JP6916783B2 - 免疫調節剤として有用な化合物 - Google Patents
免疫調節剤として有用な化合物 Download PDFInfo
- Publication number
- JP6916783B2 JP6916783B2 JP2018519301A JP2018519301A JP6916783B2 JP 6916783 B2 JP6916783 B2 JP 6916783B2 JP 2018519301 A JP2018519301 A JP 2018519301A JP 2018519301 A JP2018519301 A JP 2018519301A JP 6916783 B2 JP6916783 B2 JP 6916783B2
- Authority
- JP
- Japan
- Prior art keywords
- methoxy
- chloro
- methyl
- biphenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 **c1cc(*)c(*)cc1 Chemical compound **c1cc(*)c(*)cc1 0.000 description 9
- HHSQCLWVCAVLBS-LJAQVGFWSA-N CC(C)(C)OC(N1C[C@@H](COc2cccc(-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CNC(CO)CO)cc4Cl)c3C)c2C)CC1)=O Chemical compound CC(C)(C)OC(N1C[C@@H](COc2cccc(-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CNC(CO)CO)cc4Cl)c3C)c2C)CC1)=O HHSQCLWVCAVLBS-LJAQVGFWSA-N 0.000 description 1
- LVGVVVJUVUSQIQ-FAIXQHPJSA-N CC(C)[C@@H](C(O)=O)NCc(cc(c(OCc1cccc(-c2c(C)c(OCCCN3CCCC3)ccc2)c1C)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound CC(C)[C@@H](C(O)=O)NCc(cc(c(OCc1cccc(-c2c(C)c(OCCCN3CCCC3)ccc2)c1C)c1)Cl)c1OCc1cncc(C#N)c1 LVGVVVJUVUSQIQ-FAIXQHPJSA-N 0.000 description 1
- LLPFRMGFHFKPRI-UHFFFAOYSA-N CC(CO)(CO)NCCCOc(cccc1-c2cccc(COc(cc(c(CNC(C)(CO)CO)c3)OCc4cncc(C#N)c4)c3Cl)c2C)c1Cl Chemical compound CC(CO)(CO)NCCCOc(cccc1-c2cccc(COc(cc(c(CNC(C)(CO)CO)c3)OCc4cncc(C#N)c4)c3Cl)c2C)c1Cl LLPFRMGFHFKPRI-UHFFFAOYSA-N 0.000 description 1
- WDRAHNCHKAQGCD-UHFFFAOYSA-N CC(CO)(CO)NCc(c(OCc1cc(Cl)ccc1)c1)cc(Cl)c1OCc1cccc(-c2cccc(OCCCBr)c2Cl)c1Cl Chemical compound CC(CO)(CO)NCc(c(OCc1cc(Cl)ccc1)c1)cc(Cl)c1OCc1cccc(-c2cccc(OCCCBr)c2Cl)c1Cl WDRAHNCHKAQGCD-UHFFFAOYSA-N 0.000 description 1
- KQQOKRFPGWTAHP-UHFFFAOYSA-N CC(CO)(CO)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2CNCCN3CCOCC3)c2Cl)ccc1 Chemical compound CC(CO)(CO)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2CNCCN3CCOCC3)c2Cl)ccc1 KQQOKRFPGWTAHP-UHFFFAOYSA-N 0.000 description 1
- VKDYTNVBLTUYLD-UHFFFAOYSA-N CC(CO)(CO)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCc3ncccc3)c2Cl)ccc1 Chemical compound CC(CO)(CO)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCc3ncccc3)c2Cl)ccc1 VKDYTNVBLTUYLD-UHFFFAOYSA-N 0.000 description 1
- UMVUYFNAACTEIZ-KKLWWLSJSA-N CC(CO)(CO)NCc(c(OCc1cncc(C(N(CC2)C[C@@H]2O)=N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCCN(CC3)C[C@@H]3O)c2Cl)ccc1 Chemical compound CC(CO)(CO)NCc(c(OCc1cncc(C(N(CC2)C[C@@H]2O)=N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCCN(CC3)C[C@@H]3O)c2Cl)ccc1 UMVUYFNAACTEIZ-KKLWWLSJSA-N 0.000 description 1
- ZZCRFAXEFRSQBV-UHFFFAOYSA-N CC(CO)(CO)NCc(cc(c(OCc(cccc1-c(cccc2OCCCBr)c2Cl)c1Cl)c1)Cl)c1OCc1cc(C#N)ccc1 Chemical compound CC(CO)(CO)NCc(cc(c(OCc(cccc1-c(cccc2OCCCBr)c2Cl)c1Cl)c1)Cl)c1OCc1cc(C#N)ccc1 ZZCRFAXEFRSQBV-UHFFFAOYSA-N 0.000 description 1
- DMSXRUPMOLGZIN-UHFFFAOYSA-N CC(CO)(CO)NCc(cc(c(OCc1c(C)c(-c(cccc2OCCCNC(Cc3ncccc3)=O)c2Cl)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound CC(CO)(CO)NCc(cc(c(OCc1c(C)c(-c(cccc2OCCCNC(Cc3ncccc3)=O)c2Cl)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 DMSXRUPMOLGZIN-UHFFFAOYSA-N 0.000 description 1
- WNYGQQRYWUGLQG-UHFFFAOYSA-N CC(CO)(CO)NCc(cc(c(OCc1cccc(-c2c(C)c(C(N(C)C)=O)ccc2)c1C)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound CC(CO)(CO)NCc(cc(c(OCc1cccc(-c2c(C)c(C(N(C)C)=O)ccc2)c1C)c1)Cl)c1OCc1cncc(C#N)c1 WNYGQQRYWUGLQG-UHFFFAOYSA-N 0.000 description 1
- FAEZNJAAEKLYOT-RWYGWLOXSA-N CC(NC1CCN(CCCOc2c(C)c(-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CN(CCCC5)[C@@H]5C(O)=O)cc4Cl)c3C)ccc2)CC1)=O Chemical compound CC(NC1CCN(CCCOc2c(C)c(-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CN(CCCC5)[C@@H]5C(O)=O)cc4Cl)c3C)ccc2)CC1)=O FAEZNJAAEKLYOT-RWYGWLOXSA-N 0.000 description 1
- PNXWZINZZKLJJJ-UHFFFAOYSA-N CC1(C)OB(c2cccc(COc(ccc(C=O)c3C)c3Cl)c2C)OC1(C)C Chemical compound CC1(C)OB(c2cccc(COc(ccc(C=O)c3C)c3Cl)c2C)OC1(C)C PNXWZINZZKLJJJ-UHFFFAOYSA-N 0.000 description 1
- FRKAEMKEZPQMJH-UHFFFAOYSA-N CC1(C)OB(c2cccc(COc3cc(C)c(C=O)cc3Cl)c2C)OC1(C)C Chemical compound CC1(C)OB(c2cccc(COc3cc(C)c(C=O)cc3Cl)c2C)OC1(C)C FRKAEMKEZPQMJH-UHFFFAOYSA-N 0.000 description 1
- SWMMFWHIFSOBBC-YPLJIXMFSA-O CC1C(c2c(C)c(COc3c([CH2+])cc(CN(CCCC4)[C@@H]4C(O)=O)c(OCc4cncc(C#N)c4)c3)ccc2)=CC=CC1C(N1CC1)=O Chemical compound CC1C(c2c(C)c(COc3c([CH2+])cc(CN(CCCC4)[C@@H]4C(O)=O)c(OCc4cncc(C#N)c4)c3)ccc2)=CC=CC1C(N1CC1)=O SWMMFWHIFSOBBC-YPLJIXMFSA-O 0.000 description 1
- RJMNAMGXLRMTME-UHFFFAOYSA-N CC1CNC(CO)C1 Chemical compound CC1CNC(CO)C1 RJMNAMGXLRMTME-UHFFFAOYSA-N 0.000 description 1
- VMYFBFHPTFQLEY-LHEWISCISA-N CCN(CC)C(c1c(C)c(-c2c(C)c(COc(cc(c(CN(CCN(C3)C(OC(C)(C)C)=O)[C@@H]3C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)ccc2)ccc1)=O Chemical compound CCN(CC)C(c1c(C)c(-c2c(C)c(COc(cc(c(CN(CCN(C3)C(OC(C)(C)C)=O)[C@@H]3C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)ccc2)ccc1)=O VMYFBFHPTFQLEY-LHEWISCISA-N 0.000 description 1
