|
US5948786A
(en)
|
1996-04-12 |
1999-09-07 |
Sumitomo Pharmaceuticals Company, Limited |
Piperidinylpyrimidine derivatives
|
|
CA2402099C
(en)
|
2000-03-24 |
2011-04-26 |
Pharmagene Laboratories Ltd. |
Methods for the treatment of primary headache disorders using prostanoid ep4 receptor antagonists, and assays for agents for such treatment
|
|
HN2001000224A
(es)
|
2000-10-19 |
2002-06-13 |
Pfizer |
Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
|
|
GB0031295D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Naphthalene derivatives
|
|
GB0031302D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Napthalene derivatives
|
|
GB0103269D0
(en)
|
2001-02-09 |
2001-03-28 |
Glaxo Group Ltd |
Napthalene derivatives
|
|
AU2003216581A1
(en)
|
2002-04-12 |
2003-10-27 |
Pfizer Inc. |
Pyrazole compounds as anti-inflammatory and analgesic agents
|
|
AU2003216579A1
(en)
|
2002-04-12 |
2003-10-27 |
Pfizer Inc. |
Imidazole compounds as anti-inflammatory and analgesic agents
|
|
CN1662551A
(zh)
|
2002-05-23 |
2005-08-31 |
瑟瑞技术公司 |
前列腺素e2受体亚型ep4的拮抗肽
|
|
DE602004013938D1
(de)
|
2003-01-29 |
2008-07-03 |
Asterand Uk Ltd |
Hemmstoffe des ep4-rezeptors
|
|
RU2358975C2
(ru)
|
2003-08-26 |
2009-06-20 |
Тейдзин Фарма Лимитед |
Пирролопиримидиноновые производные
|
|
KR100747401B1
(ko)
|
2003-09-03 |
2007-08-08 |
화이자 인코포레이티드 |
프로스타글란딘 ｅ2 길항제로서의 페닐 또는 피리딜 아미드 화합물
|
|
US8084457B2
(en)
|
2003-09-15 |
2011-12-27 |
Lead Discovery Center Gmbh |
Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
|
|
GB0324269D0
(en)
|
2003-10-16 |
2003-11-19 |
Pharmagene Lab Ltd |
EP4 receptor antagonists
|
|
WO2005080367A1
(en)
|
2004-02-12 |
2005-09-01 |
Pharmagene Laboratories Limited |
Ep2 receptor agonists
|
|
JP4054369B2
(ja)
|
2004-05-04 |
2008-02-27 |
ファイザー株式会社 |
オルト置換アリールまたはヘテロアリールアミド化合物
|
|
MXPA06011555A
(es)
|
2004-05-04 |
2006-12-15 |
Pfizer |
Compuestos de metil-aril o heteroaril-amida sustituida.
|
|
GT200500284A
(es)
|
2004-10-15 |
2006-03-27 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
WO2006122403A1
(en)
|
2005-05-19 |
2006-11-23 |
Merck Frosst Canada Ltd. |
Quinoline derivatives as ep4 antagonists
|
|
WO2006128129A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating cancer
|
|
DOP2007000068A
(es)
|
2006-04-12 |
2007-10-31 |
Sanofi Aventis Us Llc |
Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
|
|
ES2392192T3
(es)
|
2006-04-24 |
2012-12-05 |
Merck Canada Inc. |
Derivados de indol amida como antagonistas del receptor EP4
|
|
WO2007143825A1
(en)
|
2006-06-12 |
2007-12-21 |
Merck Frosst Canada Ltd. |
Indoline amide derivatives as ep4 receptor ligands
|
|
US20080280891A1
(en)
|
2006-06-27 |
2008-11-13 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents and uses thereof
|
|
WO2008008059A1
(en)
|
2006-07-12 |
2008-01-17 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents ans uses thereof
|
|
PL2044056T3
(pl)
|
2006-07-14 |
2013-01-31 |
Novartis Ag |
Pochodne pirymidyny jako inhibitory ALK-5
|
|
US8969394B2
(en)
|
2006-08-11 |
2015-03-03 |
Merck Frosst Canada Ltd. |
Thiophenecarboxamide derivatives as EP4 receptor ligands
|
|
WO2008039882A1
(en)
|
2006-09-30 |
2008-04-03 |
Sanofi-Aventis U.S. Llc |
A combination of niacin and a prostaglandin d2 receptor antagonist
|
|
CA2679175C
(en)
|
2007-02-26 |
