JP2015510941A5 - - Google Patents
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- JP2015510941A5 JP2015510941A5 JP2015501819A JP2015501819A JP2015510941A5 JP 2015510941 A5 JP2015510941 A5 JP 2015510941A5 JP 2015501819 A JP2015501819 A JP 2015501819A JP 2015501819 A JP2015501819 A JP 2015501819A JP 2015510941 A5 JP2015510941 A5 JP 2015510941A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- use according
- app
- alzheimer
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940126077 BACE inhibitor Drugs 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 24
- 208000024827 Alzheimer disease Diseases 0.000 claims 21
- VCCRNZQBSJXYJD-UHFFFAOYSA-N galangin Chemical group C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=CC=C1 VCCRNZQBSJXYJD-UHFFFAOYSA-N 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 7
- 230000007423 decrease Effects 0.000 claims 6
- 229930003935 flavonoid Natural products 0.000 claims 6
- 150000002215 flavonoids Chemical class 0.000 claims 6
- 235000017173 flavonoids Nutrition 0.000 claims 6
- CIPSYTVGZURWPT-UHFFFAOYSA-N galangin Natural products OC1=C(Oc2cc(O)c(O)cc2C1=O)c3ccccc3 CIPSYTVGZURWPT-UHFFFAOYSA-N 0.000 claims 6
- SUYJZKRQHBQNCA-UHFFFAOYSA-N pinobanksin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=CC=C1 SUYJZKRQHBQNCA-UHFFFAOYSA-N 0.000 claims 6
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims 4
- 150000007942 carboxylates Chemical class 0.000 claims 4
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims 4
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims 4
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims 4
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims 4
- 235000005493 rutin Nutrition 0.000 claims 4
- 229960004555 rutoside Drugs 0.000 claims 4
- 102100021257 Beta-secretase 1 Human genes 0.000 claims 3
- 208000031124 Dementia Alzheimer type Diseases 0.000 claims 3
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 2
- 208000015756 familial Alzheimer disease Diseases 0.000 claims 2
- 229910001851 flerovium Inorganic materials 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612848P | 2012-03-19 | 2012-03-19 | |
| US61/612,848 | 2012-03-19 | ||
| US201261728688P | 2012-11-20 | 2012-11-20 | |
| US61/728,688 | 2012-11-20 | ||
| PCT/US2013/032481 WO2013142370A1 (en) | 2012-03-19 | 2013-03-15 | APP SPECIFIC BACE INHIBITORS (ASBIs) AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017233222A Division JP2018035197A (ja) | 2012-03-19 | 2017-12-05 | Ａｐｐ特異性のｂａｃｅ（ａｓｂｉ）およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510941A JP2015510941A (ja) | 2015-04-13 |
| JP2015510941A5 true JP2015510941A5 (enExample) | 2016-05-12 |
| JP6482458B2 JP6482458B2 (ja) | 2019-03-13 |
Family
ID=49223272
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501819A Active JP6482458B2 (ja) | 2012-03-19 | 2013-03-15 | Ａｐｐ特異性のｂａｃｅ（ａｓｂｉ）およびその使用 |
| JP2017233222A Pending JP2018035197A (ja) | 2012-03-19 | 2017-12-05 | Ａｐｐ特異性のｂａｃｅ（ａｓｂｉ）およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017233222A Pending JP2018035197A (ja) | 2012-03-19 | 2017-12-05 | Ａｐｐ特異性のｂａｃｅ（ａｓｂｉ）およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | USRE49873E1 (enExample) |
| EP (2) | EP3607946B1 (enExample) |
| JP (2) | JP6482458B2 (enExample) |
| KR (2) | KR102073578B1 (enExample) |
| CN (2) | CN106902108B (enExample) |
| AU (2) | AU2013235422B2 (enExample) |
| CA (1) | CA2867891C (enExample) |
| DK (1) | DK2827711T3 (enExample) |
| ES (1) | ES2745539T3 (enExample) |
| WO (1) | WO2013142370A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2745539T3 (es) * | 2012-03-19 | 2020-03-02 | Buck Inst Res Aging | Inhibidores de BACE específicos de APP (ASBI) y uso de los mismos |
| US10729777B2 (en) | 2012-04-09 | 2020-08-04 | Case Western Reserve University | Compositions and methods for inhibiting the activity of LAR family phosphatases |
| CN104800200B (zh) * | 2014-01-23 | 2019-04-02 | 上海中医药大学 | 高良姜素的医药用途 |