- XCWSTEKZHSLQLH-BHVANESWSA-N CCN(CC)C(c1c(C)c(-c2cccc(COc(cc(c(CN(CCCC3)[C@@H]3C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)c2C)ccc1)=O Chemical compound CCN(CC)C(c1c(C)c(-c2cccc(COc(cc(c(CN(CCCC3)[C@@H]3C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)c2C)ccc1)=O XCWSTEKZHSLQLH-BHVANESWSA-N 0.000 description 1
- LLVGWGHWKNFVRV-XIFFEERXSA-N CCNC(c1c(C)c(-c2c(C)c(COc3cc(OCc4cc(F)cc(F)c4)c(CN(CCOC4)[C@@H]4C(O)=O)cc3Cl)ccc2)ccc1)=O Chemical compound CCNC(c1c(C)c(-c2c(C)c(COc3cc(OCc4cc(F)cc(F)c4)c(CN(CCOC4)[C@@H]4C(O)=O)cc3Cl)ccc2)ccc1)=O LLVGWGHWKNFVRV-XIFFEERXSA-N 0.000 description 1
- UBDWYAUYPGQEAZ-UHFFFAOYSA-N CCOC(C(CO)(CC1)CN1C(OCc1ccccc1)=O)=O Chemical compound CCOC(C(CO)(CC1)CN1C(OCc1ccccc1)=O)=O UBDWYAUYPGQEAZ-UHFFFAOYSA-N 0.000 description 1
- YTEYWCKFIAXKQD-JNLXENSWSA-N CCOC(C1(CO)CN(CCCOc(cccc2-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CN(CCCC5)[C@@H]5C(O)=O)cc4Cl)c3C)c2Cl)CC1)=O Chemical compound CCOC(C1(CO)CN(CCCOc(cccc2-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(CN(CCCC5)[C@@H]5C(O)=O)cc4Cl)c3C)c2Cl)CC1)=O YTEYWCKFIAXKQD-JNLXENSWSA-N 0.000 description 1
- DIDCEGQNCOWHOW-OKAAYDHYSA-N C[C@@](CN(CCCOc(cccc1-c2cccc(COc(cc(c(CN[C@H](CO)C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)c2C)c1Cl)CC1)([C@@]1(c(cc1)ccc1Cl)O)O Chemical compound C[C@@](CN(CCCOc(cccc1-c2cccc(COc(cc(c(CN[C@H](CO)C(O)=O)c3)OCc4cncc(C#N)c4)c3Cl)c2C)c1Cl)CC1)([C@@]1(c(cc1)ccc1Cl)O)O DIDCEGQNCOWHOW-OKAAYDHYSA-N 0.000 description 1
- OHSFCUCCGNEUOK-ANPIQPAYSA-N C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCCN(CC3)C[C@H]3NC(C)=O)c2Cl)ccc1 Chemical compound C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c(cccc2OCCCN(CC3)C[C@H]3NC(C)=O)c2Cl)ccc1 OHSFCUCCGNEUOK-ANPIQPAYSA-N 0.000 description 1
- HQGSGMHVOSDMSB-GKDFLWOBSA-N C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1cc(C)cc(-c2c(C)c(OCCCN(CC3)C[C@@H]3O)ccc2)c1C Chemical compound C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1cc(C)cc(-c2c(C)c(OCCCN(CC3)C[C@@H]3O)ccc2)c1C HQGSGMHVOSDMSB-GKDFLWOBSA-N 0.000 description 1
- JAWZUCMMIQVANC-SBEKKQRLSA-N C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(S(C)(=O)=O)c1)c1)cc(Cl)c1OCc1c(C)c(-c2c(C)c(OCCCN(CC3)C[C@@H]3C(OC)=O)ccc2)ccc1 Chemical compound C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(S(C)(=O)=O)c1)c1)cc(Cl)c1OCc1c(C)c(-c2c(C)c(OCCCN(CC3)C[C@@H]3C(OC)=O)ccc2)ccc1 JAWZUCMMIQVANC-SBEKKQRLSA-N 0.000 description 1
- DGGDUZINIVKRGL-SNMXCBOWSA-N C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(S=O)c1)c1)cc(Cl)c1OCc1c(C)c(-c2cccc(OCCCN(CC3C(OC)=O)CC3O)c2C)ccc1 Chemical compound C[C@@](CO)(C(O)=O)NCc(c(OCc1cncc(S=O)c1)c1)cc(Cl)c1OCc1c(C)c(-c2cccc(OCCCN(CC3C(OC)=O)CC3O)c2C)ccc1 DGGDUZINIVKRGL-SNMXCBOWSA-N 0.000 description 1
- PTKBQCDRKDMJPS-KSXAPKRDSA-N C[C@@](CO)(C(O)=O)NCc(cc(c(OCc(cccc1-c(cccc2OCCCN(CC3)C[C@H]3NC(C)=O)c2Cl)c1Cl)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound C[C@@](CO)(C(O)=O)NCc(cc(c(OCc(cccc1-c(cccc2OCCCN(CC3)C[C@H]3NC(C)=O)c2Cl)c1Cl)c1)Cl)c1OCc1cncc(C#N)c1 PTKBQCDRKDMJPS-KSXAPKRDSA-N 0.000 description 1
- OHSFCUCCGNEUOK-XKRCVHPFSA-N C[C@@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2cccc(OCCCN(CC3)CC3NC(C)=O)c2Cl)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound C[C@@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2cccc(OCCCN(CC3)CC3NC(C)=O)c2Cl)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 OHSFCUCCGNEUOK-XKRCVHPFSA-N 0.000 description 1
- CXQAPBSXDKKHQC-JOCIVYRRSA-N C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4OC)ccc3)ccc2)CCCC1 Chemical compound C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4OC)ccc3)ccc2)CCCC1 CXQAPBSXDKKHQC-JOCIVYRRSA-N 0.000 description 1
- RXJNHOMCPYNPMC-AYAMJOBCSA-N C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3c(C)c(OCCCNC[C@@H](C(O)=O)O)ccc3)ccc2)CCCC1 Chemical compound C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3c(C)c(OCCCNC[C@@H](C(O)=O)O)ccc3)ccc2)CCCC1 RXJNHOMCPYNPMC-AYAMJOBCSA-N 0.000 description 1
- UYSWXQWBXIIPFG-SSEXGKCCSA-N C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN(CC4)CCC4C(O)=O)c3C)ccc2)CCCC1 Chemical compound C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN(CC4)CCC4C(O)=O)c3C)ccc2)CCCC1 UYSWXQWBXIIPFG-SSEXGKCCSA-N 0.000 description 1
- MJHPITHFMKZDHE-UUWRZZSWSA-N C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN(CC4)CCC4N(C)C(OC(C)(C)C)=O)c3C)ccc2)CCCC1 Chemical compound C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN(CC4)CCC4N(C)C(OC(C)(C)C)=O)c3C)ccc2)CCCC1 MJHPITHFMKZDHE-UUWRZZSWSA-N 0.000 description 1
- NEPDDNGSRDGMER-WXHLIJILSA-N C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN4CC(CO)CCC4)c3C)ccc2)CCCC1 Chemical compound C[C@H]1N(Cc(c(OCc2cncc(C#N)c2)c2)cc(Cl)c2OCc2c(C)c(-c3cccc(OCCCN4CC(CO)CCC4)c3C)ccc2)CCCC1 NEPDDNGSRDGMER-WXHLIJILSA-N 0.000 description 1
