RS61544B1 - Derivat 2,2-difluoropropionamida metil bardoksolona, njegove farmaceutske supstance i polimorfi za upotrebu za lečenje izvesnih stanja - Google Patents
Derivat 2,2-difluoropropionamida metil bardoksolona, njegove farmaceutske supstance i polimorfi za upotrebu za lečenje izvesnih stanjaInfo
- Publication number
- RS61544B1 RS61544B1 RS20210286A RSP20210286A RS61544B1 RS 61544 B1 RS61544 B1 RS 61544B1 RS 20210286 A RS20210286 A RS 20210286A RS P20210286 A RSP20210286 A RS P20210286A RS 61544 B1 RS61544 B1 RS 61544B1
- Authority
- RS
- Serbia
- Prior art keywords
- difluoropropionamide
- polymorphs
- derivative
- pharmaceutical compositions
- certain conditions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261687669P | 2012-04-27 | 2012-04-27 | |
| US201361775288P | 2013-03-08 | 2013-03-08 | |
| US201361780444P | 2013-03-13 | 2013-03-13 | |
| EP17175885.7A EP3444261B1 (en) | 2012-04-27 | 2013-04-24 | 2,2-difluoropropionamide derivative of bardoxolone methyl, pharmaceutical compositions and polymorphs thereof for use in treating certain conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS61544B1 true RS61544B1 (sr) | 2021-04-29 |
Family
ID=49483867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20210286A RS61544B1 (sr) | 2012-04-27 | 2013-04-24 | Derivat 2,2-difluoropropionamida metil bardoksolona, njegove farmaceutske supstance i polimorfi za upotrebu za lečenje izvesnih stanja |
| RS20170770A RS56154B1 (sr) | 2012-04-27 | 2013-04-24 | 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20170770A RS56154B1 (sr) | 2012-04-27 | 2013-04-24 | 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu |
Country Status (39)
| Country | Link |
|---|---|
| US (4) | US8993640B2 (sr) |
| EP (2) | EP3444261B1 (sr) |
| JP (2) | JP6410710B2 (sr) |
| KR (1) | KR102101774B1 (sr) |
| CN (1) | CN104395332B (sr) |
| AR (1) | AR092823A1 (sr) |
| AU (1) | AU2013251602B2 (sr) |
| BR (1) | BR112014026640B1 (sr) |
| CA (1) | CA2869783C (sr) |
| CL (1) | CL2014002886A1 (sr) |
| CO (1) | CO7170182A2 (sr) |
| CY (2) | CY1119333T1 (sr) |
| DK (2) | DK2841445T3 (sr) |
| DO (1) | DOP2014000236A (sr) |
| EA (1) | EA030468B1 (sr) |
| ES (2) | ES2634315T3 (sr) |
| FI (1) | FIC20240012I1 (sr) |
| FR (1) | FR24C1015I1 (sr) |
| HK (2) | HK1207086A1 (sr) |
| HR (1) | HRP20171275T1 (sr) |
| HU (3) | HUE053113T2 (sr) |
| IL (1) | IL235275B (sr) |
| LT (2) | LT3444261T (sr) |
| ME (1) | ME02926B (sr) |
| MX (1) | MX357060B (sr) |
| MY (1) | MY172750A (sr) |
| NL (1) | NL301276I2 (sr) |
| NZ (1) | NZ630222A (sr) |
| PE (1) | PE20150160A1 (sr) |
| PL (2) | PL3444261T3 (sr) |
| PT (2) | PT3444261T (sr) |
| RS (2) | RS61544B1 (sr) |
| SG (1) | SG11201406868XA (sr) |
| SI (2) | SI2841445T1 (sr) |
| TW (2) | TWI623548B (sr) |
| UA (1) | UA116209C2 (sr) |
| UY (1) | UY34764A (sr) |
| WO (1) | WO2013163344A1 (sr) |
| ZA (1) | ZA201407326B (sr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200942231A (en) | 2008-01-11 | 2009-10-16 | Reata Pharmaceuticals Inc | Synthetic triterpenoids and methods of use in the treatment of disease |
| NZ588710A (en) | 2008-04-18 | 2012-12-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
| JP5564490B2 (ja) | 2008-04-18 | 2014-07-30 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗炎症性ファルマコアを含む化合物および使用法 |
| NZ612788A (en) | 2010-12-17 | 2015-10-30 | Reata Pharmaceuticals Inc | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| RS61544B1 (sr) | 2012-04-27 | 2021-04-29 | Reata Pharmaceuticals Inc | Derivat 2,2-difluoropropionamida metil bardoksolona, njegove farmaceutske supstance i polimorfi za upotrebu za lečenje izvesnih stanja |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| TWI630212B (zh) | 2012-09-10 | 2018-07-21 | 瑞塔醫藥有限責任公司 | 丁香油素（ｏｌｅａｎｏｌｉｃ ａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法 |
