressing rnp particles in eukaryotic cells
CN101346393B (zh) 2005-11-02 2015-07-22 普洛体维生物治疗公司 修饰的siRNA分子及其应用
DK2029746T3 (da) * 2006-06-12 2012-10-08 Exegenics Inc D B A Opko Health Inc Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
US7872118B2 (en) * 2006-09-08 2011-01-18 Opko Ophthalmics, Llc siRNA and methods of manufacture
US20080287408A1 (en) * 2007-05-14 2008-11-20 Drugtech Corporation Endometriosis treatment
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2010005527A1 (en) 2008-06-30 2010-01-14 Angioblast Systems, Inc. Treatment of eye diseases and excessive neovascularization using a combined therapy
ES2600781T3 (es) * 2008-12-04 2017-02-10 Curna, Inc. Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
AU2009322279A1 (en) * 2008-12-04 2011-07-14 Opko Pharmaceuticals, Llc Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US9222086B2 (en) 2009-09-23 2015-12-29 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes expressed in cancer
JP6002382B2 (ja) * 2011-12-07 2016-10-05 株式会社バイオシンクタンク 遺伝子発現阻害剤及び阻害方法
EP2817287B1 (en) 2012-02-24 2018-10-03 Arbutus Biopharma Corporation Trialkyl cationic lipids and methods of use thereof
AU2018215440B2 (en) 2017-02-06 2024-10-24 Nissan Chemical Corporation Single-stranded oligonucleotide
EP4121018A4 (en) 2020-03-17 2024-07-03 Genevant Sciences Gmbh CATIONIC LIPIDS FOR LIPID DNANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLA CELLS
AU2021403156A1 (en) 2020-12-18 2023-07-13 Genevant Sciences Gmbh Peg lipids and lipid nanoparticles
KR20240146674A (ko) 2022-01-31 2024-10-08 제네반트 사이언시즈 게엠베하 지질 나노입자를 위한 이온화 가능한 양이온성 지질
WO2025052278A1 (en) 2023-09-05 2025-03-13 Genevant Sciences Gmbh Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
WO2025133951A1 (en) 2023-12-21 2025-06-26 Genevant Sciences Gmbh Ionizable lipids suitable for lipid nanoparticles
WO2026022656A2 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Lipid particle formulations with permanently charged cationic lipids
WO2026022677A1 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Permanently charged cationic lipids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
WO2002096927A2 (en) * 2001-05-29 2002-12-05 Ribozyme Pharmaceuticals, Incorporated Ribozyme based treatment of female reproductive diseases
JP2000501941A (ja) * 1995-12-08 2000-02-22 ハイブリドン・インコーポレイテッド 修飾ｖｅｇｆアンチセンスオリゴヌクレオチド
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis

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