- VKGNYSDJIGBDRW-MUUNZHRXSA-N C[C@H]1N(Cc(cc(c(OCc2c(C)c(-c3c(C)c(OCCCN(C)C)ccc3)ccc2)c2)Cl)c2OCc2cncc(C#N)c2)CCCC1 Chemical compound C[C@H]1N(Cc(cc(c(OCc2c(C)c(-c3c(C)c(OCCCN(C)C)ccc3)ccc2)c2)Cl)c2OCc2cncc(C#N)c2)CCCC1 VKGNYSDJIGBDRW-MUUNZHRXSA-N 0.000 description 1
- KMDYWBWWWVFYGG-RWYGWLOXSA-N C[C@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c2cccc(CN(C)CCN(CC3)CCS3(=O)=O)c2C)ccc1 Chemical compound C[C@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1c(C)c(-c2cccc(CN(C)CCN(CC3)CCS3(=O)=O)c2C)ccc1 KMDYWBWWWVFYGG-RWYGWLOXSA-N 0.000 description 1
- KKRHVVMJVOECAF-JKHGEEAXSA-N C[C@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1cccc(-c2cccc(OCCCN(CC3)CC3O)c2Cl)c1C Chemical compound C[C@](CO)(C(O)=O)NCc(c(OCc1cncc(C#N)c1)c1)cc(Cl)c1OCc1cccc(-c2cccc(OCCCN(CC3)CC3O)c2Cl)c1C KKRHVVMJVOECAF-JKHGEEAXSA-N 0.000 description 1
- WMCGJOJACFZYQO-KDXMTYKHSA-N C[C@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2c(C(F)(F)F)c(OCCCN3CCCC3)ccc2)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound C[C@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2c(C(F)(F)F)c(OCCCN3CCCC3)ccc2)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 WMCGJOJACFZYQO-KDXMTYKHSA-N 0.000 description 1
- AZEWYFDMIPUZNS-FADDAYQUSA-N C[C@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2cc(OCCC(N(CC3)C[C@@H]3O)=O)ccc2)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 Chemical compound C[C@](CO)(C(O)=O)NCc(cc(c(OCc1c(C)c(-c2cc(OCCC(N(CC3)C[C@@H]3O)=O)ccc2)ccc1)c1)Cl)c1OCc1cncc(C#N)c1 AZEWYFDMIPUZNS-FADDAYQUSA-N 0.000 description 1
- MYBLIFOJNJJVAR-UUWRZZSWSA-N Cc(c(COCCN(CC1)C[C@@H]1O)ccc1)c1-c1c(C)c(COc(cc(c(CN(C)C2(CC2)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)ccc1 Chemical compound Cc(c(COCCN(CC1)C[C@@H]1O)ccc1)c1-c1c(C)c(COc(cc(c(CN(C)C2(CC2)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)ccc1 MYBLIFOJNJJVAR-UUWRZZSWSA-N 0.000 description 1
- QOKGRGHRTNSGQJ-GOJCVTOHSA-N Cc(c(COCCN(CC1)C[C@@H]1O)ccc1)c1-c1cccc(COc2cc(OCc3cncc(C#N)c3)c(CN(C)[C@@H](CO)C(O)=O)cc2Cl)c1C Chemical compound Cc(c(COCCN(CC1)C[C@@H]1O)ccc1)c1-c1cccc(COc2cc(OCc3cncc(C#N)c3)c(CN(C)[C@@H](CO)C(O)=O)cc2Cl)c1C QOKGRGHRTNSGQJ-GOJCVTOHSA-N 0.000 description 1
- IZAAXZLPHIJCHH-MUUNZHRXSA-N Cc(c(COc(cc(c(C=O)c1)OCc2cncc(C#N)c2)c1Cl)ccc1)c1-c1cccc(OCCCN(CC2)C[C@@H]2O)c1Cl Chemical compound Cc(c(COc(cc(c(C=O)c1)OCc2cncc(C#N)c2)c1Cl)ccc1)c1-c1cccc(OCCCN(CC2)C[C@@H]2O)c1Cl IZAAXZLPHIJCHH-MUUNZHRXSA-N 0.000 description 1
- WYOWRTPYCQKBNO-UHFFFAOYSA-N Cc(c(COc1cc(OCc2cncc(C#N)c2)c(C=O)cc1Cl)ccc1)c1-c1cccc(OCCCN(CC2)CC2(c2ccccc2)O)c1C Chemical compound Cc(c(COc1cc(OCc2cncc(C#N)c2)c(C=O)cc1Cl)ccc1)c1-c1cccc(OCCCN(CC2)CC2(c2ccccc2)O)c1C WYOWRTPYCQKBNO-UHFFFAOYSA-N 0.000 description 1
- HORVKAADDRNNOD-UHFFFAOYSA-N Cc(c(OCCCBr)ccc1)c1-c1c(C)c(OCc(cc(c(CN(C)C)c2)O)c2Cl)ccc1 Chemical compound Cc(c(OCCCBr)ccc1)c1-c1c(C)c(OCc(cc(c(CN(C)C)c2)O)c2Cl)ccc1 HORVKAADDRNNOD-UHFFFAOYSA-N 0.000 description 1
- AWDIPFSMQIOMLK-ZCJYOONXSA-N Cc(c(OCCCN(CC1)C[C@@H]1O)ccc1)c1-c1cccc(COc(cc(c(CNC(CO)CO)c2)OCC(C3)C3(F)F)c2Cl)c1Cl Chemical compound Cc(c(OCCCN(CC1)C[C@@H]1O)ccc1)c1-c1cccc(COc(cc(c(CNC(CO)CO)c2)OCC(C3)C3(F)F)c2Cl)c1Cl AWDIPFSMQIOMLK-ZCJYOONXSA-N 0.000 description 1
- AKLHLLZFGLLUTG-RRTCDKLQSA-N Cc(cc(cc1)OCCCN(CC2)C[C@@H]2O)c1-c1cccc(COc(cc(c(CN[C@H](CO)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)c1C Chemical compound Cc(cc(cc1)OCCCN(CC2)C[C@@H]2O)c1-c1cccc(COc(cc(c(CN[C@H](CO)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)c1C AKLHLLZFGLLUTG-RRTCDKLQSA-N 0.000 description 1
- PCMVDQOACUQATO-UHFFFAOYSA-N Cc(cc1O)c(C=O)cc1Cl Chemical compound Cc(cc1O)c(C=O)cc1Cl PCMVDQOACUQATO-UHFFFAOYSA-N 0.000 description 1
- VGVOFWQSWIWNHO-RLTPKNJTSA-N Cc1c(/C=C/c(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OC)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(/C=C/c(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OC)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 VGVOFWQSWIWNHO-RLTPKNJTSA-N 0.000 description 1
- ABKKPZNXJOUQBW-PGUFJCEWSA-N Cc1c(C)cc(COc(cc2OCc3c(C)c(-c4c(C)c(OCCCN(CC5)C[C@@H]5O)ccc4)ccc3)c(CNC(CO)CO)cc2Cl)cc1 Chemical compound Cc1c(C)cc(COc(cc2OCc3c(C)c(-c4c(C)c(OCCCN(CC5)C[C@@H]5O)ccc4)ccc3)c(CNC(CO)CO)cc2Cl)cc1 ABKKPZNXJOUQBW-PGUFJCEWSA-N 0.000 description 1
- ZNCITVQPORVBDP-UHFFFAOYSA-N Cc1c(C=O)ccc(O)c1Cl Chemical compound Cc1c(C=O)ccc(O)c1Cl ZNCITVQPORVBDP-UHFFFAOYSA-N 0.000 description 1
- QUQRMTXBSVPTBT-UHFFFAOYSA-N Cc1c(COc(cc(c(C=O)c2)OC)c2Cl)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 Chemical compound Cc1c(COc(cc(c(C=O)c2)OC)c2Cl)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 QUQRMTXBSVPTBT-UHFFFAOYSA-N 0.000 description 1
- NXQZILGBEJQADR-UHFFFAOYSA-N Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCC(CO)(CO)CO)c1Cl Chemical compound Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCC(CO)(CO)CO)c1Cl NXQZILGBEJQADR-UHFFFAOYSA-N 0.000 description 1
- GFNMOJVZROEXTA-UHFFFAOYSA-N Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCCl)c1C#N Chemical compound Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCCl)c1C#N GFNMOJVZROEXTA-UHFFFAOYSA-N 0.000 description 1
