JP2005517452A5 - - Google Patents

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Publication number
JP2005517452A5
JP2005517452A5 JP2003569860A JP2003569860A JP2005517452A5 JP 2005517452 A5 JP2005517452 A5 JP 2005517452A5 JP 2003569860 A JP2003569860 A JP 2003569860A JP 2003569860 A JP2003569860 A JP 2003569860A JP 2005517452 A5 JP2005517452 A5 JP 2005517452A5
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JP
Japan
Prior art keywords
sirna molecule
molecule
region
nucleotide
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003569860A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005517452A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/004908 external-priority patent/WO2003070969A2/en
Publication of JP2005517452A publication Critical patent/JP2005517452A/ja
Publication of JP2005517452A5 publication Critical patent/JP2005517452A5/ja
Pending legal-status Critical Current

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JP2003569860A 2002-02-20 2003-02-18 短干渉核酸（ｓｉＮＡ）を用いるＢＣＬ２遺伝子発現のＲＮＡ干渉媒介性阻害 Pending JP2005517452A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US35858002P 2002-02-20 2002-02-20
US36312402P 2002-03-11 2002-03-11
US38678202P 2002-06-06 2002-06-06
US39690502P 2002-07-18 2002-07-18
US40678402P 2002-08-29 2002-08-29
US40837802P 2002-09-05 2002-09-05
US40929302P 2002-09-09 2002-09-09
US44012903P 2003-01-15 2003-01-15
PCT/US2003/004908 WO2003070969A2 (en) 2002-02-20 2003-02-18 RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Publications (2)

Publication Number Publication Date
JP2005517452A JP2005517452A (ja) 2005-06-16
JP2005517452A5 true JP2005517452A5 (https=) 2006-03-30

Family

ID=27761716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003569860A Pending JP2005517452A (ja) 2002-02-20 2003-02-18 短干渉核酸（ｓｉＮＡ）を用いるＢＣＬ２遺伝子発現のＲＮＡ干渉媒介性阻害

Country Status (5)

Country Link
EP (1) EP1442143A4 (https=)
JP (1) JP2005517452A (https=)
AU (1) AU2003213119A1 (https=)
CA (1) CA2463595A1 (https=)
WO (1) WO2003070969A2 (https=)

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US10011836B2 (en) 2002-11-14 2018-07-03 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
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US9719092B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting CNTD2
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US8916533B2 (en) 2009-11-23 2014-12-23 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
RS56011B1 (sr) 2010-04-29 2017-09-29 Ionis Pharmaceuticals Inc Modulacija ekspresije transtiretina
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JP5931897B2 (ja) 2010-11-12 2016-06-08 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法
CA2817982C (en) 2010-11-15 2020-06-30 The Regents Of The University Of Michigan Controlled release mucoadhesive systems
AU2012323924A1 (en) 2011-10-14 2014-05-29 The Ohio State University Methods and materials related to ovarian cancer
CA2859430A1 (en) 2011-12-13 2013-06-20 Ohio State Innovation Foundation Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
US9404108B2 (en) 2012-03-04 2016-08-02 Bonac Corporation Micro-RMA inhibitor
CA2887069A1 (en) 2012-10-05 2014-04-10 Bioneer Corporation Amphiregulin-specific double-helical oligo-rna, double-helical oligo-rna structure comprising double-helical oligo-rna, and composition for preventing or treating respiratory diseases containing same
BR112015010220A2 (pt) * 2012-11-05 2017-12-05 Pronai Therapeutics Inc métodos de utilização de biomarcadores para tratamento de câncer
CN106459974A (zh) 2014-04-04 2017-02-22 柏业公司 新颖的双链寡rna和包含它的用于预防或治疗纤维化或呼吸系统疾病的药物组合物
KR101993377B1 (ko) * 2017-07-20 2019-06-26 (주)큐리진 Bcl2 유전자 및 bi-1 유전자의 발현을 동시에 억제하는 핵산
CN113038956A (zh) * 2018-12-05 2021-06-25 日东电工株式会社 癌处置用RNAi分子
WO2020196736A1 (ja) * 2019-03-28 2020-10-01 日東電工株式会社 ＲＮＡｉ分子

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US5831066A (en) * 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5877309A (en) * 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE10100586C1 (de) * 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US7662791B2 (en) * 2000-08-02 2010-02-16 University Of Southern California Gene silencing using mRNA-cDNA hybrids

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