| UY35534A (es) * | 2013-04-24 | 2014-10-31 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| EP3212195A4 (en) | 2014-10-31 | 2018-06-06 | The Regents of The University of California | Compositions and methods for treating hiv-associated cognitive dysfunction |
| WO2016130927A1 (en) | 2015-02-12 | 2016-08-18 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
| CN108290922B (zh) | 2015-09-23 | 2021-12-07 | 里亚塔医药公司 | 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 |
| EP3538104A1 (en) | 2016-11-08 | 2019-09-18 | Reata Pharmaceuticals, Inc. | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| SG11202011502VA (en) * | 2018-05-24 | 2020-12-30 | Renibus Therapeutics Inc | Methods of treating patients at risk for renal injury and renal failure |
| WO2019241796A1 (en) | 2018-06-15 | 2019-12-19 | Reata Pharmaceuticals, Inc. | Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| UA126950C2 (uk) | 2018-08-20 | 2023-02-22 | Янссен Фармацевтика Нв | Інгібітори міжбілкової взаємодії keap1-nrf2 |
| US20220133748A1 (en) * | 2019-02-15 | 2022-05-05 | Triterpenoid Therapeutics, Inc. | Methods and compositions for inhibiting the nlrp3 inflammasome and/or lon protease |
| JP2023504194A (ja) * | 2019-12-03 | 2023-02-01 | ベイラー カレッジ オブ メディスン | インスリン耐性における使用方法のための治療化合物 |
| CA3159181A1 (en) | 2020-01-24 | 2021-07-29 | Imran ALIBHAI | Therapeutic compounds, formulations, and uses thereof |
| EP4259155A1 (en) | 2020-12-11 | 2023-10-18 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| US20240140986A1 (en) * | 2021-01-18 | 2024-05-02 | Reata Pharmaceuticals, Inc. | Synthetic ursolic acid derivatives and methods of use thereof |
| CN113197905B (zh) * | 2021-04-23 | 2022-04-19 | 浙江大学 | 三萜类化合物在制备神经母细胞瘤治疗药物中的应用 |
| CN113358627B (zh) * | 2021-06-23 | 2022-07-01 | 华中农业大学 | 一种基于拉曼检测的田间快速测定茶树品质成分的方法 |
| CN114344308A (zh) * | 2021-12-22 | 2022-04-15 | 山西医科大学第二医院 | 甲基巴多索隆在制备防治骨关节炎的药物中的应用 |
| WO2023244946A1 (en) | 2022-06-15 | 2023-12-21 | Tvardi Therapeutics, Inc. | Prodrugs of stat3 inhibitors |
| US20240124393A1 (en) | 2022-09-21 | 2024-04-18 | Sicor - Societa Italiana Corticosteroidi S.R.L. | Process and intermediates for preparation of omaveloxolone and salts thereof |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5555153Y2 (sr) | 1975-03-19 | 1980-12-20 | ||
| NZ191586A (en) | 1978-10-10 | 1981-10-19 | Sterling Drug Inc | Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions |
| US4395423A (en) | 1978-10-10 | 1983-07-26 | Sterling Drug Inc. | Polycyclic cyanoketones |
| US5064823A (en) | 1988-08-24 | 1991-11-12 | Research Triangle Institute | Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers |
| US6025395A (en) | 1994-04-15 | 2000-02-15 | Duke University | Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders |
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US6369101B1 (en) | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| NZ515675A (en) | 1999-05-14 | 2004-06-25 | Nereus Pharmaceuticals Inc | Novel interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators |
| US6649654B1 (en) | 1999-11-23 | 2003-11-18 | The Regents Of The University Of California | Methods for identifying and using IKK inhibitors |
| JP2001240573A (ja) | 2000-03-01 | 2001-09-04 | Meiji Seika Kaisha Ltd | トリテルペン誘導体及び肝疾患治療剤 |
