JP2016507520A5 - - Google Patents

Info

Publication number

JP2016507520A5

JP2016507520A5 JP2015555242A JP2015555242A JP2016507520A5 JP 2016507520 A5 JP2016507520 A5 JP 2016507520A5 JP 2015555242 A JP2015555242 A JP 2015555242A JP 2015555242 A JP2015555242 A JP 2015555242A JP 2016507520 A5 JP2016507520 A5 JP 2016507520A5

Authority

JP

Japan

Prior art keywords

polypeptide

amino acid

hbc

seq

vlp

Prior art date

2014-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 claims 19
• 102000004196 processed proteins & peptides Human genes 0.000 claims 19
• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 150000001413 amino acids Chemical class 0.000 claims 16
• 235000001014 amino acid Nutrition 0.000 claims 13
• 229940024606 amino acid Drugs 0.000 claims 8
• 238000006467 substitution reaction Methods 0.000 claims 5
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 102220364092 c.229G>C Human genes 0.000 claims 2
• 238000006243 chemical reaction Methods 0.000 claims 2
• 238000001243 protein synthesis Methods 0.000 claims 2
• 239000011541 reaction mixture Substances 0.000 claims 2
• 102220277072 rs1553408398 Human genes 0.000 claims 2
• 102220280387 rs201054129 Human genes 0.000 claims 2
• 102220184129 rs778408190 Human genes 0.000 claims 2
• 230000014616 translation Effects 0.000 claims 2
• NEMHIKRLROONTL-QMMMGPOBSA-N (2s)-2-azaniumyl-3-(4-azidophenyl)propanoate Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N=[N+]=[N-])C=C1 NEMHIKRLROONTL-QMMMGPOBSA-N 0.000 claims 1
• NNWQLZWAZSJGLY-VKHMYHEASA-N (2s)-2-azaniumyl-4-azidobutanoate Chemical compound OC(=O)[C@@H](N)CCN=[N+]=[N-] NNWQLZWAZSJGLY-VKHMYHEASA-N 0.000 claims 1
• ZXSBHXZKWRIEIA-JTQLQIEISA-N (2s)-3-(4-acetylphenyl)-2-azaniumylpropanoate Chemical compound CC(=O)C1=CC=C(C[C@H](N)C(O)=O)C=C1 ZXSBHXZKWRIEIA-JTQLQIEISA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102220493349 40S ribosomal protein S3_T70R_mutation Human genes 0.000 claims 1
• 102220528631 Aurora kinase A_I57V_mutation Human genes 0.000 claims 1
• 102220475366 Iduronate 2-sulfatase_S87N_mutation Human genes 0.000 claims 1
• 102220534940 Integrator complex subunit 13_M66T_mutation Human genes 0.000 claims 1
• 102220514255 NADH-ubiquinone oxidoreductase chain 6_L60S_mutation Human genes 0.000 claims 1
• 102220345529 c.192C>G Human genes 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102220032374 rs104895262 Human genes 0.000 claims 1
• 102200004150 rs147750704 Human genes 0.000 claims 1
• 102220074259 rs180177181 Human genes 0.000 claims 1
• 102220166168 rs201614099 Human genes 0.000 claims 1
• 102200135505 rs2273535 Human genes 0.000 claims 1
• 102200109609 rs281875332 Human genes 0.000 claims 1
• 102200108206 rs756233241 Human genes 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1