JP2013534256A5 - - Google Patents

Info

Publication number

JP2013534256A5

JP2013534256A5 JP2013525003A JP2013525003A JP2013534256A5 JP 2013534256 A5 JP2013534256 A5 JP 2013534256A5 JP 2013525003 A JP2013525003 A JP 2013525003A JP 2013525003 A JP2013525003 A JP 2013525003A JP 2013534256 A5 JP2013534256 A5 JP 2013534256A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutically acceptable

compound according

acceptable salt

ratio

Prior art date

2011-08-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 25
• 150000003839 salts Chemical class 0.000 claims 11
• AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims 10
• 241000124008 Mammalia Species 0.000 claims 9
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 5
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 5
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 5
• BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims 5
• 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 5
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 5
• 208000010877 cognitive disease Diseases 0.000 claims 5
• 229960002563 disulfiram Drugs 0.000 claims 5
• FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims 5
• VVOAZFWZEDHOOU-UHFFFAOYSA-N honokiol Natural products OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims 5
• 208000027061 mild cognitive impairment Diseases 0.000 claims 5
• GWUSZQUVEVMBPI-UHFFFAOYSA-N nimetazepam Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1 GWUSZQUVEVMBPI-UHFFFAOYSA-N 0.000 claims 5
• 229950001981 nimetazepam Drugs 0.000 claims 5
• UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 claims 5
• 229960003688 tropisetron Drugs 0.000 claims 5
• 108010064397 amyloid beta-protein (1-40) Proteins 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 2
• 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 2
• 230000003942 amyloidogenic effect Effects 0.000 claims 2
• 230000007450 amyloidogenic pathway Effects 0.000 claims 2
• 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 2
• 208000015756 familial Alzheimer disease Diseases 0.000 claims 2
• 210000005171 mammalian brain Anatomy 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 108700028369 Alleles Proteins 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 208000031124 Dementia Alzheimer type Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 108010029485 Protein Isoforms Proteins 0.000 claims 1
• 102000001708 Protein Isoforms Human genes 0.000 claims 1
• 230000003930 cognitive ability Effects 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 150000003840 hydrochlorides Chemical class 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 230000007505 plaque formation Effects 0.000 claims 1
• 230000000087 stabilizing effect Effects 0.000 claims 1