JP2018534282A5

JP2018534282A5 -

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Publication number: JP2018534282A5
Authority: JP; Japan
Prior art keywords: methoxy; chloro; methyl; biphenyl; amino
Prior art date: 2016-10-12
Legal status : Granted

Application number

JP2018519301A

Other languages

English (en)

Japanese (ja)

Other versions

JP2018534282A (ja

JP6916783B2 (ja

Filing date

2016-10-12

Publication date

2019-11-14

2016-10-11 Priority claimed from US15/290,167 external-priority patent/US10745382B2/en

2016-10-12 Application filed filed Critical

2018-11-22 Publication of JP2018534282A publication Critical patent/JP2018534282A/ja

2019-11-14 Publication of JP2018534282A5 publication Critical patent/JP2018534282A5/ja

2021-08-11 Application granted granted Critical

2021-08-11 Publication of JP6916783B2 publication Critical patent/JP6916783B2/ja

Status Active legal-status Critical Current

2036-10-12 Anticipated expiration legal-status Critical

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-1 carboxy, hydroxy Chemical group 0.000 claims 160
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 132
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 107
GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 claims 90
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims 83
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 68
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 claims 65
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 65
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 58
125000005843 halogen group Chemical group 0.000 claims 49
229910052739 hydrogen Inorganic materials 0.000 claims 49
239000001257 hydrogen Substances 0.000 claims 49
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 36
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 30
235000010290 biphenyl Nutrition 0.000 claims 29
150000002431 hydrogen Chemical class 0.000 claims 28
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 24
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 22
150000003839 salts Chemical class 0.000 claims 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
150000001875 compounds Chemical class 0.000 claims 16
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 15
125000004093 cyano group Chemical group *C#N 0.000 claims 14
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims 12
239000003795 chemical substances by application Substances 0.000 claims 11
125000000753 cycloalkyl group Chemical group 0.000 claims 11
150000001408 amides Chemical class 0.000 claims 9
125000003368 amide group Chemical group 0.000 claims 8
125000004076 pyridyl group Chemical group 0.000 claims 8
239000002253 acid Substances 0.000 claims 7
125000003118 aryl group Chemical group 0.000 claims 7
125000000623 heterocyclic group Chemical group 0.000 claims 7
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 6
125000000217 alkyl group Chemical group 0.000 claims 6
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 6
229910052717 sulfur Inorganic materials 0.000 claims 5
125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 4
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
125000001072 heteroaryl group Chemical group 0.000 claims 4
125000002757 morpholinyl group Chemical group 0.000 claims 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 3
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 3
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 3
125000000842 isoxazolyl group Chemical group 0.000 claims 3
AFJIZTKWUYPYNE-UHFFFAOYSA-N methyl 4-hydroxypiperidine-4-carboxylate Chemical compound COC(=O)C1(O)CCNCC1 AFJIZTKWUYPYNE-UHFFFAOYSA-N 0.000 claims 3
125000001624 naphthyl group Chemical group 0.000 claims 3
229910052757 nitrogen Inorganic materials 0.000 claims 3
125000004433 nitrogen atom Chemical group N* 0.000 claims 3
208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
125000001715 oxadiazolyl group Chemical group 0.000 claims 3
125000004043 oxo group Chemical group O=* 0.000 claims 3
229910052760 oxygen Inorganic materials 0.000 claims 3
125000003386 piperidinyl group Chemical group 0.000 claims 3
125000000714 pyrimidinyl group Chemical group 0.000 claims 3
125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 claims 3
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 3
125000001424 substituent group Chemical group 0.000 claims 3
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
HZJCJVOGUIXSGU-QIKUIUABSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C HZJCJVOGUIXSGU-QIKUIUABSA-N 0.000 claims 2
KAFWNDQEHUCGJC-RWYGWLOXSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)C KAFWNDQEHUCGJC-RWYGWLOXSA-N 0.000 claims 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
NXFFJDQHYLNEJK-UHFFFAOYSA-N 2-[4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1h-cyclopenta[b]indol-3-yl]acetic acid Chemical compound C1=2C(S(=O)(=O)C)=CC(F)=CC=2C=2CCC(CC(O)=O)C=2N1CC1=CC=C(Cl)C=C1 NXFFJDQHYLNEJK-UHFFFAOYSA-N 0.000 claims 2
208000035473 Communicable disease Diseases 0.000 claims 2
206010028980 Neoplasm Diseases 0.000 claims 2
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
241000700605 Viruses Species 0.000 claims 2
125000004429 atom Chemical group 0.000 claims 2
IADUEWIQBXOCDZ-UHFFFAOYSA-N azetidine-2-carboxylic acid Chemical compound OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
229940079593 drug Drugs 0.000 claims 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
125000002883 imidazolyl group Chemical group 0.000 claims 2
230000028993 immune response Effects 0.000 claims 2
208000015181 infectious disease Diseases 0.000 claims 2
RUZLIIJDZBWWSA-INIZCTEOSA-N methyl 2-[[(1s)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoate Chemical group COC(=O)C1=CC=CC=C1N[C@@H](C)C1=CC(C)=CN2C(=O)C=C(N3CCOCC3)N=C12 RUZLIIJDZBWWSA-INIZCTEOSA-N 0.000 claims 2
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 2
JSSXHAMIXJGYCS-UHFFFAOYSA-N piperazin-4-ium-2-carboxylate Chemical compound OC(=O)C1CNCCN1 JSSXHAMIXJGYCS-UHFFFAOYSA-N 0.000 claims 2
QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 2
235000019260 propionic acid Nutrition 0.000 claims 2
230000001105 regulatory effect Effects 0.000 claims 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
FRNCRXHZLYEGDP-MGBGTMOVSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(2-methylphenyl)phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C=CC=C1)C)C FRNCRXHZLYEGDP-MGBGTMOVSA-N 0.000 claims 1
UPTUQRDSCJWKPZ-UUWRZZSWSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[3-(2-morpholin-4-ylethoxy)phenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCN1CCOCC1)C UPTUQRDSCJWKPZ-UUWRZZSWSA-N 0.000 claims 1
QVTPURFKWDNZNE-CYTLCNBWSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCC(=O)N1C[C@@H](CC1)O)C QVTPURFKWDNZNE-CYTLCNBWSA-N 0.000 claims 1
QVTPURFKWDNZNE-RYCFQHDISA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[2-[(3S)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCC(=O)N1C[C@H](CC1)O)C QVTPURFKWDNZNE-RYCFQHDISA-N 0.000 claims 1
XHOCJJIDJHWBSO-VQJSHJPSSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(4-hydroxypiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)O)C)C XHOCJJIDJHWBSO-VQJSHJPSSA-N 0.000 claims 1
OQXSISXJJCMQMU-PSXMRANNSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(4-hydroxypiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)O)C)C OQXSISXJJCMQMU-PSXMRANNSA-N 0.000 claims 1
CMSQUCGAUQKDNA-KAODMTDESA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]-3-oxopropoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCC(=O)N1C[C@@H](CC1)O)C CMSQUCGAUQKDNA-KAODMTDESA-N 0.000 claims 1
CJCGMUOZFZXTCP-CYEXUTLASA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCCN1C[C@@H](CC1)O)C CJCGMUOZFZXTCP-CYEXUTLASA-N 0.000 claims 1
