JP2018523665A - 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 - Google Patents

抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 Download PDF

Info

Publication number
JP2018523665A
JP2018523665A JP2018506115A JP2018506115A JP2018523665A JP 2018523665 A JP2018523665 A JP 2018523665A JP 2018506115 A JP2018506115 A JP 2018506115A JP 2018506115 A JP2018506115 A JP 2018506115A JP 2018523665 A JP2018523665 A JP 2018523665A
Authority
JP
Japan
Prior art keywords
formula
compound
pharmaceutically acceptable
acceptable salt
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2018506115A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018523665A5 (OSRAM
Inventor
リロイ タウンゼント
リロイ タウンゼント
ジョン ドラック
ジョン ドラック
ロイ ダブリュ． ウェア
ロイ ダブリュ． ウェア
ジョン ヘンリー ザ サード ブーゲル
ジョン ヘンリー ザ サード ブーゲル
ラママーティー ブイ エス チャンガルバラ
ラママーティー ブイ エス チャンガルバラ
アーロン リー ダウニー
アーロン リー ダウニー
アーネスト ランドール ジュニア ラニアー
アーネスト ランドール ジュニア ラニアー
アンドリュー ルイス マクアイヴァー
アンドリュー ルイス マクアイヴァー
ブラッドリー デビッド ロバートソン
ブラッドリー デビッド ロバートソン
ディーン ウォレス セレセス
ディーン ウォレス セレセス
フィロゼ ベーラム セスナ
フィロゼ ベーラム セスナ
Original Assignee
キメリックス インコーポレイテッド
キメリックス インコーポレイテッド
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by キメリックス インコーポレイテッド, キメリックス インコーポレイテッド, ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン, ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン filed Critical キメリックス インコーポレイテッド
Publication of JP2018523665A publication Critical patent/JP2018523665A/ja
Publication of JP2018523665A5 publication Critical patent/JP2018523665A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
JP2018506115A 2015-08-06 2016-08-08 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 Withdrawn JP2018523665A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562202010P 2015-08-06 2015-08-06
US62/202,010 2015-08-06
GB201606645 2016-04-15
GB1606645.8 2016-04-15
PCT/US2016/046056 WO2017024310A1 (en) 2015-08-06 2016-08-08 Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents

Publications (2)

Publication Number Publication Date
JP2018523665A true JP2018523665A (ja) 2018-08-23
JP2018523665A5 JP2018523665A5 (OSRAM) 2019-09-19

Family

ID=57943734

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018506115A Withdrawn JP2018523665A (ja) 2015-08-06 2016-08-08 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体

Country Status (11)

Country Link
US (6) US9708359B2 (OSRAM)
EP (1) EP3331895B1 (OSRAM)
JP (1) JP2018523665A (OSRAM)
KR (1) KR102630013B1 (OSRAM)
CN (1) CN108026136A (OSRAM)
AU (1) AU2016301188A1 (OSRAM)
BR (1) BR112018002399A2 (OSRAM)
EA (1) EA201890454A1 (OSRAM)
MX (1) MX2018001073A (OSRAM)
PH (1) PH12018500263A1 (OSRAM)
WO (1) WO2017024310A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023538442A (ja) * 2020-08-24 2023-09-07 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物及びその使用

