JP2014043462A5 - - Google Patents
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- JP2014043462A5 JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- amino
- nucleic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- -1 2-oxo-1,2-dihydropyrimidin-1-yl group Chemical group 0.000 claims 22
- 238000001668 nucleic acid synthesis Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009248979 | 2009-10-29 | ||
| JP2009248979 | 2009-10-29 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Division JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014043462A JP2014043462A (ja) | 2014-03-13 |
| JP2014043462A5 true JP2014043462A5 (enExample) | 2014-05-29 |
| JP5669073B2 JP5669073B2 (ja) | 2015-02-12 |
Family
ID=43921860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
| JP2013244692A Active JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8541562B2 (enExample) |
| EP (1) | EP2495248B1 (enExample) |
| JP (2) | JPWO2011052436A1 (enExample) |
| CN (1) | CN102596983B (enExample) |
| AU (1) | AU2010312751B2 (enExample) |
| CA (1) | CA2778171C (enExample) |
| WO (1) | WO2011052436A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2612914B1 (en) | 2010-08-31 | 2017-06-21 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
| US20140323709A1 (en) | 2011-12-12 | 2014-10-30 | National Cerebral And Cardiovascular Center | Oligonucleotide and therapeutic agent for hyperlipidemia containing same as active ingredient |
| JP6150440B2 (ja) * | 2012-06-18 | 2017-06-21 | 第一三共株式会社 | ヌクレオシド類縁体の製造中間体及びその製造方法 |
| IN2015DN02238A (enExample) * | 2012-09-21 | 2015-08-21 | Univ Osaka | |
| WO2014109384A1 (ja) * | 2013-01-10 | 2014-07-17 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| WO2014112463A1 (ja) * | 2013-01-15 | 2014-07-24 | 国立大学法人大阪大学 | スルホンアミド構造を有するヌクレオシドおよびヌクレオチド |
| US9315535B2 (en) | 2013-02-18 | 2016-04-19 | Shionogi & Co., Ltd. | Nucleoside and nucleotide having nitrogen-containing heterocycle structure |
| WO2015020194A1 (ja) * | 2013-08-09 | 2015-02-12 | 国立大学法人大阪大学 | Ａｃｓｌ１に対するアンチセンスオリゴヌクレオチド |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| JP6722586B2 (ja) * | 2014-07-10 | 2020-07-15 | 賢二 中野 | アンチセンス抗悪性腫瘍剤 |
| EP3201339A4 (en) | 2014-10-03 | 2018-09-19 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| JP2018140938A (ja) * | 2015-07-24 | 2018-09-13 | 日産化学株式会社 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| EP3359685A1 (en) | 2015-10-09 | 2018-08-15 | University Of Southampton | Modulation of gene expression and screening for deregulated protein expression |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| KR102604132B1 (ko) | 2015-12-14 | 2023-11-17 | 콜드스프링하버러보러토리 | 상염색체 우성 정신 지체 5 및 드라베 증후군의 치료를 위한 안티센스 올리고머 |
| US11234995B2 (en) * | 2016-01-07 | 2022-02-01 | Osaka University | α-synuclein expression inhibitor |
| BR112018015164A2 (pt) | 2016-01-26 | 2018-12-26 | Nissan Chemical Corp | oligonucleotídeo de fita simples |
| EP3418289A4 (en) | 2016-02-17 | 2019-10-30 | Tokyo Institute of Technology | ARTIFICIAL NUCLEOSIDE AND ARTIFICIAL NUCLEOTIDE AND ARTIFICIAL OLIGONUCLEOTIDE |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| JP2020055750A (ja) * | 2017-01-30 | 2020-04-09 | 賢二 中野 | 癌浸潤または転移阻害核酸薬 |
| US11572558B2 (en) | 2017-02-06 | 2023-02-07 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| US11286275B2 (en) | 2017-02-21 | 2022-03-29 | Osaka University | Nucleic acid compound and oligonucleotide |
| WO2018155450A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| EP3603648B1 (en) | 2017-03-29 | 2025-09-17 | Shionogi & Co., Ltd | Complex of nucleic acid medicine and multibranched lipid |
| EP3604531A4 (en) | 2017-03-31 | 2020-12-23 | Aichi Medical University | NUCLEIC ACID ANTISENS FOR INHIBITION OF CHONDROITIN SULPHATE BIOSYNTHESIS |
| EP3633036A4 (en) | 2017-05-26 | 2021-03-17 | National Cerebral and Cardiovascular Center | NUCLEIC ACID TARGETING ANTI-SENSES PCSK9 |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| EP3628737A4 (en) | 2017-07-05 | 2021-01-20 | Osaka University | ENA-ANTISENSE-OLIGONUCLEOTIDE TO INHIBIT ALPHA-SYNUCLEIN EXPRESSION |
| EP3660153A4 (en) | 2017-07-26 | 2021-04-21 | Nissan Chemical Corporation | SINGLE-STRANDED OLIGONUCLEOTIDE |
