JP2016501520A5 - - Google Patents

Download PDF

Info

Publication number
JP2016501520A5
JP2016501520A5 JP2015543449A JP2015543449A JP2016501520A5 JP 2016501520 A5 JP2016501520 A5 JP 2016501520A5 JP 2015543449 A JP2015543449 A JP 2015543449A JP 2015543449 A JP2015543449 A JP 2015543449A JP 2016501520 A5 JP2016501520 A5 JP 2016501520A5
Authority
JP
Japan
Prior art keywords
substituted
alkynyl
alkenyl
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015543449A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016501520A (ja
JP6463687B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2013/074552 external-priority patent/WO2014080004A1/en
Publication of JP2016501520A publication Critical patent/JP2016501520A/ja
Publication of JP2016501520A5 publication Critical patent/JP2016501520A5/ja
Application granted granted Critical
Publication of JP6463687B2 publication Critical patent/JP6463687B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015543449A 2012-11-26 2013-11-25 Fgfr3の発現の調節のための組成物及び方法 Expired - Fee Related JP6463687B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261729922P 2012-11-26 2012-11-26
US61/729,922 2012-11-26
PCT/EP2013/074552 WO2014080004A1 (en) 2012-11-26 2013-11-25 Compositions and methods for modulation of fgfr3 expression

Publications (3)

Publication Number Publication Date
JP2016501520A JP2016501520A (ja) 2016-01-21
JP2016501520A5 true JP2016501520A5 (enExample) 2016-12-01
JP6463687B2 JP6463687B2 (ja) 2019-02-06

Family

ID=49639882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015543449A Expired - Fee Related JP6463687B2 (ja) 2012-11-26 2013-11-25 Fgfr3の発現の調節のための組成物及び方法

Country Status (11)

Country Link
US (1) US9725723B2 (enExample)
EP (1) EP2922955B1 (enExample)
JP (1) JP6463687B2 (enExample)
KR (1) KR20150088305A (enExample)
CN (1) CN104903448B (enExample)
BR (1) BR112015012051A2 (enExample)
CA (1) CA2889993A1 (enExample)
DK (1) DK2922955T3 (enExample)
MX (1) MX2015006289A (enExample)
RU (1) RU2015120645A (enExample)
WO (1) WO2014080004A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064146A2 (en) 2008-12-02 2010-06-10 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
CA2767253A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc. Novel nucleic acid prodrugs and methods of use thereof
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
JP6126009B2 (ja) 2010-11-17 2017-05-10 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. α−シヌクレイン発現の調節
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. キラル制御
WO2014010250A1 (en) 2012-07-13 2014-01-16 Chiralgen, Ltd. Asymmetric auxiliary group
BR112015012051A2 (pt) 2012-11-26 2017-12-12 Roche Innovation Ct Copenhagen As composições e métodos para modulação de expressão de fgfr3
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인
AU2017226389B2 (en) 2016-03-04 2023-02-02 Taiho Pharmaceutical Co., Ltd. Preparation and composition for treatment of malignant tumors
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
PL3769765T3 (pl) 2018-03-19 2024-06-10 Taiho Pharmaceutical Co., Ltd. Kompozycja farmaceutyczna zawierająca alkilosiarczan sodu
JP7762071B2 (ja) * 2020-01-31 2025-10-29 国立大学法人京都大学 軟骨形成異常症の治療
WO2022211095A1 (ja) * 2021-03-31 2022-10-06 ルクサナバイオテク株式会社 Fgfr3のアンチセンスオリゴヌクレオチド