| WO2016072522A1 (ja) * | 2014-11-06 | 2016-05-12 | 国立大学法人 長崎大学 | 新規アルツハイマー病治療薬 |
| AU2016220049C1 (en) | 2015-02-18 | 2021-02-25 | Buck Institute For Research On Aging | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau |
| CN106474101A (zh) * | 2015-06-17 | 2017-03-08 | 海南医学院 | 高良姜素在治疗糖尿病脑病药物中的应用 |
| KR101716571B1 (ko) * | 2015-06-19 | 2017-03-15 | 단국대학교 천안캠퍼스 산학협력단 | 알츠하이머성 치매 예방 또는 치료용 약제학적 조성물 |
| WO2017096049A1 (en) | 2015-12-03 | 2017-06-08 | The University Of North Carolina At Pembroke | Materials for cathepsin b enhancement and methods of use |
| WO2018073321A1 (en) | 2016-10-18 | 2018-04-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Natural product derivatives for inhibiting cellular necroptosis, ferroptosis and oxytosis |
| KR20200045446A (ko) * | 2017-06-05 | 2020-05-04 | 케이스 웨스턴 리저브 유니버시티 | 알츠하이머병의 치료를 위한 조성물 및 방법 |
| GB2574878A (en) * | 2018-06-22 | 2019-12-25 | Biofilm Ltd | Oral compositions and mucoadhesive thin films formed therefrom |
| JP7589143B2 (ja) | 2018-09-05 | 2024-11-25 | ケース ウエスタン リザーブ ユニバーシティ | 神経可塑性を誘導するための方法および組成物 |
| AU2020395610A1 (en) * | 2019-12-06 | 2022-06-30 | Gretals Australia Pty Ltd | Neurologically active flavonoid compositions and methods of use thereof |
| CN111518793A (zh) * | 2020-05-20 | 2020-08-11 | 谭骏 | 年轻人血源APPα-分泌酶在阿尔茨海默病中的应用 |
| WO2022035758A1 (en) * | 2020-08-12 | 2022-02-17 | The Cleveland Clinic Foundation | Bace1 inhibitor treatment for suppressing cytokine storm |
| CN112730839B (zh) * | 2021-01-20 | 2024-01-30 | 宁波海尔施智造有限公司 | 一种磁微粒化学发光法测定细胞角蛋白19片段含量的试剂盒 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| CH677886A5 (enExample) | 1989-06-26 | 1991-07-15 | Hans Georg Prof Dr Weder | |
| JPH06507782A (ja) | 1990-06-15 | 1994-09-08 | サイオス ノバ インコーポレイテッド | アルツハイマー病のアミロイド形成開症状を示すヒト以外の組換え哺乳動物 |
| AU652997B2 (en) | 1991-01-21 | 1994-09-15 | Elan Pharmaceuticals, Inc. | Test and model for alzheimer's disease |
| DE69233109T2 (de) | 1992-01-07 | 2004-05-19 | Elan Pharmaceuticals, Inc., San Francisco | Transgene tiermodelle fur alzheimer-krankheit |
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| AU702293B2 (en) | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| FR2730932B1 (fr) | 1995-02-27 | 1997-04-04 | Oreal | Nanoemulsion transparente a base de lipides amphiphiles non-ioniques fluides et utilisation en cosmetique ou en dermopharmacie |
| US5744346A (en) | 1995-06-07 | 1998-04-28 | Athena Neurosciences, Inc. | β-secretase |
| JPH11507538A (ja) | 1995-06-07 | 1999-07-06 | アテナ ニューロサイエンシズ インコーポレイティド | β−セクレターゼ、β−セクレターゼに対する抗体、及びβ−セクレターゼ阻害を検出するためのアッセイ |
| FR2742676B1 (fr) | 1995-12-21 | 1998-02-06 | Oreal | Nanoemulsion transparente a base de tensioactifs silicones et utilisation en cosmetique ou en dermopharmacie |
| JP4431638B2 (ja) * | 1996-01-29 | 2010-03-17 | アメリカ合衆国 | ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途 |
| FR2755854B1 (fr) | 1996-11-15 | 1998-12-24 | Oreal | Nanoemulsion a base de lipides amphiphiles non-ioniques et cationiques et utilisations |
| FR2760970B1 (fr) | 1997-03-18 | 2000-03-10 | Oreal | Nanoemulsions a base de lipides amphiphiles non-ioniques et de silicones aminees et utilisations |
| US6492377B1 (en) * | 1998-06-25 | 2002-12-10 | Boehringer Ingelheim Pharma Kg | Imidazotriazolopyrimidines with adenosine-antagonistic activity |
| AU5002399A (en) | 1998-07-17 | 2000-02-07 | National Broach And Machine Company | Full form roll finishing technique |
| ES2318902T3 (es) | 1998-09-24 | 2009-05-01 | PHARMACIA & UPJOHN COMPANY LLC | Secretasa en la enfermedad del alzheimer. |
