ATE449754T1 - Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren - Google Patents

Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren

Info

Publication number
ATE449754T1
ATE449754T1 AT05076500T AT05076500T ATE449754T1 AT E449754 T1 ATE449754 T1 AT E449754T1 AT 05076500 T AT05076500 T AT 05076500T AT 05076500 T AT05076500 T AT 05076500T AT E449754 T1 ATE449754 T1 AT E449754T1
Authority
AT
Austria
Prior art keywords
modulators
interleukin
necrosis factor
tumor necrosis
synthesis
Prior art date
Application number
AT05076500T
Other languages
English (en)
Inventor
Michael Palladino
Emmanuel Theodorakis
Original Assignee
Nereus Pharmaceuticals Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc, Univ California filed Critical Nereus Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE449754T1 publication Critical patent/ATE449754T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
AT05076500T 1999-05-14 2000-05-12 Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren ATE449754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US18685300P 2000-03-03 2000-03-03

Publications (1)

Publication Number Publication Date
ATE449754T1 true ATE449754T1 (de) 2009-12-15

Family

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Family Applications (2)

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AT00932408T ATE370928T1 (de) 1999-05-14 2000-05-12 Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren
AT05076500T ATE449754T1 (de) 1999-05-14 2000-05-12 Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren

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Country Status (17)

Country Link
US (3) US6365768B1 (de)
EP (2) EP1591437B1 (de)
JP (2) JP5059996B2 (de)
KR (3) KR100840925B1 (de)
CN (1) CN1361760A (de)
AT (2) ATE370928T1 (de)
AU (2) AU783372B2 (de)
BR (1) BR0011522A (de)
CA (1) CA2372962C (de)
DE (2) DE60043400D1 (de)
DK (1) DK1178952T5 (de)
ES (2) ES2295031T3 (de)
IL (3) IL146221A0 (de)
MX (1) MXPA01011613A (de)
NZ (3) NZ515675A (de)
PT (2) PT1178952E (de)
WO (1) WO2000073253A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037600A1 (en) * 1998-01-26 1999-07-29 Sae Han Pharm. Co., Ltd. Diterpene derivatives and anti-inflammatory analgesic agents comprising the same
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
CA2372962C (en) 1999-05-14 2008-04-08 Nereus Pharmaceuticals, Inc. Novel interleukin-1 and tumor necrosis factor-.alpha. modulators, syntheses of said modulators and methods of using said modulators
US7119223B2 (en) 1999-05-14 2006-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2002255963A1 (en) * 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use
US20030087334A1 (en) * 2001-04-02 2003-05-08 Libraria, Inc. Method of flexibly generating diverse reaction chemistries
EP1465615B1 (de) 2002-01-15 2012-08-01 Trustees of Dartmouth College Trizyklische bisenon-derivate und verfahren zu ihrer verwendung
KR100529991B1 (ko) * 2002-01-25 2005-11-22 한국생명공학연구원 간염 치료제 및 예방제 또는 간보호제로 유용한 섬오갈피추출물
JP4777970B2 (ja) * 2004-03-03 2011-09-21 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 新規なアビエタンジテルペノイド系化合物、及び榧抽出物、またはそれから分離したアビエタンジテルペノイド系化合物またはテルペノイド系化合物を有効成分とする心臓循環系疾患の予防及び治療用組成物
EP2311795A3 (de) * 2005-07-21 2011-12-28 Nereus Pharmaceuticals, Inc. Interleukin-1- und Tumornekrosefaktor-Alpha-Modulatoren, Synthese solcher Modulatoren und Verfahren unter Anwendung solcher Modulatoren
WO2008064133A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP1925301A1 (de) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Verwendung von tricyclischen Diterpenen und deren Derivaten zur Behandlung oder Vorbeugung von entzündlichen - und/oder Gelenkerkrankungen
US7875853B2 (en) * 2007-07-23 2011-01-25 Honeywell International Inc. Low-cost PIR scanning mechanism
CN104739841B (zh) 2008-01-11 2018-06-01 里亚塔医药公司 合成三萜类化合物及用以治病之方法
KR101665042B1 (ko) 2008-04-18 2016-10-11 리타 파마슈티컬스 잉크. 소염성 골격군을 포함하는 화합물 및 사용 방법
EP2279197B1 (de) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidationsmittel als entzündungsmodulierende substanz: im c-ring gesättigte oleanolsäurederivate
BRPI0911422B8 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals Inc compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
WO2010011782A1 (en) 2008-07-22 2010-01-28 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US20110293653A1 (en) * 2010-03-11 2011-12-01 University Of Massachusetts Antagonists of mir-155 for the treatment of inflammatory liver disease
AU2011240690C1 (en) 2010-04-12 2014-11-06 Reata Pharmaceuticals Holdings, LLC Method of treating obesity using antioxidant inflammation modulators
SG189159A1 (en) * 2010-10-27 2013-05-31 Sigma Tau Ind Farmaceuti Diterpenoid derivatives endowed of biological properties
NZ703649A (en) 2010-12-06 2016-08-26 Penn State Res Found Compositions and methods relating to proliferative diseases
JP5857068B2 (ja) 2010-12-17 2016-02-10 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン
TR201909788T4 (tr) 2011-03-11 2019-07-22 Reata Pharmaceuticals Inc C4-monometil triterpenoid türevleri ve bunların kullanım yöntemleri.
DK2841445T3 (en) 2012-04-27 2017-09-11 Reata Pharmaceuticals Inc 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONMETHYL, POLYMORPHE FORMS THEREOF AND PROCEDURES FOR USING IT
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
BR112015005168A2 (pt) 2012-09-10 2017-08-15 Reata Pharmaceuticals Inc Derivados de c17-alcanodiila e alquenodiila de ácido oleanólico e métodos de uso dos mesmos
ES2865163T3 (es) 2015-09-23 2021-10-15 Reata Pharmaceuticals Inc Derivados de ácido oleanólico modificado en C4 para la inhibición de il-17 y otros usos
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
CN106928095A (zh) * 2017-03-14 2017-07-07 华东师范大学 氰基烯酮类三环二萜类似物及其制备方法和应用
US10463631B2 (en) * 2017-06-12 2019-11-05 University Of South Carolina Pimarane diterpenoids for use in wound healing and angiogenesis
EP3810141A1 (de) 2018-06-20 2021-04-28 Reata Pharmaceuticals, Inc. Cysteinabhängige inverse agonisten von kernrezeptoren-ror-gamma/ror-gamma-t und verfahren zur behandlung von erkrankungen oder störungen damit
US12344631B2 (en) 2019-07-19 2025-07-01 Reata Pharmaceuticals, Inc. C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212708B2 (de) 1974-05-14 1977-04-08
JPS522910B2 (de) 1974-05-17 1977-01-25
GB1452053A (en) 1974-08-28 1976-10-06 Nippon Shinyaku Co Ltd Abietamide derivatives and a method for the preparation thereof
US4874891A (en) 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
EP0472733B1 (de) 1990-03-06 1994-12-28 Otsuka Pharmaceutical Co., Ltd. Phenanthrenderivat
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5683676A (en) 1991-12-12 1997-11-04 Glaxo Group Limited Canister containing aerosol formulations containing P134a and particulate medicaments
PT835657E (pt) 1992-11-27 2004-11-30 Mayne Pharma Usa Inc Composicao injectavel estavel de paclitaxel
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
ATE303143T1 (de) 1993-10-01 2005-09-15 Roche Palo Alto Llc Hochdosierte oral anzuwendende suspensionen enthaltendmycophenolat mofetil
KR0145941B1 (ko) * 1994-06-13 1998-08-17 김은영 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
WO1999037600A1 (en) * 1998-01-26 1999-07-29 Sae Han Pharm. Co., Ltd. Diterpene derivatives and anti-inflammatory analgesic agents comprising the same
US6051590A (en) 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
CA2372962C (en) * 1999-05-14 2008-04-08 Nereus Pharmaceuticals, Inc. Novel interleukin-1 and tumor necrosis factor-.alpha. modulators, syntheses of said modulators and methods of using said modulators
AU2002255963A1 (en) 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use

Also Published As

Publication number Publication date
EP1591437A2 (de) 2005-11-02
AU5013300A (en) 2000-12-18
NZ515675A (en) 2004-06-25
EP1178952A1 (de) 2002-02-13
KR100840925B1 (ko) 2008-06-24
KR20060110013A (ko) 2006-10-23
MXPA01011613A (es) 2003-10-14
CA2372962A1 (en) 2000-12-07
PT1591437E (pt) 2010-03-04
WO2000073253A1 (en) 2000-12-07
AU2006200240B2 (en) 2009-05-28
IL182272A0 (en) 2007-07-24
DK1178952T5 (da) 2008-03-17
AU2006200240A1 (en) 2006-02-16
JP2003500464A (ja) 2003-01-07
ES2337264T3 (es) 2010-04-22
IL146221A (en) 2007-07-04
DE60036101T2 (de) 2008-05-15
DK1178952T3 (da) 2008-01-28
US20030040640A1 (en) 2003-02-27
ES2295031T3 (es) 2008-04-16
NZ540001A (en) 2007-06-29
CA2372962C (en) 2008-04-08
KR100856353B1 (ko) 2008-09-04
US20050209325A1 (en) 2005-09-22
KR20060135080A (ko) 2006-12-28
KR20020028878A (ko) 2002-04-17
US7342125B2 (en) 2008-03-11
EP1591437A3 (de) 2006-03-08
HK1084657A1 (en) 2006-08-04
EP1178952B1 (de) 2007-08-22
PT1178952E (pt) 2007-12-04
DE60043400D1 (de) 2010-01-07
JP5059996B2 (ja) 2012-10-31
IL182272A (en) 2010-05-31
EP1591437B1 (de) 2009-11-25
BR0011522A (pt) 2002-06-04
JP2012211162A (ja) 2012-11-01
AU783372B2 (en) 2005-10-20
CN1361760A (zh) 2002-07-31
IL146221A0 (en) 2002-07-25
US6881857B2 (en) 2005-04-19
US6365768B1 (en) 2002-04-02
ATE370928T1 (de) 2007-09-15
NZ529505A (en) 2005-09-30
DE60036101D1 (de) 2007-10-04

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