AKLHLLZFGLLUTG-RRTCDKLQSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[4-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C=C(C=C1)OCCCN1C[C@@H](CC1)O)C)C AKLHLLZFGLLUTG-RRTCDKLQSA-N 0.000 claims 1
HEGUZLKAJRRYTI-WECIHKQLSA-N (2R)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[4-[4-[(3R)-3-hydroxypyrrolidin-1-yl]butoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](CO)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C=C(C=C1)OCCCCN1C[C@@H](CC1)O)C)C HEGUZLKAJRRYTI-WECIHKQLSA-N 0.000 claims 1
MSCXFQOWKRIDQN-LDLOPFEMSA-N (2R)-2-[[5-chloro-4-[[2-chloro-3-[2-chloro-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)Cl)Cl MSCXFQOWKRIDQN-LDLOPFEMSA-N 0.000 claims 1
YUXQENDNNAAIFA-OOXUFLSTSA-N (2R)-2-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-methoxyphenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@@](C(=O)O)(CO)C)C=1)OC)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C YUXQENDNNAAIFA-OOXUFLSTSA-N 0.000 claims 1
RJHPQZAUOYLXPF-YDAXCOIMSA-N (2S)-1-[3-[3-[3-[[4-[[(2S)-2-carboxypiperidin-1-yl]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H]1N(CCCC1)CC1=CC(=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2[C@@H](CCCC2)C(=O)O)C)C)C=C1OCC=1C=NC=C(C=1)C#N)Cl RJHPQZAUOYLXPF-YDAXCOIMSA-N 0.000 claims 1
UIAZXACLKWXVMA-VQOCUYOESA-N (2S)-1-[[2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-6-methylphenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(#N)C=1C=C(C=NC=1)COC1=C(CN2[C@@H](CCCC2)C(=O)O)C(=CC(=C1)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C)C UIAZXACLKWXVMA-VQOCUYOESA-N 0.000 claims 1
ULGZIYKZSPNGSX-NSJVFKKDSA-N (2S)-1-[[3-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C=C(CN2[C@@H](CCCC2)C(=O)O)C=CC=1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C ULGZIYKZSPNGSX-NSJVFKKDSA-N 0.000 claims 1
MHROUOKMFZCXOO-UMSFTDKQSA-N (2S)-1-[[4-[[3-[3-(aziridine-1-carbonyl)-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound N1(CC1)C(=O)C=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C MHROUOKMFZCXOO-UMSFTDKQSA-N 0.000 claims 1
UNEOUUZDANHSJM-RVFUZGKFSA-N (2S)-1-[[4-[[3-[3-[3-(2-carbamoylpiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(N)(=O)C1N(CCCC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C UNEOUUZDANHSJM-RVFUZGKFSA-N 0.000 claims 1
UZBGNIGOCGYXML-UYQMNGSLSA-N (2S)-1-[[4-[[3-[3-[3-(3-acetamidopyrrolidin-1-yl)propoxy]-2-chlorophenyl]-2-chlorophenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C)(=O)NC1CN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)Cl)Cl UZBGNIGOCGYXML-UYQMNGSLSA-N 0.000 claims 1
MMSRSPMCVFPNHD-XGVPZFSMSA-N (2S)-1-[[4-[[3-[3-[3-(3-acetamidopyrrolidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C)(=O)NC1CN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C MMSRSPMCVFPNHD-XGVPZFSMSA-N 0.000 claims 1
MGVRBHLMFPSNAO-ULQZDSGLSA-N (2S)-1-[[4-[[3-[3-[3-(3-carbamoylpiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(N)(=O)C1CN(CCC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C MGVRBHLMFPSNAO-ULQZDSGLSA-N 0.000 claims 1
LXKYSUBBNQVINF-KDXMTYKHSA-N (2S)-1-[[4-[[3-[3-[3-(4-acetamidopiperidin-1-yl)propoxy]-2-chlorophenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C)(=O)NC1CCN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)Cl LXKYSUBBNQVINF-KDXMTYKHSA-N 0.000 claims 1
FAEZNJAAEKLYOT-RWYGWLOXSA-N (2S)-1-[[4-[[3-[3-[3-(4-acetamidopiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C)(=O)NC1CCN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C FAEZNJAAEKLYOT-RWYGWLOXSA-N 0.000 claims 1
MKCICFRCCDHRCH-KDXMTYKHSA-N (2S)-1-[[4-[[3-[3-[3-(4-carboxypiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)C1CCN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C MKCICFRCCDHRCH-KDXMTYKHSA-N 0.000 claims 1
JPZCGVIIZHLGHG-ZWGRPSGYSA-N (2S)-1-[[4-[[3-[3-[3-[(2S,4S)-2-carboxy-4-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H]1N(C[C@H](C1)O)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C JPZCGVIIZHLGHG-ZWGRPSGYSA-N 0.000 claims 1
MMSRSPMCVFPNHD-PGSXYRMZSA-N (2S)-1-[[4-[[3-[3-[3-[(3R)-3-acetamidopyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C)(=O)N[C@H]1CN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C MMSRSPMCVFPNHD-PGSXYRMZSA-N 0.000 claims 1
OHAWKVICVDCVIK-GDYKHXCGSA-N (2S)-1-[[4-[[3-[3-[3-[(3R)-3-carboxypiperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H]1CN(CCC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C OHAWKVICVDCVIK-GDYKHXCGSA-N 0.000 claims 1
VNAFJIWKABYMFS-YSJGZBICSA-N (2S)-1-[[4-[[3-[3-[3-[(3R)-3-carboxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-methylsulfonylpyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H]1CN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)S(=O)(=O)C)C)C VNAFJIWKABYMFS-YSJGZBICSA-N 0.000 claims 1
OHAWKVICVDCVIK-AJCPBJRWSA-N (2S)-1-[[4-[[3-[3-[3-[(3S)-3-carboxypiperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@@H]1CN(CCC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C OHAWKVICVDCVIK-AJCPBJRWSA-N 0.000 claims 1
IUJWKIZOBOUHGU-XGVPZFSMSA-N (2S)-1-[[4-[[3-[3-[3-[2-(carboxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)CC1N(CCCC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C IUJWKIZOBOUHGU-XGVPZFSMSA-N 0.000 claims 1
BNHMREYDCLOVMV-YATWDLPUSA-N (2S)-1-[[4-[[3-[3-[3-[[(1S)-1-carboxy-2-pyridin-4-ylethyl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H](CC1=CC=NC=C1)NCCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C BNHMREYDCLOVMV-YATWDLPUSA-N 0.000 claims 1
CIGGZONISFOWHB-ZPGRZCPFSA-N (2S)-1-[[4-[[3-[3-[3-[[(2S)-2-carboxy-2-hydroxyethyl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(=O)(O)[C@H](CNCCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C)O CIGGZONISFOWHB-ZPGRZCPFSA-N 0.000 claims 1
SXZOJWRTQUPIFK-QLKFWGTOSA-N (2S)-1-[[4-[[3-[3-[3-[benzyl(2-hydroxyethyl)amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C(C1=CC=CC=C1)N(CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C)CCO SXZOJWRTQUPIFK-QLKFWGTOSA-N 0.000 claims 1
PALRBVOVXKUNDM-XIFFEERXSA-N (2S)-1-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C PALRBVOVXKUNDM-XIFFEERXSA-N 0.000 claims 1
LCLXNXXLDPCKJB-UMSFTDKQSA-N (2S)-1-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[3-[3-(ethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCC)=O)C)C LCLXNXXLDPCKJB-UMSFTDKQSA-N 0.000 claims 1
WMUCEIZXRSPMDZ-KDXMTYKHSA-N (2S)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(3-morpholin-4-ylpropoxy)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC1=CC(=CC=C1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCOCC1)C)C WMUCEIZXRSPMDZ-KDXMTYKHSA-N 0.000 claims 1
ZNFXYPJQWAGUOA-CLUJHZQSSA-N (2S)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[(1S,5R)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound [C@H]12COC[C@H](CC1)N2CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC1=CC(=CC=C1)C#N)C)C ZNFXYPJQWAGUOA-CLUJHZQSSA-N 0.000 claims 1
LCYARRFACAOGTE-YTTGMZPUSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC1=C(C(=CC=C1)C1=C(C2=C(OCCO2)C=C1)C)C LCYARRFACAOGTE-YTTGMZPUSA-N 0.000 claims 1
RAYXKYHBXCLEFI-LHEWISCISA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(2-pyrrolidin-1-ylethylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCCN1CCCC1)=O)C)C RAYXKYHBXCLEFI-LHEWISCISA-N 0.000 claims 1
LRMNGNGAXMTCGE-XIFFEERXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C LRMNGNGAXMTCGE-XIFFEERXSA-N 0.000 claims 1
BLCOUSYINPYDHK-LHEWISCISA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid Chemical compound C(C)(C)(C)OC(=O)N1C[C@H](N(CC1)CC1=C(C=C(C(=C1)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C)OCC=1C=NC=C(C=1)C#N)C(=O)O BLCOUSYINPYDHK-LHEWISCISA-N 0.000 claims 1