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3236972T (lt) 2014-12-26 2021-11-10 Emory University Antivirusiniai n4-hidroksicitidino dariniai
CN107278205A (zh) * 2015-02-24 2017-10-20 辉瑞大药厂 用作抗癌药的取代的核苷衍生物
EP3510040A4 (en) 2016-09-09 2020-06-03 Calithera Biosciences, Inc. ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE
EP3556764A4 (en) * 2016-12-16 2021-01-06 Gifu University NUCLEOSIDE DERIVATIVE AND USE FOR IT
WO2018183635A1 (en) * 2017-03-31 2018-10-04 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
WO2019088179A1 (ja) 2017-10-31 2019-05-09 ヤマサ醤油株式会社 ヌクレオシド誘導体及びその利用
LT3706762T (lt) 2017-12-07 2024-12-27 Emory University N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai
IL277160B2 (en) * 2018-03-07 2024-10-01 Univ Emory 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
JP7678795B2 (ja) 2019-08-22 2025-05-16 エモリー ユニバーシティー ヌクレオシドプロドラッグ及びそれに関する使用
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
US20230113110A1 (en) * 2020-03-09 2023-04-13 Organes,Tissus: Regeneration, Reparation, Remplacement Composition for the treatment of lesions of the respiratory system
US20230233591A1 (en) * 2020-04-14 2023-07-27 Oyagen, Inc. Method for treating poxviridae infections
WO2022212365A1 (en) * 2021-03-29 2022-10-06 Chimerix, Inc. Pyrrolopyrimidine nucleosides for treating or preventing a sars-cov-2 infection
EP4323362B1 (en) 2021-04-16 2025-05-07 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
CA3228162A1 (en) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
AU2024261019A1 (en) * 2023-04-28 2025-11-13 The Scripps Research Institute 4'-substituted nucleosides and nucleotides as antiviral agents
EP4553080A1 (en) * 2023-11-07 2025-05-14 Ustav Organicke Chemie a Biochemie AV CR, v.v.i. Nucleoside derivatives as antiviral agents against coronaviruses

