JP2014043462A5 - - Google Patents

Download PDF

Info

Publication number
JP2014043462A5
JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
Authority
JP
Japan
Prior art keywords
group
carbon atoms
amino
nucleic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013244692A
Other languages
English (en)
Japanese (ja)
Other versions
JP5669073B2 (ja
JP2014043462A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP2013244692A priority Critical patent/JP5669073B2/ja
Priority claimed from JP2013244692A external-priority patent/JP5669073B2/ja
Publication of JP2014043462A publication Critical patent/JP2014043462A/ja
Publication of JP2014043462A5 publication Critical patent/JP2014043462A5/ja
Application granted granted Critical
Publication of JP5669073B2 publication Critical patent/JP5669073B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013244692A 2009-10-29 2013-11-27 架橋型人工ヌクレオシドおよびヌクレオチド Active JP5669073B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013244692A JP5669073B2 (ja) 2009-10-29 2013-11-27 架橋型人工ヌクレオシドおよびヌクレオチド

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009248979 2009-10-29
JP2009248979 2009-10-29
JP2010023209 2010-02-04
JP2010023209 2010-02-04
JP2013244692A JP5669073B2 (ja) 2009-10-29 2013-11-27 架橋型人工ヌクレオシドおよびヌクレオチド

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011538366A Division JPWO2011052436A1 (ja) 2009-10-29 2010-10-19 架橋型人工ヌクレオシドおよびヌクレオチド

Publications (3)

Publication Number Publication Date
JP2014043462A JP2014043462A (ja) 2014-03-13
JP2014043462A5 true JP2014043462A5 (enExample) 2014-05-29
JP5669073B2 JP5669073B2 (ja) 2015-02-12

Family

ID=43921860

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011538366A Ceased JPWO2011052436A1 (ja) 2009-10-29 2010-10-19 架橋型人工ヌクレオシドおよびヌクレオチド
JP2013244692A Active JP5669073B2 (ja) 2009-10-29 2013-11-27 架橋型人工ヌクレオシドおよびヌクレオチド

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2011538366A Ceased JPWO2011052436A1 (ja) 2009-10-29 2010-10-19 架橋型人工ヌクレオシドおよびヌクレオチド

Country Status (7)