GHMMVWLQUBQLBV-DHUJRADRSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]piperazine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CNCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C GHMMVWLQUBQLBV-DHUJRADRSA-N 0.000 claims 1
RQMWCTSZUKNPAC-BHVANESWSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C RQMWCTSZUKNPAC-BHVANESWSA-N 0.000 claims 1
VJFHFNCQHDJZLF-BHVANESWSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(pyrrolidine-1-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCCC1)C)C VJFHFNCQHDJZLF-BHVANESWSA-N 0.000 claims 1
NBVPPJKRDBCXMQ-MOVAXLSESA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(2-methylpiperidin-1-yl)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C(CCCC1)C)C)C NBVPPJKRDBCXMQ-MOVAXLSESA-N 0.000 claims 1
WAWPWSZWGKPLJS-FUJPSHGNSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C12OCC(N(C1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN3[C@@H](CCCC3)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C)C2 WAWPWSZWGKPLJS-FUJPSHGNSA-N 0.000 claims 1
BOQCHJCGAXGRCT-RWYGWLOXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(2-pyridin-2-ylethylamino)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCCC1=NC=CC=C1)C)C BOQCHJCGAXGRCT-RWYGWLOXSA-N 0.000 claims 1
TZXGREGZJJUVTG-RWYGWLOXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(2-pyridin-4-ylethylamino)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCCC1=CC=NC=C1)C)C TZXGREGZJJUVTG-RWYGWLOXSA-N 0.000 claims 1
OWMXWQAILNOUIR-QLKFWGTOSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(4-morpholin-4-ylpiperidin-1-yl)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)N1CCOCC1)C)C OWMXWQAILNOUIR-QLKFWGTOSA-N 0.000 claims 1
CQAQLGJCFCDGJA-WBCKFURZSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)C1=NC=CC=C1)C)C CQAQLGJCFCDGJA-WBCKFURZSA-N 0.000 claims 1
KMHPCGHPRGDJQR-ZGLUAFTOSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[2-(trifluoromethyl)morpholin-4-yl]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(OCC1)C(F)(F)F)C)C KMHPCGHPRGDJQR-ZGLUAFTOSA-N 0.000 claims 1
GVIIELCZPCVLJE-FAIXQHPJSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[4-(methylamino)piperidin-1-yl]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)NC)C)C GVIIELCZPCVLJE-FAIXQHPJSA-N 0.000 claims 1
XOVQPDHZNJPVGB-WBCKFURZSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[4-[2-oxo-2-(propan-2-ylamino)ethyl]piperazin-1-yl]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)CC(=O)NC(C)C)C)C XOVQPDHZNJPVGB-WBCKFURZSA-N 0.000 claims 1
KPLBELSFDLGEAH-QLKFWGTOSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[methyl(2-phenylethyl)amino]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(CCC1=CC=CC=C1)C)C)C KPLBELSFDLGEAH-QLKFWGTOSA-N 0.000 claims 1
AXVQVISFVUMSJY-RWYGWLOXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[methyl(pyridin-2-ylmethyl)amino]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(CC1=NC=CC=C1)C)C)C AXVQVISFVUMSJY-RWYGWLOXSA-N 0.000 claims 1
ZJMRHKKOBIFKPB-RWYGWLOXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-[methyl(pyridin-3-ylmethyl)amino]propoxy]phenyl]phenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(CC=1C=NC=CC=1)C)C)C ZJMRHKKOBIFKPB-RWYGWLOXSA-N 0.000 claims 1
VMYFBFHPTFQLEY-LHEWISCISA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(diethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid Chemical compound C(C)(C)(C)OC(=O)N1C[C@H](N(CC1)CC1=C(C=C(C(=C1)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(CC)CC)=O)C)C)OCC=1C=NC=C(C=1)C#N)C(=O)O VMYFBFHPTFQLEY-LHEWISCISA-N 0.000 claims 1
XCWSTEKZHSLQLH-BHVANESWSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(diethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(CC)CC)=O)C)C XCWSTEKZHSLQLH-BHVANESWSA-N 0.000 claims 1
ZLMPPAYSPUWFAH-UMSFTDKQSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(dimethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(C)C)=O)C)C ZLMPPAYSPUWFAH-UMSFTDKQSA-N 0.000 claims 1
BGPHCSRXLIGQTE-UMSFTDKQSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(ethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCC)=O)C)C BGPHCSRXLIGQTE-UMSFTDKQSA-N 0.000 claims 1
CJMGYAAEHAAUNI-RIEGYYRVSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethoxymethyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COCCN1C[C@@H](CC1)O)C)C CJMGYAAEHAAUNI-RIEGYYRVSA-N 0.000 claims 1
VFBKDFVKHXKODD-XLWWBGEVSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethylcarbamoyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCCN1C[C@@H](CC1)O)=O)C)C VFBKDFVKHXKODD-XLWWBGEVSA-N 0.000 claims 1
NAOLLIGRUXXKCO-NYZBEGEVSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(2,3-dihydroxypropylamino)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCC(CO)O)C)C NAOLLIGRUXXKCO-NYZBEGEVSA-N 0.000 claims 1
VDKPFVAEXSRQOY-KDXMTYKHSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(4-hydroxypiperidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)O)C)C VDKPFVAEXSRQOY-KDXMTYKHSA-N 0.000 claims 1
DVULIVIWSFELQV-BHVANESWSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(dimethylamino)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(C)C)C)C DVULIVIWSFELQV-BHVANESWSA-N 0.000 claims 1
WAMFSOSDWOJITR-MDYKCEECSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](O[C@@H](C1)C)C)C)C WAMFSOSDWOJITR-MDYKCEECSA-N 0.000 claims 1
WXHZGLMRZMSFOM-ZAQUEYBZSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(2S)-2-methoxycarbonylpiperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1[C@@H](CCCC1)C(=O)OC)C)C WXHZGLMRZMSFOM-ZAQUEYBZSA-N 0.000 claims 1
CXZFQWWKVYVDEJ-LHEWISCISA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3-hydroxy-2,2-dimethylpropyl)amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCC(CO)(C)C)C)C CXZFQWWKVYVDEJ-LHEWISCISA-N 0.000 claims 1
UQSPHVPIEBKTCP-FOMDDGNBSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3S,4R)-3-hydroxy-4-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@H]([C@H](CC1)CO)O)C)C UQSPHVPIEBKTCP-FOMDDGNBSA-N 0.000 claims 1
YYZVZHJPNYTUFR-XGVPZFSMSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[2-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C(CCCC1)CO)C)C YYZVZHJPNYTUFR-XGVPZFSMSA-N 0.000 claims 1
CAKKIQUPVQWPQU-GPQVWERHSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[3-(diethylcarbamoyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CCC1)C(N(CC)CC)=O)C)C CAKKIQUPVQWPQU-GPQVWERHSA-N 0.000 claims 1
CFNUWXAYVRYVMF-KDXMTYKHSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[3-(dimethylamino)azetidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(C1)N(C)C)C)C CFNUWXAYVRYVMF-KDXMTYKHSA-N 0.000 claims 1
IWWQGXVDMVQXFT-YJLUVVSMSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[3-(hydroxymethyl)morpholin-4-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C(COCC1)CO)C)C IWWQGXVDMVQXFT-YJLUVVSMSA-N 0.000 claims 1
XEPKQYXAWGXOHP-AARGLWAYSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[3-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CCC1)CO)C)C XEPKQYXAWGXOHP-AARGLWAYSA-N 0.000 claims 1
UPMXLWCLUBKATG-FAIXQHPJSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)CCO)C)C UPMXLWCLUBKATG-FAIXQHPJSA-N 0.000 claims 1
WVHSLYJUGKJPMM-SJARJILFSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)C1=C(C=CC=C1)OC)C)C WVHSLYJUGKJPMM-SJARJILFSA-N 0.000 claims 1
OAONCUFYLAGCBV-FAIXQHPJSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)CO)C)C OAONCUFYLAGCBV-FAIXQHPJSA-N 0.000 claims 1
WPUISKYHMYDKHF-YDAXCOIMSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN[C@@H](CO)C(C)C)C)C WPUISKYHMYDKHF-YDAXCOIMSA-N 0.000 claims 1
WPUISKYHMYDKHF-RGULYWFUSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[[(2S)-1-hydroxy-3-methylbutan-2-yl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN[C@H](CO)C(C)C)C)C WPUISKYHMYDKHF-RGULYWFUSA-N 0.000 claims 1