| SI3673080T1 (sl) | 2017-08-25 | 2024-03-29 | Stoke Therapeutics, Inc. | Protismiselni oligomeri za zdravljenje bolezenskih stanj in bolezni |
| CN115920031A (zh) | 2017-08-31 | 2023-04-07 | 田边三菱制药株式会社 | 含有il-33拮抗剂的子宫内膜异位症治疗剂 |
| CN111868244A (zh) | 2018-03-20 | 2020-10-30 | 国立大学法人东京工业大学 | 降低了毒性的反义寡核苷酸 |
| BR112020022512A2 (pt) | 2018-05-04 | 2021-05-04 | Stoke Therapeutics, Inc. | métodos e composições para tratamento de doença de armazenamento de éster de colesteril |
| US11866705B2 (en) * | 2018-07-31 | 2024-01-09 | Osaka Univerity | Small cell lung cancer therapeutic agent containing oligonucleotide |
| JP7413362B2 (ja) | 2019-03-29 | 2024-01-15 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| SG11202112741XA (en) | 2019-05-31 | 2021-12-30 | Aligos Therapeutics Inc | Modified gapmer oligonucleotides and methods of use |
| US20220267778A1 (en) | 2019-07-30 | 2022-08-25 | Shionogi & Co., Ltd. | Nucleic acid drug targeting murf1 |
| JP7732637B2 (ja) | 2019-08-27 | 2025-09-02 | 国立大学法人東海国立大学機構 | 胃癌分子標的核酸医薬 |
| EP4078596A4 (en) * | 2019-12-19 | 2024-01-24 | The Regents Of The University Of California | Methods of producing target capture nucleic acids |
| WO2021132648A1 (ja) * | 2019-12-27 | 2021-07-01 | ルクサナバイオテク株式会社 | Ｒｅｃｑｌの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途 |
| US20230159924A1 (en) | 2020-03-02 | 2023-05-25 | Mitsubishi Tanabe Pharma Corporation | Prevention or treatment of aneurysms using mir-33b inhibitor |
| EP4130266A4 (en) | 2020-03-26 | 2025-10-08 | Nat Cerebral & Cardiovascular Ct | ANTISENSE NUCLEIC ACID TARGETING APOC3 |
| EP4138858A4 (en) | 2020-04-21 | 2024-07-03 | Flagship Pioneering, Inc. | BIFUNCTIONAL MOLECULES AND METHODS OF USE THEREOF |
| AU2021270720A1 (en) | 2020-05-11 | 2022-12-08 | Stoke Therapeutics, Inc. | OPA1 antisense oligomers for treatment of conditions and diseases |
| JP7725490B2 (ja) | 2020-09-25 | 2025-08-19 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| TW202233838A (zh) | 2020-11-06 | 2022-09-01 | 日商住友製藥股份有限公司 | Ｒｐｓ２５基因之表現及／或功能調節劑 |
| WO2022181807A1 (ja) | 2021-02-25 | 2022-09-01 | 国立大学法人大阪大学 | ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド |
| US20240240176A1 (en) | 2021-04-30 | 2024-07-18 | Kyoto University | Prevention or treatment of myopathy using mir-33b inhibitor |
| JPWO2022234855A1 (enExample) | 2021-05-06 | 2022-11-10 | ||
| CA3221758A1 (en) | 2021-05-28 | 2022-12-01 | Sumitomo Pharma Co., Ltd. | Antisense nucleic acid |
| JPWO2023026994A1 (enExample) | 2021-08-21 | 2023-03-02 | ||
| EP4458836A4 (en) | 2021-12-27 | 2025-05-21 | Riken Genesis Co., Ltd. | Novel artificial nucleic acid, method for producing same, and use of same |
| WO2023176920A1 (ja) | 2022-03-17 | 2023-09-21 | 学校法人 愛知医科大学 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| CN120187739A (zh) | 2022-11-10 | 2025-06-20 | 璐库萨那生物技术株式会社 | 桥联部具有胍基结构的修饰核苷和使用其的寡核苷酸的制造方法 |
| WO2025005265A1 (ja) * | 2023-06-30 | 2025-01-02 | 日産化学株式会社 | 毒性が低減されたアンチセンスオリゴヌクレオチド |
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| SI20474A (sl) * | 1998-05-26 | 2001-08-31 | Icn Pharmaceuticals, Inc. | Novi nukleozidi, ki imajo bicikličen sladkorni del |
| US7615619B2 (en) | 2002-02-13 | 2009-11-10 | Takeshi Imanishi | Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof |
| JP4731324B2 (ja) * | 2003-08-28 | 2011-07-20 | 武 今西 | Ｎ−ｏ結合性架橋構造型新規人工核酸 |
| EP2612914B1 (en) * | 2010-08-31 | 2017-06-21 | Osaka University | Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient |
-
2010
- 2010-10-19 EP EP10826568.7A patent/EP2495248B1/en active Active
- 2010-10-19 CA CA2778171A patent/CA2778171C/en active Active
- 2010-10-19 CN CN201080049279.2A patent/CN102596983B/zh active Active
- 2010-10-19 JP JP2011538366A patent/JPWO2011052436A1/ja not_active Ceased
- 2010-10-19 AU AU2010312751A patent/AU2010312751B2/en active Active
- 2010-10-19 WO PCT/JP2010/068409 patent/WO2011052436A1/ja not_active Ceased
- 2010-10-19 US US13/502,611 patent/US8541562B2/en active Active
-
2013
- 2013-11-27 JP JP2013244692A patent/JP5669073B2/ja active Active
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