| WO2002003996A1 (en) | 2000-07-12 | 2002-01-17 | RAJKUMAR, Sujatha | Use of dammarane-type tritepenoid saporins |
| US6951847B2 (en) | 2000-09-29 | 2005-10-04 | Regents Of The University Of Minnesota | Methods of treating fungal infections using lupeol |
| US6689767B2 (en) | 2000-09-29 | 2004-02-10 | Regents Of The University Of Minnesota | Triterpenes having antibacterial activity |
| US6642217B2 (en) | 2000-09-29 | 2003-11-04 | Naturtek, Llc | Triterpenes having human antifungal and antiyeast activity |
| US6878751B1 (en) | 2000-10-19 | 2005-04-12 | Imperial College Of Science Technology And Medicine | Administration of resveratrol to treat inflammatory respiratory disorders |
| AU2002243246A1 (en) | 2000-11-28 | 2002-06-24 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| WO2002092768A2 (en) | 2001-05-14 | 2002-11-21 | University Of Maryland, Baltimore | Novel alanine transaminase enzyme and methods of use |
| CA2472581C (en) | 2002-01-15 | 2012-06-26 | Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| WO2003062260A1 (en) | 2002-01-18 | 2003-07-31 | Regents Of The University Of Minnesota | Triterpene quaternary salts as biologically active surfactants |
| US6974801B2 (en) | 2002-05-13 | 2005-12-13 | The Trustees Of Dartmounth College | Inhibitors and methods of use thereof |
| WO2004089357A2 (en) | 2003-04-02 | 2004-10-21 | Regents Of The University Of Minnesota | Anti-fungal formulation of triterpene and essential oil |
| AU2005282437B2 (en) | 2004-09-07 | 2013-01-10 | Pacific Arrow Limited | Anti-tumor compounds with angeloyl groups |
| WO2005042002A2 (en) | 2003-10-30 | 2005-05-12 | Entelos, Inc. | Treatment of rhematoid arthritis with flip antagonists |
| US8288439B2 (en) | 2003-11-04 | 2012-10-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the inhibition of HIV-1 replication |
| US20060258752A1 (en) | 2004-02-12 | 2006-11-16 | Vander Jagt David L | Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors |
| JP2005314381A (ja) | 2004-03-30 | 2005-11-10 | Anges Mg Inc | 増殖性腎疾患の予防・治療・改善剤 |
| EP1959969A2 (en) | 2005-07-01 | 2008-08-27 | The Johns Hopkins University | Compositions and methods for the treatment or prevention of disorders relating to oxidative stress |
| JP2009530405A (ja) | 2006-03-23 | 2009-08-27 | アドバンスト ライフ サイエンシズ インコーポレイテッド | 合成五環性トリテルペノイド、ならびにベツリン酸およびベツリンの誘導体 |
| WO2007127791A2 (en) | 2006-04-25 | 2007-11-08 | The Administrators Of The Tulane Educational Fund | New pharmacological method for treatment of neuropathic pain |
| JP5610766B2 (ja) | 2006-06-27 | 2014-10-22 | ウェリントン ラボラトリーズ インコーポレイティッド | グリチルレチン酸誘導体 |
| WO2008016095A1 (fr) | 2006-08-02 | 2008-02-07 | Santen Pharmaceutical Co., Ltd. | REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE |
| JP2008110962A (ja) | 2006-08-02 | 2008-05-15 | Santen Pharmaceut Co Ltd | Ｎｒｆ２活性化物質を有効成分として含む角結膜障害の予防または治療剤 |
| WO2008064132A2 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| CA2670099A1 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| ES2916604T1 (es) | 2007-02-08 | 2022-07-04 | Biogen Ma Inc | Ensayos de detección de nrf2 y métodos y composiciones relacionados |
| JP2008247898A (ja) | 2007-03-08 | 2008-10-16 | Santen Pharmaceut Co Ltd | トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 |
| US20080254055A1 (en) | 2007-04-11 | 2008-10-16 | John Erich Oblong | Compositions for Regulation of Hair Growth |
| WO2008136838A1 (en) | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| US20090048205A1 (en) | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| US9012439B2 (en) | 2007-10-29 | 2015-04-21 | University Of Rochester | Use of electrophilic compounds for inducing platelet production or maintaining platelet function |