QBINIBWSILRMDV-UVNLRBHVSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[[(2S)-2,3-dihydroxypropyl]-methylamino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(C)C[C@@H](CO)O)C)C QBINIBWSILRMDV-UVNLRBHVSA-N 0.000 claims 1
NAOLLIGRUXXKCO-WNOXWKSXSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)C)C NAOLLIGRUXXKCO-WNOXWKSXSA-N 0.000 claims 1
MHNPETGCOBJUCZ-XMFIIQEFSA-N (2S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[[(3R)-1-(2,3-dihydroxypropyl)piperidin-3-yl]methoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OC[C@H]1CN(CCC1)CC(CO)O)C)C MHNPETGCOBJUCZ-XMFIIQEFSA-N 0.000 claims 1
TYWNIWSZOKVPCA-HKFHRXRESA-N (2S)-1-[[5-chloro-4-[2-[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]ethyl]-2-methoxyphenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OC)CCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C TYWNIWSZOKVPCA-HKFHRXRESA-N 0.000 claims 1
APDKHMHBKZYLGX-ZQAZVOLISA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[2-chloro-3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]phenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)Cl)Cl APDKHMHBKZYLGX-ZQAZVOLISA-N 0.000 claims 1
LVFZEKDGYTZOGN-BHVANESWSA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[2-methyl-3-(3-morpholin-4-ylpropoxy)phenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCOCC1)C)Cl LVFZEKDGYTZOGN-BHVANESWSA-N 0.000 claims 1
VSMHDLTZFRFSOK-QNGWXLTQSA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)Cl VSMHDLTZFRFSOK-QNGWXLTQSA-N 0.000 claims 1
MOJKLPUWIVKPDK-KUFVUHJUSA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl MOJKLPUWIVKPDK-KUFVUHJUSA-N 0.000 claims 1
MOJKLPUWIVKPDK-IKYOIFQTSA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3S)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@H](CC1)O)C)Cl MOJKLPUWIVKPDK-IKYOIFQTSA-N 0.000 claims 1
CPLYCDMYJDQHPH-ZJJOJAIXSA-N (2S)-1-[[5-chloro-4-[[2-chloro-3-[3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]-2-methylphenyl]phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)C)Cl CPLYCDMYJDQHPH-ZJJOJAIXSA-N 0.000 claims 1
SENNYFVWCVAEAL-KUFVUHJUSA-N (2S)-1-[[5-chloro-4-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenoxy]methyl]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)COC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C SENNYFVWCVAEAL-KUFVUHJUSA-N 0.000 claims 1
OUPXCZQGQKQGQF-LHEWISCISA-N (2S)-1-[[5-chloro-4-[[3-[2-chloro-3-[3-[4-(methylcarbamoyl)piperidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)C(NC)=O)Cl)C OUPXCZQGQKQGQF-LHEWISCISA-N 0.000 claims 1
PEZXTOUIGLUQHR-ZJJOJAIXSA-N (2S)-1-[[5-chloro-4-[[3-[2-chloro-3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)Cl)C PEZXTOUIGLUQHR-ZJJOJAIXSA-N 0.000 claims 1
BGISMZFDRLXIJT-XIFFEERXSA-N (2S)-1-[[5-chloro-4-[[3-[2-chloro-3-[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCC(CO)(CO)CO)Cl)C BGISMZFDRLXIJT-XIFFEERXSA-N 0.000 claims 1
ZMKOTIDIZAPPQD-XLWWBGEVSA-N (2S)-1-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[(5-methylsulfonylpyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)S(=O)(=O)C)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C ZMKOTIDIZAPPQD-XLWWBGEVSA-N 0.000 claims 1
WFRZSKAQSVQWCA-NSJVFKKDSA-N (2S)-1-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-methoxyphenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OC)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C WFRZSKAQSVQWCA-NSJVFKKDSA-N 0.000 claims 1
DIUHVAQCIMKHMD-CPBHLAHYSA-N (2S)-1-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-methylphenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)C)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C DIUHVAQCIMKHMD-CPBHLAHYSA-N 0.000 claims 1
ZMKOTIDIZAPPQD-BAOFOTJISA-N (2S)-1-[[5-chloro-4-[[3-[3-[3-[(3S)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[(5-methylsulfonylpyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)S(=O)(=O)C)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@H](CC1)O)C)C ZMKOTIDIZAPPQD-BAOFOTJISA-N 0.000 claims 1
OQDNABQLOPTEBE-KDXMTYKHSA-N (2S)-1-[[5-chloro-4-[[3-[3-[3-[2-(5-chloro-1-methylimidazol-4-yl)ethylamino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCCC=1N=CN(C=1Cl)C)C)C OQDNABQLOPTEBE-KDXMTYKHSA-N 0.000 claims 1
KIIBYFYYECADQV-JEXREGNNSA-N (2S)-2-[[4-[[3-[3-[3-[(3R)-3-acetamidopyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound C(C)(=O)N[C@H]1CN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN[C@](C(=O)O)(CO)C)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C KIIBYFYYECADQV-JEXREGNNSA-N 0.000 claims 1
FRNCRXHZLYEGDP-XIFFEERXSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(2-methylphenyl)phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C=CC=C1)C)C FRNCRXHZLYEGDP-XIFFEERXSA-N 0.000 claims 1
GCGQFLFPSKGYEY-LJAQVGFWSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(2-methylphenyl)phenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C=CC=C1)C)C GCGQFLFPSKGYEY-LJAQVGFWSA-N 0.000 claims 1
GBWACAMONSUZIH-DHUJRADRSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC1=C(C(=CC=C1)C1=C(C2=C(OCCO2)C=C1)C)C GBWACAMONSUZIH-DHUJRADRSA-N 0.000 claims 1
PLRUREPBFLQKRF-LJAQVGFWSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC1=C(C(=CC=C1)C1=C(C2=C(OCCO2)C=C1)C)C PLRUREPBFLQKRF-LJAQVGFWSA-N 0.000 claims 1
NDXUAZUIKWZDKP-FAIXQHPJSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(3-morpholin-4-ylpropoxy)phenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCOCC1)C)C NDXUAZUIKWZDKP-FAIXQHPJSA-N 0.000 claims 1
XAPDNYDIEMIHMG-RWYGWLOXSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-[3-(4-methyl-3-oxopiperazin-1-yl)propoxy]phenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(N(CC1)C)=O)C)C XAPDNYDIEMIHMG-RWYGWLOXSA-N 0.000 claims 1
YLVGOGGRWIFTOV-LHEWISCISA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[3-(2-morpholin-4-ylethoxy)phenyl]phenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCN1CCOCC1)C YLVGOGGRWIFTOV-LHEWISCISA-N 0.000 claims 1
XVYVXAOMZSJWOC-KDXMTYKHSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(3,3-difluoropyrrolidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CC1)(F)F)C)C XVYVXAOMZSJWOC-KDXMTYKHSA-N 0.000 claims 1
CJZVSHIUZICREW-BMJIBKAESA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-(3-hydroxy-3-phenylpyrrolidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CC1)(C1=CC=CC=C1)O)C)C CJZVSHIUZICREW-BMJIBKAESA-N 0.000 claims 1
HAYCFMPDJSGSJZ-GOJCVTOHSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl-methylamino]butanoic acid Chemical compound ClC=1C(=CC(=C(CN([C@H](C(=O)O)CC)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C HAYCFMPDJSGSJZ-GOJCVTOHSA-N 0.000 claims 1
YMLIXFKBOMUHPS-JEVSUUQRSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-2-phenylacetic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)C2=CC=CC=C2)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C YMLIXFKBOMUHPS-JEVSUUQRSA-N 0.000 claims 1
HRCCOQQFKFFDJQ-NQVJXQQZSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C HRCCOQQFKFFDJQ-NQVJXQQZSA-N 0.000 claims 1
VVHMZZJGAJVZCV-BYYXFNHRSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]hexanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CCCC)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C VVHMZZJGAJVZCV-BYYXFNHRSA-N 0.000 claims 1
AOERJEUNJATIBU-GOJCVTOHSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]pent-4-enoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CC=C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C AOERJEUNJATIBU-GOJCVTOHSA-N 0.000 claims 1
CZSFUGZMPVERRH-GOJCVTOHSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]pentanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CCC)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C CZSFUGZMPVERRH-GOJCVTOHSA-N 0.000 claims 1
LWVLYIZSDXSJCX-YSVKQWHRSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCCN1C[C@@H](CC1)O)C LWVLYIZSDXSJCX-YSVKQWHRSA-N 0.000 claims 1
