MX357060B - Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos. - Google Patents
Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos.Info
- Publication number
- MX357060B MX357060B MX2014013076A MX2014013076A MX357060B MX 357060 B MX357060 B MX 357060B MX 2014013076 A MX2014013076 A MX 2014013076A MX 2014013076 A MX2014013076 A MX 2014013076A MX 357060 B MX357060 B MX 357060B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- polymorphic forms
- bardoxolone methyl
- difluoropropionamide
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente invención se refiere generalmente al compuesto: N-((4aS,6aR,6bS,8aR, 12aS,14aR,14bS)-1 1-ciano-2,2,6a,6b,9,9,12a-h eptametil-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a ,14b-octadecahidropicen-4a-il)-2,2-difluoropropanamida, formas polimórficas del mismo, método para la preparación y uso del mismo, composiciones farmacéuticas del mismo, y equipos y artículos para la elaboración del mismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261687669P | 2012-04-27 | 2012-04-27 | |
US201361775288P | 2013-03-08 | 2013-03-08 | |
US201361780444P | 2013-03-13 | 2013-03-13 | |
PCT/US2013/038064 WO2013163344A1 (en) | 2012-04-27 | 2013-04-24 | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014013076A MX2014013076A (es) | 2015-05-11 |
MX357060B true MX357060B (es) | 2018-06-25 |
Family
ID=49483867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014013076A MX357060B (es) | 2012-04-27 | 2013-04-24 | Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos. |
Country Status (36)
Country | Link |
---|---|
US (4) | US8993640B2 (es) |
EP (2) | EP2841445B1 (es) |
JP (2) | JP6410710B2 (es) |
KR (1) | KR102101774B1 (es) |
CN (1) | CN104395332B (es) |
AR (1) | AR092823A1 (es) |
AU (1) | AU2013251602B2 (es) |
BR (1) | BR112014026640B1 (es) |
CA (1) | CA2869783C (es) |
CL (1) | CL2014002886A1 (es) |
CO (1) | CO7170182A2 (es) |
CY (2) | CY1119333T1 (es) |
DK (2) | DK2841445T3 (es) |
DO (1) | DOP2014000236A (es) |
EA (1) | EA030468B1 (es) |
ES (2) | ES2861393T3 (es) |
HK (2) | HK1207086A1 (es) |
HR (1) | HRP20171275T1 (es) |
HU (2) | HUE053113T2 (es) |
IL (1) | IL235275B (es) |
LT (2) | LT2841445T (es) |
ME (1) | ME02926B (es) |
MX (1) | MX357060B (es) |
MY (1) | MY172750A (es) |
NZ (1) | NZ630222A (es) |
PE (1) | PE20150160A1 (es) |
PL (2) | PL3444261T3 (es) |
PT (2) | PT2841445T (es) |
RS (2) | RS56154B1 (es) |
SG (1) | SG11201406868XA (es) |
SI (2) | SI3444261T1 (es) |
TW (2) | TWI623548B (es) |
UA (1) | UA116209C2 (es) |
UY (1) | UY34764A (es) |
WO (1) | WO2013163344A1 (es) |
ZA (1) | ZA201407326B (es) |
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NO2651902T3 (es) | 2010-12-17 | 2018-04-07 | ||
US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
ES2861393T3 (es) | 2012-04-27 | 2021-10-06 | Reata Pharmaceuticals Inc | Derivados de 2,2-difluoropropionamida de bardoxolona metilo, composiciones farmacéuticas y polimorfos de los mismos para su uso en el tratamiento de determinadas afecciones |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
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EA029174B1 (ru) | 2012-09-10 | 2018-02-28 | Рита Фармасьютикалз, Инк. | C17-алкандиильные и алкендиильные производные олеаноловой кислоты и способы их применения |
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