- UKKYQVIMPNTOHH-SSEXGKCCSA-N Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 UKKYQVIMPNTOHH-SSEXGKCCSA-N 0.000 description 1
- OPEIFQMAQXCNRW-SSEXGKCCSA-N Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc(cc(c(C=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 OPEIFQMAQXCNRW-SSEXGKCCSA-N 0.000 description 1
- OUPXCZQGQKQGQF-LHEWISCISA-N Cc1c(COc(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2C(NC)=O)c1Cl Chemical compound Cc1c(COc(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2C(NC)=O)c1Cl OUPXCZQGQKQGQF-LHEWISCISA-N 0.000 description 1
- MHDBRHSOPJCBAE-OCZFFWILSA-N Cc1c(COc(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OCc3cncc(S=O)c3)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@H]2O)ccc1 Chemical compound Cc1c(COc(cc(c(CN(CCCC2)[C@@H]2C(O)=O)c2)OCc3cncc(S=O)c3)c2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@H]2O)ccc1 MHDBRHSOPJCBAE-OCZFFWILSA-N 0.000 description 1
- FCWDSPWVPNDLEP-HKBQPEDESA-N Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCN(C)C[C@@H](CO)O)c1Cl Chemical compound Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCN(C)C[C@@H](CO)O)c1Cl FCWDSPWVPNDLEP-HKBQPEDESA-N 0.000 description 1
- HSFHWMKLOIHPGW-PMERELPUSA-N Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCNC[C@@H](CO)O)c1Cl Chemical compound Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCNC[C@@H](CO)O)c1Cl HSFHWMKLOIHPGW-PMERELPUSA-N 0.000 description 1
- NADAUFDJCVQDPI-PMERELPUSA-N Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1c(C)c(OCCCN2C[C@@H](CO)CCC2)ccc1 Chemical compound Cc1c(COc(cc(c(CNC(CO)CO)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c1c(C)c(OCCCN2C[C@@H](CO)CCC2)ccc1 NADAUFDJCVQDPI-PMERELPUSA-N 0.000 description 1
- ZCQYXPDVEZOWMR-UHFFFAOYSA-N Cc1c(COc(cc(c(CNC2(CO)CC2)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCBr)c1Cl Chemical compound Cc1c(COc(cc(c(CNC2(CO)CC2)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCBr)c1Cl ZCQYXPDVEZOWMR-UHFFFAOYSA-N 0.000 description 1
- MQPLTVCNSLIFBY-CONSDPRKSA-N Cc1c(COc(cc(c(CNC[C@@H](CO)O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCN(C)C[C@@H](CO)O)c1Cl Chemical compound Cc1c(COc(cc(c(CNC[C@@H](CO)O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cccc1OCCCN(C)C[C@@H](CO)O)c1Cl MQPLTVCNSLIFBY-CONSDPRKSA-N 0.000 description 1
- JTKYBETXFUXQQZ-GHJZRCEGSA-N Cc1c(COc(cc(c(CN[C@H](C2)C2(CO)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cc1)c(C)c2c1OCCO2 Chemical compound Cc1c(COc(cc(c(CN[C@H](C2)C2(CO)C(O)=O)c2)OCc3cncc(C#N)c3)c2Cl)cccc1-c(cc1)c(C)c2c1OCCO2 JTKYBETXFUXQQZ-GHJZRCEGSA-N 0.000 description 1
- NOBIDEYNKLFIEC-VZWFPNHASA-N Cc1c(COc2cc(OCc(cc3F)ccc3F)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc(cc3F)ccc3F)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 NOBIDEYNKLFIEC-VZWFPNHASA-N 0.000 description 1
- FUJNDVCQCTXMFF-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(C=O)cc2Cl)cccc1-c(cccc1OCC(CO)CO)c1Cl Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(C=O)cc2Cl)cccc1-c(cccc1OCC(CO)CO)c1Cl FUJNDVCQCTXMFF-UHFFFAOYSA-N 0.000 description 1
- HMOKQALWQNKKPR-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(C)C(CO)CO)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)CC2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(C)C(CO)CO)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)CC2O)ccc1 HMOKQALWQNKKPR-UHFFFAOYSA-N 0.000 description 1
- ZJTHXQDMTZWJLK-RIEGYYRVSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCC2(CN(CC3)C[C@@H]3O)CC2)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCC2(CN(CC3)C[C@@H]3O)CC2)ccc1 ZJTHXQDMTZWJLK-RIEGYYRVSA-N 0.000 description 1
- WRFHSRZKYYBXRR-BYYXFNHRSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 WRFHSRZKYYBXRR-BYYXFNHRSA-N 0.000 description 1
- ILJRCYPUUHCMFB-AUZZNGNRSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CC2(CO)C(O)=O)c1Cl Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CC2(CO)C(O)=O)c1Cl ILJRCYPUUHCMFB-AUZZNGNRSA-N 0.000 description 1
- KXDXZSWBCDBUQV-HMIRPBQQSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CCC2)C[C@H]2O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CCC2)C[C@H]2O)c1 KXDXZSWBCDBUQV-HMIRPBQQSA-N 0.000 description 1
- BRSVYIOXUZFYEL-QNGWXLTQSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2O)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2O)cccc1-c1c(C)c(OCCCN2CCCC2)ccc1 BRSVYIOXUZFYEL-QNGWXLTQSA-N 0.000 description 1
- NRIVRUNOOXECMJ-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CNC(CO)CO)cc2Cl)cccc1-c1cccc(NC(c2ncccc2CO)=O)c1C Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CNC(CO)CO)cc2Cl)cccc1-c1cccc(NC(c2ncccc2CO)=O)c1C NRIVRUNOOXECMJ-UHFFFAOYSA-N 0.000 description 1
- QVTPURFKWDNZNE-RYCFQHDISA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cc(OCC(N(CC2)C[C@H]2O)=O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cc(OCC(N(CC2)C[C@H]2O)=O)ccc1 QVTPURFKWDNZNE-RYCFQHDISA-N 0.000 description 1
