TWI772632B - 髮夾型單股ｒｎａ分子之製造方法、單股寡ｒｎａ分子及包含其之套組 - Google Patents

髮夾型單股ｒｎａ分子之製造方法、單股寡ｒｎａ分子及包含其之套組 Download PDF

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TWI772632B
TWI772632B TW108111164A TW108111164A TWI772632B TW I772632 B TWI772632 B TW I772632B TW 108111164 A TW108111164 A TW 108111164A TW 108111164 A TW108111164 A TW 108111164A TW I772632 B TWI772632 B TW I772632B
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stranded
linker
molecule
rna
seq
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TW108111164A
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TW202003842A (zh
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稻田英朗
伊關克彥
沖村慶一
佐野坂真人
高科安由美
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日商東麗股份有限公司
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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TW108111164A 2018-03-30 2019-03-29 髮夾型單股ｒｎａ分子之製造方法、單股寡ｒｎａ分子及包含其之套組 TWI772632B (zh)

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JP2018070423 2018-03-30
JP2018-070423 2018-03-30

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TW202003842A TW202003842A (zh) 2020-01-16
TWI772632B true TWI772632B (zh) 2022-08-01

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US (2) US11920131B2 (https=)
EP (1) EP3778886A4 (https=)
JP (2) JP6631751B1 (https=)
KR (1) KR20200136363A (https=)
CN (1) CN111819280A (https=)
AU (1) AU2019242331A1 (https=)
BR (1) BR112020017769A2 (https=)
CA (1) CA3094160A1 (https=)
IL (1) IL277346A (https=)
MX (1) MX2020009556A (https=)
PH (1) PH12020551487A1 (https=)
RU (1) RU2020130258A (https=)
SA (1) SA520420072B1 (https=)
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TWI848981B (zh) 2018-10-02 2024-07-21 日商東麗股份有限公司 新穎亞磷醯胺、及髮夾型單股ｒｎａ分子之製造方法
EP4069838A1 (en) * 2019-12-03 2022-10-12 Beam Therapeutics Inc. Synthetic guide rna, compositions, methods, and uses thereof
JP7613130B2 (ja) * 2020-03-25 2025-01-15 味の素株式会社 リガーゼ変異体
US12522629B2 (en) 2020-03-27 2026-01-13 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
KR20240046780A (ko) * 2021-08-27 2024-04-09 페킹 유니버시티 원형 rna를 제조하기 위한 구축물 및 방법
CN117660374A (zh) * 2022-09-08 2024-03-08 凯莱英医药集团（天津）股份有限公司 Rna连接酶在寡核苷酸制备上的应用
CN115774075B (zh) * 2023-02-15 2023-06-06 江苏耀海生物制药有限公司 一种基于RP-HPLC分析体外转录产物成分circRNA的方法

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PH12020551487A1 (en) 2021-08-23
ZA202005149B (en) 2022-01-26
EP3778886A1 (en) 2021-02-17
BR112020017769A2 (pt) 2021-01-05
RU2020130258A (ru) 2022-05-04
US11920131B2 (en) 2024-03-05
SA520420072B1 (ar) 2024-04-21
JPWO2019189722A1 (ja) 2020-04-30
US20210024930A1 (en) 2021-01-28
JP6631751B1 (ja) 2020-01-15
TW202003842A (zh) 2020-01-16
KR20200136363A (ko) 2020-12-07
AU2019242331A1 (en) 2020-09-10
EP3778886A4 (en) 2022-11-02
CN111819280A (zh) 2020-10-23
JP2019213567A (ja) 2019-12-19
JP7363316B2 (ja) 2023-10-18
US20240167033A1 (en) 2024-05-23
MX2020009556A (es) 2020-10-05
CA3094160A1 (en) 2019-10-03
WO2019189722A1 (ja) 2019-10-03
IL277346A (en) 2020-10-29

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