| FR2787026B1 (fr) | 1998-12-14 | 2001-01-12 | Oreal | Nanoemulsion a base d'esters mixtes d'acide gras ou d'alcool gras, d'acide carboxylique et de glyceryle, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2787027B1 (fr) | 1998-12-14 | 2001-01-12 | Oreal | Nanoemulsion a base d'esters gras de sucre ou d'ethers gras de sucre et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2787326B1 (fr) | 1998-12-17 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras de glycerol, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2787325B1 (fr) | 1998-12-17 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras de sorbitan oxyethylenes ou non oxyethylenes, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2787728B1 (fr) | 1998-12-23 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras d'acide phosphorique, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique |
| FR2787703B1 (fr) | 1998-12-29 | 2001-01-26 | Oreal | Nanoemulsion a base d'ethers gras ethoxyles ou d'esters gras ethoxyles, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2788007B1 (fr) | 1999-01-05 | 2001-02-09 | Oreal | Nanoemulsion a base de copolymeres blocs d'oxyde d'ethylene et d'oxyde de propylene, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| FR2788449B1 (fr) | 1999-01-14 | 2001-02-16 | Oreal | Nanoemulsion a base de citrates d'alkylether, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique |
| FR2789076B1 (fr) | 1999-02-02 | 2001-03-02 | Synthelabo | Derives de alpha-azacyclomethyl quinoleine, leur preparation et leur application en therapeutique |
| US7161962B1 (en) | 1999-05-27 | 2007-01-09 | Nuera Communications, Inc. | Method and apparatus for coding modem signals for transmission over voice networks |
| US6103756A (en) * | 1999-08-11 | 2000-08-15 | Vitacost Inc. | Ocular orally ingested composition for prevention and treatment of individuals |
| US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
| FR2811564B1 (fr) | 2000-07-13 | 2002-12-27 | Oreal | Nanoemulsion contenant des polymeres non ioniques, et ses utilisations notamment dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique |
| WO2002055562A2 (en) | 2001-01-11 | 2002-07-18 | Eastman Chem Co | Cyclodextrin sulfonates, guest inclusion complexes, methods of making the same and related materials |
| FR2819427B1 (fr) | 2001-01-18 | 2003-04-11 | Oreal | Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| EP2545937A1 (en) | 2001-06-05 | 2013-01-16 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| UY26816A1 (es) * | 2001-07-04 | 2003-04-30 | Horacio Heinzen | Una preparación liposomal de achyrocline satureioides ("marcela"), flavonoides y derivados semisintéticos, para la protección del tejido cerebral frente al dano isquémico- vascular y neurodegenerativo. |
| CA2703698C (en) * | 2002-04-30 | 2016-11-22 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent |
| US7476393B2 (en) | 2002-11-29 | 2009-01-13 | L'oreal | Process for the preparation of a cationic nanoemulsion, and cosmetic composition |
| CA2534950A1 (en) | 2003-08-08 | 2005-02-24 | Schering Corporation | Cyclic amine bace-1 inhibitors having a benzamide substituent |
| CN1863770B (zh) | 2003-08-08 | 2011-05-25 | 先灵公司 | 具有杂环取代基的环胺base-1抑制剂 |
| JP2005104850A (ja) | 2003-09-26 | 2005-04-21 | Kanazawa Univ Tlo Inc | アルツハイマー病の治療薬および予防薬 |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| CA2548388A1 (en) | 2003-12-15 | 2005-06-30 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7468402B2 (en) | 2004-03-17 | 2008-12-23 | Baker Hughes Incorporated | Polymeric nanoemulsion as drag reducer for multiphase flow |
| CA2579724A1 (en) | 2004-06-16 | 2006-01-26 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
| CA2578600A1 (en) | 2004-06-16 | 2006-01-26 | Wyeth | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase |
| KR100610562B1 (ko) * | 2004-06-28 | 2006-08-08 | 재단법인서울대학교산학협력재단 | 플라보노이드 유도체를 포함하는 급성 또는 만성 퇴행성뇌질환의 예방 또는 치료용 조성물 |
| JP2008507538A (ja) | 2004-07-22 | 2008-03-13 | シェーリング コーポレイション | 置換アミドβセクレターゼインヒビター |
| CA2575340A1 (en) | 2004-07-28 | 2006-02-09 | Schering Corporation | Macrocyclic beta-secretase inhibitors |
| CN100441200C (zh) * | 2004-11-26 | 2008-12-10 | 谢德隆 | 石杉碱甲、乙复合成分的蛇足石杉提取物及其制备方法 |