2015-01-13 |
Merck Frosst Canada Ltd. |
Indole and indoline cyclopropyl amide derivatives as ep4 receptor antagonists
|
|
CN101636385B
(zh)
|
2007-03-26 |
2012-09-05 |
默克弗罗斯特加拿大有限公司 |
作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物
|
|
US8030489B2
(en)
|
2007-03-26 |
2011-10-04 |
Astellas Pharma Inc. |
Ornithine derivative
|
|
EP2014657A1
(de)
|
2007-06-21 |
2009-01-14 |
Bayer Schering Pharma Aktiengesellschaft |
Diaminopyrimidine als Modulatoren des EP2-Rezeptors
|
|
JP5408434B2
(ja)
|
2007-07-03 |
2014-02-05 |
アステラス製薬株式会社 |
アミド化合物
|
|
ATE510827T1
(de)
|
2007-10-12 |
2011-06-15 |
Ingenium Pharmaceuticals Gmbh |
Inhibitoren von proteinkinasen
|
|
EP2254415B1
(en)
|
2008-02-19 |
2013-01-23 |
Janssen Pharmaceutica, N.V. |
Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
|
|
EP2565191B1
(en)
|
2008-05-14 |
2014-10-08 |
Astellas Pharma Inc. |
4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy
|
|
US20130225528A1
(en)
|
2008-05-21 |
2013-08-29 |
Ariad Pharmaceuticals, Inc. |
Phosphorus Derivatives as Kinase Inhibitors
|
|
JP5536773B2
(ja)
|
2008-08-14 |
2014-07-02 |
ベータ・ファーマ・カナダ・インコーポレイテッド |
Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体
|
|
WO2010032123A1
(en)
|
2008-09-19 |
2010-03-25 |
Biotechnology Research Corporation Limited |
Triterpenoid compounds and methods of use thereof
|
|
WO2010034110A1
(en)
|
2008-09-25 |
2010-04-01 |
Merck Frosst Canada Ltd. |
Beta-carboline sulphonylurea derivatives as ep4 receptor antagonists
|
|
US8906914B2
(en)
|
2009-08-18 |
2014-12-09 |
Janssen Pharmaceutica Nv |
Ethylene diamine modulators of fatty acid hydrolase
|
|
JP2013511544A
(ja)
|
2009-11-23 |
2013-04-04 |
レクシコン ファーマシューティカルズ インコーポレイテッド |
過敏性腸症候群を治療するための方法及びアッセイ
|
|
US8927547B2
(en)
|
2010-05-21 |
2015-01-06 |
Noviga Research Ab |
Pyrimidine derivatives
|
|
PE20131343A1
(es)
|
2010-09-21 |
2013-11-18 |
Eisai Randd Man Co Ltd |
Derivados de acido benzoico
|
|
NZ609887A
(en)
|
2010-09-29 |
2015-01-30 |
Nb Health Lab Co Ltd |
Antibody against human prostaglandin e2 receptor ep4
|
|
WO2012066065A1
(en)
|
2010-11-17 |
2012-05-24 |
Novartis Ag |
Phenyl-heteroaryl amine compounds and their uses
|
|
CN103298787A
(zh)
|
2010-11-17 |
2013-09-11 |
诺瓦提斯公司 |
3-(氨基芳基)-吡啶化合物
|
|
WO2012076063A1
(en)
|
2010-12-10 |
2012-06-14 |
Rottapharm S.P.A. |
Pyridine amide derivatives as ep4 receptor antagonists
|
|
WO2012103071A2
(en)
|
2011-01-25 |
2012-08-02 |
Eisai R&D Management Co., Ltd. |
Compounds and compositions
|
|
DK2688883T3
(en)
*
|
2011-03-24 |
2016-09-05 |
Noviga Res Ab |
pyrimidine
|
|
EP2702043A1
(en)
|
2011-04-29 |
2014-03-05 |
Exelixis, Inc. |
Inhibitors of inducible form of 6-phosphofructose-2-kinase
|
|
EP2721011B1
(en)
|
2011-06-20 |
2017-09-06 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
|
|
DK2729445T3
(en)
|
2011-07-04 |
2016-01-18 |
Rottapharm Biotech Srl |
CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
|
|
EP2554662A1
(en)
|
2011-08-05 |
2013-02-06 |
M Maria Pia Cosma |
Methods of treatment of retinal degeneration diseases
|
|
WO2013090552A1
(en)
|
2011-12-13 |
2013-06-20 |
Yale University |
Compositions and methods for reducing ctl exhaustion
|
|
MX371331B
(es)
|
2012-04-24 |
2020-01-27 |
Vertex Pharma |
Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico(adn-pk).