- BSIUOHOAFJTSTG-PSXMRANNSA-N Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(OC)=O)O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(OC)=O)O)c1 BSIUOHOAFJTSTG-PSXMRANNSA-N 0.000 description 1
- DVYMCZNVDMGVOJ-UUWRZZSWSA-N Cc1c(COc2cc(OCc3cncc(C(N)=O)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(O)=O)O)c1 Chemical compound Cc1c(COc2cc(OCc3cncc(C(N)=O)c3)c(CN[C@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCN(CC2)CCC2(C(O)=O)O)c1 DVYMCZNVDMGVOJ-UUWRZZSWSA-N 0.000 description 1
- MMTNPBFKACADCT-UHFFFAOYSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(C=O)cc2Cl)cccc1-c1cc(OCCCCl)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(C=O)cc2Cl)cccc1-c1cc(OCCCCl)ccc1 MMTNPBFKACADCT-UHFFFAOYSA-N 0.000 description 1
- ZMKOTIDIZAPPQD-XLWWBGEVSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1c(C)c(OCCCN(CC2)C[C@@H]2O)ccc1 ZMKOTIDIZAPPQD-XLWWBGEVSA-N 0.000 description 1
- MAOFSUQNDQHIJV-XLWWBGEVSA-N Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 Chemical compound Cc1c(COc2cc(OCc3cncc(S(C)(=O)=O)c3)c(CN(CCCC3)[C@@H]3C(O)=O)cc2Cl)cccc1-c1cc(OCCCN(CC2)C[C@@H]2O)ccc1 MAOFSUQNDQHIJV-XLWWBGEVSA-N 0.000 description 1
- PRNFTNDZZIUYDW-UHFFFAOYSA-N Cc1cc(Br)c(C)c(COc2cc(O)c(C=O)cc2Cl)c1 Chemical compound Cc1cc(Br)c(C)c(COc2cc(O)c(C=O)cc2Cl)c1 PRNFTNDZZIUYDW-UHFFFAOYSA-N 0.000 description 1
- CIVYPGRFVKVBAR-PGUFJCEWSA-N Cc1ccc(COc(c(CNC(CO)(CO)CO)c2)cc(OCc3cccc(-c4cccc(OCCCN(CC5)C[C@@H]5O)c4C)c3C)c2Cl)cc1C Chemical compound Cc1ccc(COc(c(CNC(CO)(CO)CO)c2)cc(OCc3cccc(-c4cccc(OCCCN(CC5)C[C@@H]5O)c4C)c3C)c2Cl)cc1C CIVYPGRFVKVBAR-PGUFJCEWSA-N 0.000 description 1
- FBSWLFXZDATTHB-UUWRZZSWSA-N Cc1cccc(C)c1COc(cc1OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4O)ccc3)ccc2)c(CNC(CO)(CO)CO)cc1Cl Chemical compound Cc1cccc(C)c1COc(cc1OCc2c(C)c(-c3c(C)c(OCCCN(CC4)C[C@@H]4O)ccc3)ccc2)c(CNC(CO)(CO)CO)cc1Cl FBSWLFXZDATTHB-UUWRZZSWSA-N 0.000 description 1
- RIFQKLPIDWXDME-IWWXRALLSA-N N=C(c1cc(COc(c(CNC[C@@H](CO)O)c2)cc(OCc(cccc3-c4cccc(OCCCN(CC5)C[C@@H]5O)c4Cl)c3Cl)c2Cl)cnc1)N(CC1)C[C@@H]1O Chemical compound N=C(c1cc(COc(c(CNC[C@@H](CO)O)c2)cc(OCc(cccc3-c4cccc(OCCCN(CC5)C[C@@H]5O)c4Cl)c3Cl)c2Cl)cnc1)N(CC1)C[C@@H]1O RIFQKLPIDWXDME-IWWXRALLSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N N[C@@H](CO)C(O)=O Chemical compound N[C@@H](CO)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562242072P | 2015-10-15 | 2015-10-15 | |
| US62/242,072 | 2015-10-15 | ||
| US15/290,167 US10745382B2 (en) | 2015-10-15 | 2016-10-11 | Compounds useful as immunomodulators |
| US15/290,167 | 2016-10-11 | ||
| PCT/US2016/056504 WO2017066227A1 (en) | 2015-10-15 | 2016-10-12 | Compounds useful as immunomodulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534282A JP2018534282A (ja) | 2018-11-22 |
| JP2018534282A5 JP2018534282A5 (https=) | 2019-11-14 |
| JP6916783B2 true JP6916783B2 (ja) | 2021-08-11 |
Family
ID=57219000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519301A Active JP6916783B2 (ja) | 2015-10-15 | 2016-10-12 | 免疫調節剤として有用な化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10745382B2 (https=) |
| EP (1) | EP3362443B1 (https=) |
| JP (1) | JP6916783B2 (https=) |
| KR (1) | KR102740320B1 (https=) |
| CN (1) | CN108368090B (https=) |
| AU (1) | AU2016338874A1 (https=) |
| BR (1) | BR112018007381A2 (https=) |
| CA (1) | CA3002008A1 (https=) |
| CL (1) | CL2018000952A1 (https=) |
| CO (1) | CO2018004964A2 (https=) |
| EA (1) | EA201890857A1 (https=) |
| ES (1) | ES2892550T3 (https=) |
| IL (1) | IL258607A (https=) |
| MA (1) | MA42990A (https=) |
| MX (1) | MX2018004347A (https=) |
| PE (1) | PE20181045A1 (https=) |
| TW (1) | TW201726606A (https=) |
| UY (1) | UY36950A (https=) |
| WO (1) | WO2017066227A1 (https=) |
| ZA (1) | ZA201802450B (https=) |
Families Citing this family (155)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6417419B2 (ja) | 2013-09-04 | 2018-11-07 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫調節剤として有用な化合物 |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| WO2018005374A1 (en) | 2016-06-27 | 2018-01-04 | Chemocentryx, Inc. | Immunomodulator compounds |
| US11078192B2 (en) | 2016-07-05 | 2021-08-03 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
| CN109689640B (zh) * | 2016-07-08 | 2022-01-04 | 百时美施贵宝公司 | 可用作免疫调节剂的化合物 |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US10144706B2 (en) * | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| IL265921B2 (en) | 2016-10-14 | 2024-05-01 | Prec Biosciences Inc | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
| JP7106572B2 (ja) | 2016-12-20 | 2022-07-26 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な化合物 |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| EP3558990B1 (en) | 2016-12-22 | 2022-08-10 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
| WO2018124766A2 (ko) | 2016-12-28 | 2018-07-05 | 주식회사 녹십자랩셀 | 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포 |