| TW200942231A (en) | 2008-01-11 | 2009-10-16 | Reata Pharmaceuticals Inc | Synthetic triterpenoids and methods of use in the treatment of disease |
| TW201004627A (en) * | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| NZ588710A (en) | 2008-04-18 | 2012-12-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
| JP5564490B2 (ja) | 2008-04-18 | 2014-07-30 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗炎症性ファルマコアを含む化合物および使用法 |
| CN104250280A (zh) | 2008-04-18 | 2014-12-31 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物 |
| JP5758801B2 (ja) | 2008-07-22 | 2015-08-05 | トラスティーズ・オブ・ダートマス・カレッジＴｒｕｓｔｅｅｓ ｏｆ Ｄａｒｔｍｏｕｔｈ Ｃｏｌｌｅｇｅ | 単環式シアノエノンおよびその使用方法説明 |
| WO2010053817A1 (en) | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| CA2744388A1 (en) | 2008-11-21 | 2010-05-27 | The Johns Hopkins University | Compositions and methods for treating or preventing radiation injury |
| PT3254675T (pt) | 2009-02-13 | 2019-06-14 | Reata Pharmaceuticals Inc | Composições de dosagem oral de libertação prolongada que contêm cddo-me amorfo |
| CA2760687A1 (en) | 2009-05-01 | 2010-11-04 | Ophthotech Corporation | Methods for treating or preventing ophthalmological diseases |
| CA2795320C (en) | 2010-04-12 | 2019-01-22 | Reata Pharmaceuticals, Inc. | Method of treating obesity using antioxidant inflammation modulators |
| WO2011140078A1 (en) | 2010-05-04 | 2011-11-10 | Concert Pharmaceuticals, Inc. | Synthetic triterpenoid derivatives |
| WO2012009171A2 (en) | 2010-07-15 | 2012-01-19 | The Schepens Eye Research Institute, Inc. | Compositions and methods of treatment of corneal endothelium disorders |
| CN102070697A (zh) | 2010-12-09 | 2011-05-25 | 中国药科大学 | 一种齐墩果酸衍生物、其制备方法及用途 |
| CN102079772A (zh) | 2010-12-09 | 2011-06-01 | 中国药科大学 | 一类五环三萜-13,28-内酯化合物、其制备方法和用途 |
| NZ612788A (en) | 2010-12-17 | 2015-10-30 | Reata Pharmaceuticals Inc | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| SG192144A1 (en) | 2011-01-31 | 2013-08-30 | Bristol Myers Squibb Co | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
| CN102153613B (zh) | 2011-02-28 | 2013-08-14 | 贵州省中国科学院天然产物化学重点实验室 | 夏枯草酸的制备方法和应用 |
| CN102093462B (zh) | 2011-02-28 | 2012-11-21 | 贵州省中国科学院天然产物化学重点实验室 | 1α,2α-二羟基齐墩果酸的制备方法和应用 |
| LT2683731T (lt) | 2011-03-11 | 2019-07-10 | Reata Pharmaceuticals, Inc. | C4-monometiltriterpenoido dariniai ir jų panaudojimo būdai |
| WO2012154554A1 (en) | 2011-05-06 | 2012-11-15 | Catabasis Pharmaceuticals, Inc. | Fatty acid triterpene derivatives and their uses |
| CN102250189B (zh) | 2011-05-20 | 2012-08-29 | 中国药科大学 | 一种具有1,12-二烯-3-酮骨架的甘草次酸衍生物、其制备方法及医药用途 |
| RS61544B1 (sr) | 2012-04-27 | 2021-04-29 | Reata Pharmaceuticals Inc | Derivat 2,2-difluoropropionamida metil bardoksolona, njegove farmaceutske supstance i polimorfi za upotrebu za lečenje izvesnih stanja |
| US8981144B2 (en) | 2012-05-08 | 2015-03-17 | Trustees Of Dartmouth College | Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof |
| WO2013169740A2 (en) | 2012-05-08 | 2013-11-14 | Trustees Of Dartmouth College | Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| WO2013188818A1 (en) * | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| RU2487884C1 (ru) | 2012-07-13 | 2013-07-20 | Общество с ограниченной ответственностью "Дакор" (ООО "Дакор") | Средство, обладающее антиоксидантной, противовоспалительной, нейропротекторной, гиполипидемической, гипохолестеринемической, гипогликемической, гепатопротекторной, иммуносупрессорной активностями |
