JP2014508781A5 - - Google Patents
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- JP2014508781A5 JP2014508781A5 JP2013557919A JP2013557919A JP2014508781A5 JP 2014508781 A5 JP2014508781 A5 JP 2014508781A5 JP 2013557919 A JP2013557919 A JP 2013557919A JP 2013557919 A JP2013557919 A JP 2013557919A JP 2014508781 A5 JP2014508781 A5 JP 2014508781A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- alkylamino
- hydrogen
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452017P | 2011-03-11 | 2011-03-11 | |
| US61/452,017 | 2011-03-11 | ||
| PCT/US2012/028569 WO2012125488A1 (en) | 2011-03-11 | 2012-03-09 | C4-monomethyl triterpenoid derivatives and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508781A JP2014508781A (ja) | 2014-04-10 |
| JP2014508781A5 true JP2014508781A5 (enExample) | 2015-04-30 |
| JP6129084B2 JP6129084B2 (ja) | 2017-05-17 |
Family
ID=45856041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557919A Active JP6129084B2 (ja) | 2011-03-11 | 2012-03-09 | Ｃ４−モノメチルトリテルペノイド誘導体およびその使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9290536B2 (enExample) |
| EP (1) | EP2683731B1 (enExample) |
| JP (1) | JP6129084B2 (enExample) |
| KR (1) | KR101956399B1 (enExample) |
| CN (1) | CN103619866B (enExample) |
| AR (1) | AR085666A1 (enExample) |
| AU (1) | AU2012229244B2 (enExample) |
| BR (1) | BR112013023174B1 (enExample) |
| CA (1) | CA2829618C (enExample) |
| CL (1) | CL2013002612A1 (enExample) |
| CO (1) | CO6801741A2 (enExample) |
| CY (1) | CY1121744T1 (enExample) |
| DK (1) | DK2683731T3 (enExample) |
| EA (1) | EA026847B1 (enExample) |
| ES (1) | ES2729405T3 (enExample) |
| HR (1) | HRP20191164T1 (enExample) |
| HU (1) | HUE044081T2 (enExample) |
| IL (1) | IL228297B (enExample) |
| LT (1) | LT2683731T (enExample) |
| ME (1) | ME03469B (enExample) |
| MX (1) | MX348862B (enExample) |
| PL (1) | PL2683731T3 (enExample) |
| PT (1) | PT2683731T (enExample) |
| RS (1) | RS59200B1 (enExample) |
| SG (1) | SG193404A1 (enExample) |
| SI (1) | SI2683731T1 (enExample) |
| SM (1) | SMT201900433T1 (enExample) |
| TR (1) | TR201909788T4 (enExample) |
| TW (1) | TWI535731B (enExample) |
| UY (1) | UY33946A (enExample) |
| WO (1) | WO2012125488A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| LT2252283T (lt) | 2008-01-11 | 2019-03-25 | Reata Pharmaceuticals, Inc. | Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| HUE033288T2 (en) | 2008-04-18 | 2017-11-28 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives |
| KR101735807B1 (ko) | 2008-04-18 | 2017-05-15 | 리타 파마슈티컬스 잉크. | Ｃ-17에 아미노 및 기타 변형을 갖는 올레아놀산 유도체를 포함하는 항산화 염증 조절제 |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| AU2009274037B2 (en) | 2008-07-22 | 2015-07-09 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| HUE038046T2 (hu) | 2010-12-17 | 2018-09-28 | Reata Pharmaceuticals Inc | Antioxidáns gyulladáscsökkentõ pirazolil és pirimidinil triciklusos enonok |
| CN103619866B (zh) | 2011-03-11 | 2016-06-22 | 里亚塔医药公司 | C4-一甲基三萜系化合物的衍生物及其使用方法 |
| ME02926B (me) * | 2012-04-27 | 2018-04-20 | Reata Pharmaceuticals Inc | 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu |
| US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| CR20150117A (es) * | 2012-09-10 | 2016-10-10 | Reata Pharmaceuticals Inc | Derivados c17-alcandilo y alquendilo del ácido oleanólico y sus métodos de uso |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| US20140073700A1 (en) * | 2012-09-10 | 2014-03-13 | Abbvie Inc. | Glycyrrhetinic acid derivatives and methods of use thereof |
| KR102237364B1 (ko) * | 2012-09-10 | 2021-04-06 | 리아타 파마슈티컬즈, 아이엔씨. | 올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법 |
| TW201514192A (zh) | 2013-03-19 | 2015-04-16 | Daiichi Sankyo Co Ltd | 萜類衍生物 |
| UY39092A (es) * | 2013-04-24 | 2021-03-26 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| CA2814303A1 (en) | 2013-04-26 | 2014-10-26 | Cellphone-Mate, Inc. | Apparatus and methods for radio frequency signal boosters |