| CA2609562A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Macrocyclic heterocyclic aspartyl protease inhibitors |
| US7759353B2 (en) | 2005-06-14 | 2010-07-20 | Schering Corporation | Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment |
| EP1896406A2 (en) | 2005-06-14 | 2008-03-12 | Shering Corporation | The preparation and use of compounds as protease inhibitors |
| ATE489370T1 (de) | 2005-06-14 | 2010-12-15 | Schering Corp | Herstellung und verwendung von verbindungen als aspartylproteasehemmer |
| US8722708B2 (en) | 2005-06-14 | 2014-05-13 | Merck Sharp & Dohme Inc. | Substituted isoindolines as aspartyl protease inhibitors |
| WO2006138264A2 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| ATE482214T1 (de) | 2005-06-14 | 2010-10-15 | Schering Corp | Aspartylproteasehemmer |
| TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| BRPI0613578A2 (pt) | 2005-06-30 | 2012-01-17 | Wyeth Corp | composito da fórmula i; uso de um composto de fórmula i; e composição farmacêutica |
| TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| RU2008106936A (ru) | 2005-09-26 | 2009-11-10 | Вайет (Us) | Соединения амино-5-[4-(дифторметокси)фенил]-5-фенилимидазолона для ингибирования бета-секретазы |
| CN101296926A (zh) | 2005-10-27 | 2008-10-29 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
| CN101351460A (zh) | 2005-10-31 | 2009-01-21 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
| JP2009532464A (ja) | 2006-04-05 | 2009-09-10 | アストラゼネカ・アクチエボラーグ | ２−アミノピリミジン−４−オン及びＡβ−関連の病理を治療又は予防するためのその使用 |
| CA2653650A1 (en) | 2006-06-12 | 2007-12-21 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW200815443A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
| TW200815449A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
| TW200815447A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
| TW200808796A (en) | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| WO2008011538A2 (en) * | 2006-07-19 | 2008-01-24 | The Salk Institute For Biological Studies | Methods of using flavonoids to enhance memory |
| MX2009006228A (es) | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa. |
| CN101631779A (zh) | 2006-12-12 | 2010-01-20 | 先灵公司 | 含有三环系统的天冬氨酰蛋白酶抑制剂 |
| US20090041201A1 (en) | 2007-08-06 | 2009-02-12 | Carestream Health, Inc. | Alignment apparatus for imaging system |
| WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体 |
| AP2011005707A0 (en) | 2008-11-11 | 2011-06-30 | Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd | Inclusion complexes of pinocembrin with cyclodextrin or its derivatives. |
| US8466195B2 (en) * | 2009-03-13 | 2013-06-18 | Salk Institute For Biological Studies | Methods and compositions for treating complications of diabetes and vascular diseases using flavones |
| CN101543505A (zh) | 2009-04-29 | 2009-09-30 | 香港科技大学 | 一种预防和治疗阿尔茨海默氏症的药物及其制备方法 |
| CN103200949B (zh) * | 2010-08-10 | 2016-10-12 | 香港科技大学 | 用于治疗神经变性疾病或神经病理性病症的组合物 |
| ES2745539T3 (es) | 2012-03-19 | 2020-03-02 | Buck Inst Res Aging | Inhibidores de BACE específicos de APP (ASBI) y uso de los mismos |
-
2013
- 2013-03-15 ES ES13763620T patent/ES2745539T3/es active Active
- 2013-03-15 KR KR1020147029321A patent/KR102073578B1/ko active Active
- 2013-03-15 CN CN201710107804.5A patent/CN106902108B/zh active Active
- 2013-03-15 JP JP2015501819A patent/JP6482458B2/ja active Active
- 2013-03-15 CN CN201380023606.0A patent/CN104270945B/zh active Active
- 2013-03-15 US US17/382,969 patent/USRE49873E1/en active Active
- 2013-03-15 WO PCT/US2013/032481 patent/WO2013142370A1/en not_active Ceased
- 2013-03-15 US US14/384,641 patent/US10357508B2/en not_active Ceased
- 2013-03-15 AU AU2013235422A patent/AU2013235422B2/en active Active
- 2013-03-15 KR KR1020207002843A patent/KR102160388B1/ko active Active
- 2013-03-15 DK DK13763620.5T patent/DK2827711T3/da active
- 2013-03-15 EP EP19180690.0A patent/EP3607946B1/en active Active
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