JP7074674B2 - Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 - Google Patents

Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 Download PDF

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JP7074674B2
JP7074674B2 JP2018534521A JP2018534521A JP7074674B2 JP 7074674 B2 JP7074674 B2 JP 7074674B2 JP 2018534521 A JP2018534521 A JP 2018534521A JP 2018534521 A JP2018534521 A JP 2018534521A JP 7074674 B2 JP7074674 B2 JP 7074674B2
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substituted
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hydrogen
alkoxy
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JP2018528275A (ja
JP2018528275A5 (enExample
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メレアン ビスニック
シン ジアン
マーサ アール． ホータマー
チタセ リー
ブラッドリー ウィリアム カプラザ
ウィリアム エイチ． ロアーク
ゲイリー ボルトン
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リアタ ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2018534521A 2015-09-23 2016-09-23 Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 Active JP7074674B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222632P 2015-09-23 2015-09-23
US62/222,632 2015-09-23
PCT/US2016/053545 WO2017053868A1 (en) 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Publications (3)

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JP2018528275A JP2018528275A (ja) 2018-09-27
JP2018528275A5 JP2018528275A5 (enExample) 2019-11-07
JP7074674B2 true JP7074674B2 (ja) 2022-05-24

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US (2) US11584775B2 (enExample)
EP (1) EP3353190B1 (enExample)
JP (1) JP7074674B2 (enExample)
KR (1) KR102796889B1 (enExample)
CN (1) CN108290922B (enExample)
AU (1) AU2016326704B2 (enExample)
BR (1) BR112018005861B1 (enExample)
CA (1) CA2998681C (enExample)
EA (1) EA201890767A1 (enExample)
ES (1) ES2865163T3 (enExample)
IL (1) IL258185B (enExample)
MX (1) MX386256B (enExample)
NZ (1) NZ741082A (enExample)
WO (1) WO2017053868A1 (enExample)

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US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
TWI630212B (zh) 2012-09-10 2018-07-21 瑞塔醫藥有限責任公司 丁香油素（ｏｌｅａｎｏｌｉｃ ａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法
TWI649330B (zh) 2013-04-24 2019-02-01 艾伯維有限公司 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法
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BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals, Inc. métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
CN108191944B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用
CN108299541B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用
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CN109248168A (zh) * 2018-10-30 2019-01-22 武汉卫无忧生物科技有限公司 齐墩果酸在制备抗幽门螺杆菌的药物中的用途
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
CN120248001A (zh) * 2019-07-19 2025-07-04 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法
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CN113185570A (zh) * 2021-05-12 2021-07-30 张洪胜 一种治疗银屑病的齐墩果酸衍生物及其制备方法
CN117964678A (zh) * 2024-01-29 2024-05-03 烟台大学 C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途

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AU2016326704A1 (en) 2018-04-26
KR102796889B1 (ko) 2025-04-17
WO2017053868A8 (en) 2018-04-19
EP3353190B1 (en) 2021-03-17
US11584775B2 (en) 2023-02-21
CN108290922A (zh) 2018-07-17
KR20180061251A (ko) 2018-06-07
CA2998681A1 (en) 2017-03-30
IL258185A (en) 2018-05-31
US20190153022A1 (en) 2019-05-23
EP3353190A1 (en) 2018-08-01
MX386256B (es) 2025-03-18
JP2018528275A (ja) 2018-09-27
BR112018005861B1 (pt) 2022-11-22
HK1258095A1 (zh) 2019-11-01
US12545701B2 (en) 2026-02-10
NZ741082A (en) 2023-06-30
BR112018005861A2 (pt) 2018-10-16
CN108290922B (zh) 2021-12-07
US20230250130A1 (en) 2023-08-10
EA201890767A1 (ru) 2019-09-30
CA2998681C (en) 2024-02-06
AU2016326704B2 (en) 2021-01-28
IL258185B (en) 2021-08-31
WO2017053868A1 (en) 2017-03-30
MX2018003569A (es) 2018-11-29
ES2865163T3 (es) 2021-10-15

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