| CN103665087A (zh) | 2012-09-03 | 2014-03-26 | 上海源力生物技术有限公司 | 一种萜类化合物及其在医药上的应用 |
| EP2892910B1 (en) | 2012-09-10 | 2016-09-07 | AbbVie Inc. | Glycyrrhetinic acid derivatives with anti-inflammatory activity |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| BR112015005200B1 (pt) | 2012-09-10 | 2022-07-05 | Reata Pharmaceuticals, Inc | Composto derivado de c17-heteroaril de ácido oleanólico, composição farmacêutica compreendendo o referido composto e uso do mesmo |
| TWI630212B (zh) | 2012-09-10 | 2018-07-21 | 瑞塔醫藥有限責任公司 | 丁香油素（ｏｌｅａｎｏｌｉｃ ａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法 |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| EP2739639A4 (en) | 2012-09-28 | 2014-11-05 | Applied Pharmaceutical Science Inc | POLYMORPHS OF CDDO ETHYL ESTER AND USES THEREOF |
| CN102875634B (zh) | 2012-10-24 | 2014-08-20 | 苏州晶云药物科技有限公司 | 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型 |
| CN102887936A (zh) | 2012-10-24 | 2013-01-23 | 苏州晶云药物科技有限公司 | 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型 |
| UY35534A (es) | 2013-04-24 | 2014-10-31 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| AU2014308600B2 (en) | 2013-08-23 | 2020-03-05 | Reata Pharmaceuticals Holdings, LLC | Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof |
| CN107074801B (zh) | 2014-01-24 | 2021-11-05 | 里亚塔医药公司 | 芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化炎症调节剂 |
| WO2016130927A1 (en) | 2015-02-12 | 2016-08-18 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
| CN108290922B (zh) | 2015-09-23 | 2021-12-07 | 里亚塔医药公司 | 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 |
| EP3538104A1 (en) | 2016-11-08 | 2019-09-18 | Reata Pharmaceuticals, Inc. | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
-
2013
- 2013-04-24 RS RS20210286A patent/RS61544B1/sr unknown
- 2013-04-24 AU AU2013251602A patent/AU2013251602B2/en active Active
- 2013-04-24 JP JP2015509119A patent/JP6410710B2/ja active Active
- 2013-04-24 BR BR112014026640-9A patent/BR112014026640B1/pt active IP Right Grant
- 2013-04-24 LT LTEP17175885.7T patent/LT3444261T/lt unknown
- 2013-04-24 MY MYPI2014003024A patent/MY172750A/en unknown
- 2013-04-24 SI SI201330749T patent/SI2841445T1/sl unknown
- 2013-04-24 DK DK13720708.0T patent/DK2841445T3/en active
- 2013-04-24 US US13/869,833 patent/US8993640B2/en active Active
- 2013-04-24 PT PT171758857T patent/PT3444261T/pt unknown
- 2013-04-24 PT PT137207080T patent/PT2841445T/pt unknown
- 2013-04-24 SI SI201331856T patent/SI3444261T1/sl unknown
- 2013-04-24 TW TW106112410A patent/TWI623548B/zh active
- 2013-04-24 EA EA201491972A patent/EA030468B1/ru unknown
- 2013-04-24 UA UAA201412683A patent/UA116209C2/uk unknown
- 2013-04-24 EP EP17175885.7A patent/EP3444261B1/en active Active
- 2013-04-24 CA CA2869783A patent/CA2869783C/en active Active
- 2013-04-24 ME MEP-2017-178A patent/ME02926B/me unknown
- 2013-04-24 LT LTEP13720708.0T patent/LT2841445T/lt unknown
- 2013-04-24 UY UY0001034764A patent/UY34764A/es active IP Right Grant
- 2013-04-24 DK DK17175885.7T patent/DK3444261T3/da active
- 2013-04-24 SG SG11201406868XA patent/SG11201406868XA/en unknown
- 2013-04-24 HU HUE17175885A patent/HUE053113T2/hu unknown
- 2013-04-24 PL PL17175885T patent/PL3444261T3/pl unknown
- 2013-04-24 ES ES13720708.0T patent/ES2634315T3/es active Active
- 2013-04-24 CN CN201380034275.0A patent/CN104395332B/zh active Active
- 2013-04-24 PE PE2014001894A patent/PE20150160A1/es active IP Right Grant
- 2013-04-24 HU HUE13720708A patent/HUE035673T2/en unknown
- 2013-04-24 NZ NZ630222A patent/NZ630222A/en unknown
