JP2018537111A5 - - Google Patents
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- Publication number
- JP2018537111A5 JP2018537111A5 JP2018531169A JP2018531169A JP2018537111A5 JP 2018537111 A5 JP2018537111 A5 JP 2018537111A5 JP 2018531169 A JP2018531169 A JP 2018531169A JP 2018531169 A JP2018531169 A JP 2018531169A JP 2018537111 A5 JP2018537111 A5 JP 2018537111A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- positions
- amino acid
- mutations
- acid positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 230000004927 fusion Effects 0.000 claims description 13
- 102200074510 rs2015352 Human genes 0.000 claims description 11
- 102220517055 Transcriptional regulator PINT87aa_I11L_mutation Human genes 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 31
- 230000035772 mutation Effects 0.000 claims 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims 8
- 229930195729 fatty acid Natural products 0.000 claims 8
- 239000000194 fatty acid Substances 0.000 claims 8
- 150000004665 fatty acids Chemical class 0.000 claims 8
- 102220245308 rs1555601006 Human genes 0.000 claims 4
- 102220557155 Alstrom syndrome protein 1_N61L_mutation Human genes 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 102200059965 rs61753185 Human genes 0.000 claims 2
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
- 102100037611 Lysophospholipase Human genes 0.000 claims 1
- 102000005488 Thioesterase Human genes 0.000 claims 1
- 102220367838 c.28G>T Human genes 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020002982 thioesterase Proteins 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 description 3
- 150000003278 haem Chemical group 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 102000034238 globular proteins Human genes 0.000 description 1
- 108091005896 globular proteins Proteins 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021164702A JP7458358B2 (ja) | 2015-12-15 | 2021-10-06 | 改良された特性を有するω－ヒドロキシラーゼ関連融合ポリペプチドバリアント |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/079832 WO2017101987A1 (en) | 2015-12-15 | 2015-12-15 | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
| EPPCT/EP2015/079832 | 2015-12-15 | ||
| PCT/US2016/066405 WO2017106205A1 (en) | 2015-12-15 | 2016-12-13 | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021164702A Division JP7458358B2 (ja) | 2015-12-15 | 2021-10-06 | 改良された特性を有するω－ヒドロキシラーゼ関連融合ポリペプチドバリアント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537111A JP2018537111A (ja) | 2018-12-20 |
| JP2018537111A5 true JP2018537111A5 (enExample) | 2021-05-13 |
| JP6957469B2 JP6957469B2 (ja) | 2021-11-02 |
Family
ID=55022448
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531169A Active JP6957469B2 (ja) | 2015-12-15 | 2016-12-13 | 改良された特性を有するω−ヒドロキシラーゼ関連融合ポリペプチドバリアント |
| JP2021164702A Active JP7458358B2 (ja) | 2015-12-15 | 2021-10-06 | 改良された特性を有するω－ヒドロキシラーゼ関連融合ポリペプチドバリアント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021164702A Active JP7458358B2 (ja) | 2015-12-15 | 2021-10-06 | 改良された特性を有するω－ヒドロキシラーゼ関連融合ポリペプチドバリアント |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10787648B2 (enExample) |
| EP (2) | EP3390620B1 (enExample) |
| JP (2) | JP6957469B2 (enExample) |
| KR (2) | KR102840377B1 (enExample) |
| CN (3) | CN108699536B (enExample) |
| AU (1) | AU2016370490B2 (enExample) |
| CA (1) | CA3008836A1 (enExample) |
| ES (1) | ES2908400T3 (enExample) |
| MX (1) | MX2018007298A (enExample) |
| MY (2) | MY194277A (enExample) |
| SI (1) | SI3390620T1 (enExample) |
| WO (2) | WO2017101987A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015195697A1 (en) * | 2014-06-16 | 2015-12-23 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptides with improved properties |