|
|
JO3296B1
(ar)
|
2012-06-29 |
2018-09-16 |
Lilly Co Eli |
مركبات فينوكسي إيثيل بيبريدين
|
|
TWI572597B
(zh)
|
2012-06-29 |
2017-03-01 |
美國禮來大藥廠 |
二甲基－苯甲酸化合物
|
|
EP2711364A1
(en)
*
|
2012-09-21 |
2014-03-26 |
Chemilia AB |
4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
|
|
EP2925744B1
(en)
|
2012-11-27 |
2020-12-30 |
Thomas Helledays Stiftelse För Medicinsk Forskning |
Pyrimidine-2,4-diamine derivatives for treatment of cancer
|
|
UA115576C2
(uk)
|
2012-12-06 |
2017-11-27 |
Байєр Фарма Акцієнгезелльшафт |
Похідні бензимідазолу як антагоністи ер4
|
|
EP2765128A1
(en)
|
2013-02-07 |
2014-08-13 |
Almirall, S.A. |
Substituted benzamides with activity towards EP4 receptors
|
|
TW201443004A
(zh)
|
2013-02-15 |
2014-11-16 |
Lilly Co Eli |
苯氧基乙氧基化合物
|
|
TWI636046B
(zh)
|
2013-05-17 |
2018-09-21 |
美國禮來大藥廠 |
苯氧基乙基二氫－１ｈ－異喹啉化合物
|
|
CA2914997C
(en)
|
2013-06-12 |
2021-07-20 |
Kaken Pharmaceutical Co., Ltd. |
4-alkynyl imidazole derivative and medicine comprising same as active ingredient
|
|
CN105705489B
(zh)
|
2013-09-04 |
2019-04-26 |
百时美施贵宝公司 |
用作免疫调节剂的化合物
|
|
HUE038169T2
(hu)
|
2013-09-06 |
2018-09-28 |
Aurigene Discovery Tech Ltd |
1,2,4-Oxadiazol származékok mint immunomodulátorok
|
|
WO2015044900A1
(en)
|
2013-09-27 |
2015-04-02 |
Aurigene Discovery Technologies Limited |
Therapeutic immunomodulating compounds
|
|
HRP20180804T1
(hr)
|
2013-10-17 |
2018-08-10 |
Vertex Pharmaceuticals Incorporated |
Inhibitori dnk-pk
|
|
JP6408569B2
(ja)
|
2013-10-17 |
2018-10-17 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ｄｎａ−ｐｋ阻害剤としての（ｓ）−ｎ−メチル−８−（１−（（２’−メチル−［４，５’−ビピリミジン］−６−イル）アミノ）プロパン−２−イル）キノリン−４−カルボキサミドおよびその重水素化誘導体の共結晶
|
|
ME02896B
(me)
|
2013-12-17 |
2018-04-20 |
Lilly Co Eli |
Fenoksietilni derivati prstenastog amina i njihova aktivnost kao modulatora receptora ep4
|
|
ME03398B
(me)
|
2013-12-17 |
2020-01-20 |
Lilly Co Eli |
Spojevi dimetilbenzojeve kiseline
|
|
TW201607943A
(zh)
|
2013-12-19 |
2016-03-01 |
拜耳製藥公司 |
作為ｅｐ４配體之新穎苯并咪唑衍生物
|
|
TW201623277A
(zh)
|
2014-03-26 |
2016-07-01 |
安斯泰來製藥股份有限公司 |
醯胺化合物
|
|
EP3137074B1
(en)
|
2014-04-29 |
2020-08-05 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
|
|
AU2015264102C1
(en)
|
2014-05-23 |
2020-10-08 |
Eisai R&D Management Co., Ltd. |
Combination therapies for the treatment of cancer
|
|
US10064869B2
(en)
|
2014-06-04 |
2018-09-04 |
Thomas Helledays Stiftelse For Medicinsk Forskning |
MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
|
|
WO2016021742A1
(en)
|
2014-08-07 |
2016-02-11 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compounds as ep4 receptor antagonists
|
|
TWI852872B
(zh)
|
2015-01-09 |
2024-08-11 |
日商小野藥品工業股份有限公司 |
三環性螺化合物之用途
|
|
EP3325490B1
(en)
|
2015-07-23 |
2019-12-18 |
Takeda Pharmaceutical Company Limited |
1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists
|
|
BR112018007664B1
(pt)
|
2015-10-16 |
2023-12-19 |
Eisai R&D Management Co., Ltd |
Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer
|
|
CR20180323A
(es)
|
2015-11-20 |
2018-08-06 |
Idorsia Pharmaceuticals Ltd |
Derivados de indol n-sustituídos como moduladores de los receptores de pge2
|
|
MA45670A
(fr)
|
2016-07-13 |
2019-05-22 |
Vertex Pharma |
Procédés, compositions et kits pour augmenter l'efficacité d'édition du génome
|
|
US11839613B2
(en)
|
2017-05-18 |
2023-12-12 |
Idorsia Pharmaceuticals Ltd |
Pyrimidine derivatives as PGE2 receptor modulators
|
|
PE20191814A1
(es)
|
2017-05-18 |
2019-12-27 |
Idorsia Pharmaceuticals Ltd |
Derivados de pirimidina como moduladores del receptor de pge2
|
|
TW201900179A
(zh)
|
2017-05-18 |
2019-01-01 |
瑞士商愛杜西亞製藥有限公司 |
作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
|
|
KR102612140B1
(ko)
|
2017-05-18 |
2023-12-08 |
이도르시아 파마슈티컬스 리미티드 |
피리미딘 유도체
|
|
TWI768043B
(zh)
|
2017-05-18 |
2022-06-21 |
瑞士商愛杜西亞製藥有限公司 |
N-取代吲哚衍生物
|