| CN104861028A (zh) * | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型熊果酸衍生物、其制备方法及其应用 |
| CN104861027A (zh) * | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型齐墩果酸衍生物、其制备方法及其应用 |
| EP3192875B1 (en) | 2014-09-10 | 2019-12-18 | Daiichi Sankyo Company, Limited | Sustained-release pharmaceutical composition for treating and preventing ophthalmic diseases |
| US11059792B2 (en) | 2015-02-12 | 2021-07-13 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| EA201890767A1 (ru) * | 2015-09-23 | 2019-09-30 | Рита Фармасьютикалз, Инк. | C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений |
| CN105820207A (zh) * | 2016-03-24 | 2016-08-03 | 庄立 | 一种茴拉西坦的药物组合物及其抗氧化作用 |
| MA46749A (fr) | 2016-11-08 | 2019-09-18 | Reata Pharmaceuticals Inc | Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| BR112020025605A2 (pt) | 2018-06-15 | 2021-03-23 | Reata Pharmaceuticals, Inc. | compostos de pirazol e imidazol para inibição de il-17 e rorgama |
| EP3810141A1 (en) | 2018-06-20 | 2021-04-28 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| MX2021003643A (es) * | 2018-09-28 | 2021-08-19 | Sichuan Haisco Pharmaceutical Co Ltd | Derivados de terpenoides y usos de los mismos. |
| KR102891865B1 (ko) * | 2019-07-19 | 2025-11-26 | 리아타 파마슈티컬즈, 아이엔씨. | C17 극성-치환된 헤테로방향족 합성 트리터페노이드 및 그의 사용 방법 |
| WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
| MX2023008454A (es) | 2021-01-18 | 2023-08-07 | Reata Pharmaceuticals Inc | Derivados sintéticos de ácido ursólico y métodos de uso de estos. |
| JP2025508716A (ja) | 2022-02-16 | 2025-04-10 | フイルメニツヒ ソシエテ アノニム | オクタヒドロ－２（１ｈ）－ナフタレノン誘導体の製造方法 |
| GB202211190D0 (en) * | 2022-08-01 | 2022-09-14 | Royal College Surgeons Ireland | Fluorination process |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| US4395423A (en) | 1978-10-10 | 1983-07-26 | Sterling Drug Inc. | Polycyclic cyanoketones |
| NZ191586A (en) | 1978-10-10 | 1981-10-19 | Sterling Drug Inc | Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions |
| US5064823A (en) | 1988-08-24 | 1991-11-12 | Research Triangle Institute | Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers |
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US6369101B1 (en) | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| DK1178952T5 (da) | 1999-05-14 | 2008-03-17 | Univ California | Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer |
| US6649654B1 (en) | 1999-11-23 | 2003-11-18 | The Regents Of The University Of California | Methods for identifying and using IKK inhibitors |
| JP2001240573A (ja) | 2000-03-01 | 2001-09-04 | Meiji Seika Kaisha Ltd | トリテルペン誘導体及び肝疾患治療剤 |
| WO2002003996A1 (en) | 2000-07-12 | 2002-01-17 | RAJKUMAR, Sujatha | Use of dammarane-type tritepenoid saporins |
| WO2002026762A1 (en) | 2000-09-29 | 2002-04-04 | Regents Of The University Of Minnesota | Triterpenes having antibacterial activity |
| US6951847B2 (en) | 2000-09-29 | 2005-10-04 | Regents Of The University Of Minnesota | Methods of treating fungal infections using lupeol |
| AU2001294953A1 (en) | 2000-09-29 | 2002-04-08 | Regents Of The University Of Minnesota | Triterpenes having fungicidal activity against yeast |
| US6878751B1 (en) | 2000-10-19 | 2005-04-12 | Imperial College Of Science Technology And Medicine | Administration of resveratrol to treat inflammatory respiratory disorders |
| WO2002047611A2 (en) | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
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| CN1636058B (zh) | 2001-05-14 | 2011-06-08 | 龚大为 | 新型丙氨酸转氨酶及其应用方法 |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| ATE417857T1 (de) | 2002-01-18 | 2009-01-15 | Univ Minnesota | Quaternäre terpensalze als biologisch aktive tenside |
| EP1507541A4 (en) | 2002-05-13 | 2009-06-03 | Dartmouth College | HEMMER AND APPLICATION METHOD THEREFOR |