| WO2017101987A1 (en) | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
| US20210189439A1 (en) * | 2018-05-10 | 2021-06-24 | Genomatica, Inc. | Multifunctional Fatty Acid Derivatives And Biosynthesis Thereof |
| KR102516485B1 (ko) | 2018-10-31 | 2023-04-03 | 삼성전자주식회사 | 폴더블 하우징을 포함하는 전자 장치 |
Family Cites Families (58)
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|---|---|---|---|---|
| CA1305083C (en) | 1987-02-18 | 1992-07-14 | Yoshiharu Kimura | Microorganism belonging to genus rhodococcus, and a process for producing alkene derivative and unsaturated fatty acid |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| CN101172952B (zh) | 2002-04-29 | 2013-03-27 | 陶氏环球技术有限责任公司 | 关于种子油工业应用的综合化学方法 |
| EP1811029A4 (en) | 2004-11-10 | 2008-03-12 | Marine Biotech Inst Co Ltd | PROCESS FOR ISOLATING THE P450 GENE |
| JP5933909B2 (ja) | 2006-05-19 | 2016-06-15 | アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー | 脂肪酸およびその誘導体の生産 |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| WO2008140468A2 (en) | 2006-10-13 | 2008-11-20 | Elevance Renewable Sciences, Inc. | METHODS OF MAKING α, ω -DICARBOXYLIC ACID ALKENE DERIVATIVES BY METATHESIS |
| WO2008046106A2 (en) | 2006-10-13 | 2008-04-17 | Elevance Renewable Sciences, Inc. | Synthesis of terminal alkenes from internal alkenes via olefin metathesis |
| WO2008113041A2 (en) | 2007-03-14 | 2008-09-18 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| CA3178593A1 (en) | 2007-03-28 | 2008-10-02 | Genomatica, Inc. | Enhanced production of fatty acid derivatives |
| US20080293060A1 (en) | 2007-04-23 | 2008-11-27 | Ls9, Inc. | Methods and Compositions for Identification of Hydrocarbon Response, Transport and Biosynthesis Genes |
| BRPI0813359A2 (pt) | 2007-05-22 | 2014-10-14 | Ls9 Inc | Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos |
| JP5324129B2 (ja) | 2007-05-25 | 2013-10-23 | 神戸天然物化学株式会社 | Ｃｙｐ１５３による芳香族化合物の製造方法 |
| WO2009009391A2 (en) | 2007-07-06 | 2009-01-15 | Ls9, Inc. | Systems and methods for the production of fatty esters |
| FR2921362B1 (fr) | 2007-09-20 | 2012-09-21 | Arkema France | Procede de synthese d'acides gras omega-insatures |
| AU2008304180B2 (en) | 2007-09-27 | 2014-02-27 | Genomatica, Inc. | Reduction of the toxic effect of impurities from raw materials by extractive fermentation |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| MX2010012192A (es) | 2008-05-16 | 2011-04-26 | Ls9 Inc | Metodos y composiciones para producir hidrocarburos. |
| US8232924B2 (en) | 2008-05-23 | 2012-07-31 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| US8273694B2 (en) | 2008-07-28 | 2012-09-25 | Jeffrey A Brown | Synthetic compositions obtained from algae |
| US20100071259A1 (en) | 2008-08-18 | 2010-03-25 | Ls9, Inc. | Systems and methods for production of mixed fatty esters |
| CN102131752A (zh) | 2008-08-28 | 2011-07-20 | 三井化学株式会社 | 烯烃制造方法 |
| MX2011003597A (es) | 2008-10-07 | 2011-06-20 | Ls9 Inc | Metodos y composiciones para producir aldehidos grasos. |
| EP2796559B1 (en) | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| US7989875B2 (en) | 2008-11-24 | 2011-08-02 | Nxp B.V. | BiCMOS integration of multiple-times-programmable non-volatile memories |
| CN110129296A (zh) | 2008-12-23 | 2019-08-16 | Reg生命科学有限责任公司 | 硫酯酶相关的方法和组合物 |
| US8071799B2 (en) | 2009-01-29 | 2011-12-06 | Energy & Environmental Research Center Foundation | Chain-selective synthesis of fuel components and chemical feedstocks |
| CN102459569B (zh) | 2009-04-10 | 2018-02-23 | Reg生命科学有限责任公司 | 脂肪酸衍生物的产生 |