| EP3564237A4 (en) * | 2016-12-29 | 2020-06-10 | Shenzhen Chipscreen Biosciences Co., Ltd. | UREA COMPOUND AND PRODUCTION METHOD AND USE THEREOF |
| KR20190133714A (ko) | 2017-03-27 | 2019-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제로서 유용한 치환된 이소퀴놀린 유도체 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
| WO2019008156A1 (en) * | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
| AU2018306619B2 (en) * | 2017-07-28 | 2022-06-02 | Chemocentryx, Inc. | Immunomodulator compounds |
| CN111225665B (zh) | 2017-08-08 | 2023-12-08 | 凯莫森特里克斯股份有限公司 | 大环免疫调节剂 |
| CN109678796B (zh) * | 2017-10-19 | 2023-01-10 | 上海长森药业有限公司 | Pd-1/pd-l1小分子抑制剂及其制备方法和用途 |
| US12116417B2 (en) | 2017-11-14 | 2024-10-15 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| KR102162283B1 (ko) * | 2017-11-28 | 2020-10-06 | 충남대학교 산학협력단 | Golga2 유전자 넉아웃 간 섬유화 마우스 모델 |
| KR102162289B1 (ko) * | 2017-11-28 | 2020-10-06 | 충남대학교 산학협력단 | Golga2 유전자 넉아웃 폐 섬유화 마우스 모델 |
| US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| WO2019120297A1 (zh) * | 2017-12-22 | 2019-06-27 | 上海海雁医药科技有限公司 | 免疫调节剂及其制法与医药上的用途 |
| KR102666727B1 (ko) | 2017-12-29 | 2024-05-21 | 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. | 방향족 비닐 또는 방향족 에틸계 유도체, 그의 제조방법, 중간체, 약물조성물 및 용도 |
| JP7214752B2 (ja) * | 2018-01-23 | 2023-01-30 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤として有用な2,8-ジアシル-2,8-ジアザスピロ[5.5]ウンデカン化合物 |
| CN110092779B (zh) * | 2018-01-29 | 2022-07-12 | 广州丹康医药生物有限公司 | 一种取代的苯基化合物及其应用 |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| JP7387616B2 (ja) | 2018-02-22 | 2023-11-28 | ケモセントリックス,インコーポレイティド | Pd-l1アンタゴニストとしてのインダン-アミン |
| PL3759109T3 (pl) | 2018-02-26 | 2024-03-04 | Gilead Sciences, Inc. | Podstawione związki pirolizyny jako inhibitory replikacji hbv |
| EP3759093B1 (en) | 2018-03-01 | 2022-11-30 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2019174533A1 (zh) * | 2018-03-13 | 2019-09-19 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| WO2019217821A1 (en) | 2018-05-11 | 2019-11-14 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
| EP3810109B1 (en) | 2018-05-31 | 2024-08-07 | Peloton Therapeutics, Inc. | Compounds and compositions for inhibiting cd73 |
| TW202015732A (zh) | 2018-05-31 | 2020-05-01 | 日商小野藥品工業股份有限公司 | 免疫檢查點阻礙藥的有效性判定用生物標記 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
| CN110872275A (zh) * | 2018-08-31 | 2020-03-10 | 深圳微芯生物科技股份有限公司 | 作为免疫调节剂的联苯化合物及其用途 |
| TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| TW202136261A (zh) | 2018-10-31 | 2021-10-01 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
| TWI721623B (zh) | 2018-10-31 | 2021-03-11 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
| KR20210089195A (ko) | 2018-11-02 | 2021-07-15 | 상하이 맥시노벨 파마수티컬스 씨오., 엘티디. | 비페닐계 화합물, 이의 중간체, 제조 방법, 약학 조성물 및 용도 |
| CN109438263A (zh) * | 2018-11-28 | 2019-03-08 | 南方医科大学 | 一种含取代联苯的萘及其应用 |
| EP3935066A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| KR102707808B1 (ko) | 2019-03-07 | 2024-09-19 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 2'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭 |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| CN113891748A (zh) | 2019-03-28 | 2022-01-04 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| KR20210146348A (ko) | 2019-03-28 | 2021-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| CN111747927B (zh) * | 2019-03-29 | 2023-08-18 | 广州丹康医药生物有限公司 | 作为免疫调节剂的化合物及其应用 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| BR112021022536A2 (pt) * | 2019-05-10 | 2021-12-28 | Shanghai Haiyan Pharmaceutical Tech Co Ltd | Derivado de fenilpropenilpiridina substituída e método de preparação do mesmo e uso médico do mesmo |
| AU2020276277B2 (en) | 2019-05-15 | 2025-03-20 | Chemocentryx, Inc. | Triaryl compounds for treatment of PD-L1 diseases |
| CN111978287A (zh) * | 2019-05-23 | 2020-11-24 | 中国科学院上海有机化学研究所 | 一类免疫检查点小分子抑制剂及其制备方法和用途 |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| JP2022534967A (ja) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 多腫瘍遺伝子シグネチャーおよびその使用 |
| KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
| WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
| CN111808086B (zh) * | 2019-06-17 | 2021-12-14 | 上海海雁医药科技有限公司 | 杂环取代的苯乙烯基-4-苯基吡啶衍生物及其制法与医药上的用途 |
| SG11202112875UA (en) | 2019-06-20 | 2021-12-30 | Chemocentryx Inc | Compounds for treatment of pd-l1 diseases |
| BR112021025888A2 (pt) | 2019-07-10 | 2022-04-26 | Chemocentryx Inc | Indanos como inibidores de pd-l1 |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| PH12022550244A1 (en) | 2019-08-05 | 2022-12-12 | Nat Cancer Ct | Biomarkers for determining the efficacy of immune checkpoint inhibitors |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| CA3153777A1 (en) | 2019-09-22 | 2021-03-25 | Bristol-Myers Squibb Company | Quantitative spatial profiling for lag-3 antagonist therapy |