| WO2004089357A2 (en) | 2003-04-02 | 2004-10-21 | Regents Of The University Of Minnesota | Anti-fungal formulation of triterpene and essential oil |
| US20050208151A1 (en) | 2003-10-30 | 2005-09-22 | Entelos, Inc. | Treatment of rheumatoid arthritis with FLIP antagonists |
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| US9012439B2 (en) | 2007-10-29 | 2015-04-21 | University Of Rochester | Use of electrophilic compounds for inducing platelet production or maintaining platelet function |
| LT2252283T (lt) | 2008-01-11 | 2019-03-25 | Reata Pharmaceuticals, Inc. | Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą |
| WO2009146216A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| KR101735807B1 (ko) | 2008-04-18 | 2017-05-15 | 리타 파마슈티컬스 잉크. | Ｃ-17에 아미노 및 기타 변형을 갖는 올레아놀산 유도체를 포함하는 항산화 염증 조절제 |
| HUE033288T2 (en) | 2008-04-18 | 2017-11-28 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
| AU2009274037B2 (en) | 2008-07-22 | 2015-07-09 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| US8778990B2 (en) | 2008-11-04 | 2014-07-15 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
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| CN101704874A (zh) * | 2009-11-26 | 2010-05-12 | 中国药科大学 | 五环三萜及其衍生物的二甲双胍盐、其制备方法及医药用途 |
| MY163031A (en) | 2010-04-12 | 2017-07-31 | Reata Pharmaceuticals Inc | Method of treating obesity using antioxidant inflammation modulators |
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| CN102070697A (zh) | 2010-12-09 | 2011-05-25 | 中国药科大学 | 一种齐墩果酸衍生物、其制备方法及用途 |
| US8846647B2 (en) | 2011-01-31 | 2014-09-30 | Bristol-Myers Squibb Company | C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity |
| CN103619866B (zh) | 2011-03-11 | 2016-06-22 | 里亚塔医药公司 | C4-一甲基三萜系化合物的衍生物及其使用方法 |
-
2012
- 2012-03-09 CN CN201280022645.4A patent/CN103619866B/zh active Active
- 2012-03-09 HR HRP20191164TT patent/HRP20191164T1/hr unknown
- 2012-03-09 SG SG2013068291A patent/SG193404A1/en unknown
- 2012-03-09 WO PCT/US2012/028569 patent/WO2012125488A1/en not_active Ceased
- 2012-03-09 UY UY0001033946A patent/UY33946A/es not_active Application Discontinuation
- 2012-03-09 RS RSP20190859 patent/RS59200B1/sr unknown
- 2012-03-09 TR TR2019/09788T patent/TR201909788T4/tr unknown
- 2012-03-09 EA EA201391313A patent/EA026847B1/ru unknown
- 2012-03-09 ES ES12709768T patent/ES2729405T3/es active Active
- 2012-03-09 MX MX2013010429A patent/MX348862B/es active IP Right Grant
- 2012-03-09 SI SI201231611T patent/SI2683731T1/sl unknown
- 2012-03-09 KR KR1020137026782A patent/KR101956399B1/ko active Active
- 2012-03-09 ME MEP-2019-168A patent/ME03469B/me unknown
- 2012-03-09 CA CA2829618A patent/CA2829618C/en active Active
- 2012-03-09 LT LTEP12709768.1T patent/LT2683731T/lt unknown
- 2012-03-09 PL PL12709768T patent/PL2683731T3/pl unknown
- 2012-03-09 HU HUE12709768A patent/HUE044081T2/hu unknown
- 2012-03-09 DK DK12709768.1T patent/DK2683731T3/da active
- 2012-03-09 BR BR112013023174-2A patent/BR112013023174B1/pt active IP Right Grant
- 2012-03-09 EP EP12709768.1A patent/EP2683731B1/en active Active
- 2012-03-09 AU AU2012229244A patent/AU2012229244B2/en active Active
- 2012-03-09 JP JP2013557919A patent/JP6129084B2/ja active Active
- 2012-03-09 SM SM20190433T patent/SMT201900433T1/it unknown
- 2012-03-09 PT PT12709768T patent/PT2683731T/pt unknown
- 2012-03-12 US US13/417,519 patent/US9290536B2/en active Active
- 2012-03-12 TW TW101108395A patent/TWI535731B/zh active
- 2012-03-12 AR ARP120100803A patent/AR085666A1/es unknown
-
2013
- 2013-09-08 IL IL228297A patent/IL228297B/en active IP Right Grant
- 2013-09-11 CL CL2013002612A patent/CL2013002612A1/es unknown
- 2013-10-09 CO CO13240105A patent/CO6801741A2/es not_active Application Discontinuation
-
2019
- 2019-07-01 CY CY20191100690T patent/CY1121744T1/el unknown
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