LUHKZMWGXSUBCR-GOJCVTOHSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CCCNC(=N)N)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCCN1C[C@@H](CC1)O)C LUHKZMWGXSUBCR-GOJCVTOHSA-N 0.000 claims 1
WDFTXYWGPDRMLN-ABPCBSMNSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[3-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CCC1)CO)C)C WDFTXYWGPDRMLN-ABPCBSMNSA-N 0.000 claims 1
RDSGBZVHTMMSJY-WBCKFURZSA-N (2S)-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)CCO)C)C RDSGBZVHTMMSJY-WBCKFURZSA-N 0.000 claims 1
MDELVQVSJWSDLU-BIMVPBQRSA-N (2S)-2-[[5-chloro-4-[[3-[2-cyano-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]phenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C#N)C MDELVQVSJWSDLU-BIMVPBQRSA-N 0.000 claims 1
YUXQENDNNAAIFA-SFRLIIPVSA-N (2S)-2-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-methoxyphenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@](C(=O)O)(CO)C)C=1)OC)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C YUXQENDNNAAIFA-SFRLIIPVSA-N 0.000 claims 1
WWKVFWFQKTXNKR-IRPSRAIASA-N (2S)-2-[[5-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-methoxyphenyl]methylamino]-3-hydroxypropanoic acid Chemical compound ClC=1C(=CC(=C(CN[C@H](C(=O)O)CO)C=1)OC)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C WWKVFWFQKTXNKR-IRPSRAIASA-N 0.000 claims 1
LQYGDNANBCLXDL-XIFFEERXSA-N (2S)-3-amino-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methylamino]propanoic acid Chemical compound NC[C@@H](C(=O)O)NCC1=C(C=C(C(=C1)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C)OCC=1C=NC=C(C=1)C#N LQYGDNANBCLXDL-XIFFEERXSA-N 0.000 claims 1
HTBNKJGYDDLXGS-GOJCVTOHSA-N (2S)-3-amino-2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[4-[(3R)-3-hydroxypyrrolidin-1-yl]butyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]propanoic acid Chemical compound NC[C@@H](C(=O)O)NCC1=C(C=C(C(=C1)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)CCCCN1C[C@@H](CC1)O)C)C)OCC=1C=NC=C(C=1)C#N HTBNKJGYDDLXGS-GOJCVTOHSA-N 0.000 claims 1
DSJBEBJYTAVEBQ-ZUKKLESISA-N (2S,4R)-1-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C DSJBEBJYTAVEBQ-ZUKKLESISA-N 0.000 claims 1
DZIFAIWXRFDCMN-YDYNHKSESA-N (2S,4R)-1-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[3-[3-(ethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCC)=O)C)C DZIFAIWXRFDCMN-YDYNHKSESA-N 0.000 claims 1
MWJFFQBCLBZDGC-ZUKKLESISA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C MWJFFQBCLBZDGC-ZUKKLESISA-N 0.000 claims 1
HZLGLRAFXYXARH-BIMVPBQRSA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C HZLGLRAFXYXARH-BIMVPBQRSA-N 0.000 claims 1
UPNZYSJANWQRQO-BIMVPBQRSA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(diethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(CC)CC)=O)C)C UPNZYSJANWQRQO-BIMVPBQRSA-N 0.000 claims 1
YQKLOYAFXJVCIR-YDYNHKSESA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(dimethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(C)C)=O)C)C YQKLOYAFXJVCIR-YDYNHKSESA-N 0.000 claims 1
SABIBZDKIDXARK-YDYNHKSESA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(ethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCC)=O)C)C SABIBZDKIDXARK-YDYNHKSESA-N 0.000 claims 1
KHHDIYKUJXAILE-BDNRVITGSA-N (2S,4R)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[4-[(3R)-3-hydroxypyrrolidin-1-yl]butyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)CCCCN1C[C@@H](CC1)O)C)C KHHDIYKUJXAILE-BDNRVITGSA-N 0.000 claims 1
DSJBEBJYTAVEBQ-UCGGBYDDSA-N (2S,4S)-1-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@@H](C2)O)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C DSJBEBJYTAVEBQ-UCGGBYDDSA-N 0.000 claims 1
HZLGLRAFXYXARH-QGRQJHSQSA-N (2S,4S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C HZLGLRAFXYXARH-QGRQJHSQSA-N 0.000 claims 1
UPNZYSJANWQRQO-QGRQJHSQSA-N (2S,4S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(diethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(CC)CC)=O)C)C UPNZYSJANWQRQO-QGRQJHSQSA-N 0.000 claims 1
YQKLOYAFXJVCIR-UVMMSNCQSA-N (2S,4S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(dimethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(C)C)=O)C)C YQKLOYAFXJVCIR-UVMMSNCQSA-N 0.000 claims 1
KHHDIYKUJXAILE-VPFJVHJXSA-N (2S,4S)-1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[4-[(3R)-3-hydroxypyrrolidin-1-yl]butyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](C[C@@H](C2)O)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)CCCCN1C[C@@H](CC1)O)C)C KHHDIYKUJXAILE-VPFJVHJXSA-N 0.000 claims 1
DDEMMGIENCZZKH-GOSISDBHSA-N (3R)-1-[3-[3-(2-methylphenyl)phenoxy]propyl]pyrrolidin-3-ol Chemical compound O[C@H]1CN(CC1)CCCOC=1C=C(C=CC=1)C1=C(C=CC=C1)C DDEMMGIENCZZKH-GOSISDBHSA-N 0.000 claims 1
CNJYNWMSPLTOPI-RUZDIDTESA-N (3R)-1-[3-[3-[3-[[2-chloro-4-[(dimethylamino)methyl]-5-hydroxyphenyl]methoxy]-2-methylphenyl]-2-methylphenoxy]propyl]pyrrolidin-3-ol Chemical compound ClC1=C(COC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2C[C@@H](CC2)O)C)C)C=C(C(=C1)CN(C)C)O CNJYNWMSPLTOPI-RUZDIDTESA-N 0.000 claims 1
CTOIVUMLXCUIST-QWQZQCCPSA-N (3R)-1-[3-[3-[3-[[4-[[[(2S)-2-carboxy-1-hydroxypropan-2-yl]amino]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]piperidine-3-carboxylic acid Chemical compound C(=O)(O)[C@@](CO)(C)NCC1=CC(=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2C[C@@H](CCC2)C(=O)O)C)C)C=C1OCC=1C=NC=C(C=1)C#N)Cl CTOIVUMLXCUIST-QWQZQCCPSA-N 0.000 claims 1
BMJFKDDYONVQQD-MHZLTWQESA-N (3S)-1-[3-[2-chloro-3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-(hydroxymethyl)phenoxy]methyl]-2-methylphenyl]phenoxy]propyl]piperidine-3-carboxylic acid Chemical compound ClC1=C(C=CC=C1OCCCN1C[C@H](CCC1)C(=O)O)C1=C(C(=CC=C1)COC1=C(C=C(C(=C1)OCC=1C=NC=C(C=1)C#N)CO)Cl)C BMJFKDDYONVQQD-MHZLTWQESA-N 0.000 claims 1
DKSNZNFMXRJNCF-HEVIKAOCSA-N (3S)-1-[3-[3-[3-[[4-[[(3S)-3-carboxypiperidin-1-yl]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]piperidine-3-carboxylic acid Chemical compound C(=O)(O)[C@@H]1CN(CCC1)CC1=CC(=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2C[C@H](CCC2)C(=O)O)C)C)C=C1OCC=1C=NC=C(C=1)C#N)Cl DKSNZNFMXRJNCF-HEVIKAOCSA-N 0.000 claims 1
CTOIVUMLXCUIST-SBIBQKHLSA-N (3S)-1-[3-[3-[3-[[4-[[[(2S)-2-carboxy-1-hydroxypropan-2-yl]amino]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]piperidine-3-carboxylic acid Chemical compound C(=O)(O)[C@@](CO)(C)NCC1=CC(=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2C[C@H](CCC2)C(=O)O)C)C)C=C1OCC=1C=NC=C(C=1)C#N)Cl CTOIVUMLXCUIST-SBIBQKHLSA-N 0.000 claims 1
FQKOYTOVYZIMBH-YTTGMZPUSA-N (3S)-4-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[2-methyl-3-[2-methyl-3-(methylcarbamoyl)phenyl]phenyl]methoxy]phenyl]methyl]morpholine-3-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](COCC2)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NC)=O)C)C FQKOYTOVYZIMBH-YTTGMZPUSA-N 0.000 claims 1
LLVGWGHWKNFVRV-XIFFEERXSA-N (3S)-4-[[5-chloro-2-[(3,5-difluorophenyl)methoxy]-4-[[3-[3-(ethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]morpholine-3-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](COCC2)C(=O)O)C=1)OCC1=CC(=CC(=C1)F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(NCC)=O)C)C LLVGWGHWKNFVRV-XIFFEERXSA-N 0.000 claims 1
CMROSCHEVPXREE-DHUJRADRSA-N (3S)-4-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(diethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]morpholine-3-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](COCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(CC)CC)=O)C)C CMROSCHEVPXREE-DHUJRADRSA-N 0.000 claims 1
XRJCZVXWERQMHB-XIFFEERXSA-N (3S)-4-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-(dimethylcarbamoyl)-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]morpholine-3-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2[C@@H](COCC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(N(C)C)=O)C)C XRJCZVXWERQMHB-XIFFEERXSA-N 0.000 claims 1
