JP2018528275A5 - - Google Patents
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- Publication number
- JP2018528275A5 JP2018528275A5 JP2018534521A JP2018534521A JP2018528275A5 JP 2018528275 A5 JP2018528275 A5 JP 2018528275A5 JP 2018534521 A JP2018534521 A JP 2018534521A JP 2018534521 A JP2018534521 A JP 2018534521A JP 2018528275 A5 JP2018528275 A5 JP 2018528275A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- hydrogen
- alkoxy
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 50
- 150000002431 hydrogen Chemical class 0.000 claims 47
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000003545 alkoxy group Chemical group 0.000 claims 38
- 125000004423 acyloxy group Chemical group 0.000 claims 36
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000003282 alkyl amino group Chemical group 0.000 claims 27
- 125000004663 dialkyl amino group Chemical group 0.000 claims 25
- 125000002252 acyl group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 23
- -1 hydroxy, amino Chemical group 0.000 claims 21
- 125000000547 substituted alkyl group Chemical group 0.000 claims 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 19
- 125000001769 aryl amino group Chemical group 0.000 claims 18
- 125000004104 aryloxy group Chemical group 0.000 claims 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 16
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 16
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 150000001408 amides Chemical class 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000003302 alkenyloxy group Chemical group 0.000 claims 9
- 125000006323 alkenyl amino group Chemical group 0.000 claims 8
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 5
- 150000001241 acetals Chemical class 0.000 claims 5
- 125000000033 alkoxyamino group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 150000002373 hemiacetals Chemical class 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 125000005035 acylthio group Chemical group 0.000 claims 4
- BWOVZCWSJFYBRM-UHFFFAOYSA-N carbononitridic isocyanate Chemical group O=C=NC#N BWOVZCWSJFYBRM-UHFFFAOYSA-N 0.000 claims 4
- 125000005241 heteroarylamino group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222632P | 2015-09-23 | 2015-09-23 | |
| US62/222,632 | 2015-09-23 | ||
| PCT/US2016/053545 WO2017053868A1 (en) | 2015-09-23 | 2016-09-23 | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528275A JP2018528275A (ja) | 2018-09-27 |
| JP2018528275A5 true JP2018528275A5 (enExample) | 2019-11-07 |
| JP7074674B2 JP7074674B2 (ja) | 2022-05-24 |
Family
ID=57137257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534521A Active JP7074674B2 (ja) | 2015-09-23 | 2016-09-23 | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11584775B2 (enExample) |
| EP (1) | EP3353190B1 (enExample) |
| JP (1) | JP7074674B2 (enExample) |
| KR (1) | KR102796889B1 (enExample) |
| CN (1) | CN108290922B (enExample) |
| AU (1) | AU2016326704B2 (enExample) |
| BR (1) | BR112018005861B1 (enExample) |
| CA (1) | CA2998681C (enExample) |
| EA (1) | EA201890767A1 (enExample) |
| ES (1) | ES2865163T3 (enExample) |
| IL (1) | IL258185B (enExample) |
| MX (1) | MX386256B (enExample) |
| NZ (1) | NZ741082A (enExample) |
| WO (1) | WO2017053868A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2276493T (lt) | 2008-04-18 | 2019-01-10 | Reata Pharmaceuticals, Inc. | Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17 |
| TW201348245A (zh) | 2012-04-27 | 2013-12-01 | Reata Pharmaceuticals Inc | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２－二氟基丙醯胺衍生物、多晶型及其使用方法 |
| MX366913B (es) | 2012-09-10 | 2019-07-30 | Reata Pharmaceuticals Inc | Derivados de c17-alcanodiilo y alquenodiilo de ácido oleanólico y métodos de uso de los mismos. |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| UY39092A (es) | 2013-04-24 | 2021-03-26 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| US10953020B2 (en) | 2016-11-08 | 2021-03-23 | Reata Pharmaceuticals, Inc. | Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof |
