JP2019195331A5 - - Google Patents
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- JP2019195331A5 JP2019195331A5 JP2019105087A JP2019105087A JP2019195331A5 JP 2019195331 A5 JP2019195331 A5 JP 2019195331A5 JP 2019105087 A JP2019105087 A JP 2019105087A JP 2019105087 A JP2019105087 A JP 2019105087A JP 2019195331 A5 JP2019195331 A5 JP 2019195331A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- microvesicles
- composition according
- tissue
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 49
- 210000001519 tissue Anatomy 0.000 claims 15
- 210000002950 fibroblast Anatomy 0.000 claims 12
- 206010072170 Skin wound Diseases 0.000 claims 10
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- 230000002062 proliferating effect Effects 0.000 claims 8
- 230000001640 apoptogenic effect Effects 0.000 claims 4
- 210000001185 bone marrow Anatomy 0.000 claims 4
- 230000012292 cell migration Effects 0.000 claims 4
- 210000002583 cell-derived microparticle Anatomy 0.000 claims 4
- 238000001493 electron microscopy Methods 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- 230000005012 migration Effects 0.000 claims 4
- 238000013508 migration Methods 0.000 claims 4
- 238000010232 migration assay Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 238000001556 precipitation Methods 0.000 claims 4
- 210000000981 epithelium Anatomy 0.000 claims 3
- 230000008929 regeneration Effects 0.000 claims 3
- 238000011069 regeneration method Methods 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 102100025222 CD63 antigen Human genes 0.000 claims 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 2
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 2
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 2
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 210000000944 nerve tissue Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000037390 scarring Effects 0.000 claims 2
- 206010006802 Burns second degree Diseases 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022027857A JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778591P | 2013-03-13 | 2013-03-13 | |
| US61/778,591 | 2013-03-13 | ||
| JP2016501590A JP6562897B2 (ja) | 2013-03-13 | 2014-03-12 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501590A Division JP6562897B2 (ja) | 2013-03-13 | 2014-03-12 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027857A Division JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019195331A JP2019195331A (ja) | 2019-11-14 |
| JP2019195331A5 true JP2019195331A5 (enExample) | 2020-07-30 |
| JP7405389B2 JP7405389B2 (ja) | 2023-12-26 |
Family
ID=51625222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501590A Active JP6562897B2 (ja) | 2013-03-13 | 2014-03-12 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
| JP2019105087A Active JP7405389B2 (ja) | 2013-03-13 | 2019-06-05 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
| JP2022027857A Active JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501590A Active JP6562897B2 (ja) | 2013-03-13 | 2014-03-12 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027857A Active JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10500231B2 (enExample) |
| EP (3) | EP2972193B1 (enExample) |
| JP (3) | JP6562897B2 (enExample) |
| CN (2) | CN105209881B (enExample) |
| AU (4) | AU2014244618A1 (enExample) |
| CA (1) | CA2906502A1 (enExample) |
| DK (2) | DK2972193T3 (enExample) |
| ES (2) | ES2949637T3 (enExample) |
| FI (1) | FI3677271T3 (enExample) |
| HU (2) | HUE049003T2 (enExample) |
| PL (2) | PL2972193T3 (enExample) |
| PT (2) | PT2972193T (enExample) |
| WO (1) | WO2014159662A1 (enExample) |
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| EP2687219A1 (en) * | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| EP2882445B1 (en) | 2012-08-13 | 2019-04-24 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| WO2014076137A1 (en) | 2012-11-13 | 2014-05-22 | Lötvall Jan | Delivery of therapeutic agent |
| HUE049003T2 (hu) | 2013-03-13 | 2020-09-28 | Univ Miami | Eljárás mikrovezikulumok izolálására és tisztítására sejttenyészet-felülúszóból és biológiai folyadékból |
| US20180104186A1 (en) | 2013-03-13 | 2018-04-19 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| WO2015038075A1 (en) | 2013-09-16 | 2015-03-19 | Agency For Science, Technology And Research | Method |
| WO2016043654A1 (en) | 2014-09-15 | 2016-03-24 | Agency For Science, Technology And Research | Methods of treating graft versus host disease (gvhd) or epidermolysis bullosa (eb) with exosomes |
| US20170173113A1 (en) | 2014-03-13 | 2017-06-22 | Research Institute At Nationwide Children's Hospital | Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes |
| WO2016172598A1 (en) | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| BR112017025562A2 (pt) | 2015-05-29 | 2018-08-07 | Merck Sharp & Dohme Corp. | métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer |
| KR20170085010A (ko) | 2016-01-12 | 2017-07-21 | 주식회사 강스템바이오텍 | 고함량의 성장인자를 함유한 줄기세포 유래 엑소좀 |
| US11918687B2 (en) | 2016-01-15 | 2024-03-05 | Orbsen Therapeutics Limited | SDC-2 exosome compositions and methods of isolation and use |
| AU2018335788B2 (en) | 2017-09-22 | 2024-08-15 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| WO2022040516A1 (en) | 2020-08-21 | 2022-02-24 | University Of Miami | Compositions and methods of treatment using microvesicles from bone marrow-derived mesenchymal stem cells |
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2014
- 2014-03-12 HU HUE14774189A patent/HUE049003T2/hu unknown
- 2014-03-12 WO PCT/US2014/024629 patent/WO2014159662A1/en not_active Ceased
- 2014-03-12 EP EP14774189.6A patent/EP2972193B1/en active Active
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- 2014-03-12 CA CA2906502A patent/CA2906502A1/en active Pending
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- 2014-03-12 DK DK14774189.6T patent/DK2972193T3/da active
- 2014-03-12 CN CN201480026884.6A patent/CN105209881B/zh active Active
- 2014-03-12 ES ES14774189T patent/ES2778098T3/es active Active
- 2014-03-12 PL PL14774189T patent/PL2972193T3/pl unknown
- 2014-03-12 EP EP19212541.7A patent/EP3677271B1/en active Active
- 2014-03-12 AU AU2014244618A patent/AU2014244618A1/en not_active Abandoned
- 2014-03-12 PL PL19212541.7T patent/PL3677271T3/pl unknown
- 2014-03-12 JP JP2016501590A patent/JP6562897B2/ja active Active
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- 2014-03-12 US US14/775,382 patent/US10500231B2/en active Active
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- 2014-03-12 HU HUE19212541A patent/HUE062348T2/hu unknown
- 2014-03-12 DK DK19212541.7T patent/DK3677271T3/da active
- 2014-03-12 EP EP23155007.0A patent/EP4218774A1/en active Pending
- 2014-03-12 CN CN202110013769.7A patent/CN112795533A/zh active Pending
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2018
- 2018-08-06 AU AU2018211351A patent/AU2018211351C1/en active Active
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- 2019-10-30 US US16/668,851 patent/US11730768B2/en active Active
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2020
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2023
- 2023-06-09 US US18/332,063 patent/US12453745B2/en active Active
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