KR20150088305A - Fgfr3 발현의 조절을 위한 조성물 및 방법 - Google Patents

Fgfr3 발현의 조절을 위한 조성물 및 방법 Download PDF

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Publication number
KR20150088305A
KR20150088305A KR1020157016841A KR20157016841A KR20150088305A KR 20150088305 A KR20150088305 A KR 20150088305A KR 1020157016841 A KR1020157016841 A KR 1020157016841A KR 20157016841 A KR20157016841 A KR 20157016841A KR 20150088305 A KR20150088305 A KR 20150088305A
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South Korea
Prior art keywords
oligonucleotide
fgfr3
seq
oligonucleotides
expression
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KR1020157016841A
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English (en)
Korean (ko)
Inventor
마이 헤티애른
쇠렌 오토센
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로슈 이노베이션 센터 코펜하겐 에이/에스
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Publication of KR20150088305A publication Critical patent/KR20150088305A/ko
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/34—Allele or polymorphism specific uses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
KR1020157016841A 2012-11-26 2013-11-25 Fgfr3 발현의 조절을 위한 조성물 및 방법 Withdrawn KR20150088305A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261729922P 2012-11-26 2012-11-26
US61/729,922 2012-11-26

Publications (1)

Publication Number Publication Date
KR20150088305A true KR20150088305A (ko) 2015-07-31

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KR1020157016841A Withdrawn KR20150088305A (ko) 2012-11-26 2013-11-25 Fgfr3 발현의 조절을 위한 조성물 및 방법

Country Status (11)

Country Link
US (1) US9725723B2 (enExample)
EP (1) EP2922955B1 (enExample)
JP (1) JP6463687B2 (enExample)
KR (1) KR20150088305A (enExample)
CN (1) CN104903448B (enExample)
BR (1) BR112015012051A2 (enExample)
CA (1) CA2889993A1 (enExample)
DK (1) DK2922955T3 (enExample)
MX (1) MX2015006289A (enExample)
RU (1) RU2015120645A (enExample)
WO (1) WO2014080004A1 (enExample)

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Also Published As

Publication number Publication date
JP6463687B2 (ja) 2019-02-06
BR112015012051A2 (pt) 2017-12-12
MX2015006289A (es) 2015-12-03
HK1208702A1 (en) 2016-03-11
JP2016501520A (ja) 2016-01-21
CA2889993A1 (en) 2014-05-30
CN104903448A (zh) 2015-09-09
US20150307886A1 (en) 2015-10-29
DK2922955T3 (da) 2019-05-13
RU2015120645A (ru) 2017-01-10
EP2922955A1 (en) 2015-09-30
US9725723B2 (en) 2017-08-08
EP2922955B1 (en) 2019-03-06
WO2014080004A1 (en) 2014-05-30
CN104903448B (zh) 2017-07-11

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Patent event code: PA01051R01D

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