MX2018007298A - Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa. - Google Patents
Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.Info
- Publication number
- MX2018007298A MX2018007298A MX2018007298A MX2018007298A MX2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A
- Authority
- MX
- Mexico
- Prior art keywords
- omega
- hydroxylase
- variants
- fusion polypeptide
- properties related
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01005—Lysophospholipase (3.1.1.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/079832 WO2017101987A1 (en) | 2015-12-15 | 2015-12-15 | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
| PCT/US2016/066405 WO2017106205A1 (en) | 2015-12-15 | 2016-12-13 | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018007298A true MX2018007298A (es) | 2019-01-10 |
Family
ID=55022448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018007298A MX2018007298A (es) | 2015-12-15 | 2016-12-13 | Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10787648B2 (enExample) |
| EP (2) | EP3390620B1 (enExample) |
| JP (2) | JP6957469B2 (enExample) |
| KR (2) | KR102840377B1 (enExample) |
| CN (3) | CN116334013A (enExample) |
| AU (1) | AU2016370490B2 (enExample) |
| CA (1) | CA3008836A1 (enExample) |
| ES (1) | ES2908400T3 (enExample) |
| MX (1) | MX2018007298A (enExample) |
| MY (2) | MY194277A (enExample) |
| SI (1) | SI3390620T1 (enExample) |
| WO (2) | WO2017101987A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014277874B2 (en) | 2013-06-14 | 2020-12-03 | Genomatica, Inc. | Methods of producing omega-hydroxylated fatty acid derivatives |
| MX372803B (es) * | 2014-06-16 | 2020-07-03 | Genomatica Inc | Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas. |
| WO2017101987A1 (en) * | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
| US20210189439A1 (en) * | 2018-05-10 | 2021-06-24 | Genomatica, Inc. | Multifunctional Fatty Acid Derivatives And Biosynthesis Thereof |
| KR102516485B1 (ko) | 2018-10-31 | 2023-04-03 | 삼성전자주식회사 | 폴더블 하우징을 포함하는 전자 장치 |
Family Cites Families (58)
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| CA1305083C (en) | 1987-02-18 | 1992-07-14 | Yoshiharu Kimura | Microorganism belonging to genus rhodococcus, and a process for producing alkene derivative and unsaturated fatty acid |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| EP0528881A4 (en) | 1990-04-24 | 1993-05-26 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| CN100379716C (zh) | 2002-04-29 | 2008-04-09 | 陶氏环球技术公司 | 关于种子油工业应用的综合化学方法 |
| EP1811029A4 (en) | 2004-11-10 | 2008-03-12 | Marine Biotech Inst Co Ltd | PROCESS FOR ISOLATING THE P450 GENE |
| AU2007254151A1 (en) | 2006-05-19 | 2007-11-29 | Ls9, Inc. | Production of fatty acids and derivatives thereof |
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| FR2921362B1 (fr) | 2007-09-20 | 2012-09-21 | Arkema France | Procede de synthese d'acides gras omega-insatures |
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| AU2014277874B2 (en) * | 2013-06-14 | 2020-12-03 | Genomatica, Inc. | Methods of producing omega-hydroxylated fatty acid derivatives |
| MX372803B (es) * | 2014-06-16 | 2020-07-03 | Genomatica Inc | Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas. |
| WO2017101987A1 (en) * | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
-
2015
- 2015-12-15 WO PCT/EP2015/079832 patent/WO2017101987A1/en not_active Ceased
-
2016
- 2016-12-13 WO PCT/US2016/066405 patent/WO2017106205A1/en not_active Ceased
- 2016-12-13 MX MX2018007298A patent/MX2018007298A/es unknown
- 2016-12-13 MY MYPI2018000942A patent/MY194277A/en unknown
- 2016-12-13 CN CN202210871940.2A patent/CN116334013A/zh active Pending
- 2016-12-13 ES ES16836213T patent/ES2908400T3/es active Active
- 2016-12-13 EP EP16836213.5A patent/EP3390620B1/en active Active
- 2016-12-13 KR KR1020187020089A patent/KR102840377B1/ko active Active
- 2016-12-13 CN CN202210859052.9A patent/CN116334012A/zh active Pending
- 2016-12-13 KR KR1020257025119A patent/KR20250117480A/ko active Pending
- 2016-12-13 CA CA3008836A patent/CA3008836A1/en active Pending
- 2016-12-13 US US16/063,198 patent/US10787648B2/en active Active
- 2016-12-13 AU AU2016370490A patent/AU2016370490B2/en not_active Ceased
- 2016-12-13 JP JP2018531169A patent/JP6957469B2/ja active Active
- 2016-12-13 CN CN201680081302.3A patent/CN108699536B/zh active Active
- 2016-12-13 EP EP21209002.1A patent/EP4026899A1/en active Pending
- 2016-12-13 SI SI201631502T patent/SI3390620T1/sl unknown
- 2016-12-13 MY MYPI2021004987A patent/MY196584A/en unknown
-
2020
- 2020-08-24 US US17/001,015 patent/US11384341B2/en active Active
-
2021
- 2021-10-06 JP JP2021164702A patent/JP7458358B2/ja active Active
-
2022
- 2022-06-07 US US17/834,681 patent/US12180515B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4026899A1 (en) | 2022-07-13 |
| JP6957469B2 (ja) | 2021-11-02 |
| EP3390620B1 (en) | 2022-01-05 |
| BR112018012193A2 (pt) | 2018-12-04 |
| ES2908400T3 (es) | 2022-04-29 |
| CN108699536A (zh) | 2018-10-23 |
| CN116334012A (zh) | 2023-06-27 |
| US10787648B2 (en) | 2020-09-29 |
| WO2017101987A1 (en) | 2017-06-22 |
| US12180515B2 (en) | 2024-12-31 |
| JP2022002535A (ja) | 2022-01-11 |
| SI3390620T1 (sl) | 2022-05-31 |
| WO2017106205A1 (en) | 2017-06-22 |
| KR20250117480A (ko) | 2025-08-04 |
| AU2016370490B2 (en) | 2023-01-05 |
| US20210230562A1 (en) | 2021-07-29 |
| JP7458358B2 (ja) | 2024-03-29 |
| US20190002845A1 (en) | 2019-01-03 |
| US20230159901A1 (en) | 2023-05-25 |
| US11384341B2 (en) | 2022-07-12 |
| KR20180132604A (ko) | 2018-12-12 |
| AU2016370490A1 (en) | 2018-06-21 |
| EP3390620A1 (en) | 2018-10-24 |
| MY196584A (en) | 2023-04-19 |
| CA3008836A1 (en) | 2017-06-22 |
| CN116334013A (zh) | 2023-06-27 |
| MY194277A (en) | 2022-11-25 |
| KR102840377B1 (ko) | 2025-08-01 |
| CN108699536B (zh) | 2022-08-02 |
| JP2018537111A (ja) | 2018-12-20 |
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