JXSQLYGGBUYKRS-SAIUNTKASA-N (3S)-4-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxybutanoic acid Chemical compound ClC=1C(=CC(=C(CNC[C@H](CC(=O)O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCCN1C[C@@H](CC1)O)C JXSQLYGGBUYKRS-SAIUNTKASA-N 0.000 claims 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
XJLSEXAGTJCILF-RXMQYKEDSA-N (R)-nipecotic acid zwitterion Chemical compound OC(=O)[C@@H]1CCCNC1 XJLSEXAGTJCILF-RXMQYKEDSA-N 0.000 claims 1
PZTFMTHLCBLARN-UHFFFAOYSA-N 1-[3-[3-[3-[[2-chloro-5-[(3,5-difluorophenyl)methoxy]-4-(hydroxymethyl)phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]pyrrolidin-3-ol Chemical compound CC1=C(COC2=C(Cl)C=C(CO)C(OCC3=CC(F)=CC(F)=C3)=C2)C=CC=C1C1=CC=CC(OCCCN2CCC(O)C2)=C1C PZTFMTHLCBLARN-UHFFFAOYSA-N 0.000 claims 1
RSHUYZAOVBEPNF-UHFFFAOYSA-N 1-[3-[3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-formylphenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]-4-hydroxypiperidine-4-carboxylic acid Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)OCCCN2CCC(CC2)(C(=O)O)O)C)C)C=C(C(=C1)C=O)OCC=1C=NC=C(C=1)C#N RSHUYZAOVBEPNF-UHFFFAOYSA-N 0.000 claims 1
SFUDATKZXARFOD-KDXMTYKHSA-N 1-[3-[3-[3-[[4-[[(2S)-2-carboxypiperidin-1-yl]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]-4-(hydroxymethyl)piperidine-4-carboxylic acid Chemical compound C(=O)(O)C1(CCN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C)CO SFUDATKZXARFOD-KDXMTYKHSA-N 0.000 claims 1
PXQLTRCOQZWIFY-LHEWISCISA-N 1-[3-[3-[3-[[4-[[(2S)-2-carboxypiperidin-1-yl]methyl]-2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]phenoxy]methyl]-2-methylphenyl]-2-methylphenoxy]propyl]-4-hydroxypiperidine-4-carboxylic acid Chemical compound C(=O)(O)C1(CCN(CC1)CCCOC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COC1=CC(=C(CN2[C@@H](CCCC2)C(=O)O)C=C1Cl)OCC=1C=NC=C(C=1)C#N)C)C)O PXQLTRCOQZWIFY-LHEWISCISA-N 0.000 claims 1
BTFJAEFSZVGNFL-UHFFFAOYSA-N 1-[3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-formylphenoxy]methyl]-2-methylphenyl]-2-methylphenyl]-3-(cyclopropylmethyl)urea Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)NC(=O)NCC2CC2)C)C)C=C(C(=C1)C=O)OCC=1C=NC=C(C=1)C#N BTFJAEFSZVGNFL-UHFFFAOYSA-N 0.000 claims 1
MQWABGRAMHNPSG-UHFFFAOYSA-N 1-[3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-formylphenoxy]methyl]-2-methylphenyl]-2-methylphenyl]-3-pyridin-2-ylurea Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)NC(=O)NC2=NC=CC=C2)C)C)C=C(C(=C1)C=O)OCC=1C=NC=C(C=1)C#N MQWABGRAMHNPSG-UHFFFAOYSA-N 0.000 claims 1
QICPADIOCLJYPP-MGBGTMOVSA-N 1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethoxymethyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]cyclopropane-1-carboxylic acid Chemical compound ClC=1C(=CC(=C(CNC2(CC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)COCCN1C[C@@H](CC1)O)C)C QICPADIOCLJYPP-MGBGTMOVSA-N 0.000 claims 1
OLJMIUOORVDMQG-MGBGTMOVSA-N 1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl-methylamino]cyclopropane-1-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN(C2(CC2)C(=O)O)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C OLJMIUOORVDMQG-MGBGTMOVSA-N 0.000 claims 1
DNUDAKRAXITTBP-VIFFVDDJSA-N 1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methyl]-2-methylpiperidine-2-carboxylic acid Chemical compound ClC=1C(=CC(=C(CN2C(CCCC2)(C(=O)O)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C DNUDAKRAXITTBP-VIFFVDDJSA-N 0.000 claims 1
DFPBEZLVOGGDAZ-JGCGQSQUSA-N 1-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]cyclopropane-1-carboxylic acid Chemical compound ClC=1C(=CC(=C(CNC2(CC2)C(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C DFPBEZLVOGGDAZ-JGCGQSQUSA-N 0.000 claims 1
CZOFBUXSTNAMMY-UOQVMRJOSA-N 2-[[3-chloro-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C=C(CNC(C(=O)O)(CO)C)C=CC=1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C CZOFBUXSTNAMMY-UOQVMRJOSA-N 0.000 claims 1
BHPUBAPWJWNTPA-UHFFFAOYSA-N 2-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[(5-cyanopyridin-3-yl)methoxy]phenyl]-2-methylphenyl]methoxy]phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid Chemical compound ClC=1C(=CC(=C(CNC(C(=O)O)(CO)C)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCC=1C=NC=C(C=1)C#N)C BHPUBAPWJWNTPA-UHFFFAOYSA-N 0.000 claims 1
QGPMQENOTVQTQU-RUZDIDTESA-N 2-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-(2,2-difluoroethoxy)phenyl]methylamino]propane-1,3-diol Chemical compound ClC=1C(=CC(=C(CNC(CO)CO)C=1)OCC(F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl QGPMQENOTVQTQU-RUZDIDTESA-N 0.000 claims 1
BWQMPTCLWJOKDW-GDLZYMKVSA-N 2-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-(3-methylbut-2-enoxy)phenyl]methylamino]propane-1,3-diol Chemical compound ClC=1C(=CC(=C(CNC(CO)CO)C=1)OCC=C(C)C)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl BWQMPTCLWJOKDW-GDLZYMKVSA-N 0.000 claims 1
RBMSBKLSJYYJOP-MUUNZHRXSA-N 2-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-(cyclopropylmethoxy)phenyl]methylamino]propane-1,3-diol Chemical compound ClC=1C(=CC(=C(CNC(CO)CO)C=1)OCC1CC1)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl RBMSBKLSJYYJOP-MUUNZHRXSA-N 0.000 claims 1
AWDIPFSMQIOMLK-ZCJYOONXSA-N 2-[[5-chloro-4-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-[(2,2-difluorocyclopropyl)methoxy]phenyl]methylamino]propane-1,3-diol Chemical compound ClC=1C(=CC(=C(CNC(CO)CO)C=1)OCC1C(C1)(F)F)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl AWDIPFSMQIOMLK-ZCJYOONXSA-N 0.000 claims 1
125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 claims 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
JGTQHDVHCKWFPM-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(3,5-difluorophenyl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-N-ethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NCC)C)C)C=C(C(=C1)CNC(CO)CO)OCC1=CC(=CC(=C1)F)F JGTQHDVHCKWFPM-UHFFFAOYSA-N 0.000 claims 1
MZGFOZXATXOYNI-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(3,5-difluorophenyl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N,2-dimethylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NC)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC1=CC(=CC(=C1)F)F MZGFOZXATXOYNI-UHFFFAOYSA-N 0.000 claims 1
KRMOGPZEWHHSDW-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(3,5-difluorophenyl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N-ethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NCC)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC1=CC(=CC(=C1)F)F KRMOGPZEWHHSDW-UHFFFAOYSA-N 0.000 claims 1
ZUZYPJRHABYYBL-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)benzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NCCN2CCCC2)C)C)C=C(C(=C1)CNC(CO)CO)OCC=1C=NC=C(C=1)C#N ZUZYPJRHABYYBL-UHFFFAOYSA-N 0.000 claims 1
AJXBVEQGISMVAV-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-N,2-dimethylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NC)C)C)C=C(C(=C1)CNC(CO)CO)OCC=1C=NC=C(C=1)C#N AJXBVEQGISMVAV-UHFFFAOYSA-N 0.000 claims 1
ZVAVYQYCAKNYAD-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-N,N,2-trimethylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)N(C)C)C)C)C=C(C(=C1)CNC(CO)CO)OCC=1C=NC=C(C=1)C#N ZVAVYQYCAKNYAD-UHFFFAOYSA-N 0.000 claims 1
SCRXWDMJZJIKAQ-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-N,N-diethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)N(CC)CC)C)C)C=C(C(=C1)CNC(CO)CO)OCC=1C=NC=C(C=1)C#N SCRXWDMJZJIKAQ-UHFFFAOYSA-N 0.000 claims 1
PZSHVZCAIZWHIU-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]-2-methylphenyl]-N-ethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NCC)C)C)C=C(C(=C1)CNC(CO)CO)OCC=1C=NC=C(C=1)C#N PZSHVZCAIZWHIU-UHFFFAOYSA-N 0.000 claims 1