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699808A (en) 1944-10-06 1955-01-18 Mark W Lowe Apparatus for peeling tomatoes
US2699508A (en) 1951-12-21 1955-01-11 Selectronics Inc Method of mounting and construction of mounting for low frequency piezoelectric crystals
US4962029A (en) 1987-10-02 1990-10-09 Cetus Corporation Covalent oligonucleotide-horseradish peroxidase conjugate
US4914210A (en) 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
JPH08504559A (ja) 1992-12-14 1996-05-14 ハネウエル・インコーポレーテッド 個別に制御される冗長巻線を有するモータシステム
US5656408A (en) 1996-04-29 1997-08-12 Xerox Corporation Coated carrier particles
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
ATE293123T1 (de) 1997-09-12 2005-04-15 Exiqon As Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US20030087854A1 (en) * 2001-09-10 2003-05-08 Isis Pharmaceuticals Inc. Antisense modulation of fibroblast growth factor receptor 3 expression
CA2372085C (en) 1999-05-04 2009-10-27 Exiqon A/S L-ribo-lna analogues
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
US7087229B2 (en) 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US8604183B2 (en) 2002-11-05 2013-12-10 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
CA2504694C (en) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
DE60329220D1 (de) 2002-11-18 2009-10-22 Santaris Pharma As Antisense-entwurf
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
JP4731324B2 (ja) 2003-08-28 2011-07-20 武 今西 N−o結合性架橋構造型新規人工核酸
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
EP1964837A4 (en) * 2005-11-22 2010-12-22 Eisai R&D Man Co Ltd Antitumor agent against multiple myeloma
EP1984381B1 (en) 2006-01-27 2010-09-29 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
EP2023940B1 (en) 2006-05-05 2011-06-22 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of sglt2
DK2066684T3 (da) 2006-05-11 2012-10-22 Isis Pharmaceuticals Inc 5´-Modificerede bicycliske nukleinsyreanaloge
MX2009002859A (es) 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos.
EP2076257A4 (en) 2006-09-15 2014-04-16 Belrose Pharma Inc POLYMER CONJUGATES WITH POSITIVELY LOADED PARTS
US9398493B2 (en) 2006-10-30 2016-07-19 Nokia Technologies Oy Method, apparatus, and system providing operator controlled mobility for user equipment
US8580756B2 (en) 2007-03-22 2013-11-12 Santaris Pharma A/S Short oligomer antagonist compounds for the modulation of target mRNA
AU2008260277C1 (en) 2007-05-30 2014-04-17 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
DK2173760T4 (en) 2007-06-08 2016-02-08 Isis Pharmaceuticals Inc Carbocyclic bicyclic nukleinsyreanaloge
CN101796062B (zh) 2007-07-05 2014-07-30 Isis制药公司 6-双取代双环核酸类似物
WO2009090182A1 (en) * 2008-01-14 2009-07-23 Santaris Pharma A/S C4'-substituted - dna nucleotide gapmer oligonucleotides
AT507215B1 (de) 2009-01-14 2010-03-15 Boehler Edelstahl Gmbh & Co Kg Verschleissbeständiger werkstoff
HUE025726T2 (en) * 2009-03-25 2016-04-28 Genentech Inc Anti-FGFR3 antibodies and their use
WO2011139842A2 (en) * 2010-04-28 2011-11-10 Marina Biotech, Inc. Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof
US9984408B1 (en) 2012-05-30 2018-05-29 Amazon Technologies, Inc. Method, medium, and system for live video cooperative shopping
BR112015012051A2 (pt) 2012-11-26 2017-12-12 Roche Innovation Ct Copenhagen As composições e métodos para modulação de expressão de fgfr3
US9778708B1 (en) 2016-07-18 2017-10-03 Lenovo Enterprise Solutions (Singapore) Pte. Ltd. Dual sided latching retainer for computer modules

Similar Documents

Publication Publication Date Title
JP2016501520A5 (enExample)
JP2016503300A5 (enExample)
JP2013508347A5 (enExample)
JP2012140436A5 (ja) 物質
JP2013505929A5 (enExample)
JP2015042636A5 (ja) 有機化合物
JP2017119663A5 (enExample)
JP2015181191A5 (enExample)
JP2009535462A5 (enExample)
JP2013102146A5 (ja) 化合物
JP2013521295A5 (enExample)
JP2014509612A5 (enExample)
JP2010254680A5 (ja) 複素環化合物、及び発光素子
JP2014526533A5 (enExample)
JP2012528196A5 (enExample)
JP2010254679A5 (ja) トリアゾール誘導体、発光素子、及び発光装置
JP2011016798A5 (enExample)
JP2010254681A5 (ja) 複素環化合物、及び発光素子
JP2014508179A5 (enExample)
JP2018531301A5 (enExample)
JP2011079866A5 (enExample)
JP2015083560A5 (ja) 有機金属錯体
JP2014101364A5 (enExample)
JP2015044793A5 (ja) 有機化合物
JP2011079832A5 (enExample)