| CN112574183B (zh) * | 2019-09-29 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种pd-1抑制剂及其制备方法和用途 |
| CN119770638A (zh) | 2019-09-30 | 2025-04-08 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| KR20220079893A (ko) * | 2019-10-04 | 2022-06-14 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제로서 유용한 화합물 |
| CN114555080B (zh) | 2019-10-16 | 2025-10-10 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的杂芳基联苯胺 |
| AU2020368393B2 (en) | 2019-10-16 | 2026-01-08 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases |
| BR112022008191A2 (pt) | 2019-11-08 | 2022-07-12 | Bristol Myers Squibb Co | Terapia com antagonista de lag-3 para melanoma |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| US12410418B2 (en) | 2019-12-06 | 2025-09-09 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| CA3163389A1 (en) | 2020-01-03 | 2021-07-08 | Mi ZENG | Biphenyl derivative inhibitor, preparation method therefor and use thereof |
| CN111187172B (zh) * | 2020-01-20 | 2021-10-29 | 中国药科大学 | 硝基苯醚类化合物、其制备方法和药物组合物与用途 |
| CN111205196B (zh) * | 2020-03-04 | 2021-04-02 | 中国科学院昆明植物研究所 | 一种苯酚类ab环结构化合物及其制备方法和应用 |
| US11718637B2 (en) | 2020-03-20 | 2023-08-08 | Gilead Sciences, Inc. | Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same |
| CN111320606B (zh) * | 2020-04-10 | 2021-07-27 | 安徽实特医药科技有限公司 | 苯联吡唑并环类衍生物及其在抗肿瘤药物中的应用 |
| EP4134134A4 (en) | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONISTIC COMPOUND |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN111559981B (zh) * | 2020-04-15 | 2023-08-01 | 杭州庆正鸿科技有限公司 | 一种联苯-嘧啶偶联物及其制备方法和应用 |
| BR112022022335A2 (pt) | 2020-05-05 | 2023-01-10 | Teon Therapeutics Inc | Moduladores de receptor canabinoide tipo 2 (cb2) e usos dos mesmos |
| CN114075123B (zh) | 2020-08-11 | 2023-06-06 | 中国人民解放军军事科学院军事医学研究院 | 苄胺类衍生物及其制备方法与用途 |
| BR112023003427A2 (pt) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia com antagonista de lag-3 para carcinoma hepatocelular |
| AU2021334361A1 (en) | 2020-08-31 | 2023-05-11 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| TW202214568A (zh) * | 2020-09-09 | 2022-04-16 | 大陸商廣州再極醫藥科技有限公司 | 芳香乙烯類化合物、其製備方法、中間體、藥物組合物及其應用 |
| CN114276328B (zh) * | 2020-09-28 | 2023-09-01 | 北京康辰药业股份有限公司 | 作为小分子免疫抑制剂的化合物、其制备方法及其应用 |
| WO2022087402A1 (en) | 2020-10-23 | 2022-04-28 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| CN112834643B (zh) * | 2020-12-31 | 2022-03-18 | 郑州原理生物科技有限公司 | 测定2,6-二羟基-4-甲基吡啶及2,6-二羟基-3-氰基-4-甲基吡啶的方法 |
| CN116981660A (zh) * | 2021-03-22 | 2023-10-31 | 南京明德新药研发有限公司 | 氟代乙烯基联苯衍生物及其应用 |
| US20240181052A1 (en) | 2021-03-29 | 2024-06-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
| CN113135895A (zh) * | 2021-04-30 | 2021-07-20 | 中国药科大学 | 一种新型联苯类衍生物及其制备方法与医药用途 |
| US20240327389A1 (en) * | 2021-05-05 | 2024-10-03 | Bristol-Myers Squibb Company | Lactone and lactam containing compounds useful as immunomodulators |
| EP4337223A1 (en) | 2021-05-13 | 2024-03-20 | Gilead Sciences, Inc. | Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics |
| JP7673255B2 (ja) | 2021-06-11 | 2025-05-08 | ギリアード サイエンシーズ, インコーポレイテッド | Mcl-1阻害剤と抗体薬物コンジュゲートとの組み合わせ |
| TWI910028B (zh) | 2021-06-11 | 2025-12-21 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗癌劑之組合 |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| WO2023034530A1 (en) | 2021-09-02 | 2023-03-09 | Teon Therapeutics, Inc. | Methods of improving growth and function of immune cells |
| KR20240099362A (ko) | 2021-10-29 | 2024-06-28 | 브리스톨-마이어스 스큅 컴퍼니 | 혈액암에 대한 lag-3 길항제 요법 |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| CN114085184B (zh) * | 2021-11-17 | 2023-08-29 | 中山大学 | 含环丙烷结构的联苯类衍生物及其制备方法和应用 |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| CN114181144B (zh) * | 2021-12-06 | 2023-04-04 | 浙江工业大学 | 一种氟代联苯甲基间苯二酚醚类衍生物、其制备方法和应用 |
| WO2023104744A1 (en) | 2021-12-06 | 2023-06-15 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
| CA3249004A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Polytherapy for Hepatocellular Carcinoma |
| US20230326022A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures |
| EP4554943A1 (en) | 2022-07-14 | 2025-05-21 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| WO2024043227A1 (ja) | 2022-08-23 | 2024-02-29 | 小野薬品工業株式会社 | 二重特異性抗体 |
| CN115368277B (zh) * | 2022-09-15 | 2024-03-29 | 华侨大学 | 一种含异羟肟酸结构的联苯类化合物及其应用 |
| CN118265699A (zh) * | 2022-10-26 | 2024-06-28 | 西安新通药物研究股份有限公司 | 一种非对称性联苯衍生物及其制备方法与医药用途 |
| CN120731228A (zh) | 2022-12-21 | 2025-09-30 | 百时美施贵宝公司 | 肺癌的组合疗法 |
| KR20250150141A (ko) | 2023-02-23 | 2025-10-17 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 피리도피리미딘 유도체 및 이의 용도 |
| WO2024183756A1 (zh) * | 2023-03-07 | 2024-09-12 | 上海再极医药科技有限公司 | 一种含苯环类化合物及其制备方法和应用 |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025245489A1 (en) | 2024-05-24 | 2025-11-27 | Bristol-Myers Squibb Company | Treatment of tumors in subjects having fgl-1 positive samples |
