JP2014043462A5 - - Google Patents
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- JP2014043462A5 JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
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- JP
- Japan
- Prior art keywords
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- carbon atoms
- amino
- nucleic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- -1 2-oxo-1,2-dihydropyrimidin-1-yl group Chemical group 0.000 claims 22
- 238000001668 nucleic acid synthesis Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009248979 | 2009-10-29 | ||
| JP2009248979 | 2009-10-29 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Division JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014043462A JP2014043462A (ja) | 2014-03-13 |
| JP2014043462A5 true JP2014043462A5 (enExample) | 2014-05-29 |
| JP5669073B2 JP5669073B2 (ja) | 2015-02-12 |
Family
ID=43921860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
| JP2013244692A Active JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8541562B2 (enExample) |
| EP (1) | EP2495248B1 (enExample) |
| JP (2) | JPWO2011052436A1 (enExample) |
| CN (1) | CN102596983B (enExample) |
| AU (1) | AU2010312751B2 (enExample) |
| CA (1) | CA2778171C (enExample) |
| WO (1) | WO2011052436A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9127280B2 (en) | 2010-08-31 | 2015-09-08 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
| JPWO2013089157A1 (ja) | 2011-12-12 | 2015-04-27 | 独立行政法人国立循環器病研究センター | オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する高脂血症治療剤 |
| WO2013191129A1 (ja) | 2012-06-18 | 2013-12-27 | 第一三共株式会社 | ヌクレオシド類縁体の製造中間体及びその製造方法 |
| JP6048982B2 (ja) * | 2012-09-21 | 2016-12-21 | 国立大学法人大阪大学 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
| JP6270742B2 (ja) * | 2013-01-10 | 2018-01-31 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| US20150337002A1 (en) * | 2013-01-15 | 2015-11-26 | Shionogi & Co., Ltd. | Nucleoside and nucleotide having sulfonamide structure |
| EP2957567B1 (en) * | 2013-02-18 | 2019-06-05 | Shionogi & Co., Ltd. | Nucleoside and nucleotide, having nitrogen-containing hetercycle structure |
| WO2015020194A1 (ja) * | 2013-08-09 | 2015-02-12 | 国立大学法人大阪大学 | Ａｃｓｌ１に対するアンチセンスオリゴヌクレオチド |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| US20170211073A1 (en) * | 2014-07-10 | 2017-07-27 | Kenji Nakano | Antisense antineoplastic agent |
| EP3201339A4 (en) | 2014-10-03 | 2018-09-19 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| JP2018140938A (ja) * | 2015-07-24 | 2018-09-13 | 日産化学株式会社 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| AU2016334804B2 (en) | 2015-10-09 | 2022-03-31 | University Of Southampton | Modulation of gene expression and screening for deregulated protein expression |
| ES2882500T3 (es) | 2015-12-14 | 2021-12-02 | Cold Spring Harbor Laboratory | Oligómeros antisentido para el tratamiento del síndrome de Dravet |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| WO2017119463A1 (ja) * | 2016-01-07 | 2017-07-13 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| CN116064544A (zh) | 2016-01-26 | 2023-05-05 | 日产化学株式会社 | 单链寡核苷酸 |
| JP6853537B2 (ja) | 2016-02-17 | 2021-03-31 | 国立大学法人東京工業大学 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| JP2020055750A (ja) * | 2017-01-30 | 2020-04-09 | 賢二 中野 | 癌浸潤または転移阻害核酸薬 |
| US11572558B2 (en) | 2017-02-06 | 2023-02-07 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| JP7138349B2 (ja) * | 2017-02-21 | 2022-09-16 | 国立大学法人大阪大学 | 核酸化合物およびオリゴヌクレオチド |
| EP3587576A4 (en) | 2017-02-21 | 2021-01-06 | Osaka University | ANTISENSE OLIGONUCLEIC ACID |
| JP7190794B2 (ja) | 2017-03-29 | 2022-12-16 | 塩野義製薬株式会社 | 核酸医薬及び多分岐脂質の複合体 |
| WO2018180005A1 (ja) | 2017-03-31 | 2018-10-04 | 国立研究開発法人日本医療研究開発機構 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| US11273222B2 (en) | 2017-05-26 | 2022-03-15 | National Cerebral And Cardiovascular Center | Antisense nucleic acid targeting PCSK9 |
| EP3628737A4 (en) | 2017-07-05 | 2021-01-20 | Osaka University | ENA-ANTISENSE-OLIGONUCLEOTIDE TO INHIBIT ALPHA-SYNUCLEIN EXPRESSION |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| TWI902655B (zh) | 2017-07-26 | 2025-11-01 | 日商日產化學股份有限公司 | 單股寡核苷酸 |
| SI3673080T1 (sl) | 2017-08-25 | 2024-03-29 | Stoke Therapeutics, Inc. | Protismiselni oligomeri za zdravljenje bolezenskih stanj in bolezni |
| AU2018325645C1 (en) | 2017-08-31 | 2025-01-30 | Hyogo College Of Medicine | IL-33 antagonist-containing therapeutic agent for endometriosis |
| CN111868244A (zh) | 2018-03-20 | 2020-10-30 | 国立大学法人东京工业大学 | 降低了毒性的反义寡核苷酸 |
| WO2019213525A1 (en) | 2018-05-04 | 2019-11-07 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| WO2020027227A1 (ja) | 2018-07-31 | 2020-02-06 | 国立大学法人大阪大学 | オリゴヌクレオチドを含有する小細胞肺癌治療薬 |
| KR20210134003A (ko) | 2019-02-27 | 2021-11-08 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 안티센스 올리고머 |
| JP7413362B2 (ja) | 2019-03-29 | 2024-01-15 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| EP3976056A2 (en) | 2019-05-31 | 2022-04-06 | Aligos Therapeutics, Inc. | Modified gapmer oligonucleotides and methods of use |
| WO2021020412A1 (ja) | 2019-07-30 | 2021-02-04 | 塩野義製薬株式会社 | Ｍｕｒｆ１を標的とする核酸医薬 |
| JP7732637B2 (ja) | 2019-08-27 | 2025-09-02 | 国立大学法人東海国立大学機構 | 胃癌分子標的核酸医薬 |
| WO2021127406A1 (en) * | 2019-12-19 | 2021-06-24 | The Regents Of The University Of California | Methods of producing target capture nucleic acids |
| WO2021132648A1 (ja) * | 2019-12-27 | 2021-07-01 | ルクサナバイオテク株式会社 | Ｒｅｃｑｌの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途 |
| TW202146651A (zh) | 2020-03-02 | 2021-12-16 | 日商田邊三菱製藥股份有限公司 | ｍｉＲ－３３ｂ阻礙物質所致之動脈瘤的預防或治療 |
| CN115485381A (zh) | 2020-03-26 | 2022-12-16 | 国立研究开发法人国立循环器病研究中心 | 以apoc3为靶点的反义核酸 |
| CA3176196A1 (en) | 2020-04-21 | 2021-10-28 | Flagship Pioneering, Inc. | Bifunctional molecules and methods of using thereof |
| BR112022022889A2 (pt) | 2020-05-11 | 2023-04-04 | Stoke Therapeutics Inc | Oligômeros antissentido de opa1 para tratamento de condições e doenças |
| CN116322706B (zh) | 2020-09-25 | 2025-12-05 | 株式会社理真思 | 新人工核酸、其制造方法和用途 |
| TWI910261B (zh) | 2020-11-06 | 2026-01-01 | 日商住友製藥股份有限公司 | Ｒｐｓ２５基因之表現及／或功能調節劑 |
| WO2022181807A1 (ja) | 2021-02-25 | 2022-09-01 | 国立大学法人大阪大学 | ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド |
| JPWO2022230987A1 (enExample) | 2021-04-30 | 2022-11-03 | ||
| EP4335859A4 (en) | 2021-05-06 | 2025-07-30 | Luxna Biotech Co Ltd | METHOD FOR DESIGNING AN OLIGONUCLEOTIDE HAVING REDUCED CENTRAL TOXICITY |
| CN117500925A (zh) | 2021-05-28 | 2024-02-02 | 住友制药株式会社 | 反义核酸 |
| US20240390508A1 (en) | 2021-08-21 | 2024-11-28 | Takeda Pharmaceutical Company Limited | Human transferrin receptor binding peptide-drug conjugate |
| EP4458836A4 (en) | 2021-12-27 | 2025-05-21 | Riken Genesis Co., Ltd. | Novel artificial nucleic acid, method for producing same, and use of same |
| JPWO2023176920A1 (enExample) | 2022-03-17 | 2023-09-21 | ||
| KR20250108634A (ko) | 2022-11-10 | 2025-07-15 | 룩스나 바이오테크 가부시키가이샤 | 가교부에 구아니디노 구조를 갖는 수식 뉴클레오시드 및 그것을 이용한 올리고뉴클레오티드의 제조 방법 |
| EP4674962A1 (en) | 2023-02-28 | 2026-01-07 | The University of Osaka | Oligonucleotide, and rest expression suppressing agent and pharmaceutical composition using same |
| TW202511485A (zh) | 2023-06-16 | 2025-03-16 | 日商住友製藥股份有限公司 | 調節ｒｐｓ２５基因之表現及／或其功能的反義寡核苷酸 |
| JPWO2025005265A1 (enExample) * | 2023-06-30 | 2025-01-02 | ||
| WO2025240506A1 (en) | 2024-05-14 | 2025-11-20 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| EP1082012A4 (en) | 1998-05-26 | 2002-01-16 | Icn Pharmaceuticals | NEW NUCLEOSIDES WITH BICYCLICAL SUGAR PART |
| EP1481983A4 (en) | 2002-02-13 | 2008-04-02 | Takeshi Imanishi | NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF |
| EP1661905B9 (en) | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| US9127280B2 (en) * | 2010-08-31 | 2015-09-08 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
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2010
- 2010-10-19 US US13/502,611 patent/US8541562B2/en active Active
- 2010-10-19 EP EP10826568.7A patent/EP2495248B1/en active Active
- 2010-10-19 JP JP2011538366A patent/JPWO2011052436A1/ja not_active Ceased
- 2010-10-19 CA CA2778171A patent/CA2778171C/en active Active
- 2010-10-19 CN CN201080049279.2A patent/CN102596983B/zh active Active
- 2010-10-19 WO PCT/JP2010/068409 patent/WO2011052436A1/ja not_active Ceased
- 2010-10-19 AU AU2010312751A patent/AU2010312751B2/en active Active
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2013
- 2013-11-27 JP JP2013244692A patent/JP5669073B2/ja active Active