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037980A (en) * 1955-08-18 1962-06-05 Burroughs Wellcome Co Pyrrolopyrimidine vasodilators and method of making them
US3423398A (en) 1965-05-10 1969-01-21 Pfizer & Co C Sangivamycin and derivatives thereof
US4140851A (en) 1977-11-21 1979-02-20 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides
JPS61189225A (ja) 1985-02-15 1986-08-22 Airin:Kk 抗アレルギ−剤
US4892865A (en) 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
US5763596A (en) 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
US5721356A (en) 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
US5726302A (en) 1989-09-15 1998-03-10 Gensia Inc. Water soluble adenosine kinase inhibitors
US5646128A (en) 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5177064A (en) 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
WO1992005200A1 (en) 1990-09-18 1992-04-02 Chemex Pharmaceuticals, Inc. Xenobiotic-antibody conjugates
JPH06510020A (ja) 1991-03-29 1994-11-10 ユニバーシティ・オブ・フロリダ 混成リン酸エステル誘導体を経た標的への薬剤供給
EP0530537B1 (en) 1991-08-12 1997-01-08 Takeda Chemical Industries, Ltd. Condensed pyrimidine derivatives, their production and use as antitumor agents
ATE244259T1 (de) 1992-02-12 2003-07-15 Chromagen Inc Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
US5502187A (en) 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
GB9226879D0 (en) 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
CA2154681A1 (en) 1993-02-03 1994-08-18 Mark David Erion Adenosine kinase inhibitors comprising lyxofuranosyl derivatives
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
JPH07124252A (ja) 1993-11-07 1995-05-16 Masashi Funayama 化学療法剤を固定化した不溶性担体を用いた、負に帯電した 生理活性物質の吸着、分離および定量方法。
WO1995033752A1 (en) 1994-06-09 1995-12-14 Smithkline Beecham Corporation Endothelin receptor antagonists
US5554608A (en) 1994-09-28 1996-09-10 Ahluwalia; Gurpreet S. Inhibition of hair growth
US6051578A (en) 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
WO1997046569A2 (en) 1996-06-06 1997-12-11 Novartis Ag 2'-substituted nucleosides and oligonucleotide derivatives
US6468991B1 (en) 1997-01-16 2002-10-22 Cyclis Pharmaceuticals, Inc. Method of treating rhinoviral infections
US5955446A (en) 1997-01-16 1999-09-21 Pentose Pharmaceuticals, Inc. Method of treating herpes infections with 2',5'-oligoadenylate-2',3'-cyclophosphate compounds
US6419934B1 (en) * 1999-02-24 2002-07-16 Edward L. Tobinick TNF modulators for treating neurological disorders associated with viral infection
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
CO5271670A1 (es) 1999-10-29 2003-04-30 Pfizer Prod Inc Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
BR0016415A (pt) 1999-12-16 2002-12-24 Alcon Inc Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico
KR100385281B1 (ko) 2000-02-15 2003-05-23 이승기 새로운 세포 주기 조절 인자 억제제
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
EP1149583A3 (en) 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
CN1267446C (zh) 2001-01-22 2006-08-02 默克公司 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物
WO2002069949A2 (en) 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
US20020127593A1 (en) 2001-03-12 2002-09-12 Regents Of The University Of California Fluorescence assay for DNA modifying enzymes
AU2002329970A1 (en) 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
WO2003022214A2 (en) 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
US7361671B2 (en) 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
WO2003051899A1 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
WO2003055896A2 (en) * 2001-12-21 2003-07-10 Micrologix Biotech Inc. Anti-viral 7-deaza l-nucleosides
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
WO2003068244A1 (en) 2002-02-13 2003-08-21 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
FR2836995B1 (fr) 2002-03-05 2006-09-22 Centre Nat Rech Scient Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications
FR2836996A1 (fr) 2002-03-05 2003-09-12 Centre Nat Rech Scient PRECURSEURS DE TRACEURS IMMUNOLOGIQUES NON-PEPTIDIQUES COMPRENANT UN MOTIF TYROSYL-(X)n-LYSINE-(X)n-TYROSINE, PROCEDE DE PREPARATION ET LEURS APPLICATIONS
US6664266B2 (en) 2002-03-14 2003-12-16 Children's Medical Center Corporation Axon regeneration with PKC inhibitiors
US20040014108A1 (en) 2002-05-24 2004-01-22 Eldrup Anne B. Oligonucleotides having modified nucleoside units
CA2488484A1 (en) 2002-06-27 2004-01-08 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004007512A2 (en) 2002-07-16 2004-01-22 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US7094768B2 (en) 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
NZ538457A (en) 2002-09-30 2008-04-30 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
JP4689274B2 (ja) 2002-10-31 2011-05-25 リガンド・ファーマシューティカルズ・インコーポレイテッド 新規なシタラビン・モノホスフェートプロドラッグ
EP2957568B1 (en) 2002-11-05 2016-12-21 Ionis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
PT1576138T (pt) * 2002-11-15 2017-05-03 Idenix Pharmaceuticals Llc 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae
US20040175384A1 (en) 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US7358262B2 (en) 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
WO2007038613A2 (en) 2005-09-26 2007-04-05 The Regents Of The University Of California Selective serine/threonine kinase inhibitors
US20040259934A1 (en) 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
US7230007B2 (en) 2003-06-12 2007-06-12 Sanofi-Aventis Deutschland Gmbh Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
EP3279328A1 (en) 2003-11-14 2018-02-07 Children's Medical Center Corporation Self-cleaving ribozymes and uses thereof
WO2005051944A1 (en) 2003-11-21 2005-06-09 University Of Connecticut Heterocyclyl-substituted oxetanes for the treatment of proliferative or infectious diseases
US20050203151A1 (en) 2003-12-19 2005-09-15 Kalypsys, Inc. Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions
AU2005267421B2 (en) 2004-06-24 2010-06-03 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
US20070015771A1 (en) 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
KR101331786B1 (ko) 2004-09-22 2013-11-21 얀센 파마슈티카 엔.브이. Ｍｄｍ2 및 ｐ53간의 상호작용 저해제
DE102004054634A1 (de) 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
NZ560320A (en) 2005-01-25 2011-02-25 Prolexys Pharmaceuticals Inc Quinoxaline derivatives as antitumor agents
US20070161644A1 (en) 2005-01-25 2007-07-12 Stockwell Brent R Erastin analogs and uses thereof
AU2006210787C1 (en) 2005-02-02 2013-01-17 Nexgenix Pharmaceuticals, L.L.C. Local treatment of neurofibromas
WO2006116512A1 (en) 2005-04-26 2006-11-02 The Board Of Trustees Of The University Of Illinois, Urbana, Il Nucleoside compounds and methods of use thereof
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
WO2007024944A1 (en) 2005-08-25 2007-03-01 Schering Corporation Imidazole derivatives as functionally selective alpha2c adrenoreceptor agonists
JP2007124252A (ja) 2005-10-27 2007-05-17 Sony Corp 放送受信装置と放送受信方法およびプログラム
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
CN1923173B (zh) 2006-02-24 2010-05-19 济南康泉医药科技有限公司 一种同载抗癌抗生素及其增效剂的抗癌药物缓释剂
CN1923171B (zh) 2006-02-24 2010-05-19 济南康泉医药科技有限公司 同载抗癌抗生素及其增效剂的复方抗癌药物缓释剂
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008021981A2 (en) 2006-08-09 2008-02-21 Nexgenix Pharmaceuticals, Llc. Local treatment of epidermal and dermal hyperproliferative lesions
US20080153903A1 (en) 2006-12-22 2008-06-26 Alcon Manufacturing, Ltd. Inhibitors of protein kinase c-delta for the treatment of glaucoma
TW200838550A (en) 2007-02-09 2008-10-01 Novartis Ag Organic compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2008127613A1 (en) 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
US20100129933A1 (en) 2007-04-26 2010-05-27 Forschungszentrum Karlsruhe Gmbh Method for detecting the binding between mdm2 and the proteasome
FR2921342B1 (fr) 2007-09-20 2010-03-12 Airbus France Carenage aerodynamique arriere inferieur pour dispositif d'accrochage d'un moteur d'aeronef
US20110218210A1 (en) 2007-11-02 2011-09-08 Taiga Biotechnologies Compounds for treating abnormal cellular proliferation
US20090318380A1 (en) * 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009105234A2 (en) 2008-02-19 2009-08-27 Combinatorx, Incorporated Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein
WO2009108551A2 (en) 2008-02-25 2009-09-03 H. Lundbeck A/S Heteroaryl amide analogues
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010015637A1 (en) * 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
WO2010015643A1 (en) 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
US20120014911A1 (en) 2009-01-09 2012-01-19 Serge Fuchs Regulators of the Interferon-Alpha Receptor 1 (IFNAR1) Chain of the Interferon Receptor
US8785446B2 (en) 2009-01-17 2014-07-22 Children's Medical Center Corporation Treating post-seizure patients
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
US8642602B2 (en) 2009-02-04 2014-02-04 University Of Georgia Research Foundation, Inc. Method of inhibiting fibrogenesis and treating fibrotic disease
BRPI1005401A2 (pt) * 2009-02-06 2019-04-02 Rfs Pharma, Llc pro-farmácos de purina nucleosídeo monofosfato para o tratamento de câncer e infecções virais
US8475804B2 (en) 2009-02-20 2013-07-02 U.S. Army Medical Research And Material Command Compositions and methods for treatment of filovirus-mediated diseases
WO2010135520A1 (en) 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
EP2942060A1 (en) 2009-09-29 2015-11-11 Joslin Diabetes Center, Inc. Use of Protein Kinase C Delta (PKCD) Inhibitors to Treat Diabetes, Obesity and, Hepatic Steatosis
HRP20141150T1 (hr) 2009-10-19 2015-01-30 Synta Pharmaceuticals Corp. Kombinacijska terapija raka sa hsp90 inhibitornim spojevima
WO2011057204A2 (en) 2009-11-06 2011-05-12 The Johns Hopkins University Lrrk2-mediated neuronal toxicity
JP2013515724A (ja) 2009-12-23 2013-05-09 サノフイ ベータ−トリプターゼ阻害剤としてのトロピノンベンジルアミン類
WO2011079103A1 (en) 2009-12-23 2011-06-30 Sanofi Spiropiperidine benzylamines as beta-tryptase inhibitors
WO2011088137A2 (en) 2010-01-12 2011-07-21 H. Lee Moffitt Cancer Center & Research Institute Bad pathway gene signature
CN102191233B (zh) 2010-03-04 2014-06-04 中国人民解放军军事医学科学院毒物药物研究所 新颖的10-23脱氧核酶类似物及其用途
CN102869254A (zh) 2010-04-16 2013-01-09 安龙制药公司 腺嘌呤核苷酸类似物聚合共轭物
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
EP2805960A1 (en) 2010-07-19 2014-11-26 Gilead Sciences, Inc. Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
WO2012041965A1 (en) 2010-09-29 2012-04-05 Universidad Nacional De Quilmes Process for producing dialkylphosphotriesters of nucleosides by enzymatic transesterification and deprotection thereof for producing nucleoside monophosphates
EP2640392B1 (en) 2010-11-18 2015-01-07 Kasina Laila Innova Pharmaceuticals Private Ltd. Substituted 4-(selenophen-2(or 3)-ylamino)pyrimidine compounds and methods of use thereof
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
US9085599B2 (en) 2011-03-16 2015-07-21 Enanta Pharmaceuticals, Inc. 2′allene-substituted nucleoside derivatives
GB201107768D0 (en) 2011-05-10 2011-06-22 Univ Manchester Riboswitches
CN102286048A (zh) 2011-06-24 2011-12-21 吉林大学 4-氨基-6-(3-(3-溴苯基)苯基)-5-氰基-7-(β-L-呋喃木糖)吡咯并[2, 3-d]嘧啶、同类衍生物及用于制备抗肿瘤药物
WO2013044030A1 (en) 2011-09-23 2013-03-28 Enanta Pharmaceuticals, Inc. 2'-chloroacetylenyl substituted nucleoside derivatives
WO2013071415A1 (en) 2011-11-15 2013-05-23 University Health Network Targeting the rb pathway for the prevention of cancer
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
CA2905306A1 (en) 2013-04-29 2014-11-06 Plasmia Biotech, S.L. Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023538442A (ja) * 2020-08-24 2023-09-07 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物及びその使用
JP7559223B2 (ja) 2020-08-24 2024-10-01 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物及びその使用