Country Link
US (1) US8541562B2 (enExample)
EP (1) EP2495248B1 (enExample)
JP (2) JPWO2011052436A1 (enExample)
CN (1) CN102596983B (enExample)
AU (1) AU2010312751B2 (enExample)
CA (1) CA2778171C (enExample)
WO (1) WO2011052436A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9127280B2 (en) 2010-08-31 2015-09-08 Osaka University Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient
EP2792746A4 (en) 2011-12-12 2015-09-16 Nat Cerebral & Cardiovascular Ct OLIGONUCLEOTIDE AND THERAPEUTIC FOR HYPERLIPIDEMIA WITH THIS AS AN ACTIVE SUBSTANCE
ES2798301T3 (es) * 2012-06-18 2020-12-10 Daiichi Sankyo Co Ltd Intermedio para producción de análogos de nucleósidos, y procedimiento para su producción
EP2899197B1 (en) * 2012-09-21 2017-03-22 Osaka University Oligonucleotide and artificial nucleoside having guanidine bridge
WO2014109384A1 (ja) * 2013-01-10 2014-07-17 塩野義製薬株式会社 架橋型核酸誘導体の製造方法
WO2014112463A1 (ja) * 2013-01-15 2014-07-24 国立大学法人大阪大学 スルホンアミド構造を有するヌクレオシドおよびヌクレオチド
WO2014126229A1 (ja) 2013-02-18 2014-08-21 塩野義製薬株式会社 含窒素複素環構造を有するヌクレオシド及びヌクレオチド
WO2015020194A1 (ja) * 2013-08-09 2015-02-12 国立大学法人大阪大学 Acsl1に対するアンチセンスオリゴヌクレオチド
GB201410693D0 (en) 2014-06-16 2014-07-30 Univ Southampton Splicing modulation
WO2016006697A1 (ja) * 2014-07-10 2016-01-14 賢二 中野 アンチセンス抗悪性腫瘍剤
CN107109411B (zh) 2014-10-03 2022-07-01 冷泉港实验室 核基因输出的定向增加
JP2018140938A (ja) * 2015-07-24 2018-09-13 日産化学株式会社 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド
TW201718618A (zh) 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸GuNA,其製造方法,及中間體化合物
CN108603230A (zh) 2015-10-09 2018-09-28 南安普敦大学 基因表达的调节与蛋白质表达失调的筛选
CN116059236A (zh) 2015-12-14 2023-05-05 冷泉港实验室 用于治疗常染色体显性精神发育迟滞5型和Dravet综合征的反义寡聚体
US11096956B2 (en) 2015-12-14 2021-08-24 Stoke Therapeutics, Inc. Antisense oligomers and uses thereof
US11234995B2 (en) * 2016-01-07 2022-02-01 Osaka University α-synuclein expression inhibitor
EP3409779A4 (en) 2016-01-26 2019-07-03 Nissan Chemical Corporation Single-stranded oligonucleotide
US11384112B2 (en) 2016-02-17 2022-07-12 Tokyo Institute Of Technology Artificial nucleoside and artificial nucleotide, and artificial oligonucleotide
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
JP2020055750A (ja) * 2017-01-30 2020-04-09 賢二 中野 癌浸潤または転移阻害核酸薬
JP7188087B2 (ja) 2017-02-06 2022-12-13 日産化学株式会社 一本鎖オリゴヌクレオチド
US11261440B2 (en) 2017-02-21 2022-03-01 Osaka University Antisense oligonucleic acid
US11286275B2 (en) 2017-02-21 2022-03-29 Osaka University Nucleic acid compound and oligonucleotide
EP3603648B1 (en) 2017-03-29 2025-09-17 Shionogi & Co., Ltd Complex of nucleic acid medicine and multibranched lipid
WO2018180005A1 (ja) 2017-03-31 2018-10-04 国立研究開発法人日本医療研究開発機構 コンドロイチン硫酸生合成を阻害するアンチセンス核酸
US11273222B2 (en) 2017-05-26 2022-03-15 National Cerebral And Cardiovascular Center Antisense nucleic acid targeting PCSK9
WO2019009298A1 (ja) * 2017-07-05 2019-01-10 国立大学法人大阪大学 α-シヌクレイン発現抑制剤
US20200172903A1 (en) 2017-07-05 2020-06-04 Osaka University ENA ANTISENSE OLIGONUCLEOTIDE FOR INHIBITION OF alpha-SYNUCLEIN EXPRESSION
US11555188B2 (en) 2017-07-26 2023-01-17 Nissan Chemical Corporation Single-stranded oligonucleotide
KR20260009385A (ko) 2017-08-25 2026-01-19 스톡 테라퓨틱스, 인크. 병태 및 질환 치료용 안티센스 올리고머
WO2019045075A1 (ja) 2017-08-31 2019-03-07 田辺三菱製薬株式会社 Il-33アンタゴニストを含む子宮内膜症治療剤
EP3770256A4 (en) 2018-03-20 2021-12-22 Tokyo Institute of Technology ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY
JP2021523227A (ja) 2018-05-04 2021-09-02 ストーク セラピューティクス,インク. コレステリルエステル蓄積症の処置のための方法及び組成物
EP3831837A4 (en) * 2018-07-31 2023-06-14 Osaka University OLIGONUCLEOTIDE THERAPEUTIC AGENT FOR SMALL CELL LUNG CANCER
KR20210134003A (ko) 2019-02-27 2021-11-08 스톡 테라퓨틱스, 인크. 병태 및 질환의 치료를 위한 안티센스 올리고머
JP7413362B2 (ja) 2019-03-29 2024-01-15 シスメックス株式会社 新規人工核酸、その製造方法及び用途
KR20220024192A (ko) 2019-05-31 2022-03-03 알리고스 테라퓨틱스 인코포레이티드 변형된 갭머 올리고뉴클레오타이드 및 사용 방법
JP7692829B2 (ja) 2019-07-30 2025-06-16 塩野義製薬株式会社 Murf1を標的とする核酸医薬