PXARNWXONLSBJO-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N,2-dimethylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NC)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC=1C=NC=C(C=1)C#N PXARNWXONLSBJO-UHFFFAOYSA-N 0.000 claims 1
WNYGQQRYWUGLQG-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N,N,2-trimethylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)N(C)C)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC=1C=NC=C(C=1)C#N WNYGQQRYWUGLQG-UHFFFAOYSA-N 0.000 claims 1
TXZIHJQXEBSJBS-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N,N-diethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)N(CC)CC)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC=1C=NC=C(C=1)C#N TXZIHJQXEBSJBS-UHFFFAOYSA-N 0.000 claims 1
CULIJFIWTJLMGI-UHFFFAOYSA-N 3-[3-[[2-chloro-5-[(5-cyanopyridin-3-yl)methoxy]-4-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]-2-methylphenyl]-N-ethyl-2-methylbenzamide Chemical compound ClC1=C(OCC=2C(=C(C=CC=2)C2=C(C(=CC=C2)C(=O)NCC)C)C)C=C(C(=C1)CNC(CO)(CO)C)OCC=1C=NC=C(C=1)C#N CULIJFIWTJLMGI-UHFFFAOYSA-N 0.000 claims 1
UESOHMSZKSAOAY-JGCGQSQUSA-N 3-[[5-chloro-2-[(5-cyanopyridin-3-yl)methoxy]-4-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenyl]methylamino]propanoic acid Chemical compound ClC=1C(=CC(=C(CNCCC(=O)O)C=1)OCC=1C=NC=C(C=1)C#N)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C UESOHMSZKSAOAY-JGCGQSQUSA-N 0.000 claims 1
HZSAPNSHGPNDHF-UHFFFAOYSA-N 3-methylsulfonylpyridine Chemical compound CS(=O)(=O)C1=CC=CN=C1 HZSAPNSHGPNDHF-UHFFFAOYSA-N 0.000 claims 1
URLGWNKGOJVMCN-UHFFFAOYSA-N 4-chloro-5-[[3-[2-chloro-3-(3-piperidin-1-ylpropoxy)phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenol Chemical compound ClC1=CC(=C(C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)Cl)C)O)CO URLGWNKGOJVMCN-UHFFFAOYSA-N 0.000 claims 1
KNURBJPLXSOUFY-UHFFFAOYSA-N 4-chloro-5-[[3-[2-chloro-3-[3-[3-(dimethylamino)azetidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenol Chemical compound ClC1=CC(=C(C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(C1)N(C)C)Cl)C)O)CO KNURBJPLXSOUFY-UHFFFAOYSA-N 0.000 claims 1
NAMGWRSFXFZXRQ-MGBGTMOVSA-N 5-[[2-[(tert-butylamino)methyl]-4-chloro-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound C(C)(C)(C)NCC1=C(OCC=2C=NC=C(C#N)C=2)C=C(C(=C1)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C NAMGWRSFXFZXRQ-MGBGTMOVSA-N 0.000 claims 1
DCLSTBUPDVVSDU-UUWRZZSWSA-N 5-[[2-[[bis(2-hydroxyethyl)amino]methyl]-4-chloro-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-3-methylphenoxy]methyl]pyridine-3-carbonitrile Chemical compound OCCN(CCO)CC1=C(OCC=2C=NC=C(C#N)C=2)C=C(C(=C1C)Cl)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C DCLSTBUPDVVSDU-UUWRZZSWSA-N 0.000 claims 1
QGIXDOQYVLDGIP-PGUFJCEWSA-N 5-[[2-[[bis(2-hydroxyethyl)amino]methyl]-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-3-methylphenoxy]methyl]pyridine-3-carbonitrile Chemical compound OCCN(CCO)CC1=C(OCC=2C=NC=C(C#N)C=2)C=C(C=C1C)OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C QGIXDOQYVLDGIP-PGUFJCEWSA-N 0.000 claims 1
NIRFEEAGZAEEKJ-WJOKGBTCSA-N 5-[[4-chloro-2-(hydroxymethyl)-5-[[3-[3-[3-[(3R)-3-methoxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)OC)C)C)CO NIRFEEAGZAEEKJ-WJOKGBTCSA-N 0.000 claims 1
ICMFHFUUKTUFKB-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)C)CNC(CO)CO ICMFHFUUKTUFKB-UHFFFAOYSA-N 0.000 claims 1
QDEYTSVTJKVRMB-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C)CNC(CO)CO QDEYTSVTJKVRMB-UHFFFAOYSA-N 0.000 claims 1
YZHDNOAHTFBXFD-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-(pyrrolidine-1-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCCC1)C)C)CNC(CO)CO YZHDNOAHTFBXFD-UHFFFAOYSA-N 0.000 claims 1
QLVPNEOIDOKZQL-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OC1=C2CCNC(C2=CC=C1)=O)C)C)CNC(CO)CO QLVPNEOIDOKZQL-UHFFFAOYSA-N 0.000 claims 1
SJUZMHJGZNOEAB-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-[(6-morpholin-4-ylpyrimidin-4-yl)amino]phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)NC1=NC=NC(=C1)N1CCOCC1)C)C)CNC(CO)CO SJUZMHJGZNOEAB-UHFFFAOYSA-N 0.000 claims 1
NOHXOUUMRNCDPA-SANMLTNESA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-3-[[(3S)-pyrrolidin-3-yl]methoxy]phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OC[C@@H]1CNCC1)C)C)CNC(CO)CO NOHXOUUMRNCDPA-SANMLTNESA-N 0.000 claims 1
WEWLPCCUHLSYOC-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[2-methyl-3-[2-methyl-4-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C=C(C=C1)C(=O)N1CCOCC1)C)C)CNC(CO)CO WEWLPCCUHLSYOC-UHFFFAOYSA-N 0.000 claims 1
PYOGWDNVXVTUKA-UHFFFAOYSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[3-[3-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCC(CC1)CO)C)C)CNC(CO)CO PYOGWDNVXVTUKA-UHFFFAOYSA-N 0.000 claims 1
CGJVBCCXZHZIMS-YTTGMZPUSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[3-[3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)C)C)CNC(CO)CO CGJVBCCXZHZIMS-YTTGMZPUSA-N 0.000 claims 1
HYRVAEAZLUOXCB-PGUFJCEWSA-N 5-[[4-chloro-2-[(1,3-dihydroxypropan-2-ylamino)methyl]-5-[[3-[3-[4-[(3R)-3-hydroxypyrrolidin-1-yl]butyl]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)CCCCN1C[C@@H](CC1)O)C)C)CNC(CO)CO HYRVAEAZLUOXCB-PGUFJCEWSA-N 0.000 claims 1
GUAGGPLWXNGDJZ-ZBAKNJOASA-N 5-[[4-chloro-2-[1-(1,3-dihydroxypropan-2-ylamino)ethyl]-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C)C(C)NC(CO)CO GUAGGPLWXNGDJZ-ZBAKNJOASA-N 0.000 claims 1
JOHOUTOVUFYNAN-UHFFFAOYSA-N 5-[[4-chloro-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]-5-[[2-methyl-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)C)CNC(CO)(CO)C JOHOUTOVUFYNAN-UHFFFAOYSA-N 0.000 claims 1
VUMPKGVYFWGAAY-UHFFFAOYSA-N 5-[[4-chloro-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]-5-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C)CNC(CO)(CO)C VUMPKGVYFWGAAY-UHFFFAOYSA-N 0.000 claims 1
HBKGKVUKXDTGND-UHFFFAOYSA-N 5-[[4-chloro-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]-5-[[2-methyl-3-[2-methyl-3-(pyrrolidine-1-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCCC1)C)C)CNC(CO)(CO)C HBKGKVUKXDTGND-UHFFFAOYSA-N 0.000 claims 1
RYIZBGPWDZXLII-KKLWWLSJSA-N 5-[[4-chloro-2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C)CN1C[C@@H](CC1)O RYIZBGPWDZXLII-KKLWWLSJSA-N 0.000 claims 1
OFICYWSMCSAWPZ-UHFFFAOYSA-N 5-[[4-chloro-2-[[2,3-dihydroxypropyl(methyl)amino]methyl]-5-[[3-[3-[3-[2,3-dihydroxypropyl(methyl)amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(C)CC(CO)O)C)C)CN(C)CC(CO)O OFICYWSMCSAWPZ-UHFFFAOYSA-N 0.000 claims 1
SESSWVWUJADLNR-UHFFFAOYSA-N 5-[[4-chloro-2-[[2-(hydroxymethyl)piperidin-1-yl]methyl]-5-[[3-[3-[3-[2-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C(CCCC1)CO)C)C)CN1C(CCCC1)CO SESSWVWUJADLNR-UHFFFAOYSA-N 0.000 claims 1
YPSZAMWMBXGXEP-PGUFJCEWSA-N 5-[[4-chloro-2-[[3-(dimethylamino)propylamino]methyl]-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C)CNCCCN(C)C YPSZAMWMBXGXEP-PGUFJCEWSA-N 0.000 claims 1
VESWXUDIILBCIQ-PGUFJCEWSA-N 5-[[4-chloro-2-[[3-(dimethylamino)propylamino]methyl]-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)OCCCN1C[C@@H](CC1)O)C)CNCCCN(C)C VESWXUDIILBCIQ-PGUFJCEWSA-N 0.000 claims 1
KZJQJGVNJZXVIP-UHFFFAOYSA-N 5-[[4-chloro-2-[[3-(dimethylamino)propylamino]methyl]-5-[[3-[3-[[3-(dimethylamino)propylamino]methyl]phenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=CC(=CC=C1)CNCCCN(C)C)C)CNCCCN(C)C KZJQJGVNJZXVIP-UHFFFAOYSA-N 0.000 claims 1
SVNYULNAPHLROK-UHFFFAOYSA-N 5-[[4-chloro-2-[[3-(hydroxymethyl)piperidin-1-yl]methyl]-5-[[3-[3-[3-[3-(hydroxymethyl)piperidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CCC1)CO)C)C)CN1CC(CCC1)CO SVNYULNAPHLROK-UHFFFAOYSA-N 0.000 claims 1