Also Published As

Publication number Publication date
PH12018500263A1 (en) 2018-08-13
CA2992278A1 (en) 2017-02-09
KR102630013B1 (ko) 2024-01-25
US9701706B2 (en) 2017-07-11
US20170044202A1 (en) 2017-02-16
US20170253628A1 (en) 2017-09-07
US20170137454A1 (en) 2017-05-18
EA201890454A1 (ru) 2018-07-31
US20250084119A1 (en) 2025-03-13
CN108026136A (zh) 2018-05-11
EP3331895B1 (en) 2020-07-29
US20200199167A1 (en) 2020-06-25
WO2017024310A1 (en) 2017-02-09
AU2016301188A1 (en) 2018-02-15
US10407457B2 (en) 2019-09-10
EP3331895A1 (en) 2018-06-13
US10941175B2 (en) 2021-03-09
US9708359B2 (en) 2017-07-18
MX2018001073A (es) 2018-06-12
US11981700B2 (en) 2024-05-14
BR112018002399A2 (pt) 2018-09-25
KR20180039666A (ko) 2018-04-18
US20220002335A1 (en) 2022-01-06

Similar Documents

Publication Publication Date Title
KR102630013B1 (ko) 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체
JP6043338B2 (ja) 抗ウイルス治療用の１’−置換ピリミジンｎ−ヌクレオシド類似体
AU2024205205A1 (en) Methods for treating SARS CoV-2 infections
CA3139977A1 (en) Peptidomimetics for the treatment of coronavirus and picornavirus infections
EP3181555B1 (en) Benzothiazole compounds and their pharmaceutical use
RU2599013C2 (ru) Способы и композиции для ингибирования полимеразы
JP6402259B2 (ja) 多環式カルバモイルピリドン化合物およびそれらの薬学的使用
EP3900717B1 (en) Vidofludimus for use in the treatment or prevention of viral diseases
RS59144B1 (sr) Inhibitori replikacije virusa influence
CN117362344A (zh) 一类磷酸酯类化合物、其制备方法及应用
JP2025517992A (ja) デング感染の治療のための投薬レジメン
JP2016540776A (ja) 分枝鎖非環式ヌクレオシドホスホン酸エステルならびにその合成法および使用
CA2992278C (en) Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
ES2829254T3 (es) Nucleósidos de pirrolopirimidina y análogos de los mismos útiles como agentes antivíricos
WO2021231784A1 (en) Perk inhibiting imidazolopyrazine compounds
HK40062780A (en) Vidofludimus for use in the treatment or prevention of viral diseases
KR20220034049A (ko) B형 간염 바이러스의 옥살아미도-치환된 삼환형 억제제
EA045093B1 (ru) Производное n4-гидроксицитидина, содержащая его фармацевтическая композиция и связанные с этим противовирусные применения
NZ616732B2 (en) 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
HK1237770B (en) Benzothiazole compounds and their pharmaceutical use

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180323

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190806

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190806

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20190822