US20220282248A1 (en) 2019-08-27 2022-09-08 National University Corporation Tokai National Higher Education And Research System Molecular targeted nucleic acid medicine for gastric cancer
WO2021127406A1 (en) * 2019-12-19 2021-06-24 The Regents Of The University Of California Methods of producing target capture nucleic acids
WO2021132648A1 (ja) * 2019-12-27 2021-07-01 ルクサナバイオテク株式会社 Recqlの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途
JP7773730B2 (ja) 2020-03-02 2025-11-20 国立大学法人京都大学 miR-33b阻害物質による動脈瘤の予防または治療
CN115485381A (zh) 2020-03-26 2022-12-16 国立研究开发法人国立循环器病研究中心 以apoc3为靶点的反义核酸
JP2023522957A (ja) 2020-04-21 2023-06-01 フラッグシップ パイオニアリング, インコーポレイテッド 二機能性分子およびその使用方法
US12338437B2 (en) 2020-05-11 2025-06-24 Stoke Therapeutics, Inc. OPA1 antisense oligomers for treatment of conditions and diseases
EP4219517A4 (en) 2020-09-25 2024-09-25 Riken Genesis Co., Ltd. NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF
TWI910261B (zh) 2020-11-06 2026-01-01 日商住友製藥股份有限公司 Rps25基因之表現及/或功能調節劑
US20240148775A1 (en) 2021-02-25 2024-05-09 Osaka University Oligonucleotide for inducing n-exon skipping during rest mrna precursor processing
EP4331606A4 (en) 2021-04-30 2025-05-07 Kyoto University PREVENTION OR TREATMENT OF MYOPATHY USING A MIR-33B INHIBITOR
EP4335859A4 (en) 2021-05-06 2025-07-30 Luxna Biotech Co Ltd METHOD FOR DESIGNING AN OLIGONUCLEOTIDE HAVING REDUCED CENTRAL TOXICITY
AU2022279820A1 (en) 2021-05-28 2023-12-14 Sumitomo Pharma Co., Ltd. Antisense nucleic acid
WO2023026994A1 (ja) 2021-08-21 2023-03-02 武田薬品工業株式会社 ヒトトランスフェリンレセプター結合ペプチド-薬物コンジュゲート
WO2023127857A1 (ja) 2021-12-27 2023-07-06 株式会社理研ジェネシス 新規人工核酸、その製造方法及び用途
US20250223596A1 (en) 2022-03-17 2025-07-10 Aichi Medical University Antisense nucleic acid capable of inhibiting biosynthesis of chondroitin sulfate
JPWO2024101446A1 (enExample) 2022-11-10 2024-05-16
EP4674962A1 (en) 2023-02-28 2026-01-07 The University of Osaka Oligonucleotide, and rest expression suppressing agent and pharmaceutical composition using same
JPWO2024257847A1 (enExample) 2023-06-16 2024-12-19
JPWO2025005265A1 (enExample) * 2023-06-30 2025-01-02
WO2025063261A1 (ja) 2023-09-22 2025-03-27 塩野義製薬株式会社 ウイルス由来タンパク質をコードするポリヌクレオチド
US20250368996A1 (en) 2024-05-14 2025-12-04 Aligos Therapeutics, Inc. Modified antisense oligonucleotides for treating hepatitis b virus
WO2026149921A1 (en) * 2025-01-09 2026-07-16 Roche Molecular Systems, Inc. Methods for producing rna molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
SK17432000A3 (sk) 1998-05-26 2001-07-10 Icn Pharmaceuticals, Inc. Zlúčenina, ktorá zahŕňa nukleozid s 2',4'-mostíkom a oligonukleotid z nej odvodený
JP4383176B2 (ja) 2002-02-13 2009-12-16 武 今西 ヌクレオシド類縁体およびそのヌクレオチド類縁体を含むオリゴヌクレオチド誘導体
DK1661905T3 (da) 2003-08-28 2012-07-23 Takeshi Imanishi Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
US9127280B2 (en) * 2010-08-31 2015-09-08 Osaka University Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient

Similar Documents

Publication Publication Date Title
JP2013535220A5 (enExample)
RU2015126856A (ru) Дисульфидные маскированные пролекарственные композиции и способы
JP2016501520A5 (enExample)
JP2019512478A5 (enExample)
JP2017119663A5 (enExample)
JP2016503300A5 (enExample)
EP4458348A3 (en) Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
JP2012140458A5 (enExample)
JP2013521295A5 (enExample)
JP2013102146A5 (ja) 化合物
NZ593712A (en) Intermediates for synthesising nucleoside aryl phosphoramidates
JP2017536344A5 (enExample)
JP2010235633A5 (enExample)
JP2018519343A5 (enExample)
JP2014526533A5 (enExample)
JP2012140436A5 (ja) 物質
PH12014502771A1 (en) Nucleoside phosphoramidate prodrugs
JP2013010731A5 (ja) 複素環化合物
JP2013532122A5 (enExample)
JP2009504772A5 (enExample)
JP2010515731A5 (enExample)
CY1114318T1 (el) Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες
RU2019138475A (ru) Соединение, представляющее собой модифицированный мономер нуклеиновой кислоты, и аналог олигонуклеиновой кислоты
EP3388426A3 (en) Compounds for protection of cells
JP2017503833A5 (enExample)