- 2013-04-24 EP EP13720708.0A patent/EP2841445B1/en active Active
- 2013-04-24 WO PCT/US2013/038064 patent/WO2013163344A1/en active Application Filing
- 2013-04-24 RS RS20170770A patent/RS56154B1/sr unknown
- 2013-04-24 TW TW102114730A patent/TW201348245A/zh unknown
- 2013-04-24 ES ES17175885T patent/ES2861393T3/es active Active
- 2013-04-24 PL PL13720708T patent/PL2841445T3/pl unknown
- 2013-04-24 KR KR1020147032968A patent/KR102101774B1/ko active IP Right Grant
- 2013-04-24 MX MX2014013076A patent/MX357060B/es active IP Right Grant
- 2013-04-24 AR ARP130101383A patent/AR092823A1/es not_active Application Discontinuation
-
2014
- 2014-10-09 ZA ZA2014/07326A patent/ZA201407326B/en unknown
- 2014-10-21 DO DO2014000236A patent/DOP2014000236A/es unknown
- 2014-10-22 IL IL235275A patent/IL235275B/en active IP Right Grant
- 2014-10-24 CL CL2014002886A patent/CL2014002886A1/es unknown
- 2014-10-29 CO CO14240045A patent/CO7170182A2/es unknown
-
2015
- 2015-02-19 US US14/625,829 patent/US9701709B2/en active Active
- 2015-08-05 HK HK15107527.0A patent/HK1207086A1/xx unknown
- 2015-08-05 HK HK15107525.2A patent/HK1207085A1/xx unknown
-
2017
- 2017-06-14 US US15/622,568 patent/US11078230B2/en active Active
- 2017-08-22 HR HRP20171275TT patent/HRP20171275T1/hr unknown
- 2017-09-12 CY CY20171100959T patent/CY1119333T1/el unknown
-
2018
- 2018-09-25 JP JP2018178470A patent/JP6637136B2/ja active Active
-
2021
- 2021-03-26 CY CY20211100266T patent/CY1124130T1/el unknown
- 2021-06-25 US US17/304,778 patent/US12065464B2/en active Active
-
2024
- 2024-04-17 FR FR24C1015C patent/FR24C1015I1/fr active Active
- 2024-04-18 HU HUS2400010C patent/HUS2400010I1/hu unknown
- 2024-04-18 FI FIC20240012C patent/FIC20240012I1/fi unknown
- 2024-05-29 NL NL301276C patent/NL301276I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3444261T3 (pl) | Pochodne 2,2-difluoropropionamidowe bardoksolonu metylu, ich kompozycje farmaceutyczne i formy polimorficzne do zastosowania w leczeniu określonych stanów | |
| HRP20190318T1 (hr) | Farmaceutski ili kozmetički pripravak za liječenje alopecije | |
| IL236221A (en) | History of theophyridone and pharmacological preparations containing them for the treatment of diseases | |
| HK1212217A1 (en) | Methods of treating alzheimers disease and pharmaceutical compositions thereof | |
| ZA201406145B (en) | Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use | |
| PL2672966T3 (pl) | Kompozycja farmaceutyczna, sposoby leczenia i jej zastosowania | |
| PL2729151T3 (pl) | Kompozycja farmaceutyczna, sposoby leczenia i jej zastosowania | |
| HK1202415A1 (en) | Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15- hetre and methods of use thereof dgla15-ohepa/ 15-hetre | |
| IL234884A0 (en) | Inhibitors of kynurenine-3-monooxygenase pharmaceutical compositions, and methods of their use | |
| IL236057B (en) | History of 4,2,1-triazine-6-carboxamide and pharmaceutical preparations containing them | |
| HK1200366A1 (en) | Pharmaceutical compositions and methods of use of 4-pregenen-11ss-17- 21-triol-3,20-dione derivatives 4--11-17-21--320- | |
| DK3292875T3 (en) | Compositions and methods for treating diseases | |
| HK1188791A1 (zh) | 新型八氫噻吩並喹啉衍生物、包含所述衍生物的藥物組合物及它們的用途 | |
| ZA201309559B (en) | Comptothecin derivative, method for preparing same, pharmaceutical composition and use thereof | |
| IL254289A0 (en) | History of fatty acids and pharmaceutical preparations containing them for the treatment of schizophrenia | |
| EP2789613A4 (en) | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF AND ITS USE |