| CN102459622B (zh) | 2009-04-27 | 2020-08-18 | 基因组股份公司 | 脂肪酸酯的产生 |
| EP2424989A2 (en) | 2009-05-01 | 2012-03-07 | The Regents of The University of California | Product of fatty acid esters from biomass polymers |
| WO2011038134A1 (en) | 2009-09-25 | 2011-03-31 | Ls9, Inc. | Production of fatty acid derivatives |
| US8237003B2 (en) | 2009-11-09 | 2012-08-07 | Exxonmobil Chemical Patents Inc. | Metathesis catalyst and process for use thereof |
| US8809563B2 (en) | 2009-11-09 | 2014-08-19 | Exxonmobil Chemical Patents Inc. | Metathesis catalyst and process for use thereof |
| US8361769B1 (en) * | 2009-11-16 | 2013-01-29 | U.S. Department Of Energy | Regioselective alkane hydroxylation with a mutant CYP153A6 enzyme |
| WO2011062987A2 (en) | 2009-11-17 | 2011-05-26 | Ls9, Inc. | Methods and compositions for producing hydrocarbons |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| AR084377A1 (es) | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
| SG10201504197SA (en) | 2010-05-28 | 2015-06-29 | Solazyme Inc | Food Compositions Comprising Tailored Oils |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| WO2012071439A1 (en) | 2010-11-22 | 2012-05-31 | The Regents Of The University Of California | Host cells and methods for producing diacid compounds |
| CN110066836A (zh) | 2011-02-02 | 2019-07-30 | 柯碧恩生物技术公司 | 产自重组产油微生物的定制油 |
| MY184871A (en) | 2011-07-06 | 2021-04-28 | Radici Chimica S P A | Biological methods for preparing a fatty dicarboxylic acid |
| DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
| EP2639308A1 (de) | 2012-03-12 | 2013-09-18 | Evonik Industries AG | Enzymatische omega-Oxidation und -Aminierung von Fettsäuren |
| FR3003577B1 (fr) | 2013-03-19 | 2016-05-06 | Ferropem | Inoculant a particules de surface |
| KR20220053681A (ko) * | 2013-06-14 | 2022-04-29 | 게노마티카 인코포레이티드 | 오메가-수산화 지방산 유도체를 생성하는 방법들 |
| WO2015195697A1 (en) * | 2014-06-16 | 2015-12-23 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptides with improved properties |
| WO2017101987A1 (en) * | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
-
2015
- 2015-12-15 WO PCT/EP2015/079832 patent/WO2017101987A1/en not_active Ceased
-
2016
- 2016-12-13 MX MX2018007298A patent/MX2018007298A/es unknown
- 2016-12-13 MY MYPI2018000942A patent/MY194277A/en unknown
- 2016-12-13 ES ES16836213T patent/ES2908400T3/es active Active
- 2016-12-13 SI SI201631502T patent/SI3390620T1/sl unknown
- 2016-12-13 CN CN201680081302.3A patent/CN108699536B/zh active Active
- 2016-12-13 JP JP2018531169A patent/JP6957469B2/ja active Active
- 2016-12-13 US US16/063,198 patent/US10787648B2/en active Active
- 2016-12-13 WO PCT/US2016/066405 patent/WO2017106205A1/en not_active Ceased
- 2016-12-13 CN CN202210871940.2A patent/CN116334013A/zh active Pending
- 2016-12-13 AU AU2016370490A patent/AU2016370490B2/en not_active Ceased
- 2016-12-13 MY MYPI2021004987A patent/MY196584A/en unknown
- 2016-12-13 CN CN202210859052.9A patent/CN116334012A/zh active Pending
- 2016-12-13 EP EP16836213.5A patent/EP3390620B1/en active Active
- 2016-12-13 CA CA3008836A patent/CA3008836A1/en active Pending
- 2016-12-13 KR KR1020187020089A patent/KR102840377B1/ko active Active
- 2016-12-13 EP EP21209002.1A patent/EP4026899A1/en active Pending
- 2016-12-13 KR KR1020257025119A patent/KR20250117480A/ko active Pending
-
2020
- 2020-08-24 US US17/001,015 patent/US11384341B2/en active Active
-
2021
- 2021-10-06 JP JP2021164702A patent/JP7458358B2/ja active Active
-
2022
- 2022-06-07 US US17/834,681 patent/US12180515B2/en active Active
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