NXZCCMMUZQVBRX-UHFFFAOYSA-N 5-[[4-chloro-2-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-5-[[3-[3-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCN(CC1)CCO)C)C)CN1CCN(CC1)CCO NXZCCMMUZQVBRX-UHFFFAOYSA-N 0.000 claims 1
DUUNZKQFKQOBCP-ACHIHNKUSA-N 5-[[4-chloro-2-[[[(2S)-2,3-dihydroxypropyl]amino]methyl]-5-[[3-[3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)C)C)CNC[C@@H](CO)O DUUNZKQFKQOBCP-ACHIHNKUSA-N 0.000 claims 1
FAUBPTAAWNDJTR-UHFFFAOYSA-N 5-[[4-chloro-2-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methyl]-5-[[2-methyl-3-[2-methyl-3-(morpholine-4-carbonyl)phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)C(=O)N1CCOCC1)C)C)CNC(CO)(CO)CO FAUBPTAAWNDJTR-UHFFFAOYSA-N 0.000 claims 1
FBQHRKGWZFYVEL-UHFFFAOYSA-N 5-[[4-chloro-2-formyl-5-[[2-methyl-3-[2-methyl-3-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]phenyl]phenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OC1=C2CCNC(C2=CC=C1)=O)C)C)C=O FBQHRKGWZFYVEL-UHFFFAOYSA-N 0.000 claims 1
KJWCGFKGJVCRGY-WJOKGBTCSA-N 5-[[4-chloro-2-formyl-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2,6-dimethylphenyl]-2-methylphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1C)OCCCN1C[C@@H](CC1)O)C)C)C=O KJWCGFKGJVCRGY-WJOKGBTCSA-N 0.000 claims 1
XTXQSWNTFLBLRT-GDLZYMKVSA-N 5-[[4-chloro-2-formyl-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methoxyphenyl]methoxy]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)OC)C=O XTXQSWNTFLBLRT-GDLZYMKVSA-N 0.000 claims 1
WVBUKKNJLGBWHM-UHFFFAOYSA-N 5-[[4-chloro-5-[[2-chloro-3-[2-chloro-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)Cl)Cl)CO WVBUKKNJLGBWHM-UHFFFAOYSA-N 0.000 claims 1
UYOGPAASLVAVFH-GDLZYMKVSA-N 5-[[4-chloro-5-[[2-chloro-3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]phenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)Cl)CNC(CO)(CO)C UYOGPAASLVAVFH-GDLZYMKVSA-N 0.000 claims 1
HAIOWJQVLGVMSE-UHFFFAOYSA-N 5-[[4-chloro-5-[[2-chloro-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)Cl)CNC(CO)CO HAIOWJQVLGVMSE-UHFFFAOYSA-N 0.000 claims 1
XQNXCTJOJIAACB-UHFFFAOYSA-N 5-[[4-chloro-5-[[2-chloro-3-[2-methyl-3-(3-piperidin-1-ylpropoxy)phenyl]phenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)C)Cl)CNC(CO)(CO)C XQNXCTJOJIAACB-UHFFFAOYSA-N 0.000 claims 1
ZRTXZQIWIXNCAN-WJOKGBTCSA-N 5-[[4-chloro-5-[[2-chloro-3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]phenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)Cl)CNC(CO)CO ZRTXZQIWIXNCAN-WJOKGBTCSA-N 0.000 claims 1
WCAWUEOPLGFCFJ-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(2,3-dihydroxypropoxy)phenyl]-2-methylphenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCC(CO)O)Cl)C)CNC(CO)(CO)C WCAWUEOPLGFCFJ-UHFFFAOYSA-N 0.000 claims 1
VKDYTNVBLTUYLD-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(2-pyridin-2-ylethoxy)phenyl]-2-methylphenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCC1=NC=CC=C1)Cl)C)CNC(CO)(CO)C VKDYTNVBLTUYLD-UHFFFAOYSA-N 0.000 claims 1
AAUHDIPLVAJORS-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(3-hydroxy-3-methylbutoxy)phenyl]-2-methylphenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCC(C)(C)O)Cl)C)CNC(CO)(CO)C AAUHDIPLVAJORS-UHFFFAOYSA-N 0.000 claims 1
JQBBQUCGMXOOHD-MHZLTWQESA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(3-hydroxypropoxy)phenyl]-2-methylphenyl]methoxy]-2-[[[(2S)-2,3-dihydroxypropyl]amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCO)Cl)C)CNC[C@@H](CO)O JQBBQUCGMXOOHD-MHZLTWQESA-N 0.000 claims 1
IIZYSMQUYAZXMO-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(3-piperidin-1-ylpropoxy)phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)Cl)C)CO IIZYSMQUYAZXMO-UHFFFAOYSA-N 0.000 claims 1
TWEVYHQUXYCNFL-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-(3-piperidin-1-ylpropoxy)phenyl]-2-methylphenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CCCCC1)Cl)C)CNC(CO)CO TWEVYHQUXYCNFL-UHFFFAOYSA-N 0.000 claims 1
KQQOKRFPGWTAHP-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[(2-morpholin-4-ylethylamino)methyl]phenyl]-2-methylphenyl]methoxy]-2-[[(1,3-dihydroxy-2-methylpropan-2-yl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)CNCCN1CCOCC1)Cl)C)CNC(CO)(CO)C KQQOKRFPGWTAHP-UHFFFAOYSA-N 0.000 claims 1
JJSCVFDFTUGURC-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-(1,3-dihydroxypropan-2-ylamino)propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC(CO)CO)Cl)C)CO JJSCVFDFTUGURC-UHFFFAOYSA-N 0.000 claims 1
TYWHHOCUYQYBSZ-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-(2-pyridin-3-ylethylamino)propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCCC=1C=NC=CC=1)Cl)C)CNC(CO)CO TYWHHOCUYQYBSZ-UHFFFAOYSA-N 0.000 claims 1
YQIHUPACQOYCAW-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-(2-pyridin-4-ylethylamino)propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(2-pyridin-4-ylethylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNCCC1=CC=NC=C1)Cl)C)CNCCC1=CC=NC=C1 YQIHUPACQOYCAW-UHFFFAOYSA-N 0.000 claims 1
XQJQOFLDMHHDIR-MUUNZHRXSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C)CO XQJQOFLDMHHDIR-MUUNZHRXSA-N 0.000 claims 1
LXPFBTFCKPNGMP-WJOKGBTCSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C)CNC(CO)CO LXPFBTFCKPNGMP-WJOKGBTCSA-N 0.000 claims 1
CZOVCEPJPXSBCA-MGBGTMOVSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[(1,3-dimethoxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C)CNC(COC)COC CZOVCEPJPXSBCA-MGBGTMOVSA-N 0.000 claims 1
UYMBCRAILUZFCM-CZNDPXEESA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[[(3R)-3-(hydroxymethyl)morpholin-4-yl]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C)CN1[C@@H](COCC1)CO UYMBCRAILUZFCM-CZNDPXEESA-N 0.000 claims 1
QFPWHCZKHJZAKQ-ROJLCIKYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]phenyl]-2-methylphenyl]methoxy]-2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)Cl)C)CN1C[C@@H](CC1)O QFPWHCZKHJZAKQ-ROJLCIKYSA-N 0.000 claims 1
QPVBECZEFFDYSK-NDEPHWFRSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[[(2S)-2,3-dihydroxypropyl]-methylamino]propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN(C)C[C@@H](CO)O)Cl)C)CO QPVBECZEFFDYSK-NDEPHWFRSA-N 0.000 claims 1
IDDPUDJTWIEWJO-MHZLTWQESA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[[(2S)-2,3-dihydroxypropyl]amino]propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC[C@@H](CO)O)Cl)C)CO IDDPUDJTWIEWJO-MHZLTWQESA-N 0.000 claims 1
CWQRCEIEEIGDQY-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[2-chloro-3-[3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propoxy]phenyl]-2-methylphenyl]methoxy]-2-(hydroxymethyl)phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCNC(CO)(CO)CO)Cl)C)CO CWQRCEIEEIGDQY-UHFFFAOYSA-N 0.000 claims 1
XVTPFDFJWVBPNC-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[3-[3-(3,3-difluoropyrrolidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[(1,3-dihydroxypropan-2-ylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CC1)(F)F)C)C)CNC(CO)CO XVTPFDFJWVBPNC-UHFFFAOYSA-N 0.000 claims 1
ATXSPZPWDZHSML-UHFFFAOYSA-N 5-[[4-chloro-5-[[3-[3-[3-(3,3-difluoropyrrolidin-1-yl)propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[[2-hydroxyethyl(3-hydroxypropyl)amino]methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1CC(CC1)(F)F)C)C)CN(CCCO)CCO ATXSPZPWDZHSML-UHFFFAOYSA-N 0.000 claims 1
RESLRWIVRNOKKW-PSXMRANNSA-N 5-[[4-chloro-5-[[3-[3-[3-[(3R)-3-hydroxypyrrolidin-1-yl]propoxy]-2-methylphenyl]-2-methylphenyl]methoxy]-2-[(2-morpholin-4-ylethylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile Chemical compound ClC1=CC(=C(OCC=2C=NC=C(C#N)C=2)C=C1OCC=1C(=C(C=CC=1)C1=C(C(=CC=C1)OCCCN1C[C@@H](CC1)O)C)C)CNCCN1CCOCC1 RESLRWIVRNOKKW-PSXMRANNSA-N 0.000 claims 1
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JP2018519301A 2015-10-15 2016-10-12 免疫調節剤として有用な化合物 Active JP6916783B2 (ja)