| WO2026035860A1 (en) | 2024-08-07 | 2026-02-12 | Teon Therapeutics, Inc. | Formulations of adenosine receptor antagonist |
| CN119504834B (zh) * | 2024-11-21 | 2025-10-17 | 南开大学 | 一种以含硅基团为疏水标签的pd-l1蛋白降解剂及其制备方法、药物组合物和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| AU2003281040A1 (en) | 2002-07-10 | 2004-02-02 | Sumitomo Pharmaceuticals Co., Ltd. | Biaryl derivatives |
| AU2003277576A1 (en) * | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| EP1603858A2 (en) | 2003-03-11 | 2005-12-14 | NeuroSearch A/S | Kcnq channel modulating compounds and their pharmaceutical use |
| JP2005179281A (ja) | 2003-12-19 | 2005-07-07 | Sumitomo Pharmaceut Co Ltd | ビフェニル化合物 |
| AU2004309271A1 (en) * | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | 3−(4−ベンジルオキシフェニル)プロパン酸誘導体 |
| WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| CA2618486A1 (en) | 2005-08-09 | 2007-02-15 | Asterand Uk Limited | Ep2 receptor agonists |
| TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| EP2139843B1 (en) | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| WO2011082400A2 (en) * | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| JP6417419B2 (ja) | 2013-09-04 | 2018-11-07 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫調節剤として有用な化合物 |
| CN105793236B (zh) * | 2013-12-17 | 2017-10-10 | 伊莱利利公司 | 二甲基苯甲酸化合物 |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CN109689640B (zh) | 2016-07-08 | 2022-01-04 | 百时美施贵宝公司 | 可用作免疫调节剂的化合物 |
| US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
-
2016
- 2016-10-11 US US15/290,167 patent/US10745382B2/en active Active
- 2016-10-12 WO PCT/US2016/056504 patent/WO2017066227A1/en not_active Ceased
- 2016-10-12 MA MA042990A patent/MA42990A/fr unknown
- 2016-10-12 BR BR112018007381A patent/BR112018007381A2/pt not_active Application Discontinuation
- 2016-10-12 KR KR1020187013269A patent/KR102740320B1/ko active Active
- 2016-10-12 JP JP2018519301A patent/JP6916783B2/ja active Active
- 2016-10-12 MX MX2018004347A patent/MX2018004347A/es unknown
- 2016-10-12 EP EP16788857.7A patent/EP3362443B1/en active Active
- 2016-10-12 CN CN201680073641.7A patent/CN108368090B/zh active Active
- 2016-10-12 ES ES16788857T patent/ES2892550T3/es active Active
- 2016-10-12 CA CA3002008A patent/CA3002008A1/en not_active Abandoned
- 2016-10-12 EA EA201890857A patent/EA201890857A1/ru unknown
- 2016-10-12 AU AU2016338874A patent/AU2016338874A1/en not_active Abandoned
- 2016-10-14 UY UY0001036950A patent/UY36950A/es unknown
- 2016-10-14 TW TW105133344A patent/TW201726606A/zh unknown
- 2016-12-12 PE PE2018000533A patent/PE20181045A1/es unknown
-
2018
- 2018-04-10 IL IL258607A patent/IL258607A/en unknown
- 2018-04-13 ZA ZA2018/02450A patent/ZA201802450B/en unknown
- 2018-04-13 CL CL2018000952A patent/CL2018000952A1/es unknown
- 2018-05-10 CO CONC2018/0004964A patent/CO2018004964A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108368090B (zh) | 2022-04-12 |
| EA201890857A1 (ru) | 2018-09-28 |
| AU2016338874A1 (en) | 2018-05-31 |
| KR102740320B1 (ko) | 2024-12-10 |
| ZA201802450B (en) | 2020-01-29 |
| US10745382B2 (en) | 2020-08-18 |
| TW201726606A (zh) | 2017-08-01 |
| JP2018534282A (ja) | 2018-11-22 |
| EP3362443A1 (en) | 2018-08-22 |
| IL258607A (en) | 2018-06-28 |
| EP3362443B1 (en) | 2021-08-25 |
| ES2892550T3 (es) | 2022-02-04 |
| CN108368090A (zh) | 2018-08-03 |
| BR112018007381A2 (pt) | 2018-10-23 |
| MA42990A (fr) | 2021-03-31 |
| PE20181045A1 (es) | 2018-07-03 |
| KR20180061367A (ko) | 2018-06-07 |
| WO2017066227A1 (en) | 2017-04-20 |
| CO2018004964A2 (es) | 2018-10-10 |
| UY36950A (es) | 2017-04-28 |
| CL2018000952A1 (es) | 2018-08-10 |
| CA3002008A1 (en) | 2017-04-20 |
| US20170107202A1 (en) | 2017-04-20 |
| MX2018004347A (es) | 2018-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6916783B2 (ja) | 免疫調節剤として有用な化合物 | |
| JP7150745B2 (ja) | 免疫調節剤としての置換イソキノリン誘導体 | |
| JP7106572B2 (ja) | 免疫調節剤として有用な化合物 | |
| US11578054B2 (en) | Compounds useful as immunomodulators | |
| US10144706B2 (en) | Compounds useful as immunomodulators | |
| KR102276644B1 (ko) | 면역조절제로서 유용한 화합물 | |
| JP6556755B2 (ja) | 免疫調節剤として有用な化合物 | |
| JP2021512150A (ja) | 免疫調節剤として有用な2,8−ジアシル−2,8−ジアザスピロ[5.5]ウンデカン化合物 | |
| JP7642625B2 (ja) | 免疫調節剤として有用な化合物 | |
| EP4587429A1 (en) | Substituted oxoisoindolinyl piperidine-2,6-dione compounds | |
| HK1223366B (en) | Compounds useful as immunomodulators |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191007 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191007 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200910 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200929 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201224 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210226 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210622 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210716 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6916783 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |