ATE370928T1 - Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren - Google Patents
Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatorenInfo
- Publication number
- ATE370928T1 ATE370928T1 AT00932408T AT00932408T ATE370928T1 AT E370928 T1 ATE370928 T1 AT E370928T1 AT 00932408 T AT00932408 T AT 00932408T AT 00932408 T AT00932408 T AT 00932408T AT E370928 T1 ATE370928 T1 AT E370928T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- interleukin
- necrosis factor
- tumor necrosis
- synthesis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/35—Unsaturated compounds having unsaturation outside the rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13429599P | 1999-05-14 | 1999-05-14 | |
US18685300P | 2000-03-03 | 2000-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE370928T1 true ATE370928T1 (de) | 2007-09-15 |
Family
ID=26832188
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00932408T ATE370928T1 (de) | 1999-05-14 | 2000-05-12 | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
AT05076500T ATE449754T1 (de) | 1999-05-14 | 2000-05-12 | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05076500T ATE449754T1 (de) | 1999-05-14 | 2000-05-12 | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
Country Status (18)
Country | Link |
---|---|
US (3) | US6365768B1 (de) |
EP (2) | EP1591437B1 (de) |
JP (2) | JP5059996B2 (de) |
KR (3) | KR100840925B1 (de) |
CN (1) | CN1361760A (de) |
AT (2) | ATE370928T1 (de) |
AU (2) | AU783372B2 (de) |
BR (1) | BR0011522A (de) |
CA (1) | CA2372962C (de) |
DE (2) | DE60036101T2 (de) |
DK (1) | DK1178952T5 (de) |
ES (2) | ES2337264T3 (de) |
HK (1) | HK1084657A1 (de) |
IL (3) | IL146221A0 (de) |
MX (1) | MXPA01011613A (de) |
NZ (3) | NZ515675A (de) |
PT (2) | PT1591437E (de) |
WO (1) | WO2000073253A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1171846C (zh) * | 1998-01-26 | 2004-10-20 | 新韩制药有限公司 | 二萜衍生物以及包含该衍生物的消炎镇痛药 |
US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
NZ515675A (en) | 1999-05-14 | 2004-06-25 | Nereus Pharmaceuticals Inc | Novel interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators |
US7119223B2 (en) * | 1999-05-14 | 2006-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators |
US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
WO2002079137A1 (en) * | 2001-03-28 | 2002-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
US20030087334A1 (en) * | 2001-04-02 | 2003-05-08 | Libraria, Inc. | Method of flexibly generating diverse reaction chemistries |
EP1465615B1 (de) | 2002-01-15 | 2012-08-01 | Trustees of Dartmouth College | Trizyklische bisenon-derivate und verfahren zu ihrer verwendung |
JP2005532992A (ja) * | 2002-01-25 | 2005-11-04 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 肝炎治療剤及び予防剤または肝臓保護剤として有用なソムオガルピ(AcanthopanaxKoreanum)抽出物 |
JP4777970B2 (ja) * | 2004-03-03 | 2011-09-21 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規なアビエタンジテルペノイド系化合物、及び榧抽出物、またはそれから分離したアビエタンジテルペノイド系化合物またはテルペノイド系化合物を有効成分とする心臓循環系疾患の予防及び治療用組成物 |
WO2007015757A2 (en) | 2005-07-21 | 2007-02-08 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-a modulators; syntheses of such modulators and methods of using such modulators |
WO2008064132A2 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
CA2670099A1 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
EP1925301A1 (de) * | 2006-11-24 | 2008-05-28 | DSMIP Assets B.V. | Verwendung von tricyclischen Diterpenen und deren Derivaten zur Behandlung oder Vorbeugung von entzündlichen - und/oder Gelenkerkrankungen |
US7875853B2 (en) * | 2007-07-23 | 2011-01-25 | Honeywell International Inc. | Low-cost PIR scanning mechanism |
EA022166B1 (ru) | 2008-01-11 | 2015-11-30 | Ритэ Фамэсутиклс, Инк. | Синтетические тритерпеноиды и их применение в лечении заболеваний |
TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
CN102083442B (zh) | 2008-04-18 | 2014-08-13 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:在c-17具有氨基和其它修饰的齐墩果酸衍生物 |
CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
US7943778B2 (en) | 2008-04-18 | 2011-05-17 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives |
CN102164941B (zh) | 2008-04-18 | 2015-05-27 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物 |
US8314137B2 (en) | 2008-07-22 | 2012-11-20 | Trustess Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
US20110293653A1 (en) * | 2010-03-11 | 2011-12-01 | University Of Massachusetts | Antagonists of mir-155 for the treatment of inflammatory liver disease |
SG10201808661XA (en) | 2010-04-12 | 2018-11-29 | Reata Pharmaceuticals Inc | Method of treating obesity using antioxidant inflammation modulators |
EP2632892B1 (de) * | 2010-10-27 | 2014-07-30 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Mit biologischen eigenschaften dotierte diterpenoidderivate |
EP2648706A4 (de) | 2010-12-06 | 2014-07-23 | Penn State Res Found | Zusammensetzungen und verfahren im zusammenhang mit proliferativen erkrankungen |
WO2012083306A2 (en) | 2010-12-17 | 2012-06-21 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
CN103619866B (zh) | 2011-03-11 | 2016-06-22 | 里亚塔医药公司 | C4-一甲基三萜系化合物的衍生物及其使用方法 |
BR112014026640B1 (pt) | 2012-04-27 | 2021-05-18 | Reata Pharmaceuticals, Inc | compostos derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimórficas, composição farmacêutica, e uso dos mesmos |
US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
KR102237359B1 (ko) | 2012-09-10 | 2021-04-06 | 리아타 파마슈티컬즈, 아이엔씨. | 올레아놀산의 c17―알칸디일 및 알켄디일 유도체 및 그의 사용 방법 |
US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
CN108290922B (zh) | 2015-09-23 | 2021-12-07 | 里亚塔医药公司 | 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 |
NZ753546A (en) | 2016-11-08 | 2022-10-28 | Reata Pharmaceuticals Holdings Llc | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
CN106928095A (zh) * | 2017-03-14 | 2017-07-07 | 华东师范大学 | 氰基烯酮类三环二萜类似物及其制备方法和应用 |
US10463631B2 (en) * | 2017-06-12 | 2019-11-05 | University Of South Carolina | Pimarane diterpenoids for use in wound healing and angiogenesis |
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JPS5212708B2 (de) | 1974-05-14 | 1977-04-08 | ||
JPS522910B2 (de) | 1974-05-17 | 1977-01-25 | ||
GB1452053A (en) | 1974-08-28 | 1976-10-06 | Nippon Shinyaku Co Ltd | Abietamide derivatives and a method for the preparation thereof |
US4874891A (en) | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
EP0472733B1 (de) | 1990-03-06 | 1994-12-28 | Otsuka Pharmaceutical Co., Ltd. | Phenanthrenderivat |
US5276182A (en) | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
DE4039602A1 (de) | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
US5653962A (en) | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
DE69333605T2 (de) | 1992-11-27 | 2005-02-03 | Mayne Pharma (Usa) Inc. | Stabile injizierbare Paclitaxel Lösung |
US5654286A (en) | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
EP0721335B1 (de) | 1993-10-01 | 2005-08-31 | Roche Palo Alto LLC | Hochdosierte oral anzuwendende suspensionen enthaltendmycophenolat mofetil |
KR0145941B1 (ko) * | 1994-06-13 | 1998-08-17 | 김은영 | 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물 |
US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
US5653987A (en) | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
CN1171846C (zh) * | 1998-01-26 | 2004-10-20 | 新韩制药有限公司 | 二萜衍生物以及包含该衍生物的消炎镇痛药 |
US6051590A (en) | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
NZ515675A (en) * | 1999-05-14 | 2004-06-25 | Nereus Pharmaceuticals Inc | Novel interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators |
WO2002079137A1 (en) | 2001-03-28 | 2002-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
-
2000
- 2000-05-12 NZ NZ515675A patent/NZ515675A/en not_active IP Right Cessation
- 2000-05-12 NZ NZ529505A patent/NZ529505A/en not_active IP Right Cessation
- 2000-05-12 MX MXPA01011613A patent/MXPA01011613A/es active IP Right Grant
- 2000-05-12 DE DE60036101T patent/DE60036101T2/de not_active Expired - Lifetime
- 2000-05-12 PT PT05076500T patent/PT1591437E/pt unknown
- 2000-05-12 AU AU50133/00A patent/AU783372B2/en not_active Ceased
- 2000-05-12 AT AT00932408T patent/ATE370928T1/de active
- 2000-05-12 US US09/570,202 patent/US6365768B1/en not_active Expired - Fee Related
- 2000-05-12 IL IL14622100A patent/IL146221A0/xx active IP Right Grant
- 2000-05-12 JP JP2000621320A patent/JP5059996B2/ja not_active Expired - Lifetime
- 2000-05-12 DE DE60043400T patent/DE60043400D1/de not_active Expired - Lifetime
- 2000-05-12 BR BR0011522-3A patent/BR0011522A/pt not_active Application Discontinuation
- 2000-05-12 DK DK00932408T patent/DK1178952T5/da active
- 2000-05-12 CN CN00810323A patent/CN1361760A/zh active Pending
- 2000-05-12 CA CA002372962A patent/CA2372962C/en not_active Expired - Fee Related
- 2000-05-12 KR KR1020067025785A patent/KR100840925B1/ko not_active IP Right Cessation
- 2000-05-12 EP EP05076500A patent/EP1591437B1/de not_active Expired - Lifetime
- 2000-05-12 ES ES05076500T patent/ES2337264T3/es not_active Expired - Lifetime
- 2000-05-12 PT PT00932408T patent/PT1178952E/pt unknown
- 2000-05-12 NZ NZ540001A patent/NZ540001A/en not_active IP Right Cessation
- 2000-05-12 ES ES00932408T patent/ES2295031T3/es not_active Expired - Lifetime
- 2000-05-12 EP EP00932408A patent/EP1178952B1/de not_active Expired - Lifetime
- 2000-05-12 KR KR1020017014545A patent/KR100856353B1/ko not_active IP Right Cessation
- 2000-05-12 KR KR1020067020613A patent/KR20060110013A/ko not_active Application Discontinuation
- 2000-05-12 AT AT05076500T patent/ATE449754T1/de active
- 2000-05-12 WO PCT/US2000/013202 patent/WO2000073253A1/en active IP Right Grant
-
2001
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2002
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2005
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2006
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2007
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2012
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