| CN108299541B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用 |
| CN108191944B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用 |
| WO2019246461A1 (en) | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| CN109248168A (zh) * | 2018-10-30 | 2019-01-22 | 武汉卫无忧生物科技有限公司 | 齐墩果酸在制备抗幽门螺杆菌的药物中的用途 |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| TWI861163B (zh) * | 2019-07-19 | 2024-11-11 | 美商瑞塔醫藥有限責任公司 | C17經極性取代之雜芳合成三萜類化合物及其使用方法 |
| AU2021397631A1 (en) | 2020-12-11 | 2023-07-20 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| JP2024504637A (ja) * | 2021-01-18 | 2024-02-01 | リアタ ファーマシューティカルズ インコーポレイテッド | 合成ウルソール酸誘導体及びその使用方法 |
| CN113185570A (zh) * | 2021-05-12 | 2021-07-30 | 张洪胜 | 一种治疗银屑病的齐墩果酸衍生物及其制备方法 |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
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| ATE449754T1 (de) | 1999-05-14 | 2009-12-15 | Nereus Pharmaceuticals Inc | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
| US6649654B1 (en) | 1999-11-23 | 2003-11-18 | The Regents Of The University Of California | Methods for identifying and using IKK inhibitors |
| WO2002003996A1 (en) | 2000-07-12 | 2002-01-17 | RAJKUMAR, Sujatha | Use of dammarane-type tritepenoid saporins |
| AU2001294953A1 (en) | 2000-09-29 | 2002-04-08 | Regents Of The University Of Minnesota | Triterpenes having fungicidal activity against yeast |
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| US6878751B1 (en) | 2000-10-19 | 2005-04-12 | Imperial College Of Science Technology And Medicine | Administration of resveratrol to treat inflammatory respiratory disorders |
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| CA2430454A1 (en) | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
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| SMT201700501T1 (it) | 2012-09-10 | 2017-11-15 | Reata Pharmaceuticals Inc | Derivati c17-eteroarilici dell'acido oleanolico e metodi d'uso degli stessi |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| MX366913B (es) | 2012-09-10 | 2019-07-30 | Reata Pharmaceuticals Inc | Derivados de c17-alcanodiilo y alquenodiilo de ácido oleanólico y métodos de uso de los mismos. |
| MY198522A (en) | 2013-08-23 | 2023-09-04 | Reata Pharmaceuticals Inc | Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof |
| CN104861027A (zh) | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型齐墩果酸衍生物、其制备方法及其应用 |
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| US10953020B2 (en) | 2016-11-08 | 2021-03-23 | Reata Pharmaceuticals, Inc. | Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof |
-
2016
- 2016-09-23 JP JP2018534521A patent/JP7074674B2/ja active Active
- 2016-09-23 US US15/760,662 patent/US11584775B2/en active Active
- 2016-09-23 AU AU2016326704A patent/AU2016326704B2/en active Active
- 2016-09-23 CA CA2998681A patent/CA2998681C/en active Active
- 2016-09-23 EA EA201890767A patent/EA201890767A1/ru unknown
- 2016-09-23 CN CN201680067912.8A patent/CN108290922B/zh active Active
- 2016-09-23 KR KR1020187011430A patent/KR102796889B1/ko active Active
- 2016-09-23 EP EP16781915.0A patent/EP3353190B1/en active Active
- 2016-09-23 BR BR112018005861-0A patent/BR112018005861B1/pt active IP Right Grant
- 2016-09-23 ES ES16781915T patent/ES2865163T3/es active Active
- 2016-09-23 WO PCT/US2016/053545 patent/WO2017053868A1/en not_active Ceased
- 2016-09-23 NZ NZ741082A patent/NZ741082A/en unknown
- 2016-09-23 MX MX2018003569A patent/MX386256B/es unknown
-
2018
- 2018-03-18 IL IL258185A patent/IL258185B/en unknown
-
2023
- 2023-01-04 US US18/149,696 patent/US20230250130A1/en active Pending
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